JP4896721B2 - ベンゾイミダゾール誘導体、それを含む組成物、その製造方法およびその使用 - Google Patents

ベンゾイミダゾール誘導体、それを含む組成物、その製造方法およびその使用 Download PDF

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Publication number
JP4896721B2
JP4896721B2 JP2006527490A JP2006527490A JP4896721B2 JP 4896721 B2 JP4896721 B2 JP 4896721B2 JP 2006527490 A JP2006527490 A JP 2006527490A JP 2006527490 A JP2006527490 A JP 2006527490A JP 4896721 B2 JP4896721 B2 JP 4896721B2
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Japan
Prior art keywords
alkyl
cycloalkyl
methyl
butyl
alkenyl
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Expired - Lifetime
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JP2006527490A
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Japanese (ja)
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JP2007506721A (ja
JP2007506721A5 (enExample
Inventor
ジーピン・リウー
ダニエル・パージェ
クリストファー・ウォールポール
ホワ・ヤン
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AstraZeneca AB
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AstraZeneca AB
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2006527490A 2003-09-26 2004-09-24 ベンゾイミダゾール誘導体、それを含む組成物、その製造方法およびその使用 Expired - Lifetime JP4896721B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0302573A SE0302573D0 (sv) 2003-09-26 2003-09-26 Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
SE0302573-1 2003-09-26
PCT/GB2004/004124 WO2005030732A1 (en) 2003-09-26 2004-09-24 Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof

Publications (3)

Publication Number Publication Date
JP2007506721A JP2007506721A (ja) 2007-03-22
JP2007506721A5 JP2007506721A5 (enExample) 2007-11-08
JP4896721B2 true JP4896721B2 (ja) 2012-03-14

Family

ID=29246982

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006527490A Expired - Lifetime JP4896721B2 (ja) 2003-09-26 2004-09-24 ベンゾイミダゾール誘導体、それを含む組成物、その製造方法およびその使用

Country Status (33)

Country Link
US (1) US8633235B2 (enExample)
EP (1) EP1670769B1 (enExample)
JP (1) JP4896721B2 (enExample)
KR (1) KR101170184B1 (enExample)
CN (2) CN1886379A (enExample)
AR (1) AR045819A1 (enExample)
AT (1) ATE430135T1 (enExample)
AU (1) AU2004276062B2 (enExample)
BR (1) BRPI0414780B8 (enExample)
CA (1) CA2539738C (enExample)
CO (1) CO5680443A2 (enExample)
CY (1) CY1110332T1 (enExample)
DE (1) DE602004020907D1 (enExample)
DK (1) DK1670769T3 (enExample)
ES (1) ES2324669T3 (enExample)
HR (1) HRP20090388T1 (enExample)
IL (1) IL174215A0 (enExample)
IS (1) IS8422A (enExample)
MX (1) MXPA06003197A (enExample)
MY (1) MY140630A (enExample)
NO (1) NO20061839L (enExample)
NZ (1) NZ545736A (enExample)
PL (1) PL1670769T3 (enExample)
PT (1) PT1670769E (enExample)
RU (1) RU2346938C2 (enExample)
SA (1) SA04250310B1 (enExample)
SE (1) SE0302573D0 (enExample)
SI (1) SI1670769T1 (enExample)
TW (1) TW200521117A (enExample)
UA (1) UA86776C2 (enExample)
UY (1) UY28536A1 (enExample)
WO (1) WO2005030732A1 (enExample)
ZA (3) ZA200602446B (enExample)

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KR101269869B1 (ko) 2004-09-24 2013-06-07 네오메드 인스티튜트 벤즈이미다졸 유도체, 그를 함유하는 조성물, 그의 제조방법 및 그의 용도
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CN101052639B (zh) * 2004-09-24 2010-10-27 阿斯利康(瑞典)有限公司 苯并咪唑衍生物、含有它们的组合物、其制备方法和其用途
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TW200745049A (en) * 2006-03-23 2007-12-16 Astrazeneca Ab New crystalline forms
TW200808769A (en) * 2006-04-18 2008-02-16 Astrazeneca Ab Therapeutic compounds
US20080139846A1 (en) * 2006-09-01 2008-06-12 Astrazeneca Ab New Process 298
JP5159630B2 (ja) * 2006-09-13 2013-03-06 協和発酵キリン株式会社 縮環複素環誘導体
US20110086853A1 (en) * 2009-10-08 2011-04-14 William Brown Therapeutic Compounds
RU2414899C1 (ru) * 2009-12-29 2011-03-27 Аверин Константин Михайлович Средства для лечения рассеянного склероза
RU2454234C1 (ru) * 2011-03-16 2012-06-27 Константин Михайлович Аверин Соли 1,3-диэтилбензимидазолия - иммуностимулирующие средства и фармацевтические композиции на их основе
UA119740C2 (uk) * 2012-06-13 2019-08-12 Сайтек Текнолоджи Корп. Композиції стабілізатора, що містять заміщені хроманові сполуки, і способи застосування
MA37700B1 (fr) 2012-06-26 2018-03-30 Bayer Pharma AG N-[4-(quinolin-4-yloxy)cyclohexyl(méthyl)](hétéro)arylcarboxamides utilisables en tant qu'antagonistes des récepteurs aux androgènes, leur production et leur utilisation en tant que médicaments
US20210017174A1 (en) 2018-03-07 2021-01-21 Bayer Aktiengesellschaft Identification and use of erk5 inhibitor
EP3972963A1 (en) 2019-05-21 2022-03-30 Bayer Aktiengesellschaft Identification and use of kras inhibitors
CN112010789A (zh) * 2019-05-31 2020-12-01 中国科学院上海药物研究所 乙烯基磺酰胺或乙烯基酰胺类化合物及其制备方法和用途
GB202019335D0 (en) * 2020-12-08 2021-01-20 Artelo Biosciences Ltd Pharmaceutical compositions
EP4488276A1 (en) * 2022-03-04 2025-01-08 Samjin Pharmaceutical Co., Ltd. Novel heterocyclic compound and pharmaceutical composition comprising same

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Also Published As

Publication number Publication date
AU2004276062A1 (en) 2005-04-07
CY1110332T1 (el) 2015-01-14
SE0302573D0 (sv) 2003-09-26
MY140630A (en) 2010-01-15
EP1670769A1 (en) 2006-06-21
KR20070001052A (ko) 2007-01-03
DE602004020907D1 (de) 2009-06-10
AR045819A1 (es) 2005-11-16
PL1670769T3 (pl) 2009-09-30
IS8422A (is) 2006-04-21
HK1089436A1 (en) 2006-12-01
JP2007506721A (ja) 2007-03-22
CO5680443A2 (es) 2006-09-29
ZA200602446B (en) 2007-09-26
UY28536A1 (es) 2005-04-29
RU2346938C2 (ru) 2009-02-20
RU2006113371A (ru) 2007-11-10
TW200521117A (en) 2005-07-01
BRPI0414780B1 (pt) 2018-10-23
CN1886379A (zh) 2006-12-27
WO2005030732A1 (en) 2005-04-07
ATE430135T1 (de) 2009-05-15
AU2004276062B2 (en) 2008-05-22
CA2539738C (en) 2011-11-22
KR101170184B1 (ko) 2012-07-31
BRPI0414780A (pt) 2006-11-21
NO20061839L (no) 2006-06-26
CA2539738A1 (en) 2005-04-07
SI1670769T1 (sl) 2009-10-31
IL174215A0 (en) 2006-08-01
ZA200702131B (en) 2008-08-27
US20080207612A1 (en) 2008-08-28
UA86776C2 (ru) 2009-05-25
PT1670769E (pt) 2009-07-09
DK1670769T3 (da) 2009-08-10
ZA200702226B (en) 2009-01-28
HRP20090388T1 (hr) 2009-08-31
ES2324669T3 (es) 2009-08-12
BRPI0414780B8 (pt) 2021-05-25
SA04250310B1 (ar) 2009-01-19
US8633235B2 (en) 2014-01-21
NZ545736A (en) 2009-11-27
CN102010373A (zh) 2011-04-13
EP1670769B1 (en) 2009-04-29
MXPA06003197A (es) 2006-06-23

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