RU2355385C2 - Композиции пролонгированного действия с контролируемым высвобождением - Google Patents

Композиции пролонгированного действия с контролируемым высвобождением Download PDF

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Publication number
RU2355385C2
RU2355385C2 RU2005117164/15A RU2005117164A RU2355385C2 RU 2355385 C2 RU2355385 C2 RU 2355385C2 RU 2005117164/15 A RU2005117164/15 A RU 2005117164/15A RU 2005117164 A RU2005117164 A RU 2005117164A RU 2355385 C2 RU2355385 C2 RU 2355385C2
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Prior art keywords
polymer
therapeutic agent
gel
solvent
administration
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RU2005117164/15A
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English (en)
Russian (ru)
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RU2005117164A (ru
Inventor
Гуохуа ЧЕН (US)
Гуохуа ЧЕН
Пол ХЬЮСТОН (US)
Пол ХЬЮСТОН
Рой БАННИСТЕР (US)
Рой БАННИСТЕР
Тереза КАМЕДА (US)
Тереза КАМЕДА
Дэвид ПРЕБЕ (US)
Дэвид ПРЕБЕ
Лотар КЛЕЙНЕР (US)
Лотар КЛЕЙНЕР
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Алза Корпорейшн
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Application filed by Алза Корпорейшн filed Critical Алза Корпорейшн
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurosurgery (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
RU2005117164/15A 2002-11-06 2003-11-04 Композиции пролонгированного действия с контролируемым высвобождением RU2355385C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42442802P 2002-11-06 2002-11-06
US60/424,428 2002-11-06

Publications (2)

Publication Number Publication Date
RU2005117164A RU2005117164A (ru) 2006-01-20
RU2355385C2 true RU2355385C2 (ru) 2009-05-20

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RU2005117164/15A RU2355385C2 (ru) 2002-11-06 2003-11-04 Композиции пролонгированного действия с контролируемым высвобождением

Country Status (25)

Country Link
US (1) US7368126B2 (enExample)
EP (1) EP1581181B1 (enExample)
JP (1) JP2006508127A (enExample)
KR (1) KR20050088288A (enExample)
CN (1) CN1713890A (enExample)
AR (1) AR041913A1 (enExample)
AT (1) ATE418323T1 (enExample)
AU (1) AU2003295409B2 (enExample)
BR (1) BR0315304A (enExample)
CA (1) CA2504608C (enExample)
CL (1) CL2003002277A1 (enExample)
DE (1) DE60325511D1 (enExample)
EC (2) ECSP055838A (enExample)
MA (1) MA27523A1 (enExample)
MX (1) MXPA05004927A (enExample)
MY (1) MY140155A (enExample)
NO (1) NO20052635L (enExample)
NZ (1) NZ539810A (enExample)
PE (1) PE20040675A1 (enExample)
PL (1) PL377333A1 (enExample)
RU (1) RU2355385C2 (enExample)
TW (1) TW200503774A (enExample)
UY (1) UY28067A1 (enExample)
WO (1) WO2004043432A2 (enExample)
ZA (1) ZA200504529B (enExample)

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WO2012125914A1 (en) * 2011-03-16 2012-09-20 University Of Delaware Injectable delivery system for heparan sulfate binding growth factors
RU2574667C2 (ru) * 2009-07-31 2016-02-10 Санофи-Авентис Дойчланд Гмбх Пролекарства, содержащие конъюгат инсулина и линкера
RU2586306C2 (ru) * 2011-04-25 2016-06-10 Шандонг Люие Фармацеутикал Ко., Лтд Состав с микросферами для длительного непрерывного высвобождения рисперидона
RU2640912C2 (ru) * 2011-07-28 2018-01-12 Липосин Инк. Пероральные композиции, содержащие сложный эфир 17-гидроксипрогестерона, и соответствующие способы

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