RU2346938C2 - Производные бензимидазола, содержащие их композиции, их получение и применение - Google Patents

Производные бензимидазола, содержащие их композиции, их получение и применение Download PDF

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Publication number
RU2346938C2
RU2346938C2 RU2006113371/04A RU2006113371A RU2346938C2 RU 2346938 C2 RU2346938 C2 RU 2346938C2 RU 2006113371/04 A RU2006113371/04 A RU 2006113371/04A RU 2006113371 A RU2006113371 A RU 2006113371A RU 2346938 C2 RU2346938 C2 RU 2346938C2
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Russia
Prior art keywords
alkyl
ethyl
methyl
butyl
tert
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RU2006113371/04A
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English (en)
Russian (ru)
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RU2006113371A (ru
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Зипинг ЛИУ (CA)
Зипинг ЛИУ
Даниель ПАЖЕ (CA)
Даниель ПАЖЕ
Кристофер УОЛПОЛ (CA)
Кристофер Уолпол
Хуа ЯНГ (CA)
Хуа Янг
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Астразенека Аб
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
RU2006113371/04A 2003-09-26 2004-09-24 Производные бензимидазола, содержащие их композиции, их получение и применение RU2346938C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0302573-1 2003-09-26
SE0302573A SE0302573D0 (sv) 2003-09-26 2003-09-26 Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
GB0302573-1 2003-09-26

Publications (2)

Publication Number Publication Date
RU2006113371A RU2006113371A (ru) 2007-11-10
RU2346938C2 true RU2346938C2 (ru) 2009-02-20

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RU2006113371/04A RU2346938C2 (ru) 2003-09-26 2004-09-24 Производные бензимидазола, содержащие их композиции, их получение и применение

Country Status (33)

Country Link
US (1) US8633235B2 (enExample)
EP (1) EP1670769B1 (enExample)
JP (1) JP4896721B2 (enExample)
KR (1) KR101170184B1 (enExample)
CN (2) CN102010373A (enExample)
AR (1) AR045819A1 (enExample)
AT (1) ATE430135T1 (enExample)
AU (1) AU2004276062B2 (enExample)
BR (1) BRPI0414780B8 (enExample)
CA (1) CA2539738C (enExample)
CO (1) CO5680443A2 (enExample)
CY (1) CY1110332T1 (enExample)
DE (1) DE602004020907D1 (enExample)
DK (1) DK1670769T3 (enExample)
ES (1) ES2324669T3 (enExample)
HR (1) HRP20090388T1 (enExample)
IL (1) IL174215A0 (enExample)
IS (1) IS8422A (enExample)
MX (1) MXPA06003197A (enExample)
MY (1) MY140630A (enExample)
NO (1) NO20061839L (enExample)
NZ (1) NZ545736A (enExample)
PL (1) PL1670769T3 (enExample)
PT (1) PT1670769E (enExample)
RU (1) RU2346938C2 (enExample)
SA (1) SA04250310B1 (enExample)
SE (1) SE0302573D0 (enExample)
SI (1) SI1670769T1 (enExample)
TW (1) TW200521117A (enExample)
UA (1) UA86776C2 (enExample)
UY (1) UY28536A1 (enExample)
WO (1) WO2005030732A1 (enExample)
ZA (3) ZA200602446B (enExample)

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WO2012125071A1 (ru) * 2011-03-16 2012-09-20 Averin Konstantin Mikhailovich Соли 1,3-диэтилбензимидазолия - иммуностимулирующие средства и фармацевтические композиции на их основе

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RU2414899C1 (ru) * 2009-12-29 2011-03-27 Аверин Константин Михайлович Средства для лечения рассеянного склероза
EP2864310B1 (en) * 2012-06-13 2022-10-26 Cytec Technology Corp. Stabilizer compositions containing substituted chroman compounds and methods of use
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CN112010789A (zh) * 2019-05-31 2020-12-01 中国科学院上海药物研究所 乙烯基磺酰胺或乙烯基酰胺类化合物及其制备方法和用途
GB202019335D0 (en) * 2020-12-08 2021-01-20 Artelo Biosciences Ltd Pharmaceutical compositions
KR102771568B1 (ko) * 2022-03-04 2025-02-24 삼진제약주식회사 신규한 헤테로 고리 화합물 및 이를 포함하는 약학적 조성물

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Publication number Priority date Publication date Assignee Title
WO2012125071A1 (ru) * 2011-03-16 2012-09-20 Averin Konstantin Mikhailovich Соли 1,3-диэтилбензимидазолия - иммуностимулирующие средства и фармацевтические композиции на их основе

Also Published As

Publication number Publication date
IS8422A (is) 2006-04-21
MY140630A (en) 2010-01-15
TW200521117A (en) 2005-07-01
UA86776C2 (ru) 2009-05-25
PL1670769T3 (pl) 2009-09-30
BRPI0414780B8 (pt) 2021-05-25
BRPI0414780B1 (pt) 2018-10-23
NZ545736A (en) 2009-11-27
SI1670769T1 (sl) 2009-10-31
WO2005030732A1 (en) 2005-04-07
AR045819A1 (es) 2005-11-16
EP1670769B1 (en) 2009-04-29
CA2539738A1 (en) 2005-04-07
EP1670769A1 (en) 2006-06-21
ZA200702226B (en) 2009-01-28
IL174215A0 (en) 2006-08-01
US20080207612A1 (en) 2008-08-28
CO5680443A2 (es) 2006-09-29
DK1670769T3 (da) 2009-08-10
HK1089436A1 (en) 2006-12-01
ATE430135T1 (de) 2009-05-15
JP4896721B2 (ja) 2012-03-14
KR101170184B1 (ko) 2012-07-31
ES2324669T3 (es) 2009-08-12
SE0302573D0 (sv) 2003-09-26
MXPA06003197A (es) 2006-06-23
SA04250310B1 (ar) 2009-01-19
HRP20090388T1 (hr) 2009-08-31
UY28536A1 (es) 2005-04-29
PT1670769E (pt) 2009-07-09
BRPI0414780A (pt) 2006-11-21
ZA200602446B (en) 2007-09-26
AU2004276062B2 (en) 2008-05-22
DE602004020907D1 (de) 2009-06-10
ZA200702131B (en) 2008-08-27
RU2006113371A (ru) 2007-11-10
CY1110332T1 (el) 2015-01-14
US8633235B2 (en) 2014-01-21
CN102010373A (zh) 2011-04-13
CA2539738C (en) 2011-11-22
JP2007506721A (ja) 2007-03-22
KR20070001052A (ko) 2007-01-03
AU2004276062A1 (en) 2005-04-07
NO20061839L (no) 2006-06-26
CN1886379A (zh) 2006-12-27

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