ES2137136A1 - Empleo de derivados de aril (o heteroaril) azolilcarbinoles en la elaboracion de un medicamento para el tratamiento de la inflamacion neurogenica. - Google Patents
Empleo de derivados de aril (o heteroaril) azolilcarbinoles en la elaboracion de un medicamento para el tratamiento de la inflamacion neurogenica.Info
- Publication number
- ES2137136A1 ES2137136A1 ES009801021A ES9801021A ES2137136A1 ES 2137136 A1 ES2137136 A1 ES 2137136A1 ES 009801021 A ES009801021 A ES 009801021A ES 9801021 A ES9801021 A ES 9801021A ES 2137136 A1 ES2137136 A1 ES 2137136A1
- Authority
- ES
- Spain
- Prior art keywords
- heteroaryl
- aryl
- treatment
- inflammation
- medicament
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Empleo de derivados de aril (o heteroaril) azolilcarbinoles en la elaboración de un medicamento para el tratamiento de la inflamación neurogénica.Los derivados de aril (o heteroaril) azolilcarbinol (I), donde R1 es un átomo de hidrógeno o un grupo alquilo inferior; R2 es un radical dialquilaminoelquilo o azaheterociclilalquilo; Ar es un radical fenilo o tienilo, opcionalmente sustituidos; y Het es un heterociclo aromático nitrogenado de 5 miembros que contiene de uno a tres átomos de nitrógeno, opcionalmente sustituido; son adecuados para el tratamiento de la inflamación neurogénica, presente en diferentes procesos, tales como diabetes, asma, cistitis, gingivitis, migraña, dermatitis, rinitis, psoriasis, inflamación de nervios ciáticoy lumbares, procesos gastrointestinales, inflamación ocular, etc., en mamíferos, incluido el hombre.
Priority Applications (26)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES009801021A ES2137136B1 (es) | 1998-05-18 | 1998-05-18 | Empleo de derivados de aril (o heteroaril) azolilcarbinoles en la elaboracion de un medicamento para el tratamiento de la inflamacion neurogenica. |
NZ508316A NZ508316A (en) | 1998-05-18 | 1999-01-13 | A treatment for neurogenic inflammation in a variety of pathological conditions involving the activation of non-myelinated nerve fibres |
ARP990102325A AR019555A1 (es) | 1998-05-18 | 1999-05-14 | Empleo de derivados de aril(o heteroaril)azolilcarbinoles en la elaboracion de un medicamento para el tratamiento de la inflamacion neurogenica |
ES99919290T ES2196800T3 (es) | 1998-05-18 | 1999-05-18 | Usos de derivados de aril (oheteroaril) azolilcarbinoles en la elaboracion de un medicamento para el tratamiento de la inflamacion nueurogenica. |
CA002332711A CA2332711A1 (en) | 1998-05-18 | 1999-05-18 | Use of derivatives of aryl(or heteroaryl)azolylcarbinols in the manufacture of a medicament for the treatment of neurogenic inflammation |
RU2000131615/14A RU2212237C2 (ru) | 1998-05-18 | 1999-05-18 | Средство для лечения нейрогенного воспаления |
HU0102112A HUP0102112A3 (en) | 1998-05-18 | 1999-05-18 | Utilization of aryl(or heteroaryl)azolylcarbinol derivatives in the preparation of a medicament for the treatment of neurogenic inflammation |
PL99344742A PL344742A1 (en) | 1998-05-18 | 1999-05-18 | Utilization of aryl(or heteroaryl)azolylcarbinol derivatives in the preparation of a medicament for the treatment of neurogenic inflammation |
AU37118/99A AU759229B2 (en) | 1998-05-18 | 1999-05-18 | Utilization of aryl(or heteroaryl)azolylcarbinol derivatives in the preparation of a medicament for the treatment of neurogenic inflammation |
TR2000/03434T TR200003434T2 (tr) | 1998-05-18 | 1999-05-18 | Nörojenik iltihabın tedavisi için bir ilacın hazırlanması. |
KR1020007012955A KR100572416B1 (ko) | 1998-05-18 | 1999-05-18 | 신경원성 질환의 치료를 위한 약물의 제조에 사용되는아릴(또는 헤테로아릴) 아졸일카르비놀 유도체 |
DK99919290T DK1086682T3 (da) | 1998-05-18 | 1999-05-18 | Anvendelse af aryl(eller heteroaryl)azolylcarbinolderivater ved fremstilling af et lægemiddel til behandling af neurogen betændelse |
BR9910587-0A BR9910587A (pt) | 1998-05-18 | 1999-05-18 | Uso de derivados de aril(ou heteroaril) azolilcarbinóis na fabricacão de um medicamento para tratamento de inflamação neurogênica |
AT99919290T ATE237328T1 (de) | 1998-05-18 | 1999-05-18 | Verwendung von aryl(oder heteroaryl)- azolylcarbinolderivaten in der herstellung von medikamenten zur behandlung von neurogenen entzündungen |
DE69906969T DE69906969T2 (de) | 1998-05-18 | 1999-05-18 | Verwendung von aryl(oder heteroaryl)-azolylcarbinolderivaten in der herstellung von medikamenten zur behandlung von neurogenen entzündungen |
IL13974498A IL139744A0 (en) | 1998-05-18 | 1999-05-18 | Use of derivates of aryl (or heteroaryl) azolycarbinols in the manufacture of a medicament for the treatment of neurogenic inflamation |
EP99919290A EP1086682B1 (en) | 1998-05-18 | 1999-05-18 | Utilization of aryl(or heteroaryl)azolylcarbinol derivatives in the preparation of a medicament for the treatment of neurogenic inflammation |
JP2000549190A JP2002515409A (ja) | 1998-05-18 | 1999-05-18 | 神経性炎症の治療のための薬の製造におけるアリール(又はヘテロアリール)アゾリルカルビノール誘導体の使用 |
CZ20004282A CZ291593B6 (cs) | 1998-05-18 | 1999-05-18 | Léčivo pro léčbu neurogenních zánětů |
CNB998077216A CN1221257C (zh) | 1998-05-18 | 1999-05-18 | 芳基(或杂芳基)唑基甲醇衍生物在制备用于治疗神经原性炎症的药物中的应用 |
PCT/ES1999/000142 WO1999059524A2 (es) | 1998-05-18 | 1999-05-18 | Empleo de derivados de aril(o heteroaril)azolilcarbinoles en la elaboracion de un medicamento para el tratamiento de la inflamacion neurogenica |
PT99919290T PT1086682E (pt) | 1998-05-18 | 1999-05-18 | Utilizacao de derivados de arilo(ou heteroaril)azolil-carbinol na preparacao de um medicamento para o tratamento de inflamacao neurogenica |
TW088108432A TW570796B (en) | 1998-05-18 | 1999-05-24 | Use of derivatives of aryl(or heteroaryl)azolylcarbinols in the manufacture of a medicament for the treatment of neurogenic inflammation |
IL139744A IL139744A (en) | 1998-05-18 | 2000-11-17 | Use of derivatives of aryl or troaryl azolylcarbinols in the manufacture of a drug for the treatment of neurogenic inflammation |
ZA200006732A ZA200006732B (en) | 1998-05-18 | 2000-11-17 | Utilization of Aryl (or heteroaryl)azolylcarbinol derivatives in the preparation of a medicament for the treatment of neurogenic inflammation. |
NO20005837A NO20005837L (no) | 1998-05-18 | 2000-11-17 | Anvendelse av aryl (eller heteroaryl) azolylkarbinolderivater ved fremstilling av et medikament for behandling av neurogen inflammasjon |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES009801021A ES2137136B1 (es) | 1998-05-18 | 1998-05-18 | Empleo de derivados de aril (o heteroaril) azolilcarbinoles en la elaboracion de un medicamento para el tratamiento de la inflamacion neurogenica. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2137136A1 true ES2137136A1 (es) | 1999-12-01 |
ES2137136B1 ES2137136B1 (es) | 2000-07-01 |
Family
ID=8303801
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES009801021A Expired - Fee Related ES2137136B1 (es) | 1998-05-18 | 1998-05-18 | Empleo de derivados de aril (o heteroaril) azolilcarbinoles en la elaboracion de un medicamento para el tratamiento de la inflamacion neurogenica. |
ES99919290T Expired - Lifetime ES2196800T3 (es) | 1998-05-18 | 1999-05-18 | Usos de derivados de aril (oheteroaril) azolilcarbinoles en la elaboracion de un medicamento para el tratamiento de la inflamacion nueurogenica. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES99919290T Expired - Lifetime ES2196800T3 (es) | 1998-05-18 | 1999-05-18 | Usos de derivados de aril (oheteroaril) azolilcarbinoles en la elaboracion de un medicamento para el tratamiento de la inflamacion nueurogenica. |
Country Status (24)
Country | Link |
---|---|
EP (1) | EP1086682B1 (es) |
JP (1) | JP2002515409A (es) |
KR (1) | KR100572416B1 (es) |
CN (1) | CN1221257C (es) |
AR (1) | AR019555A1 (es) |
AT (1) | ATE237328T1 (es) |
AU (1) | AU759229B2 (es) |
BR (1) | BR9910587A (es) |
CA (1) | CA2332711A1 (es) |
CZ (1) | CZ291593B6 (es) |
DE (1) | DE69906969T2 (es) |
DK (1) | DK1086682T3 (es) |
ES (2) | ES2137136B1 (es) |
HU (1) | HUP0102112A3 (es) |
IL (2) | IL139744A0 (es) |
NO (1) | NO20005837L (es) |
NZ (1) | NZ508316A (es) |
PL (1) | PL344742A1 (es) |
PT (1) | PT1086682E (es) |
RU (1) | RU2212237C2 (es) |
TR (1) | TR200003434T2 (es) |
TW (1) | TW570796B (es) |
WO (1) | WO1999059524A2 (es) |
ZA (1) | ZA200006732B (es) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002080908A1 (es) * | 2001-04-06 | 2002-10-17 | Laboratorios Del Dr. Esteve, S.A. | Derivados de aril (o heteroaril) azolilcarbinoles para el tratamiento de enfermedades respiratorias |
WO2003004022A1 (es) * | 2001-07-06 | 2003-01-16 | Laboratorios Del Dr. Esteve, S.A. | Derivados de aril(o heteroaril)azolilcarbinoles para el tratamiento de la incontinencia urinaria |
ES2335181A1 (es) * | 2006-02-10 | 2010-03-22 | Laboratorios Del Dr. Esteve, S.A. | Combinacion de sustancias activas. |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2150353B1 (es) * | 1998-04-15 | 2001-07-01 | Esteve Labor Dr | Tienilazolilalcoxietanaminas, su preparacion y su aplicacion como medicamentos. |
CN1674919A (zh) * | 2002-08-12 | 2005-09-28 | 比克尔·斯韦恩森 | Cgrp拮抗剂化合物在治疗牛皮癣中的应用 |
WO2006010627A1 (en) * | 2004-07-30 | 2006-02-02 | Laboratorios Del Dr. Esteve, S.A. | Aryl (or heteroaryl) azolylcarbinols |
EP1632227A1 (en) * | 2004-09-07 | 2006-03-08 | Laboratorios del Dr. Esteve S.A. | Derivatives of aryl (or heteroaryl) azolylcarbinols (in particular cizolirtin citrate) for the treatment of opioid addiction |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0289380A1 (fr) * | 1987-04-10 | 1988-11-02 | Laboratorios Del Dr. Esteve, S.A. | Dérivés d'aryl-hétéroaryl carbinols avec activité analgésique |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2681322B1 (fr) * | 1991-09-12 | 1993-12-17 | Laboratorios Dr Esteve Sa | Derives d'aryl-heteroaryl-{n-[2-(3,4-dimethoxyphenyl)-ethyl]-n-methyl-3-aminopropoxy}-methane leur preparation et leur application en tant que medicaments . |
ES2150353B1 (es) * | 1998-04-15 | 2001-07-01 | Esteve Labor Dr | Tienilazolilalcoxietanaminas, su preparacion y su aplicacion como medicamentos. |
-
1998
- 1998-05-18 ES ES009801021A patent/ES2137136B1/es not_active Expired - Fee Related
-
1999
- 1999-01-13 NZ NZ508316A patent/NZ508316A/en unknown
- 1999-05-14 AR ARP990102325A patent/AR019555A1/es unknown
- 1999-05-18 CN CNB998077216A patent/CN1221257C/zh not_active Expired - Fee Related
- 1999-05-18 BR BR9910587-0A patent/BR9910587A/pt not_active Application Discontinuation
- 1999-05-18 TR TR2000/03434T patent/TR200003434T2/xx unknown
- 1999-05-18 PL PL99344742A patent/PL344742A1/xx not_active Application Discontinuation
- 1999-05-18 AT AT99919290T patent/ATE237328T1/de not_active IP Right Cessation
- 1999-05-18 JP JP2000549190A patent/JP2002515409A/ja active Pending
- 1999-05-18 AU AU37118/99A patent/AU759229B2/en not_active Ceased
- 1999-05-18 HU HU0102112A patent/HUP0102112A3/hu unknown
- 1999-05-18 CA CA002332711A patent/CA2332711A1/en not_active Abandoned
- 1999-05-18 CZ CZ20004282A patent/CZ291593B6/cs not_active IP Right Cessation
- 1999-05-18 PT PT99919290T patent/PT1086682E/pt unknown
- 1999-05-18 ES ES99919290T patent/ES2196800T3/es not_active Expired - Lifetime
- 1999-05-18 RU RU2000131615/14A patent/RU2212237C2/ru not_active IP Right Cessation
- 1999-05-18 WO PCT/ES1999/000142 patent/WO1999059524A2/es active IP Right Grant
- 1999-05-18 DE DE69906969T patent/DE69906969T2/de not_active Expired - Fee Related
- 1999-05-18 IL IL13974498A patent/IL139744A0/xx not_active IP Right Cessation
- 1999-05-18 DK DK99919290T patent/DK1086682T3/da active
- 1999-05-18 KR KR1020007012955A patent/KR100572416B1/ko not_active IP Right Cessation
- 1999-05-18 EP EP99919290A patent/EP1086682B1/en not_active Expired - Lifetime
- 1999-05-24 TW TW088108432A patent/TW570796B/zh not_active IP Right Cessation
-
2000
- 2000-11-17 ZA ZA200006732A patent/ZA200006732B/xx unknown
- 2000-11-17 NO NO20005837A patent/NO20005837L/no not_active Application Discontinuation
- 2000-11-17 IL IL139744A patent/IL139744A/en unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0289380A1 (fr) * | 1987-04-10 | 1988-11-02 | Laboratorios Del Dr. Esteve, S.A. | Dérivés d'aryl-hétéroaryl carbinols avec activité analgésique |
Non-Patent Citations (2)
Title |
---|
HUESO-RODRIGUEZ, J.A. et al. Preparation of the enantiomers of the analgesic E-3710. Bioorganic & Medicinal Chemistry letters, 1993, Vol. 3 no 2, paginas 269-272 * |
MATTIOLI, F y GUIA, M.W. Dialkylamino alkyl ethers of phenyl-(5-substituted 1-phenyl-1H-pyrazol-4-yl)methanols with analgesic and anti-inflamatory activity. J. Heterocyclic. Chem. 1997, Vol. 34, paginas 963-968 * |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002080908A1 (es) * | 2001-04-06 | 2002-10-17 | Laboratorios Del Dr. Esteve, S.A. | Derivados de aril (o heteroaril) azolilcarbinoles para el tratamiento de enfermedades respiratorias |
ES2174756A1 (es) * | 2001-04-06 | 2002-11-01 | Esteve Labor Dr | Derivados de aril (o heteroaril) azolilcarbinoles para el tratamiento de enfermedades respiratorias. |
WO2003004022A1 (es) * | 2001-07-06 | 2003-01-16 | Laboratorios Del Dr. Esteve, S.A. | Derivados de aril(o heteroaril)azolilcarbinoles para el tratamiento de la incontinencia urinaria |
ES2180449A1 (es) * | 2001-07-06 | 2003-02-01 | Esteve Labor Dr | Derivados de aril (o heteroaril) azolilcarbinoles para el tratamiento de la incontinencia urinaria. |
ES2335181A1 (es) * | 2006-02-10 | 2010-03-22 | Laboratorios Del Dr. Esteve, S.A. | Combinacion de sustancias activas. |
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