RU2470936C2 - Соединения-ингибиторы фосфоинозитид 3-киназы и способы применения - Google Patents

Соединения-ингибиторы фосфоинозитид 3-киназы и способы применения Download PDF

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RU2470936C2
RU2470936C2 RU2009125916/04A RU2009125916A RU2470936C2 RU 2470936 C2 RU2470936 C2 RU 2470936C2 RU 2009125916/04 A RU2009125916/04 A RU 2009125916/04A RU 2009125916 A RU2009125916 A RU 2009125916A RU 2470936 C2 RU2470936 C2 RU 2470936C2
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Prior art keywords
pyrimidin
morpholinothieno
methyl
aminopyrimidin
amine
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RU2009125916/04A
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English (en)
Russian (ru)
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RU2009125916A (ru
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Жоржетт КАСТАНЕДО
Дженнафер ДОТСОН
Ричард ГОЛДСМИТ
Дженет ГАНЗНЕР
Тим ХЕФФРОН
Симон МАТЬЕ
Алан ОЛИВЕРО
Стивен СТЭЙБЕН
Даниел П. САТЕРЛИН
Вики ЦЗУИ
Шумэй Ван
Бин-Янь ЧЖУ
Трейси БЕЙЛИСС
Ирина ЧУКАУРИ
Адриан ФОУЛКС
Нань Чи ВАНЬ
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Дженентек, Инк.
Ф. Хоффманн-Ля Рош Аг
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Application filed by Дженентек, Инк., Ф. Хоффманн-Ля Рош Аг filed Critical Дженентек, Инк.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
RU2009125916/04A 2006-12-07 2007-12-05 Соединения-ингибиторы фосфоинозитид 3-киназы и способы применения RU2470936C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87342206P 2006-12-07 2006-12-07
US60/873,422 2006-12-07
PCT/US2007/086533 WO2008073785A2 (en) 2006-12-07 2007-12-05 Phosphoinositide 3-kinase inhibitor compounds and methods of use

Publications (2)

Publication Number Publication Date
RU2009125916A RU2009125916A (ru) 2011-01-20
RU2470936C2 true RU2470936C2 (ru) 2012-12-27

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RU2009125916/04A RU2470936C2 (ru) 2006-12-07 2007-12-05 Соединения-ингибиторы фосфоинозитид 3-киназы и способы применения

Country Status (19)

Country Link
US (1) US9487533B2 (enExample)
EP (1) EP2114950B1 (enExample)
JP (1) JP5500990B2 (enExample)
KR (1) KR101507182B1 (enExample)
CN (1) CN101675053B (enExample)
AR (1) AR064154A1 (enExample)
AU (1) AU2007333243B2 (enExample)
BR (1) BRPI0717907A2 (enExample)
CA (1) CA2671845C (enExample)
CL (1) CL2007003523A1 (enExample)
ES (1) ES2571028T3 (enExample)
IL (1) IL199151A (enExample)
MX (1) MX2009005925A (enExample)
NO (1) NO342697B1 (enExample)
PE (1) PE20081353A1 (enExample)
RU (1) RU2470936C2 (enExample)
TW (1) TW200829594A (enExample)
WO (1) WO2008073785A2 (enExample)
ZA (1) ZA200904531B (enExample)

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