RU2473549C2 - Пиримидиновые соединения, композиции и способы применения - Google Patents

Пиримидиновые соединения, композиции и способы применения Download PDF

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Publication number
RU2473549C2
RU2473549C2 RU2011107278/04A RU2011107278A RU2473549C2 RU 2473549 C2 RU2473549 C2 RU 2473549C2 RU 2011107278/04 A RU2011107278/04 A RU 2011107278/04A RU 2011107278 A RU2011107278 A RU 2011107278A RU 2473549 C2 RU2473549 C2 RU 2473549C2
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Prior art keywords
pyrimidin
phenyl
tetrahydropyrido
methylmorpholino
urea
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RU2011107278/04A
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English (en)
Russian (ru)
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RU2011107278A (ru
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Филипп Бергерон
Фредерик Коэн
Энтони ЭСТРАДА
Майкл Ф. Т. КОУЛЕР
Кевин Хон Луен ЛО
Куонг ЛИ
Джозеф П. ЛИССИКАТОС
Дэниел Фред ОРТВАЙН
Чжунхуа ПЭЙ
Сянжуй ЧЖАО
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Дженентек, Инк.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2011107278/04A 2008-07-31 2009-07-31 Пиримидиновые соединения, композиции и способы применения RU2473549C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8530908P 2008-07-31 2008-07-31
US61/085,309 2008-07-31
PCT/US2009/052469 WO2010014939A1 (en) 2008-07-31 2009-07-31 Pyrimidine compounds, compositions and methods of use

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RU2011107278A RU2011107278A (ru) 2012-09-10
RU2473549C2 true RU2473549C2 (ru) 2013-01-27

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EP (1) EP2318377B1 (https=)
JP (1) JP2011529920A (https=)
KR (1) KR20110046514A (https=)
CN (1) CN102171194A (https=)
AR (1) AR073354A1 (https=)
AU (1) AU2009276339B2 (https=)
BR (1) BRPI0911688A2 (https=)
CA (1) CA2729045A1 (https=)
CL (1) CL2011000191A1 (https=)
CO (1) CO6311051A2 (https=)
EC (1) ECSP11010796A (https=)
ES (1) ES2432821T3 (https=)
IL (1) IL210462A0 (https=)
MA (1) MA32580B1 (https=)
MX (1) MX2011001196A (https=)
NZ (1) NZ590777A (https=)
PE (1) PE20110403A1 (https=)
RU (1) RU2473549C2 (https=)
TW (1) TW201018681A (https=)
UA (1) UA101676C2 (https=)
WO (1) WO2010014939A1 (https=)
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RU2649141C2 (ru) * 2015-04-20 2018-03-30 государственное бюджетное образовательное учреждение высшего профессионального образования "Пермская государственная фармацевтическая академия" Министерства здравоохранения Российской Федерации (ГБОУ ВПО ПГФА Минздрава России) 3,4-диметил-6-(3-пиридил)-N-фенил-2-оксо-1,2,3,6-тетрагидропиримидин-5-карбоксамид, проявляющий противогрибковое действие в отношении штамма Candida albicans
RU2771201C2 (ru) * 2017-11-06 2022-04-28 Медшайн Дискавери Инк. ПИРИДОПИРИМИДИНОВЫЕ СОЕДИНЕНИЯ, ВЫПОЛНЯЮЩИЕ ФУНКЦИЮ ДВОЙНЫХ ИНГИБИТОРОВ mTORC 1/2
RU2811969C2 (ru) * 2018-04-24 2024-01-19 Мерк Патент Гмбх Антипролиферативные соединения и их применения
US12195453B2 (en) 2018-04-24 2025-01-14 Merck Patent Gmbh Antiproliferation compounds and uses thereof

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