RU2453548C2 - Азаиндолы, полезные в качестве ингибиторов янус-киназ - Google Patents

Азаиндолы, полезные в качестве ингибиторов янус-киназ Download PDF

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Publication number
RU2453548C2
RU2453548C2 RU2008133613/04A RU2008133613A RU2453548C2 RU 2453548 C2 RU2453548 C2 RU 2453548C2 RU 2008133613/04 A RU2008133613/04 A RU 2008133613/04A RU 2008133613 A RU2008133613 A RU 2008133613A RU 2453548 C2 RU2453548 C2 RU 2453548C2
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Russia
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compound
dmso
compound according
ring
optionally substituted
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RU2008133613/04A
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English (en)
Russian (ru)
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RU2008133613A (ru
Inventor
Люк ФАРМЕР (US)
Люк Фармер
Габриэль МАРТИНЕС-БОТЕЛЛА (US)
Габриэль МАРТИНЕС-БОТЕЛЛА
Альберт ПИРС (US)
Альберт ПИРС
Франческо САЛИТУРО (US)
Франческо САЛИТУРО
Цзянь ВАН (US)
Цзянь ВАН
Мэрион ВАННАМКЕР (US)
Мэрион ВАННАМКЕР
Тяньшэн ВАН (US)
Тяньшэн Ван
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Вертекс Фармасьютикалз Инкорпорейтед
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
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    • C07D495/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/10—Protein-tyrosine kinases (2.7.10)
    • C12Y207/10002—Non-specific protein-tyrosine kinase (2.7.10.2), i.e. spleen tyrosine kinase

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Psychology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Oncology (AREA)
RU2008133613/04A 2006-01-17 2007-01-17 Азаиндолы, полезные в качестве ингибиторов янус-киназ RU2453548C2 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US75936706P 2006-01-17 2006-01-17
US60/759,367 2006-01-17
US84247106P 2006-09-06 2006-09-06
US60/842,471 2006-09-06

Related Child Applications (1)

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RU2011151085/02A Division RU2011151085A (ru) 2006-01-17 2011-12-14 Азаиндолы, полезные в качестве ингибиторов янус-киназ

Publications (2)

Publication Number Publication Date
RU2008133613A RU2008133613A (ru) 2010-02-27
RU2453548C2 true RU2453548C2 (ru) 2012-06-20

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ID=38197739

Family Applications (2)

Application Number Title Priority Date Filing Date
RU2008133613/04A RU2453548C2 (ru) 2006-01-17 2007-01-17 Азаиндолы, полезные в качестве ингибиторов янус-киназ
RU2011151085/02A RU2011151085A (ru) 2006-01-17 2011-12-14 Азаиндолы, полезные в качестве ингибиторов янус-киназ

Family Applications After (1)

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RU2011151085/02A RU2011151085A (ru) 2006-01-17 2011-12-14 Азаиндолы, полезные в качестве ингибиторов янус-киназ

Country Status (19)

Country Link
US (6) US7767816B2 (xx)
EP (3) EP2537849A3 (xx)
JP (4) JP5591471B2 (xx)
KR (3) KR101409727B1 (xx)
CN (3) CN102532133A (xx)
AR (1) AR060316A1 (xx)
AU (1) AU2007207533B8 (xx)
BR (2) BRPI0706537A2 (xx)
CA (1) CA2636189A1 (xx)
CL (1) CL2008002140A1 (xx)
HK (1) HK1210780A1 (xx)
IL (1) IL191902A0 (xx)
NO (1) NO20083501L (xx)
NZ (3) NZ601687A (xx)
RU (2) RU2453548C2 (xx)
TW (4) TW201412738A (xx)
UA (1) UA95940C2 (xx)
WO (1) WO2007084557A2 (xx)
ZA (2) ZA200805053B (xx)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2669922C2 (ru) * 2013-03-19 2018-10-17 Мерк Шарп И Доум Корп. N-(2-цианогетероциклил)пиразолопиридоны в качестве ингибиторов янус-киназы

Families Citing this family (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1730146E (pt) * 2004-03-30 2011-07-11 Vertex Pharma Azaindoles úteis como inibidores de jak e outras proteínas quinases
EP2354140A1 (en) * 2005-05-20 2011-08-10 Vertex Pharmaceuticals Incorporated Pyrrolopyridines useful as inhibitors of protein kinase
CA2621261C (en) 2005-09-22 2014-05-20 Incyte Corporation Azepine inhibitors of janus kinases
UA116187C2 (uk) 2005-12-13 2018-02-26 Інсайт Холдінгс Корпорейшн ГЕТЕРОАРИЛЗАМІЩЕНІ ПІРОЛО[2,3-b]ПІРИДИНИ Й ПІРОЛО[2,3-b]ПІРИМІДИНИ ЯК ІНГІБІТОРИ ЯНУС-КІНАЗИ
UA95940C2 (xx) 2006-01-17 2011-09-26 Вертекс Фармасьютикалс Інкорпорейтед Азаіндоли як інгібітори кіназ януса$азаиндолы как ингибиторы киназ януса
AU2007235487A1 (en) * 2006-04-05 2007-10-18 Vertex Pharmaceuticals Incorporated Deazapurines useful as inhibitors of janus kinases
US7754838B2 (en) * 2006-08-08 2010-07-13 E.I. Du Pont De Nemours And Company Poly(meth)acrylamides and poly(meth)acrylates containing fluorinated amide
US8247421B2 (en) 2006-12-21 2012-08-21 Vertex Pharmaceuticals Incorporated 5-cyano-4-(pyrrolo [2,3B] pyridine-3-yl)-pyrimidine derivatives useful as protein kinase inhibitors
US8513270B2 (en) 2006-12-22 2013-08-20 Incyte Corporation Substituted heterocycles as Janus kinase inhibitors
AU2008228768A1 (en) * 2007-03-22 2008-09-25 Vertex Pharmaceuticals Incorporated N-heterocyclic compounds useful as inhibitors of Janus Kinases
CL2008001709A1 (es) 2007-06-13 2008-11-03 Incyte Corp Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras.
ES2714092T3 (es) 2007-06-13 2019-05-27 Incyte Holdings Corp Uso de sales del inhibidor de quinasas Janus (R)-3-(4-(7H-pirrolo[2,3-d]pirimidin-4-il)-1H-pirazol-1-il)-3-ciclopentilpropanonitrilo
WO2009145814A2 (en) * 2008-03-10 2009-12-03 Vertex Pharmaceuticals Incorporated Pyrimidines and pyridines useful as inhibitors of protein kinases
PT2288610T (pt) 2008-03-11 2016-10-17 Incyte Holdings Corp Derivados de azetidina e de ciclobutano como inibidores de jak
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TWI405761B (zh) 2013-08-21
AU2007207533B2 (en) 2012-05-31
EP2559694A2 (en) 2013-02-20
NO20083501L (no) 2008-10-14
TW201412738A (zh) 2014-04-01
TW200806664A (en) 2008-02-01
CL2008002140A1 (es) 2009-03-06
CN102532134A (zh) 2012-07-04
TWI424999B (zh) 2014-02-01
US20130237516A1 (en) 2013-09-12
JP2009525962A (ja) 2009-07-16
WO2007084557A3 (en) 2007-09-27
EP1973911A2 (en) 2008-10-01
KR20130041313A (ko) 2013-04-24
EP2537849A3 (en) 2013-04-03
NZ569899A (en) 2011-06-30
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US7767816B2 (en) 2010-08-03
AU2007207533B8 (en) 2012-06-28
US20140336171A1 (en) 2014-11-13
KR101409727B1 (ko) 2014-06-20
RU2008133613A (ru) 2010-02-27
EP1973911B1 (en) 2016-01-13
NZ601687A (en) 2014-03-28
KR20080085174A (ko) 2008-09-23
US8450489B2 (en) 2013-05-28
RU2011151085A (ru) 2013-06-20
EP2537849A2 (en) 2012-12-26

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