RU2281954C2 - Очищенный препарат уриказы млекопитающего, способ его получения, препарат активного уриказного конъюгата и фармацевтический состав - Google Patents
Очищенный препарат уриказы млекопитающего, способ его получения, препарат активного уриказного конъюгата и фармацевтический состав Download PDFInfo
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- RU2281954C2 RU2281954C2 RU2002120486/13A RU2002120486A RU2281954C2 RU 2281954 C2 RU2281954 C2 RU 2281954C2 RU 2002120486/13 A RU2002120486/13 A RU 2002120486/13A RU 2002120486 A RU2002120486 A RU 2002120486A RU 2281954 C2 RU2281954 C2 RU 2281954C2
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- uricase
- poly
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- mammalian
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
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| US09/501,730 | 2000-02-10 | ||
| US09/501,730 US6783965B1 (en) | 2000-02-10 | 2000-02-10 | Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates |
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| RU2006107110/13A Division RU2352354C2 (ru) | 2000-02-10 | 2001-02-07 | Свободная от агрегатов уратоксидаза для приготовления неиммуногенных полимерных конъюгатов |
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| RU2006107110/13A RU2352354C2 (ru) | 2000-02-10 | 2001-02-07 | Свободная от агрегатов уратоксидаза для приготовления неиммуногенных полимерных конъюгатов |
| RU2009104003/10A RU2557318C9 (ru) | 2000-02-10 | 2009-02-06 | Очищенный препарат уратоксидазы, очищенная рекомбинантная уратоксидаза, конъюгат (варианты) и фармацевтическая композиция для снижения уровней мочевой кислоты в жидкости или ткани организма млекопитающего, очищенные фрагменты уратоксидазы и способ очистки уратоксидазы. |
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| RU2006107110/13A RU2352354C2 (ru) | 2000-02-10 | 2001-02-07 | Свободная от агрегатов уратоксидаза для приготовления неиммуногенных полимерных конъюгатов |
| RU2009104003/10A RU2557318C9 (ru) | 2000-02-10 | 2009-02-06 | Очищенный препарат уратоксидазы, очищенная рекомбинантная уратоксидаза, конъюгат (варианты) и фармацевтическая композиция для снижения уровней мочевой кислоты в жидкости или ткани организма млекопитающего, очищенные фрагменты уратоксидазы и способ очистки уратоксидазы. |
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| US12669498B2 (en) | 2009-06-25 | 2026-06-30 | Horizon Therapeutics Usa, Inc. | Methods and kits for predicting infusion reaction risk and antibody mediated loss of response by monitoring serum uric acid during pegylated uricase therapy |
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