RU2249041C2 - Способ получения и выделения белка, обладающего активностью фактора viii, линия клеток нкв, экспрессирующая белок, обладающий активностью фактора viii (варианты) - Google Patents
Способ получения и выделения белка, обладающего активностью фактора viii, линия клеток нкв, экспрессирующая белок, обладающий активностью фактора viii (варианты) Download PDFInfo
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- RU2249041C2 RU2249041C2 RU2001119156/13A RU2001119156A RU2249041C2 RU 2249041 C2 RU2249041 C2 RU 2249041C2 RU 2001119156/13 A RU2001119156/13 A RU 2001119156/13A RU 2001119156 A RU2001119156 A RU 2001119156A RU 2249041 C2 RU2249041 C2 RU 2249041C2
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- factor viii
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/028—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a herpesvirus
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- Health & Medical Sciences (AREA)
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- Biotechnology (AREA)
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- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/209,916 | 1998-12-10 | ||
| US09/209,916 US6358703B1 (en) | 1998-12-10 | 1998-12-10 | Expression system for factor VIII |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2001119156A RU2001119156A (ru) | 2003-07-27 |
| RU2249041C2 true RU2249041C2 (ru) | 2005-03-27 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2001119156/13A RU2249041C2 (ru) | 1998-12-10 | 1999-12-08 | Способ получения и выделения белка, обладающего активностью фактора viii, линия клеток нкв, экспрессирующая белок, обладающий активностью фактора viii (варианты) |
Country Status (26)
| Country | Link |
|---|---|
| US (10) | US6358703B1 (https=) |
| EP (1) | EP1137797B1 (https=) |
| JP (1) | JP4240818B2 (https=) |
| KR (1) | KR100616028B1 (https=) |
| AT (1) | ATE412765T1 (https=) |
| AU (1) | AU761801B2 (https=) |
| BG (1) | BG65431B1 (https=) |
| BR (1) | BRPI9916069B8 (https=) |
| CA (1) | CA2354845C (https=) |
| CZ (1) | CZ302330B6 (https=) |
| DE (1) | DE69939839D1 (https=) |
| DK (1) | DK1137797T3 (https=) |
| ES (1) | ES2315026T3 (https=) |
| HU (1) | HU228489B1 (https=) |
| IL (2) | IL143353A0 (https=) |
| NO (1) | NO329544B1 (https=) |
| NZ (1) | NZ512234A (https=) |
| PL (1) | PL200676B1 (https=) |
| PT (1) | PT1137797E (https=) |
| RO (1) | RO121604B1 (https=) |
| RU (1) | RU2249041C2 (https=) |
| SI (1) | SI20644B (https=) |
| SK (1) | SK286945B6 (https=) |
| TR (1) | TR200101592T2 (https=) |
| UA (1) | UA77383C2 (https=) |
| WO (1) | WO2000034505A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2600886C2 (ru) * | 2011-05-13 | 2016-10-27 | Октафарма Аг | Способ повышения продуктивности эукариотических клеток в продуцировании рекомбинантного fviii |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6475725B1 (en) | 1997-06-20 | 2002-11-05 | Baxter Aktiengesellschaft | Recombinant cell clones having increased stability and methods of making and using the same |
| US6180108B1 (en) * | 1998-12-10 | 2001-01-30 | Bayer Corporation | Vectors having terminal repeat sequence of Epstein-Barr virus |
| US6358703B1 (en) | 1998-12-10 | 2002-03-19 | Bayer Corporation | Expression system for factor VIII |
| KR100581574B1 (ko) * | 2000-03-22 | 2006-05-22 | 옥타게네 게엠베하 | 인간 세포주 내 재조합 혈액 응고 인자의 제조 |
| US7205278B2 (en) * | 2001-06-14 | 2007-04-17 | The Scripps Research Institute | Stabilized proteins with engineered disulfide bonds |
| WO2004075923A2 (en) * | 2003-02-26 | 2004-09-10 | Nektar Therapeutics Al, Corporation | Polymer-factor viii moiety conjugates |
| US7485291B2 (en) * | 2003-06-03 | 2009-02-03 | Cell Genesys, Inc. | Compositions and methods for generating multiple polypeptides from a single vector using a virus derived peptide cleavage site, and uses thereof |
| WO2005017149A1 (en) * | 2003-06-03 | 2005-02-24 | Cell Genesys, Inc. | Compositions and methods for enhanced expression of recombinant polypeptides from a single vector using a peptide cleavage site |
| EP1812557A4 (en) * | 2004-10-29 | 2009-11-04 | Centocor Ortho Biotech Inc | COMPOSITIONS OF CHEMICALLY DEFINED MEDIA |
| KR101468345B1 (ko) * | 2004-11-12 | 2014-12-03 | 바이엘 헬스케어 엘엘씨 | Ｆｖｉｉｉ의 부위 지향 변형 |
| AR058568A1 (es) | 2005-12-20 | 2008-02-13 | Bristol Myers Squibb Co | Metodos para producir una composicion con moleculas ctla4-ig a partir de un medio de cultivo |
| EP2253644B1 (en) | 2005-12-20 | 2013-10-16 | Bristol-Myers Squibb Company | Compositions and methods for producing a composition |
| PL2235197T3 (pl) | 2007-12-27 | 2018-01-31 | Baxalta GmbH | Sposoby hodowli komórek |
| KR101005967B1 (ko) | 2008-04-12 | 2011-01-05 | (주)셀트리온 | 우수한 재조합 단백질을 생산하기 위한 인간 숙주 세포 |
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