BR0211237A - Uso de derivados de aril (ou heteroaril) azolil-carbinóis para o tratamento de incontinência urinária e composição farmacêutica - Google Patents

Uso de derivados de aril (ou heteroaril) azolil-carbinóis para o tratamento de incontinência urinária e composição farmacêutica

Info

Publication number
BR0211237A
BR0211237A BR0211237-0A BR0211237A BR0211237A BR 0211237 A BR0211237 A BR 0211237A BR 0211237 A BR0211237 A BR 0211237A BR 0211237 A BR0211237 A BR 0211237A
Authority
BR
Brazil
Prior art keywords
heteroaryl
aryl
urinary incontinence
azolyl
treatment
Prior art date
Application number
BR0211237-0A
Other languages
English (en)
Inventor
Ramon Merce-Vidal
Blas Andaluz Mataro
Jordi Frigola Constansa
Original Assignee
Esteve Labor Dr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esteve Labor Dr filed Critical Esteve Labor Dr
Publication of BR0211237A publication Critical patent/BR0211237A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"USO DE DERIVADOS DE ARIL (OU HETEROARIL) AZOLIL-CARBINóIS PARA O TRATAMENTO DE INCONTINêNCIA URINáRIA E COMPOSIçãO FARMACêUTICA". Os derivados de aril (ou heteroaril) azolil-carbinóis de fórmula geral (I), na qual Ar representa um radical fenil ou um radical tienil, opcionalmente substituído, R~ 1~ representa um átomo de hidrogênio ou um grupo alquila baixo, R~ 2~ representa um dialquil-aminoalquil ou aza-heterocilclil-alquil e Het representa um azol não substituído ou opcionalmente substituído por um ou dois substituintes, e seus sais fisiologicamente aceitáveis; são úteis como medicamentos em terapêutica humana e/ou veterinária para tratar incontinência urinária em mamíferos, incluindo o homem.
BR0211237-0A 2001-07-06 2002-07-01 Uso de derivados de aril (ou heteroaril) azolil-carbinóis para o tratamento de incontinência urinária e composição farmacêutica BR0211237A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200101587A ES2180449B1 (es) 2001-07-06 2001-07-06 Derivados de aril (o heteroaril) azolilcarbinoles para el tratamiento de la incontinencia urinaria.
PCT/ES2002/000326 WO2003004022A1 (es) 2001-07-06 2002-07-01 Derivados de aril(o heteroaril)azolilcarbinoles para el tratamiento de la incontinencia urinaria

Publications (1)

Publication Number Publication Date
BR0211237A true BR0211237A (pt) 2004-08-10

Family

ID=8498326

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0211237-0A BR0211237A (pt) 2001-07-06 2002-07-01 Uso de derivados de aril (ou heteroaril) azolil-carbinóis para o tratamento de incontinência urinária e composição farmacêutica

Country Status (23)

Country Link
US (2) US20030022925A1 (pt)
EP (1) EP1413305B1 (pt)
JP (1) JP2004521150A (pt)
KR (1) KR20040030788A (pt)
CN (1) CN1543344A (pt)
AR (1) AR034679A1 (pt)
AT (1) ATE327752T1 (pt)
BR (1) BR0211237A (pt)
CA (1) CA2452646A1 (pt)
CY (1) CY1105113T1 (pt)
DE (1) DE60211913T2 (pt)
DK (1) DK1413305T3 (pt)
ES (2) ES2180449B1 (pt)
MA (1) MA27056A1 (pt)
MX (1) MXPA04000065A (pt)
NO (1) NO20040031L (pt)
NZ (1) NZ530817A (pt)
PL (1) PL369062A1 (pt)
PT (1) PT1413305E (pt)
RU (1) RU2308268C2 (pt)
UA (1) UA79238C2 (pt)
WO (1) WO2003004022A1 (pt)
ZA (1) ZA200400780B (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040142929A1 (en) * 2001-07-06 2004-07-22 Ramon Merce-Vidal Derivatives of aryl (or heteroaryl) azolylcarbinoles for the treatment of urinary incontinence
DE10335566A1 (de) * 2003-07-31 2005-02-24 Grünenthal GmbH Arzneimittel enthaltend Derivate von Aryl( oder Heteroaryl)azolylcarbinolen
TW200533657A (en) * 2004-02-17 2005-10-16 Esteve Labor Dr Substituted pyrazoline compounds, their preparation and use as medicaments
EP1584335A3 (en) * 2004-04-05 2006-02-22 Laboratorios Del Dr. Esteve, S.A. Active substance combination comprising a carbinol composition and an opioid
ES2244326B1 (es) * 2004-04-05 2007-02-16 Laboratorios Del Dr. Esteve, S.A. Combinacion de substancias activas.
US20060040924A1 (en) * 2004-06-22 2006-02-23 Laboratorios Dr. Esteve S.A. Derivatives of aryl (or heteroaryl) azolylcarbinols for the treatment of renal colic
EP1784178A1 (en) * 2004-07-30 2007-05-16 Laboratorios Del Dr. Esteve, S.A. Aryl (or heteroaryl) azolylcarbinols
EP1757587A1 (en) * 2005-07-15 2007-02-28 Laboratorios Del Dr. Esteve, S.A. Substituted pyrazoline compounds, their preparation and use as medicaments
EP1743890A1 (en) * 2005-07-15 2007-01-17 Laboratorios Del Dr. Esteve, S.A. 4,5-Dihydro-1H-pyrazole derivatives, their preparation and use as medicaments
US7897589B2 (en) * 2005-07-15 2011-03-01 Laboratorios Del Dr. Esteve, S.A. Substituted pyrazoline compounds, their preparation and use as medicaments
EP1743892A1 (en) * 2005-07-15 2007-01-17 Laboratorios del Dr. Esteve S.A. Substituted pyrazoline compounds, their preparation and use as medicaments
US20070021485A1 (en) * 2005-07-22 2007-01-25 Gomis Antonio F Aryl (or heteroaryl) azolylcarbinols
WO2007017127A2 (en) * 2005-07-29 2007-02-15 Laboratorios Del Dr. Esteve, S.A Controlled realease dosage form of pirazole compounds to treat urinary incontinence
US8722079B2 (en) 2008-04-18 2014-05-13 Warsaw Orthopedic, Inc. Methods for treating conditions such as dystonia and post-stroke spasticity with clonidine
EP2151234A1 (en) * 2008-07-28 2010-02-10 Laboratorios Del. Dr. Esteve, S.A. Pharmaceutical formulation comprising a CB1-receptor compound in a solid solution and/or solid dispersion
WO2010123999A2 (en) * 2009-04-21 2010-10-28 Auspex Pharmaceuticals, Inc. 1-methylpyrazole modulators of substance p, calcitonin gene-related peptide, adrenergic receptor, and/or 5-ht receptor

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE891865A (fr) * 1981-01-30 1982-07-22 Sandoz Sa Nouveaux medicaments a base de derives condenses de l'imidazole pour le traitement des troubles urinaires
ES2150353B1 (es) * 1998-04-15 2001-07-01 Esteve Labor Dr Tienilazolilalcoxietanaminas, su preparacion y su aplicacion como medicamentos.
ES2137136B1 (es) * 1998-05-18 2000-07-01 Esteve Labor Dr Empleo de derivados de aril (o heteroaril) azolilcarbinoles en la elaboracion de un medicamento para el tratamiento de la inflamacion neurogenica.
ES2150378B1 (es) * 1998-08-07 2001-07-01 Esteve Labor Dr Empleo de derivados de aril(o heteroaril)azolilcarbinoles en la elaboracion de un medicamento para el tratamiento de los trastornos mediados por un exceso de substancia p.

Also Published As

Publication number Publication date
DE60211913D1 (de) 2006-07-06
PL369062A1 (en) 2005-04-18
JP2004521150A (ja) 2004-07-15
ES2180449A1 (es) 2003-02-01
ZA200400780B (en) 2005-01-31
CY1105113T1 (el) 2010-03-03
EP1413305B1 (en) 2006-05-31
ES2263792T3 (es) 2006-12-16
US20030022925A1 (en) 2003-01-30
RU2308268C2 (ru) 2007-10-20
KR20040030788A (ko) 2004-04-09
MA27056A1 (fr) 2004-12-20
ATE327752T1 (de) 2006-06-15
NO20040031L (no) 2004-03-02
CN1543344A (zh) 2004-11-03
EP1413305A1 (en) 2004-04-28
ES2180449B1 (es) 2004-01-16
US20050131049A1 (en) 2005-06-16
CA2452646A1 (en) 2003-01-16
NZ530817A (en) 2005-07-29
UA79238C2 (en) 2007-06-11
MXPA04000065A (es) 2004-05-21
DK1413305T3 (da) 2006-09-18
AR034679A1 (es) 2004-03-03
PT1413305E (pt) 2006-09-29
WO2003004022A1 (es) 2003-01-16
RU2004103475A (ru) 2005-06-10
DE60211913T2 (de) 2007-05-24

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A,7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2060 DE 29/06/2010.