RU2391672C2 - Устройство для количественного анализа профиля метаболитов - Google Patents

Устройство для количественного анализа профиля метаболитов Download PDF

Info

Publication number
RU2391672C2
RU2391672C2 RU2008102835/14A RU2008102835A RU2391672C2 RU 2391672 C2 RU2391672 C2 RU 2391672C2 RU 2008102835/14 A RU2008102835/14 A RU 2008102835/14A RU 2008102835 A RU2008102835 A RU 2008102835A RU 2391672 C2 RU2391672 C2 RU 2391672C2
Authority
RU
Russia
Prior art keywords
metabolites
analysis
drugs
internal standard
biological sample
Prior art date
Application number
RU2008102835/14A
Other languages
English (en)
Russian (ru)
Other versions
RU2008102835A (ru
Inventor
Стивен Луис РАМСЕЙ (AT)
Стивен Луис РАМСЕЙ
Вольфганг ГУГГЕНБИХЛЕР (AT)
Вольфганг ГУГГЕНБИХЛЕР
Клаус Михаэль ВАЙНБЕРГЕР (AT)
Клаус Михаэль ВАЙНБЕРГЕР
Армин ГРАБЕР (AT)
Армин ГРАБЕР
Вольфганг Маркус ШТЁГГЛЬ (AT)
Вольфганг Маркус ШТЁГГЛЬ
Original Assignee
Байокрейтс Лайф Сайенсиз Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Байокрейтс Лайф Сайенсиз Аг filed Critical Байокрейтс Лайф Сайенсиз Аг
Publication of RU2008102835A publication Critical patent/RU2008102835A/ru
Application granted granted Critical
Publication of RU2391672C2 publication Critical patent/RU2391672C2/ru

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5038—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving detection of metabolites per se
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00594—Quality control, including calibration or testing of components of the analyser
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B50/00—ICT programming tools or database systems specially adapted for bioinformatics
    • G16B50/30—Data warehousing; Computing architectures
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2570/00—Omics, e.g. proteomics, glycomics or lipidomics; Methods of analysis focusing on the entire complement of classes of biological molecules or subsets thereof, i.e. focusing on proteomes, glycomes or lipidomes
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B50/00—ICT programming tools or database systems specially adapted for bioinformatics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Biophysics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioethics (AREA)
  • Databases & Information Systems (AREA)
  • Evolutionary Biology (AREA)
  • Medical Informatics (AREA)
  • Toxicology (AREA)
  • Quality & Reliability (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
RU2008102835/14A 2005-06-30 2006-06-29 Устройство для количественного анализа профиля метаболитов RU2391672C2 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US69498405P 2005-06-30 2005-06-30
US69498305P 2005-06-30 2005-06-30
US60/694,983 2005-06-30
US60/694,984 2005-06-30

Publications (2)

Publication Number Publication Date
RU2008102835A RU2008102835A (ru) 2009-08-10
RU2391672C2 true RU2391672C2 (ru) 2010-06-10

Family

ID=36783737

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2008102835/14A RU2391672C2 (ru) 2005-06-30 2006-06-29 Устройство для количественного анализа профиля метаболитов

Country Status (16)

Country Link
US (2) US8265877B2 (https=)
EP (2) EP1897014B1 (https=)
JP (2) JP5155160B2 (https=)
KR (1) KR100967573B1 (https=)
CN (1) CN100594501C (https=)
AU (1) AU2006265381B2 (https=)
BR (1) BRPI0613478B8 (https=)
CA (2) CA2608963C (https=)
DK (2) DK1875401T3 (https=)
ES (1) ES2452025T3 (https=)
IL (1) IL187470A (https=)
IN (1) IN2014DN02241A (https=)
NO (1) NO339319B1 (https=)
NZ (1) NZ563431A (https=)
RU (1) RU2391672C2 (https=)
WO (2) WO2007003343A1 (https=)

Families Citing this family (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995030763A2 (en) 1994-05-09 1995-11-16 Chiron Viagene, Inc. Retroviral vectors having a reduced recombination rate
US8969089B2 (en) 2004-10-12 2015-03-03 Quest Diagnostics Investments, Inc. Analysis of amino acids in body fluid by liquid chromatography-mass spectrometry
DK1875401T3 (da) * 2005-06-30 2014-04-07 Biocrates Life Sciences Ag Indretning til kvantitativ analyse af en metabolitprofil
CA2651227C (en) * 2006-05-05 2016-03-01 Perkinelmer Las, Inc. Quantitative analysis of surface-derived samples using mass spectrometry
EP1923806A1 (en) * 2006-11-14 2008-05-21 Metanomics GmbH Fast metabolomic analysis and system therefor
US7999084B2 (en) * 2007-05-16 2011-08-16 Agilent Technologies, Inc. Devices and methods for reducing matrix effects
AU2008256444A1 (en) * 2007-05-31 2008-12-04 Biocrates Life Sciences Ag Inflammation and oxidative stress level assay
DK2164980T3 (da) * 2007-05-31 2013-10-21 Biocrates Life Sciences Ag Biomarkør og fremgangsmåde til fastlæggelse af et oxidativt stressniveau
CN101796408B (zh) * 2007-06-29 2014-05-07 奎斯特诊断投资公司 用液相层析-质谱法分析体液内的氨基酸
US12367163B2 (en) 2007-06-29 2025-07-22 Quest Diagnostics Investments Llc Analysis of amino acids in body fluid by liquid chromatography—mass spectrometry
JP5306345B2 (ja) * 2007-07-26 2013-10-02 フェノメノーム ディスカバリーズ インク 自閉症スペクトラム障害の診断、リスク評価、及びモニタリングを行うための方法
DE102007043614B3 (de) * 2007-09-13 2008-11-20 Biocrates Life Sciences Gmbh Halterung für ein Trägermittel zum Einsetzen in eine zylinderförmige Öffnung
WO2009043149A1 (en) * 2007-10-01 2009-04-09 Mds Analytical Technologies, A Business Unit Of Mds Inc., Doing Business Through Its Sciex Division Analysis of conjugated metabolites of alcohol consumption
JP2011504596A (ja) * 2007-11-26 2011-02-10 ウオーターズ・テクノロジーズ・コーポレイシヨン サンプル中の分析物を定量測定する際に使用するための内部標準および方法
EP2297771A2 (en) * 2008-06-13 2011-03-23 Smiths Detection-Montreal Inc. Analytical instrument
GB2463401B (en) 2008-11-12 2014-01-29 Caris Life Sciences Luxembourg Holdings S A R L Characterizing prostate disorders by analysis of microvesicles
WO2011109440A1 (en) 2010-03-01 2011-09-09 Caris Life Sciences Luxembourg Holdings Biomarkers for theranostics
EP2192196A1 (en) 2008-11-27 2010-06-02 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Prediction of lipid-metabotype-related physiological susceptibilities
DE112010000967T5 (de) 2009-03-05 2012-08-16 Hitachi High-Technologies Corp. Analysator
EP2425448B1 (en) * 2009-04-30 2019-12-04 Purdue Research Foundation Ion generation using wetted porous material
US9500572B2 (en) 2009-04-30 2016-11-22 Purdue Research Foundation Sample dispenser including an internal standard and methods of use thereof
ES2799327T3 (es) 2009-05-05 2020-12-16 Infandx Ag Método para diagnosticar asfixia
CA2763948C (en) 2009-06-02 2019-03-12 Biocrates Life Sciences Ag Combination of amino acids, acylcarnitines and biogenic amines for the assessment of chronic kidney disease
CA2782284A1 (en) 2009-11-30 2011-06-03 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Methods and systems for isolating, storing, and analyzing vesicles
US20140148348A1 (en) 2010-01-13 2014-05-29 Christine Kuslich Dectection of gastrointestinal disorders
WO2011127219A1 (en) 2010-04-06 2011-10-13 Caris Life Sciences Luxembourg Holdings Circulating biomarkers for disease
DE202011111050U1 (de) * 2010-10-29 2018-11-20 Thermo Fisher Scientific Oy Automatisiertes System zur Probenaufbereitung und -analyse
SG190048A1 (en) * 2010-10-29 2013-06-28 Atonarp Inc Analysis apparatus
EP2492690A1 (en) * 2011-02-22 2012-08-29 BIOCRATES Life Sciences AG Method and use of metabolites for the diagnosis of inflammatory brain injury in preterm born infants
EP2587264A1 (en) 2011-10-25 2013-05-01 InfanDx AG Method and use of metabolites for the diagnosis and differentiation of neonatal encephalopathy
WO2013078222A1 (en) 2011-11-23 2013-05-30 Quest Diagnostics Investments Incorporated Kisspeptin-54 detection by tandem mass spectrometry
JP6198408B2 (ja) * 2012-04-02 2017-09-20 株式会社日立ハイテクノロジーズ サンプル液に含まれる揮発性物質の分析方法
US8870028B2 (en) 2012-05-25 2014-10-28 Restek Corporation Dispensing device
US9546994B2 (en) * 2012-08-13 2017-01-17 Helmholtz Zentrum Munchen-Deutsches Forschungszentrum fur Geseundheit und Umwelt (GmbH) Biomarkers for type 2 diabetes
EP2917738A1 (de) 2012-11-12 2015-09-16 BIOCRATES Life Sciences AG Verwendung von qualitätsindikatoren zum nachweis von auftauprozessen in gefrorenen gewebeproben
WO2014110196A1 (en) * 2013-01-10 2014-07-17 Restek Corporation Dispensing device and method
BR112015018484A2 (pt) 2013-01-31 2017-07-18 Purdue Research Foundation métodos de analisar o petróleo bruto
CN104956462B (zh) 2013-01-31 2017-10-10 普度研究基金会 用于分析所提取样本的系统和方法
EP3014647B1 (en) 2013-06-25 2018-12-19 Purdue Research Foundation Mass spectrometry analysis of microorganisms in samples
CN103558354B (zh) 2013-11-15 2015-07-15 南京大学 一种基于生物组学整合技术的水体毒性分析方法
JP2017101924A (ja) * 2014-03-31 2017-06-08 積水メディカル株式会社 内部標準物質試薬
CN104200087B (zh) * 2014-06-05 2018-10-02 清华大学 用于机器学习的参数寻优及特征调优的方法及系统
US9786478B2 (en) 2014-12-05 2017-10-10 Purdue Research Foundation Zero voltage mass spectrometry probes and systems
EP3254297B1 (en) 2015-02-06 2024-04-03 Purdue Research Foundation Probes, systems, and cartridges
EP3171173A1 (en) 2015-11-19 2017-05-24 Medizinische Universität Innsbruck Method of diagnosis of a thoracic aortic aneurysm
EP3397972A2 (en) * 2015-12-31 2018-11-07 Universal Diagnostics, S.L. Systems and methods for automated, customizable sample preparation tool, software script, and calibration routine for detection of metabolites and lipids
DE102017112612A1 (de) * 2016-06-10 2017-12-14 Hitachi High-Tech Science Corporation Flüssigkeitschromatograph und Verfahren zum Korrigieren von Schwankungen eines Detektorausgabewerts des Flüssigkeitschromatographen
US10607723B2 (en) 2016-07-05 2020-03-31 University Of Kentucky Research Foundation Method and system for identification of metabolites using mass spectra
US11719702B2 (en) * 2016-11-07 2023-08-08 Battelle Memorial Institute Methods and systems of proteome analysis and imaging
EP3535418B1 (en) * 2016-11-07 2021-12-15 Battelle Memorial Institute Nanoscale biochemical sample preparation and analysis
EP3351938A1 (en) 2017-01-18 2018-07-25 BIOCRATES Life Sciences AG New biomarkers for assessing ovarian cancer
EP3376230A1 (en) 2017-03-13 2018-09-19 Biocross, S.L. Identification of signatures for neurodegeneration diseases diagnoses
WO2018174876A1 (en) * 2017-03-22 2018-09-27 Mprobe Inc. Methods and compositions for providing a preeclampsia assessment with metabolites
CN107727850B (zh) * 2017-10-10 2021-08-27 常州博闻迪医药股份有限公司 一种侧向流层析检测反应启动控制方法
EP3624691B1 (en) * 2017-05-17 2025-08-06 Radiometer Medical ApS Porous optical fiber for the detection of an analyte in a fluid
CN107561150A (zh) * 2017-07-03 2018-01-09 宁波华仪宁创智能科技有限公司 吸毒的检测方法
CN107798981A (zh) * 2017-10-31 2018-03-13 楚雄医药高等专科学校 一种永久性教学用微囊标本片及其制作方法
CN109030673A (zh) * 2018-07-04 2018-12-18 易达精准（杭州）科技有限公司 干血片中免疫抑制剂的检测方法以及检测试剂盒
CN109298115B (zh) * 2018-10-19 2020-07-28 深圳市绘云生物科技有限公司 生物样品中多种代谢物定量检测方法及代谢芯片
WO2020099683A1 (en) 2018-11-16 2020-05-22 Biocrates Life Sciences Ag Metabolites for use in ovarian cancer detection and diagnosis
FR3091351B1 (fr) 2018-12-27 2021-05-21 Univ Rouen Centre Hospitalier Biomarqueur de la maladie de fabry
KR102035162B1 (ko) * 2019-03-12 2019-11-08 한국과학기술원 질병 표적 대사 효소에 특이적인 인체 대사 물질을 이용하여 질병에 대한 약물 후보를 예측하는 방법
WO2020236921A1 (en) 2019-05-20 2020-11-26 Battelle Energy Alliance, Llc Spark plasma sintering methods for fabricating dense graphite
GB201916046D0 (en) * 2019-11-04 2019-12-18 Amazentis Sa Diagnostic method
CN111579665B (zh) * 2020-05-20 2021-11-05 苏州帕诺米克生物医药科技有限公司 一种基于uplc/hrms的代谢组学相对定量分析方法
US20230204544A1 (en) * 2020-05-21 2023-06-29 Mayo Foundation For Medical Education And Research Calibration methods for mass spectrometry measurements
CN111704654B (zh) * 2020-06-18 2021-12-03 上海交通大学医学院附属仁济医院 肽类化合物及其制备方法与应用
US20250224410A1 (en) * 2021-10-21 2025-07-10 Pinpoint Testing, Llc Ready-to-constitute analytical platforms for chemical analyses and quantification of analytes in biological samples
US12100484B2 (en) 2021-11-01 2024-09-24 Matterworks Inc Methods and compositions for analyte quantification
US11754536B2 (en) 2021-11-01 2023-09-12 Matterworks Inc Methods and compositions for analyte quantification
JP7206365B1 (ja) * 2021-12-22 2023-01-17 浜松ホトニクス株式会社 試料支持体
CN117686624A (zh) * 2022-09-02 2024-03-12 首都医科大学附属北京朝阳医院 一种同时测定血清中28种氨基酸、肉毒碱、溶血卵磷脂和神经酰胺的方法
KR102547430B1 (ko) * 2022-11-16 2023-06-23 (주)애터미오롯 노니 함유 조성물의 정성 분석 방법
AU2023391474A1 (en) * 2022-12-05 2025-06-19 Washington University Improved method for scalable untargeted metabolomic workflow
GB2636339A (en) 2023-08-30 2025-06-18 Cambridge Entpr Ltd Biomarkers for bipolar disorder
CN117538530B (zh) * 2023-11-07 2024-07-19 中国医学科学院肿瘤医院 一种检测转移性乳腺癌的生物标志组合物和试剂盒及其应用
GB202413717D0 (en) 2024-09-17 2024-10-30 Quadram Inst Bioscience Exopolysaccharide compositions and use thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2017155C1 (ru) * 1993-05-05 1994-07-30 Геннадий Степанович Власов Диагностическое устройство для иммунохимического анализа

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5756362A (en) 1993-10-12 1998-05-26 Cornell Research Foundation, Inc. Liposome-enhanced immunoaggregation assay and test device
US6358752B1 (en) 1996-09-27 2002-03-19 Cornell Research Foundation, Inc. Liposome-enhanced test device and method
GB9718129D0 (en) * 1997-08-27 1997-10-29 Isis Innovation Branched structures
US6258605B1 (en) 1999-03-26 2001-07-10 Neo Gen Screening, Inc. Clinical method for the genetic screening of newborns using tandem mass spectrometry
US6455321B1 (en) * 1999-01-30 2002-09-24 Neo Gen Screening, Inc. Method for interpreting tandem mass spectrometry data for clinical diagnosis
US20020009394A1 (en) 1999-04-02 2002-01-24 Hubert Koster Automated process line
DE60031357T2 (de) * 1999-12-29 2007-08-30 PerkinElmer Life Sciences, Inc., Norton Geräte, Kits und Verfahren zum Testen von Körperflüssigkeiten zum Screening vonNeugeborenen durch Tandem-Massenspektrometrie-Kits
US20020009740A1 (en) * 2000-04-14 2002-01-24 Rima Kaddurah-Daouk Methods for drug discovery, disease treatment, and diagnosis using metabolomics
US6680203B2 (en) * 2000-07-10 2004-01-20 Esperion Therapeutics, Inc. Fourier transform mass spectrometry of complex biological samples
EP1313543A4 (en) * 2000-07-18 2004-06-30 Invitrogen Corp DEVICE AND METHODS FOR SUBDIVISION AND FILTRATION OF GEL MATERIAL AND FOR EXTRACTION OF MOLECULES THEREOF
US6627444B1 (en) 2000-08-07 2003-09-30 Smiths Detection - Toronto Ltd. Method and solid phase calibration sample for calibration of analytical instructions
US20020155587A1 (en) 2001-04-20 2002-10-24 Sequenom, Inc. System and method for testing a biological sample
EP1417629B1 (en) 2001-07-06 2008-02-20 Lipomics Technologies, Inc. Generating, viewing, interpreting, and utilizing a quantitative database of metabolites
ATE508361T1 (de) * 2001-08-14 2011-05-15 Harvard College Absolute quantifizierung von proteinen und modifizierten formen davon mittels mehrstufiger massenspektrometrie
US6929944B2 (en) * 2001-08-31 2005-08-16 Beckman Coulter, Inc. Analysis using a distributed sample
US6939716B2 (en) 2001-09-19 2005-09-06 Washington University Method for detecting conditions indicative of sepsis
US20030129760A1 (en) * 2001-11-13 2003-07-10 Aguilera Frank Reinaldo Morales Mass intensity profiling system and uses thereof
US20040023295A1 (en) * 2001-11-21 2004-02-05 Carol Hamilton Methods and systems for analyzing complex biological systems
GB0128498D0 (en) 2001-11-28 2002-01-23 Inst Of Child Health International standards for sphingolipids
EP1456667B2 (en) 2001-12-08 2010-01-20 Micromass UK Limited Method of mass spectrometry
AUPS177202A0 (en) 2002-04-16 2002-05-23 Diakyne Pty Ltd Multi-element screening of trace elements
WO2004038602A1 (en) 2002-10-24 2004-05-06 Warner-Lambert Company, Llc Integrated spectral data processing, data mining, and modeling system for use in diverse screening and biomarker discovery applications
WO2004038381A2 (en) 2002-10-25 2004-05-06 Metabolon, Inc. Methods for drug discovery, disease treatment, and diagnosis using metabolomics
US20040119010A1 (en) * 2002-11-01 2004-06-24 The Regents Of The University Of Colorado Quantitative analysis of protein isoforms using matrix-assisted laser desorption/ionization time of flight mass spectrometry
US20040121305A1 (en) 2002-12-18 2004-06-24 Wiegand Roger Charles Generation of efficacy, toxicity and disease signatures and methods of use thereof
US6909981B2 (en) 2003-01-27 2005-06-21 Ciphergen Biosystems, Inc. Data management system and method for processing signals from sample spots
US7964343B2 (en) 2003-05-13 2011-06-21 Ibis Biosciences, Inc. Method for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
WO2005031304A2 (en) * 2003-09-22 2005-04-07 Becton, Dickinson And Company Quantification of analytes using internal standards
KR20050050714A (ko) * 2003-11-26 2005-06-01 매그나칩 반도체 유한회사 반도체소자의 트랜지스터 제조방법
US7745226B2 (en) * 2005-04-06 2010-06-29 Quest Diagnostics Investments Incorporated Methods for detecting vitamin D metabolites
DK1875401T3 (da) * 2005-06-30 2014-04-07 Biocrates Life Sciences Ag Indretning til kvantitativ analyse af en metabolitprofil

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2017155C1 (ru) * 1993-05-05 1994-07-30 Геннадий Степанович Власов Диагностическое устройство для иммунохимического анализа

Also Published As

Publication number Publication date
CA2608965A1 (en) 2007-01-11
BRPI0613478B1 (pt) 2019-07-09
US8265877B2 (en) 2012-09-11
NZ563431A (en) 2012-05-25
JP2008547030A (ja) 2008-12-25
ES2452025T3 (es) 2014-03-31
CA2608963A1 (en) 2007-01-11
EP1897014A1 (en) 2008-03-12
WO2007003344A3 (en) 2007-04-26
JP4829297B2 (ja) 2011-12-07
BRPI0613478A2 (pt) 2012-01-17
AU2006265381A1 (en) 2007-01-11
EP1875401B1 (en) 2014-03-05
IL187470A (en) 2015-02-26
AU2006265381B2 (en) 2010-06-10
EP1897014B1 (en) 2014-01-15
KR20080025092A (ko) 2008-03-19
IL187470A0 (en) 2008-03-20
DK1897014T3 (en) 2014-03-10
CA2608963C (en) 2014-08-26
BRPI0613478B8 (pt) 2021-07-27
CN100594501C (zh) 2010-03-17
JP2008547031A (ja) 2008-12-25
JP5155160B2 (ja) 2013-02-27
IN2014DN02241A (https=) 2015-07-10
CA2608965C (en) 2014-08-19
US20070003965A1 (en) 2007-01-04
RU2008102835A (ru) 2009-08-10
US20070004044A1 (en) 2007-01-04
DK1875401T3 (da) 2014-04-07
KR100967573B1 (ko) 2010-07-05
US8116983B2 (en) 2012-02-14
WO2007003344A2 (en) 2007-01-11
CN101208697A (zh) 2008-06-25
WO2007003343A1 (en) 2007-01-11
NO339319B1 (no) 2016-11-28
NO20080559L (no) 2008-01-30
EP1875401A2 (en) 2008-01-09

Similar Documents

Publication Publication Date Title
RU2391672C2 (ru) Устройство для количественного анализа профиля метаболитов
Neumann et al. Spatial metabolomics of the human kidney using MALDI trapped ion mobility imaging mass spectrometry
Kim et al. Simple, miniaturized blood plasma extraction method
Donatti et al. Circulating metabolites as potential biomarkers for neurological disorders—metabolites in neurological disorders
Wong et al. A review on liquid chromatography-tandem mass spectrometry methods for rapid quantification of oncology drugs
Burton et al. Enriching extracellular vesicles for mass spectrometry
Mittal Tandem mass spectroscopy in diagnosis and clinical research
Bahmany et al. Highly sensitive and rapid determination of tacrolimus in peripheral blood mononuclear cells by liquid chromatography–tandem mass spectrometry
KR20030069205A (ko) 신규 프로테옴 분석 방법 및 이를 위한 장치
Gątarek et al. Integrated metabolomics and proteomics analysis of plasma lipid metabolism in Parkinson’s disease
Bindila et al. A companion to the preclinical common data elements for proteomics, lipidomics, and metabolomics data in rodent epilepsy models. A report of the TASK3‐WG4 omics working group of the ILAE/AES joint translational TASK force
Ayre et al. Dried matrix spoting-an innovative sample preparation tool in bioanalysis
Yin et al. Sample collection and preparation of biofluids and extracts for liquid chromatography-mass spectrometry
Vora et al. Exosomes and Other Extracellular Vesicles: Process, Design, and Characterization
Veiga et al. Quantitative metabolomics in Alzheimer’s disease: Technical considerations for improved reproducibility
Toft-Bertelsen et al. Differential Lipid Signatures of Lumbar and Cisternal Cerebrospinal Fluid
US20260034544A1 (en) Materials, methods, and sampling devices for preserving and extracting extracellular vesicles in biofluids
Looby Therapeutic drug monitoring, clinical metabolomics and pharmacometabolomics via solid phase microextraction (SPME): The first step towards an alternative rapid diagnostic tool
Stanisheuski Advancements in Ultrasensitive Bioanalytical Mass Spectrometry
Patel et al. Proteomics in the Pharmaceutical Industry: Prospects and Challenges