RU2308268C2 - Производные арил- или гетероарилазолилкарбинолов для лечения недержания мочи - Google Patents
Производные арил- или гетероарилазолилкарбинолов для лечения недержания мочи Download PDFInfo
- Publication number
- RU2308268C2 RU2308268C2 RU2004103475/15A RU2004103475A RU2308268C2 RU 2308268 C2 RU2308268 C2 RU 2308268C2 RU 2004103475/15 A RU2004103475/15 A RU 2004103475/15A RU 2004103475 A RU2004103475 A RU 2004103475A RU 2308268 C2 RU2308268 C2 RU 2308268C2
- Authority
- RU
- Russia
- Prior art keywords
- methyl
- dimethylamino
- ethoxy
- pyrazole
- benzyl
- Prior art date
Links
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- 150000001875 compounds Chemical class 0.000 claims abstract description 20
- 150000003839 salts Chemical class 0.000 claims abstract description 7
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
Landscapes
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- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
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- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
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- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
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|---|---|---|---|
| ESP200101587 | 2001-07-06 | ||
| ES200101587A ES2180449B1 (es) | 2001-07-06 | 2001-07-06 | Derivados de aril (o heteroaril) azolilcarbinoles para el tratamiento de la incontinencia urinaria. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2004103475A RU2004103475A (ru) | 2005-06-10 |
| RU2308268C2 true RU2308268C2 (ru) | 2007-10-20 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2004103475/15A RU2308268C2 (ru) | 2001-07-06 | 2002-07-01 | Производные арил- или гетероарилазолилкарбинолов для лечения недержания мочи |
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|---|---|
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| EP (1) | EP1413305B1 (enExample) |
| JP (1) | JP2004521150A (enExample) |
| KR (1) | KR20040030788A (enExample) |
| CN (1) | CN1543344A (enExample) |
| AR (1) | AR034679A1 (enExample) |
| AT (1) | ATE327752T1 (enExample) |
| BR (1) | BR0211237A (enExample) |
| CA (1) | CA2452646A1 (enExample) |
| CY (1) | CY1105113T1 (enExample) |
| DE (1) | DE60211913T2 (enExample) |
| DK (1) | DK1413305T3 (enExample) |
| ES (2) | ES2180449B1 (enExample) |
| MA (1) | MA27056A1 (enExample) |
| MX (1) | MXPA04000065A (enExample) |
| NO (1) | NO20040031L (enExample) |
| NZ (1) | NZ530817A (enExample) |
| PL (1) | PL369062A1 (enExample) |
| PT (1) | PT1413305E (enExample) |
| RU (1) | RU2308268C2 (enExample) |
| UA (1) | UA79238C2 (enExample) |
| WO (1) | WO2003004022A1 (enExample) |
| ZA (1) | ZA200400780B (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US20040142929A1 (en) * | 2001-07-06 | 2004-07-22 | Ramon Merce-Vidal | Derivatives of aryl (or heteroaryl) azolylcarbinoles for the treatment of urinary incontinence |
| DE10335566A1 (de) * | 2003-07-31 | 2005-02-24 | Grünenthal GmbH | Arzneimittel enthaltend Derivate von Aryl( oder Heteroaryl)azolylcarbinolen |
| TW200533657A (en) * | 2004-02-17 | 2005-10-16 | Esteve Labor Dr | Substituted pyrazoline compounds, their preparation and use as medicaments |
| ES2244326B1 (es) * | 2004-04-05 | 2007-02-16 | Laboratorios Del Dr. Esteve, S.A. | Combinacion de substancias activas. |
| EP1584335A3 (en) * | 2004-04-05 | 2006-02-22 | Laboratorios Del Dr. Esteve, S.A. | Active substance combination comprising a carbinol composition and an opioid |
| US20060040924A1 (en) * | 2004-06-22 | 2006-02-23 | Laboratorios Dr. Esteve S.A. | Derivatives of aryl (or heteroaryl) azolylcarbinols for the treatment of renal colic |
| WO2006010627A1 (en) * | 2004-07-30 | 2006-02-02 | Laboratorios Del Dr. Esteve, S.A. | Aryl (or heteroaryl) azolylcarbinols |
| EP1757587A1 (en) * | 2005-07-15 | 2007-02-28 | Laboratorios Del Dr. Esteve, S.A. | Substituted pyrazoline compounds, their preparation and use as medicaments |
| US7897589B2 (en) * | 2005-07-15 | 2011-03-01 | Laboratorios Del Dr. Esteve, S.A. | Substituted pyrazoline compounds, their preparation and use as medicaments |
| EP1743890A1 (en) * | 2005-07-15 | 2007-01-17 | Laboratorios Del Dr. Esteve, S.A. | 4,5-Dihydro-1H-pyrazole derivatives, their preparation and use as medicaments |
| EP1743892A1 (en) * | 2005-07-15 | 2007-01-17 | Laboratorios del Dr. Esteve S.A. | Substituted pyrazoline compounds, their preparation and use as medicaments |
| US20070021485A1 (en) * | 2005-07-22 | 2007-01-25 | Gomis Antonio F | Aryl (or heteroaryl) azolylcarbinols |
| ES2334548B1 (es) * | 2005-07-29 | 2010-10-27 | Laboratorios Del Dr. Esteve, S.A | Forma de dosificacion de liberacion controlada de compuestos de pirazol para el tratamiento de la incontinencia urinaria. |
| US8722079B2 (en) | 2008-04-18 | 2014-05-13 | Warsaw Orthopedic, Inc. | Methods for treating conditions such as dystonia and post-stroke spasticity with clonidine |
| EP2151234A1 (en) * | 2008-07-28 | 2010-02-10 | Laboratorios Del. Dr. Esteve, S.A. | Pharmaceutical formulation comprising a CB1-receptor compound in a solid solution and/or solid dispersion |
| WO2010123999A2 (en) * | 2009-04-21 | 2010-10-28 | Auspex Pharmaceuticals, Inc. | 1-methylpyrazole modulators of substance p, calcitonin gene-related peptide, adrenergic receptor, and/or 5-ht receptor |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0289380A1 (fr) * | 1987-04-10 | 1988-11-02 | Laboratorios Del Dr. Esteve, S.A. | Dérivés d'aryl-hétéroaryl carbinols avec activité analgésique |
| WO1999052525A1 (es) * | 1998-04-15 | 1999-10-21 | Laboratorios Del Dr. Esteve, S.A. | Tienilazolilalcoxietanaminas, su preparacion y su aplicacion como medicamentos |
| ES2137136A1 (es) * | 1998-05-18 | 1999-12-01 | Esteve Labor Dr | Empleo de derivados de aril (o heteroaril) azolilcarbinoles en la elaboracion de un medicamento para el tratamiento de la inflamacion neurogenica. |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE891865A (fr) * | 1981-01-30 | 1982-07-22 | Sandoz Sa | Nouveaux medicaments a base de derives condenses de l'imidazole pour le traitement des troubles urinaires |
| ES2150378B1 (es) * | 1998-08-07 | 2001-07-01 | Esteve Labor Dr | Empleo de derivados de aril(o heteroaril)azolilcarbinoles en la elaboracion de un medicamento para el tratamiento de los trastornos mediados por un exceso de substancia p. |
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2001
- 2001-07-06 ES ES200101587A patent/ES2180449B1/es not_active Expired - Fee Related
-
2002
- 2002-01-07 UA UA2004020880A patent/UA79238C2/uk unknown
- 2002-07-01 DK DK02745440T patent/DK1413305T3/da active
- 2002-07-01 PT PT02745440T patent/PT1413305E/pt unknown
- 2002-07-01 AT AT02745440T patent/ATE327752T1/de not_active IP Right Cessation
- 2002-07-01 MX MXPA04000065A patent/MXPA04000065A/es unknown
- 2002-07-01 KR KR10-2004-7000056A patent/KR20040030788A/ko not_active Withdrawn
- 2002-07-01 EP EP02745440A patent/EP1413305B1/en not_active Expired - Lifetime
- 2002-07-01 DE DE60211913T patent/DE60211913T2/de not_active Expired - Fee Related
- 2002-07-01 PL PL02369062A patent/PL369062A1/xx not_active Application Discontinuation
- 2002-07-01 CA CA002452646A patent/CA2452646A1/en not_active Abandoned
- 2002-07-01 BR BR0211237-0A patent/BR0211237A/pt not_active IP Right Cessation
- 2002-07-01 JP JP2003510033A patent/JP2004521150A/ja active Pending
- 2002-07-01 NZ NZ530817A patent/NZ530817A/en unknown
- 2002-07-01 CN CNA028161009A patent/CN1543344A/zh active Pending
- 2002-07-01 AR ARP020102482A patent/AR034679A1/es not_active Application Discontinuation
- 2002-07-01 WO PCT/ES2002/000326 patent/WO2003004022A1/es not_active Ceased
- 2002-07-01 ES ES02745440T patent/ES2263792T3/es not_active Expired - Lifetime
- 2002-07-01 RU RU2004103475/15A patent/RU2308268C2/ru not_active IP Right Cessation
- 2002-07-03 US US10/189,915 patent/US20030022925A1/en not_active Abandoned
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2004
- 2004-01-05 NO NO20040031A patent/NO20040031L/no not_active Application Discontinuation
- 2004-01-30 ZA ZA200400780A patent/ZA200400780B/en unknown
- 2004-02-04 MA MA27514A patent/MA27056A1/fr unknown
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2005
- 2005-01-28 US US11/045,708 patent/US20050131049A1/en not_active Abandoned
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2006
- 2006-07-28 CY CY20061101049T patent/CY1105113T1/el unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0289380A1 (fr) * | 1987-04-10 | 1988-11-02 | Laboratorios Del Dr. Esteve, S.A. | Dérivés d'aryl-hétéroaryl carbinols avec activité analgésique |
| WO1999052525A1 (es) * | 1998-04-15 | 1999-10-21 | Laboratorios Del Dr. Esteve, S.A. | Tienilazolilalcoxietanaminas, su preparacion y su aplicacion como medicamentos |
| ES2137136A1 (es) * | 1998-05-18 | 1999-12-01 | Esteve Labor Dr | Empleo de derivados de aril (o heteroaril) azolilcarbinoles en la elaboracion de un medicamento para el tratamiento de la inflamacion neurogenica. |
Non-Patent Citations (1)
| Title |
|---|
| Гиперактивность мочевого пузыря. ТЕВЛИН К.П., Пушкарь Д.Ю., Щавелева О.Б. Русский Медицинский Журнал, 2000, том 8, №3. Руководство по медицине. Диагностика и терапия в 2-х т, т.2: Пер. с англ./ Под ред. Р.БЕРКОУ, Э.Флетчера. - М.: Мир, 1997, т.2, с.150-153. «Drug therapy of female urinary incontinence» FLAMMANT G. Gillet J.Y., Presse Med. 1995 Jan 7; 24(1):31-4. (реферат Medline-online). * |
Also Published As
| Publication number | Publication date |
|---|---|
| MA27056A1 (fr) | 2004-12-20 |
| RU2004103475A (ru) | 2005-06-10 |
| ES2180449B1 (es) | 2004-01-16 |
| DE60211913T2 (de) | 2007-05-24 |
| PT1413305E (pt) | 2006-09-29 |
| BR0211237A (pt) | 2004-08-10 |
| DK1413305T3 (da) | 2006-09-18 |
| EP1413305A1 (en) | 2004-04-28 |
| CA2452646A1 (en) | 2003-01-16 |
| US20030022925A1 (en) | 2003-01-30 |
| AR034679A1 (es) | 2004-03-03 |
| MXPA04000065A (es) | 2004-05-21 |
| WO2003004022A1 (es) | 2003-01-16 |
| CY1105113T1 (el) | 2010-03-03 |
| DE60211913D1 (de) | 2006-07-06 |
| JP2004521150A (ja) | 2004-07-15 |
| UA79238C2 (en) | 2007-06-11 |
| ES2180449A1 (es) | 2003-02-01 |
| PL369062A1 (en) | 2005-04-18 |
| NZ530817A (en) | 2005-07-29 |
| US20050131049A1 (en) | 2005-06-16 |
| CN1543344A (zh) | 2004-11-03 |
| ZA200400780B (en) | 2005-01-31 |
| ES2263792T3 (es) | 2006-12-16 |
| EP1413305B1 (en) | 2006-05-31 |
| KR20040030788A (ko) | 2004-04-09 |
| NO20040031L (no) | 2004-03-02 |
| ATE327752T1 (de) | 2006-06-15 |
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Legal Events
| Date | Code | Title | Description |
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| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20080702 |