ZA200702131B - Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof l - Google Patents

Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof l

Info

Publication number
ZA200702131B
ZA200702131B ZA200702131A ZA200702131A ZA200702131B ZA 200702131 B ZA200702131 B ZA 200702131B ZA 200702131 A ZA200702131 A ZA 200702131A ZA 200702131 A ZA200702131 A ZA 200702131A ZA 200702131 B ZA200702131 B ZA 200702131B
Authority
ZA
South Africa
Prior art keywords
preparation
compositions containing
benzimidazole derivatives
benzimidazole
derivatives
Prior art date
Application number
ZA200702131A
Other languages
English (en)
Inventor
Page Daniel
Tremblay Maxime
Yang Hua
Liu Ziping
Walpole Christopher
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of ZA200702131B publication Critical patent/ZA200702131B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18Halogen atoms or nitro radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08Radicals containing only hydrogen and carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38Nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14Radicals substituted by nitrogen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA200702131A 2003-09-26 2007-03-13 Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof l ZA200702131B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0302573A SE0302573D0 (sv) 2003-09-26 2003-09-26 Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
PCT/GB2004/004124 WO2005030732A1 (en) 2003-09-26 2004-09-24 Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof

Publications (1)

Publication Number Publication Date
ZA200702131B true ZA200702131B (en) 2008-08-27

Family

ID=29246982

Family Applications (3)

Application Number Title Priority Date Filing Date
ZA200602446A ZA200602446B (en) 2003-09-26 2006-03-24 Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
ZA200702131A ZA200702131B (en) 2003-09-26 2007-03-13 Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof l
ZA200702226A ZA200702226B (en) 2003-09-26 2007-03-16 Compounds, compositions containing them, preparations thereof and uses thereof II

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ZA200602446A ZA200602446B (en) 2003-09-26 2006-03-24 Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
ZA200702226A ZA200702226B (en) 2003-09-26 2007-03-16 Compounds, compositions containing them, preparations thereof and uses thereof II

Country Status (34)

Country Link
US (1) US8633235B2 (xx)
EP (1) EP1670769B1 (xx)
JP (1) JP4896721B2 (xx)
KR (1) KR101170184B1 (xx)
CN (2) CN1886379A (xx)
AR (1) AR045819A1 (xx)
AT (1) ATE430135T1 (xx)
AU (1) AU2004276062B2 (xx)
BR (1) BRPI0414780B8 (xx)
CA (1) CA2539738C (xx)
CO (1) CO5680443A2 (xx)
CY (1) CY1110332T1 (xx)
DE (1) DE602004020907D1 (xx)
DK (1) DK1670769T3 (xx)
ES (1) ES2324669T3 (xx)
HK (1) HK1089436A1 (xx)
HR (1) HRP20090388T1 (xx)
IL (1) IL174215A0 (xx)
IS (1) IS8422A (xx)
MX (1) MXPA06003197A (xx)
MY (1) MY140630A (xx)
NO (1) NO20061839L (xx)
NZ (1) NZ545736A (xx)
PL (1) PL1670769T3 (xx)
PT (1) PT1670769E (xx)
RU (1) RU2346938C2 (xx)
SA (1) SA04250310B1 (xx)
SE (1) SE0302573D0 (xx)
SI (1) SI1670769T1 (xx)
TW (1) TW200521117A (xx)
UA (1) UA86776C2 (xx)
UY (1) UY28536A1 (xx)
WO (1) WO2005030732A1 (xx)
ZA (3) ZA200602446B (xx)

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CN101052639B (zh) * 2004-09-24 2010-10-27 阿斯利康(瑞典)有限公司 苯并咪唑衍生物、含有它们的组合物、其制备方法和其用途
JP2008514592A (ja) * 2004-09-24 2008-05-08 アストラゼネカ・アクチエボラーグ ベンゾイミダゾール誘導体、それらを含有する組成物、それらの製造及びそれらの使用iii
CA2581232C (en) * 2004-09-24 2015-04-07 Astrazeneca Ab Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof i
BRPI0515897A (pt) 2004-09-24 2008-08-12 Astrazeneca Ab composto, uso do mesmo, composição farmacêutica, e, método para a terapia de dor em um animal de sangue quente, e para a preparação de um composto
CA2586179C (en) 2004-11-02 2011-02-08 Pfizer Inc. Sulfonyl benzimidazole derivatives
US20080167488A1 (en) * 2005-07-29 2008-07-10 Astrazeneca Ab Process for the Preparation of Geminal ((Difluorocycloalkyl)Methyl) Amines
TW200745049A (en) 2006-03-23 2007-12-16 Astrazeneca Ab New crystalline forms
TW200808769A (en) * 2006-04-18 2008-02-16 Astrazeneca Ab Therapeutic compounds
US20080139846A1 (en) * 2006-09-01 2008-06-12 Astrazeneca Ab New Process 298
WO2008032764A1 (fr) * 2006-09-13 2008-03-20 Kyowa Hakko Kirin Co., Ltd. Dérivé hétérocyclique fusionné
US20110086853A1 (en) * 2009-10-08 2011-04-14 William Brown Therapeutic Compounds
RU2454234C1 (ru) * 2011-03-16 2012-06-27 Константин Михайлович Аверин Соли 1,3-диэтилбензимидазолия - иммуностимулирующие средства и фармацевтические композиции на их основе
RU2662823C2 (ru) * 2012-06-13 2018-07-31 Сайтек Текнолоджи Корп. Стабилизирующие композиции, содержащие замещенные хромановые соединения, и способы применения
EA028063B1 (ru) 2012-06-26 2017-10-31 Байер Фарма Акциенгезельшафт N-[4-(хинолин-4-илокси)циклогексил(метил)](гетеро)арилкарбоксамиды в качестве антагонистов андрогенного рецептора, их получение и применение в качестве лекарственных средств
CA3093189A1 (en) 2018-03-07 2019-09-12 Bayer Aktiengesellschaft Identification and use of erk5 inhibitors
WO2020234103A1 (en) 2019-05-21 2020-11-26 Bayer Aktiengesellschaft Identification and use of kras inhibitors
CN112010789A (zh) * 2019-05-31 2020-12-01 中国科学院上海药物研究所 乙烯基磺酰胺或乙烯基酰胺类化合物及其制备方法和用途
WO2023166450A1 (ko) * 2022-03-04 2023-09-07 삼진제약주식회사 신규한 헤테로 고리 화합물 및 이를 포함하는 약학적 조성물

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EP1797076A1 (en) 2004-09-24 2007-06-20 AstraZeneca AB Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
BRPI0515897A (pt) * 2004-09-24 2008-08-12 Astrazeneca Ab composto, uso do mesmo, composição farmacêutica, e, método para a terapia de dor em um animal de sangue quente, e para a preparação de um composto
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TW200808772A (en) 2006-06-13 2008-02-16 Astrazeneca Ab Therapeutic compounds

Also Published As

Publication number Publication date
AR045819A1 (es) 2005-11-16
UY28536A1 (es) 2005-04-29
CN102010373A (zh) 2011-04-13
BRPI0414780B1 (pt) 2018-10-23
BRPI0414780A (pt) 2006-11-21
MXPA06003197A (es) 2006-06-23
IL174215A0 (en) 2006-08-01
SI1670769T1 (sl) 2009-10-31
IS8422A (is) 2006-04-21
US20080207612A1 (en) 2008-08-28
CY1110332T1 (el) 2015-01-14
ZA200602446B (en) 2007-09-26
DK1670769T3 (da) 2009-08-10
HRP20090388T1 (en) 2009-08-31
MY140630A (en) 2010-01-15
US8633235B2 (en) 2014-01-21
ATE430135T1 (de) 2009-05-15
BRPI0414780B8 (pt) 2021-05-25
EP1670769B1 (en) 2009-04-29
PT1670769E (pt) 2009-07-09
SA04250310B1 (ar) 2009-01-19
CA2539738C (en) 2011-11-22
AU2004276062A1 (en) 2005-04-07
ES2324669T3 (es) 2009-08-12
SE0302573D0 (sv) 2003-09-26
HK1089436A1 (en) 2006-12-01
EP1670769A1 (en) 2006-06-21
ZA200702226B (en) 2009-01-28
DE602004020907D1 (de) 2009-06-10
RU2006113371A (ru) 2007-11-10
KR101170184B1 (ko) 2012-07-31
CO5680443A2 (es) 2006-09-29
JP2007506721A (ja) 2007-03-22
TW200521117A (en) 2005-07-01
PL1670769T3 (pl) 2009-09-30
NZ545736A (en) 2009-11-27
KR20070001052A (ko) 2007-01-03
AU2004276062B2 (en) 2008-05-22
CN1886379A (zh) 2006-12-27
JP4896721B2 (ja) 2012-03-14
UA86776C2 (ru) 2009-05-25
WO2005030732A1 (en) 2005-04-07
NO20061839L (no) 2006-06-26
CA2539738A1 (en) 2005-04-07
RU2346938C2 (ru) 2009-02-20

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