RU2270679C2 - Лекарственное средство для лечения гипертензии - Google Patents

Лекарственное средство для лечения гипертензии Download PDF

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Publication number
RU2270679C2
RU2270679C2 RU2001124604/15A RU2001124604A RU2270679C2 RU 2270679 C2 RU2270679 C2 RU 2270679C2 RU 2001124604/15 A RU2001124604/15 A RU 2001124604/15A RU 2001124604 A RU2001124604 A RU 2001124604A RU 2270679 C2 RU2270679 C2 RU 2270679C2
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RU
Russia
Prior art keywords
group
alkyl
hypertension
phenyl
compounds
Prior art date
Application number
RU2001124604/15A
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English (en)
Russian (ru)
Other versions
RU2001124604A (ru
Inventor
Мартин Р. УИЛКИНЗ (GB)
Мартин Р. УИЛКИНЗ
Дирк ТОРМЭЛЕН (DE)
Дирк ТОРМЭЛЕН
Харальд ВАЛЬДЕК (DE)
Харальд Вальдек
Original Assignee
Зольвай Фармасьютиклз Гмбх
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Application filed by Зольвай Фармасьютиклз Гмбх filed Critical Зольвай Фармасьютиклз Гмбх
Publication of RU2001124604A publication Critical patent/RU2001124604A/ru
Application granted granted Critical
Publication of RU2270679C2 publication Critical patent/RU2270679C2/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
RU2001124604/15A 1999-02-16 2000-02-10 Лекарственное средство для лечения гипертензии RU2270679C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19906310.9 1999-02-16
DE19906310A DE19906310A1 (de) 1999-02-16 1999-02-16 Arzneimittel zur Behandlung von Bluthochdruck

Publications (2)

Publication Number Publication Date
RU2001124604A RU2001124604A (ru) 2003-05-20
RU2270679C2 true RU2270679C2 (ru) 2006-02-27

Family

ID=7897580

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2001124604/15A RU2270679C2 (ru) 1999-02-16 2000-02-10 Лекарственное средство для лечения гипертензии

Country Status (28)

Country Link
US (1) US6482820B2 (https=)
EP (1) EP1154777B1 (https=)
JP (1) JP2002537258A (https=)
KR (2) KR20010101922A (https=)
CN (1) CN1198619C (https=)
AR (1) AR036864A1 (https=)
AT (1) ATE295174T1 (https=)
AU (1) AU773240C (https=)
BR (1) BR0008260A (https=)
CA (1) CA2362273C (https=)
CZ (1) CZ301499B6 (https=)
DE (2) DE19906310A1 (https=)
DZ (1) DZ3014A1 (https=)
ES (1) ES2238268T3 (https=)
HK (1) HK1042247B (https=)
HU (1) HUP0105491A3 (https=)
IL (1) IL144622A (https=)
NO (1) NO329588B1 (https=)
NZ (1) NZ514058A (https=)
PL (1) PL195283B1 (https=)
PT (1) PT1154777E (https=)
RU (1) RU2270679C2 (https=)
SK (1) SK287254B6 (https=)
TR (1) TR200102386T2 (https=)
TW (1) TWI221770B (https=)
UA (1) UA63032C2 (https=)
WO (1) WO2000048601A1 (https=)
ZA (1) ZA200105828B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2557048C2 (ru) * 2008-01-31 2015-07-20 Вандербилт Юнивесити Способы терапии заболеваний легких

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DE19932555A1 (de) * 1999-07-13 2001-01-18 Solvay Pharm Gmbh Arzneimittel mit protektiver Wirkung gegen oxidativ-toxische und insbesondere gegen kardiotoxische Substanzen
DE60040089D1 (de) * 1999-11-19 2008-10-09 Solvay Pharm Bv Menschliches homolog aus der familie der metalloproteasen
ATE367815T1 (de) * 2000-10-04 2007-08-15 Astellas Pharma Inc Verwendung von einem vasopressin-antagonisten wie conivaptan zur herstellung eines medikaments für die behandlung der pulmonalen hypertension
JP2004536063A (ja) * 2001-05-18 2004-12-02 ゾルファイ　ファーマスーティカルズ　ゲゼルシャフト　ミット　ベシュレンクテル　ハフツング 医薬の製造における組み合わせたｎｅｐ／ｍｐ−抑制活性を有する化合物の使用
AP1758A (en) * 2001-09-10 2007-07-30 Tibotec Pharm Ltd Method for the preparation of hexahydro-furo [2,3-b]furan-3-ol.
RU2303041C2 (ru) 2002-01-16 2007-07-20 Солвей Фармасьютикалс Б.В. Твердые соли бензазепиновых соединений и их применение при получении фармацевтических соединений
AR038681A1 (es) * 2002-02-14 2005-01-26 Solvay Pharm Bv Formulacion oral de solucion solida de una sustancia activa pobremente soluble en agua
WO2004062692A1 (en) * 2003-01-13 2004-07-29 Solvay Pharmaceuticals B.V. Formulation of poorly water-soluble active substances
US7452875B2 (en) 2003-09-26 2008-11-18 Solvay Pharmaceuticals Gmbh Amidomethyl-substituted 1-(carboxyalkyl) cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them
US7262184B2 (en) 2003-09-26 2007-08-28 Solvay Pharmaceuticals Gmbh Amidomethyl-substituted 1-(carboxyalkyl) cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them
SA04250283B1 (ar) * 2003-09-26 2008-05-26 سولفاي فارماسيتيكالز جي أم بي أتش مشتقات من amidomethy1-substituted1-(carboxyalkyl)-cyclopentylcarbonylamino-benzazepine-N-acetic acid
US7427611B2 (en) 2003-09-26 2008-09-23 Solvay Pharmaceuticals Gmbh Amidomethyl-substituted 1-(carboxyalkyl)-cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them
JP4824573B2 (ja) 2003-11-18 2011-11-30 ゾルファイ ファーマスーティカルズ ゲゼルシャフト ミット ベシュレンクテル ハフツング 腎不全、腎疾患または腎障害、特に糖尿病患者におけるこれらの治療のための医薬組成物
US20050267072A1 (en) * 2004-05-14 2005-12-01 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions containing dually acting inhibitors of neutral endopeptidase for the treatment of sexual dysfunction
US20050267124A1 (en) * 2004-05-14 2005-12-01 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous producing system and PDEV inhibiitors
US20050288272A1 (en) * 2004-06-23 2005-12-29 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous endothelin producing system and AT1 receptor antagonists
RU2410118C2 (ru) 2004-12-15 2011-01-27 Зольвай Фармасьютиклз Гмбх ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ, ВКЛЮЧАЮЩИЕ ИНГИБИТОРЫ НЭП (НЕЙТРАЛЬНОЙ ЭНДОПЕПТИДАЗЫ), ИНГИБИТОРЫ ЭНДОГЕННОЙ ПРОДУЦИРУЮЩЕЙ ЭНДОТЕЛИН СИСТЕМЫ И ИНГИБИТОРЫ ГМГ (ГИДРОКСИМЕТИЛГЛУТАРИЛ)СоА РЕДУКТАЗЫ
US20060205625A1 (en) * 2005-02-18 2006-09-14 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous endothelin producing system and diuretics
US20070292503A1 (en) * 2006-06-16 2007-12-20 Gorissen Henricus R Oral pharmaceutical composition of poorly water-soluble active substance
US20070299054A1 (en) * 2006-06-22 2007-12-27 Rajesh Jain Oral pharmaceutical composition of a poorly water-soluble active agent

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2207351A (en) * 1987-06-08 1989-02-01 Squibb & Sons Inc Inhibitors of neutral endopeptidase
US5087702A (en) * 1991-01-30 1992-02-11 Merck & Co., Inc. Microbial transformation process for producing an antihypertensive product
DE19510566A1 (de) * 1995-03-23 1996-09-26 Kali Chemie Pharma Gmbh Benzazepin-, Benzoxazepin- und Benzothiazepin-N-essigsäurederivate sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE19638020A1 (de) * 1996-09-18 1998-03-19 Solvay Pharm Gmbh Die gastrointestinale Durchblutung fördernde Arzneimittel

Family Cites Families (3)

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US4749688A (en) * 1986-06-20 1988-06-07 Schering Corporation Use of neutral metalloendopeptidase inhibitors in the treatment of hypertension
EP0254032A3 (en) * 1986-06-20 1990-09-05 Schering Corporation Neutral metalloendopeptidase inhibitors in the treatment of hypertension
US5362727A (en) * 1993-07-26 1994-11-08 Bristol-Myers Squibb Substituted azepino[2,1-a]isoquinoline compounds

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2207351A (en) * 1987-06-08 1989-02-01 Squibb & Sons Inc Inhibitors of neutral endopeptidase
US5087702A (en) * 1991-01-30 1992-02-11 Merck & Co., Inc. Microbial transformation process for producing an antihypertensive product
DE19510566A1 (de) * 1995-03-23 1996-09-26 Kali Chemie Pharma Gmbh Benzazepin-, Benzoxazepin- und Benzothiazepin-N-essigsäurederivate sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE19638020A1 (de) * 1996-09-18 1998-03-19 Solvay Pharm Gmbh Die gastrointestinale Durchblutung fördernde Arzneimittel

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Д.А.Харкевич. Фармакология. - М.: Медицина, 1987, с.47-48. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2557048C2 (ru) * 2008-01-31 2015-07-20 Вандербилт Юнивесити Способы терапии заболеваний легких

Also Published As

Publication number Publication date
CN1198619C (zh) 2005-04-27
TR200102386T2 (tr) 2002-01-21
AU773240C (en) 2004-11-18
WO2000048601A1 (de) 2000-08-24
SK287254B6 (sk) 2010-04-07
CA2362273C (en) 2010-05-25
CN1339966A (zh) 2002-03-13
DZ3014A1 (fr) 2004-03-27
CZ301499B6 (cs) 2010-03-24
AR036864A1 (es) 2004-10-13
JP2002537258A (ja) 2002-11-05
HK1042247A1 (en) 2002-08-09
PT1154777E (pt) 2005-07-29
HUP0105491A2 (en) 2002-06-29
AU773240B2 (en) 2004-05-20
NZ514058A (en) 2001-09-28
CZ20012672A3 (cs) 2002-02-13
BR0008260A (pt) 2001-11-06
SK10822001A3 (sk) 2002-03-05
NO20013958L (no) 2001-10-15
KR20010101922A (ko) 2001-11-15
DE19906310A1 (de) 2000-08-17
CA2362273A1 (en) 2000-08-24
KR20070027719A (ko) 2007-03-09
US6482820B2 (en) 2002-11-19
IL144622A (en) 2006-08-20
KR100797665B1 (ko) 2008-01-23
UA63032C2 (en) 2004-01-15
NO329588B1 (no) 2010-11-15
PL195283B1 (pl) 2007-08-31
DE50010284D1 (de) 2005-06-16
AU2547600A (en) 2000-09-04
PL350167A1 (en) 2002-11-18
TWI221770B (en) 2004-10-11
EP1154777A1 (de) 2001-11-21
ATE295174T1 (de) 2005-05-15
HUP0105491A3 (en) 2002-08-28
EP1154777B1 (de) 2005-05-11
NO20013958D0 (no) 2001-08-15
ZA200105828B (en) 2002-07-15
US20020052361A1 (en) 2002-05-02
HK1042247B (zh) 2005-09-23
ES2238268T3 (es) 2005-09-01

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MM4A The patent is invalid due to non-payment of fees

Effective date: 20120211