NO20042141L - Terapeutiske quinolonforbindelser med 5-HT-antagonistiske egenskaper - Google Patents

Terapeutiske quinolonforbindelser med 5-HT-antagonistiske egenskaper

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Publication number
NO20042141L
NO20042141L NO20042141A NO20042141A NO20042141L NO 20042141 L NO20042141 L NO 20042141L NO 20042141 A NO20042141 A NO 20042141A NO 20042141 A NO20042141 A NO 20042141A NO 20042141 L NO20042141 L NO 20042141L
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disorders
compounds
therapeutic
antagonistic properties
useful
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NO20042141A
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English (en)
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Marc Jerome Chapdelaine
Timothy Davenport
Markus Haeberlein
Carey Horchler
John Mccauley
Edward Pierson
Daniel Sohn
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Astrazeneca Ab Global Ip
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Publication of NO20042141L publication Critical patent/NO20042141L/no

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    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

Forbindeler som har formel (1): hvor (Rer typisk et tertiært nitrogenatom, som enten er alkylsubstituert eller et ledd i en heterosyklisk ring; Rer typisk en monosyklisk eller bisyklisk aromatisk ring eller en heterosyklisk ring) hvor nevnte forbindelser er nyttige for behandlingen av psykiatriske forstyrrelser inkludert, men ikke begrenset til, depresjon, generalisert angst, spiseforstyrrelser, demens, panisk forstyrrelse og søvnforstyrrelser. Forbindelsene kan også være nyttige i behandlingen av gastrointestinale forstyrrelser, kardiovaskulær regulering, motoriske forstyrrelser, endokrine forstyrrelser, vasospasme og seksuell dysfunksjon. Forbindelsene er 5-HTog. 5-HTantagonister.
NO20042141A 2001-11-01 2004-05-25 Terapeutiske quinolonforbindelser med 5-HT-antagonistiske egenskaper NO20042141L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0103648A SE0103648D0 (sv) 2001-11-01 2001-11-01 Therapeutic quinolone compounds
PCT/SE2002/001987 WO2003037871A1 (en) 2001-11-01 2002-11-01 Therapeutic quinolone compounds with 5-ht-antagonistic properties

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NO20042141L true NO20042141L (no) 2004-07-22

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US (1) US20050085457A1 (no)
EP (1) EP1451157A1 (no)
JP (1) JP2005511568A (no)
KR (1) KR20050042214A (no)
CN (1) CN1608054A (no)
BR (1) BR0213748A (no)
CA (1) CA2465344A1 (no)
CO (1) CO5580826A2 (no)
HU (1) HUP0402576A3 (no)
IL (1) IL161509A0 (no)
IS (1) IS7237A (no)
MX (1) MXPA04004074A (no)
NO (1) NO20042141L (no)
PL (1) PL370073A1 (no)
RU (1) RU2004112777A (no)
SE (1) SE0103648D0 (no)
UA (1) UA77012C2 (no)
WO (1) WO2003037871A1 (no)
ZA (1) ZA200403207B (no)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL211300B1 (pl) 2002-04-17 2012-05-31 Cytokinetics Inc Związek i kompozycja zawierająca ten związek
EP1539727B1 (en) 2002-07-17 2009-02-18 Cytokinetics, Inc. Compounds, compositions, and methods for treating cellular proliferative diseases
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
GB0321473D0 (en) 2003-09-12 2003-10-15 Glaxo Group Ltd Novel compounds
TWI357901B (en) * 2004-03-12 2012-02-11 Lundbeck & Co As H Substituted morpholine and thiomorpholine derivati
SE0400759D0 (sv) * 2004-03-23 2004-03-23 Astrazeneca Ab Novel amination process
EP1734963A4 (en) 2004-04-02 2008-06-18 Merck & Co Inc METHOD FOR TREATING PEOPLE WITH METABOLIC AND ANTHROPOMETRIC DISORDER
CA2580787A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes
US8071603B2 (en) 2004-09-20 2011-12-06 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
BRPI0515488A (pt) 2004-09-20 2008-07-29 Xenon Pharmaceuticals Inc derivados de heterocìclicos e seu uso como agentes terapêuticos
JP4958786B2 (ja) 2004-09-20 2012-06-20 ゼノン・ファーマシューティカルズ・インコーポレイテッド 複素環誘導体および治療薬としてのそれらの使用
EP1799668A1 (en) 2004-09-20 2007-06-27 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as mediators of stearoyl-coa desaturase
US7592343B2 (en) 2004-09-20 2009-09-22 Xenon Pharmaceuticals Inc. Pyridazine-piperazine compounds and their use as stearoyl-CoA desaturase inhibitors
WO2006034341A2 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Pyridazine derivatives for inhibiting human stearoyl-coa-desaturase
BRPI0611187A2 (pt) 2005-06-03 2010-08-24 Xenon Pharmaceuticals Inc derivados aminotiazàis como inibidores da estearoil-coa desaturase humana
CN101365682A (zh) 2005-12-08 2009-02-11 千禧药品公司 具有激酶抑制活性的双环化合物
AR059356A1 (es) * 2006-02-14 2008-03-26 Astrazeneca Ab Nuevos radioligandos
WO2007097697A1 (en) * 2006-02-23 2007-08-30 Astrazeneca Ab Therapeutic quinoline compounds that are 5ht1b modulators
CN101516852B (zh) 2006-09-28 2011-11-16 弗·哈夫曼-拉罗切有限公司 具有5-ht结合特性的喹啉衍生物
CA3089569C (en) 2007-06-04 2023-12-05 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
US20100120694A1 (en) 2008-06-04 2010-05-13 Synergy Pharmaceuticals, Inc. Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders
TWI366565B (en) * 2007-06-06 2012-06-21 Otsuka Pharma Co Ltd Quinolone compound and pharmaceutical composition
EP2321341B1 (en) 2008-07-16 2017-02-22 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US8524740B2 (en) * 2010-07-15 2013-09-03 Tairx, Inc. Synthesis and anticancer activity of aryl and heteroaryl-quinolin derivatives
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN108676076A (zh) 2011-03-01 2018-10-19 辛纳吉制药公司 制备鸟苷酸环化酶c激动剂的方法
EP2970384A1 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
JP2016514670A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド 他の薬物と組み合わせたグアニル酸シクラーゼ受容体アゴニスト
RS65632B1 (sr) 2013-06-05 2024-07-31 Bausch Health Ireland Ltd Ultra-prečišćeni agonisti guanilat-ciklaze c, postupak njihove pripreme i upotrebe
CN104327030A (zh) * 2014-10-20 2015-02-04 云南民族大学 一种4-色酮衍生物的简便合成方法
WO2020183011A1 (en) 2019-03-14 2020-09-17 Institut Curie Htr1d inhibitors and uses thereof in the treatment of cancer
AR120680A1 (es) 2019-12-06 2022-03-09 Vertex Pharma Tetrahidrofuranos sustituidos como moduladores de canales de sodio
CN115073490B (zh) * 2021-03-12 2024-08-02 上海医药工业研究院 一种瑞卢戈利及其中间体的制备方法
AR126073A1 (es) 2021-06-04 2023-09-06 Vertex Pharma N-(hidroxialquil(hetero)aril)tetrahidrofuran carboxamidas como moduladores de canales de sodio

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