RU2487873C2 - 5-замещенные индазолы в качестве ингибиторов киназы - Google Patents

5-замещенные индазолы в качестве ингибиторов киназы Download PDF

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Publication number
RU2487873C2
RU2487873C2 RU2009149696/04A RU2009149696A RU2487873C2 RU 2487873 C2 RU2487873 C2 RU 2487873C2 RU 2009149696/04 A RU2009149696/04 A RU 2009149696/04A RU 2009149696 A RU2009149696 A RU 2009149696A RU 2487873 C2 RU2487873 C2 RU 2487873C2
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RU
Russia
Prior art keywords
indazol
triazol
carboxamide
benzyl
indazole
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RU2009149696/04A
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English (en)
Russian (ru)
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RU2009149696A (ru
Inventor
Ирини АКРИТОПОУЛОУ-ЗАНЗЕ
Брайан Д. УЭЙКФИЛД
Хельмут Мак
Шон К. ТЕРНЕР
Алан Ф. ГАСИКИ
Виджая Дж. ГРАСИАС
Кэти Саррис
Дуглас М. КАЛВИН
Мелисса Дж. МИЧМЕРХУЗЕН
Ци ШУАЙ
Джиоти Р. ПАТЕЛ
Маргарета БАККЕР
Николь ТОЙШ
Эрик Ф. ДЖОНСОН
Питер Дж. КОВАР
Стивен В. ДЬЮРИК
Эндрю Дж. ЛОНГ
Анил ВАСУДЕВАН
Адриан ХОБСОН
ДЖОН МУР Найджел СТ.
Лу ВАН
Дон ДЖОРЖ
Бицинь ЛИ
Кристин ФРАНК
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Эбботт Лэборетриз
Эбботт Гмбх Унд Ко. Кг
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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C—CHEMISTRY; METALLURGY
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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Reproductive Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Psychology (AREA)
  • Communicable Diseases (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
RU2009149696/04A 2007-06-08 2008-06-04 5-замещенные индазолы в качестве ингибиторов киназы RU2487873C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US93396007P 2007-06-08 2007-06-08
US60/933,960 2007-06-08
PCT/US2008/065727 WO2008154241A1 (fr) 2007-06-08 2008-06-04 Indazoles à substitution 5-hétéroaryle servant d'inhibiteurs de kinases

Publications (2)

Publication Number Publication Date
RU2009149696A RU2009149696A (ru) 2011-07-20
RU2487873C2 true RU2487873C2 (ru) 2013-07-20

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RU2009149696/04A RU2487873C2 (ru) 2007-06-08 2008-06-04 5-замещенные индазолы в качестве ингибиторов киназы

Country Status (13)

Country Link
EP (1) EP2167491A1 (fr)
JP (2) JP5451602B2 (fr)
KR (1) KR20100032886A (fr)
CN (1) CN101790526A (fr)
AU (1) AU2008262038A1 (fr)
BR (1) BRPI0811065A2 (fr)
CA (1) CA2689117A1 (fr)
IL (1) IL202318A0 (fr)
MX (1) MX2009013213A (fr)
RU (1) RU2487873C2 (fr)
SG (1) SG182187A1 (fr)
WO (1) WO2008154241A1 (fr)
ZA (1) ZA200908624B (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2725979C2 (ru) * 2014-06-25 2020-07-08 Ф. Хоффманн-Ля Рош Аг ИМИДАЗО[1,2-а]ПИРАЗИН-1-ИЛ-БЕНЗАМИДЫ ДЛЯ ЛЕЧЕНИЯ СПИНАЛЬНОЙ МЫШЕЧНОЙ АТРОФИИ
US10899742B1 (en) 2016-12-01 2021-01-26 Arvinas Operations, Inc. Tetrahydronaphthalene and tetrahydroisoquinoline derivatives as estrogen receptor degraders

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US8546404B2 (en) 2005-12-13 2013-10-01 Merck Sharp & Dohme Compounds that are ERK inhibitors
EP1984331B1 (fr) 2006-02-16 2010-10-20 Schering Corporation Dérivés de pyrrolidine comme inhibiteurs de la erk
US8648069B2 (en) * 2007-06-08 2014-02-11 Abbvie Inc. 5-substituted indazoles as kinase inhibitors
US20110301155A1 (en) * 2007-06-19 2011-12-08 Tsuneo Yasuma Indazole compounds for activating glucokinase
EP2173728A2 (fr) 2007-07-17 2010-04-14 Amgen Inc. Modulateurs hétérocycliques de pkb
CA2693473A1 (fr) 2007-07-17 2009-01-22 Amgen Inc. Thiadiazoles modulateurs de l'activite de pkb
KR20100046275A (ko) * 2007-08-30 2010-05-06 다케다 야쿠힌 고교 가부시키가이샤 치환 피라졸 유도체
US8716483B2 (en) 2008-02-21 2014-05-06 Merck Sharp & Dohme Corp. Compounds that are ERK inhibitors
CL2009001158A1 (es) * 2008-05-15 2009-10-23 Nerviano Medical Sciences Srl Compuestos derivados de los acidos carboxilicos, tales como 5,6-dihiro-4h-pirrolo[3,4-c]pirazol, furo[3,2-c]pirazol, tieno[2,3-c]pirazol, 4,5,6,7-tetrahidropirazol[4,3-c]piridina e indazol; composicion farmaceutica; y su uso en el tratamiento de trastornos proliferativos celulares asociados a la actividad de proteina quinasa alterada, tal como el cancer.
WO2010059658A1 (fr) * 2008-11-20 2010-05-27 Glaxosmithkline Llc Composés chimiques
HUE028259T2 (en) 2009-08-10 2016-12-28 Samumed Llc Inhibitors of Wnt signaling signal indazole and their therapeutic use
JP5822844B2 (ja) 2009-12-21 2015-11-24 サミュメッド リミテッド ライアビリティ カンパニー １Ｈ−ピラゾロ［３，４−ｂ］ピリジンおよびその治療的使用
UY33213A (es) * 2010-02-18 2011-09-30 Almirall Sa Derivados de pirazol como inhibidores de jak
KR101233082B1 (ko) 2010-02-25 2013-02-14 주식회사 이큐스앤자루 신규한 이미다졸피라진 유도체 화합물 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 항바이러스 치료용 약학적 조성물
EP2542549B1 (fr) 2010-03-03 2016-05-11 Probiodrug AG Inhibiteurs de glutaminyl cyclase
TW201144310A (en) * 2010-04-28 2011-12-16 Daiichi Sankyo Co Ltd [5,6] heterocyclic compound
EP2566333A4 (fr) * 2010-05-07 2014-04-02 Univ Leland Stanford Junior Identification de stabilisants de protéines multimériques
ES2592713T3 (es) 2010-12-20 2016-12-01 Merck Serono S.A. Derivados de indazolil-triazol como inhibidores de IRAK
WO2012087833A1 (fr) 2010-12-22 2012-06-28 Abbott Laboratories Inhibiteurs de l'hépatite c et leurs utilisations
US9090592B2 (en) * 2010-12-30 2015-07-28 AbbVie Deutschland GmbH & Co. KG Heterocyclic compounds and their use as glycogen synthase kinase-3 inhibitors
CN102675286B (zh) * 2011-03-07 2015-08-19 中国科学院上海药物研究所 一类吲唑类化合物及其制备方法、用途和药物组合物
HUE026323T2 (en) * 2011-04-07 2016-05-30 Bayer Ip Gmbh Imidazopyridazines as AKT kinase inhibitors
KR20140071361A (ko) * 2011-08-12 2014-06-11 에프. 호프만-라 로슈 아게 피라졸로[3,4-c]피리딘 화합물 및 사용 방법
IN2014CN02646A (fr) 2011-09-14 2015-08-07 Samumed Llc
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