AR036864A1 - Uso de compuestos de acido benzacepin-n-acetico, y procedimiento para la preparacion de dichos compuestos - Google Patents
Uso de compuestos de acido benzacepin-n-acetico, y procedimiento para la preparacion de dichos compuestosInfo
- Publication number
- AR036864A1 AR036864A1 ARP000100257A ARP000100257A AR036864A1 AR 036864 A1 AR036864 A1 AR 036864A1 AR P000100257 A ARP000100257 A AR P000100257A AR P000100257 A ARP000100257 A AR P000100257A AR 036864 A1 AR036864 A1 AR 036864A1
- Authority
- AR
- Argentina
- Prior art keywords
- compounds
- preparation
- radical
- benzacepin
- procedure
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Uso de compuestos de la fórmula general (1) en la cual R1 representa un radical fenilalquilo inferior eventualmente sustituido en el ciclo fenilo por alquilo inferior, alcoxi inferior o halógeno, o un radical naftil-alquilo inferior, R2 representa hidrógeno o un radical capaz de formar un éster biolábil, R3 representa hidrógeno o un radical capaz de formar un éster biolábil, y sales fisiológicamente tolerables de los ácidos de la fórmula (1) para la preparación de composiciones farmacéuticas para el tratamiento de la hipertensión, particularmente de aquellas formas de la hipertensión secundaria causadas por condiciones cardíacas en mamíferos superiores y seres humanos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19906310A DE19906310A1 (de) | 1999-02-16 | 1999-02-16 | Arzneimittel zur Behandlung von Bluthochdruck |
Publications (1)
Publication Number | Publication Date |
---|---|
AR036864A1 true AR036864A1 (es) | 2004-10-13 |
Family
ID=7897580
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP000100257A AR036864A1 (es) | 1999-02-16 | 2000-01-20 | Uso de compuestos de acido benzacepin-n-acetico, y procedimiento para la preparacion de dichos compuestos |
Country Status (28)
Country | Link |
---|---|
US (1) | US6482820B2 (es) |
EP (1) | EP1154777B1 (es) |
JP (1) | JP2002537258A (es) |
KR (2) | KR100797665B1 (es) |
CN (1) | CN1198619C (es) |
AR (1) | AR036864A1 (es) |
AT (1) | ATE295174T1 (es) |
AU (1) | AU773240C (es) |
BR (1) | BR0008260A (es) |
CA (1) | CA2362273C (es) |
CZ (1) | CZ301499B6 (es) |
DE (2) | DE19906310A1 (es) |
DZ (1) | DZ3014A1 (es) |
ES (1) | ES2238268T3 (es) |
HK (1) | HK1042247B (es) |
HU (1) | HUP0105491A3 (es) |
IL (1) | IL144622A (es) |
NO (1) | NO329588B1 (es) |
NZ (1) | NZ514058A (es) |
PL (1) | PL195283B1 (es) |
PT (1) | PT1154777E (es) |
RU (1) | RU2270679C2 (es) |
SK (1) | SK287254B6 (es) |
TR (1) | TR200102386T2 (es) |
TW (1) | TWI221770B (es) |
UA (1) | UA63032C2 (es) |
WO (1) | WO2000048601A1 (es) |
ZA (1) | ZA200105828B (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19932555A1 (de) * | 1999-07-13 | 2001-01-18 | Solvay Pharm Gmbh | Arzneimittel mit protektiver Wirkung gegen oxidativ-toxische und insbesondere gegen kardiotoxische Substanzen |
EP1234025B1 (en) * | 1999-11-19 | 2008-08-27 | Solvay Pharmaceuticals B.V. | Human enzymes of the metalloprotease family |
IL145684A (en) * | 2000-10-04 | 2007-06-17 | Warner Lambert Co | Medications for the treatment of pulmonary hypertension |
RU2003136077A (ru) * | 2001-05-18 | 2005-08-10 | Зольвай Фармасьютиклз Гмбх (De) | Применение соединений, обладающих совместной ингибирующей активностью в отношении nep (нейтральная эндопептидаза) и мр (металлопротеаза), для приготовления лекарственных средств |
ATE453648T1 (de) * | 2001-09-10 | 2010-01-15 | Tibotec Pharm Ltd | Verfahren zur herstellung von hexahydrofuroc2,3- büfuran-3-ol |
CN100591689C (zh) * | 2002-01-16 | 2010-02-24 | 索尔瓦药物有限公司 | 苯并氮杂环庚三烯化合物的固体盐及其在制备药物化合物中的应用 |
AR038681A1 (es) * | 2002-02-14 | 2005-01-26 | Solvay Pharm Bv | Formulacion oral de solucion solida de una sustancia activa pobremente soluble en agua |
WO2004062692A1 (en) * | 2003-01-13 | 2004-07-29 | Solvay Pharmaceuticals B.V. | Formulation of poorly water-soluble active substances |
US7427611B2 (en) | 2003-09-26 | 2008-09-23 | Solvay Pharmaceuticals Gmbh | Amidomethyl-substituted 1-(carboxyalkyl)-cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them |
US7262184B2 (en) | 2003-09-26 | 2007-08-28 | Solvay Pharmaceuticals Gmbh | Amidomethyl-substituted 1-(carboxyalkyl) cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them |
US7452875B2 (en) | 2003-09-26 | 2008-11-18 | Solvay Pharmaceuticals Gmbh | Amidomethyl-substituted 1-(carboxyalkyl) cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them |
SA04250283B1 (ar) * | 2003-09-26 | 2008-05-26 | سولفاي فارماسيتيكالز جي أم بي أتش | مشتقات من amidomethy1-substituted1-(carboxyalkyl)-cyclopentylcarbonylamino-benzazepine-N-acetic acid |
PL1687006T3 (pl) * | 2003-11-18 | 2008-01-31 | Solvay Pharm Gmbh | Kompozycje farmaceutyczne do leczenia zaburzeń czynności nerek |
US20050267124A1 (en) * | 2004-05-14 | 2005-12-01 | Solvay Pharmaceuticals Gmbh | Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous producing system and PDEV inhibiitors |
US20050267072A1 (en) * | 2004-05-14 | 2005-12-01 | Solvay Pharmaceuticals Gmbh | Pharmaceutical compositions containing dually acting inhibitors of neutral endopeptidase for the treatment of sexual dysfunction |
US20050288272A1 (en) * | 2004-06-23 | 2005-12-29 | Solvay Pharmaceuticals Gmbh | Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous endothelin producing system and AT1 receptor antagonists |
JP2008524159A (ja) | 2004-12-15 | 2008-07-10 | ゾルファイ ファーマスーティカルズ ゲゼルシャフト ミット ベシュレンクテル ハフツング | NEP阻害剤、内因性エンドセリン産生系の阻害剤およびHMGCoAレダクターゼ阻害剤を含有する医薬組成物 |
US20060205625A1 (en) * | 2005-02-18 | 2006-09-14 | Solvay Pharmaceuticals Gmbh | Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous endothelin producing system and diuretics |
US20070292503A1 (en) * | 2006-06-16 | 2007-12-20 | Gorissen Henricus R | Oral pharmaceutical composition of poorly water-soluble active substance |
US20070299054A1 (en) * | 2006-06-22 | 2007-12-27 | Rajesh Jain | Oral pharmaceutical composition of a poorly water-soluble active agent |
CN104083352A (zh) * | 2008-01-31 | 2014-10-08 | 范德比尔特大学 | 对于肺部病症的治疗 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4749688A (en) * | 1986-06-20 | 1988-06-07 | Schering Corporation | Use of neutral metalloendopeptidase inhibitors in the treatment of hypertension |
EP0254032A3 (en) * | 1986-06-20 | 1990-09-05 | Schering Corporation | Neutral metalloendopeptidase inhibitors in the treatment of hypertension |
CA1337400C (en) * | 1987-06-08 | 1995-10-24 | Norma G. Delaney | Inhibitors of neutral endopeptidase |
US5362727A (en) * | 1993-07-26 | 1994-11-08 | Bristol-Myers Squibb | Substituted azepino[2,1-a]isoquinoline compounds |
DE19510566A1 (de) | 1995-03-23 | 1996-09-26 | Kali Chemie Pharma Gmbh | Benzazepin-, Benzoxazepin- und Benzothiazepin-N-essigsäurederivate sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
DE19638020A1 (de) * | 1996-09-18 | 1998-03-19 | Solvay Pharm Gmbh | Die gastrointestinale Durchblutung fördernde Arzneimittel |
-
1999
- 1999-02-16 DE DE19906310A patent/DE19906310A1/de not_active Ceased
-
2000
- 2000-01-20 AR ARP000100257A patent/AR036864A1/es unknown
- 2000-01-21 TW TW089101041A patent/TWI221770B/zh not_active IP Right Cessation
- 2000-02-10 PL PL00350167A patent/PL195283B1/pl not_active IP Right Cessation
- 2000-02-10 CZ CZ20012672A patent/CZ301499B6/cs not_active IP Right Cessation
- 2000-02-10 KR KR1020077001387A patent/KR100797665B1/ko not_active IP Right Cessation
- 2000-02-10 BR BR0008260-0A patent/BR0008260A/pt not_active Application Discontinuation
- 2000-02-10 HU HU0105491A patent/HUP0105491A3/hu unknown
- 2000-02-10 SK SK1082-2001A patent/SK287254B6/sk not_active IP Right Cessation
- 2000-02-10 ES ES00903681T patent/ES2238268T3/es not_active Expired - Lifetime
- 2000-02-10 NZ NZ514058A patent/NZ514058A/en not_active IP Right Cessation
- 2000-02-10 AU AU25476/00A patent/AU773240C/en not_active Ceased
- 2000-02-10 AT AT00903681T patent/ATE295174T1/de active
- 2000-02-10 DE DE50010284T patent/DE50010284D1/de not_active Expired - Lifetime
- 2000-02-10 JP JP2000599393A patent/JP2002537258A/ja active Pending
- 2000-02-10 WO PCT/EP2000/001068 patent/WO2000048601A1/de not_active Application Discontinuation
- 2000-02-10 CA CA2362273A patent/CA2362273C/en not_active Expired - Fee Related
- 2000-02-10 PT PT00903681T patent/PT1154777E/pt unknown
- 2000-02-10 RU RU2001124604/15A patent/RU2270679C2/ru not_active IP Right Cessation
- 2000-02-10 KR KR1020017009705A patent/KR20010101922A/ko active Application Filing
- 2000-02-10 EP EP00903681A patent/EP1154777B1/de not_active Expired - Lifetime
- 2000-02-10 TR TR2001/02386T patent/TR200102386T2/xx unknown
- 2000-02-10 CN CNB008038236A patent/CN1198619C/zh not_active Expired - Fee Related
- 2000-02-13 DZ DZ000029A patent/DZ3014A1/xx active
- 2000-10-02 UA UA2001096336A patent/UA63032C2/uk unknown
-
2001
- 2001-07-16 ZA ZA200105828A patent/ZA200105828B/en unknown
- 2001-07-30 IL IL144622A patent/IL144622A/en not_active IP Right Cessation
- 2001-08-15 NO NO20013958A patent/NO329588B1/no not_active IP Right Cessation
- 2001-08-16 US US09/930,186 patent/US6482820B2/en not_active Expired - Lifetime
-
2002
- 2002-05-31 HK HK02104121.2A patent/HK1042247B/zh not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB | Suspension of granting procedure |