RU2199541C2 - Тиенопиримидины, способ их получения (варианты), фармацевтическая композиция и способ ее получения - Google Patents

Тиенопиримидины, способ их получения (варианты), фармацевтическая композиция и способ ее получения Download PDF

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Publication number
RU2199541C2
RU2199541C2 RU99104796/04A RU99104796A RU2199541C2 RU 2199541 C2 RU2199541 C2 RU 2199541C2 RU 99104796/04 A RU99104796/04 A RU 99104796/04A RU 99104796 A RU99104796 A RU 99104796A RU 2199541 C2 RU2199541 C2 RU 2199541C2
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RU
Russia
Prior art keywords
pyrimidine
chloro
pyridin
thieno
methylthieno
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RU99104796/04A
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English (en)
Russian (ru)
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RU99104796A (ru
Inventor
Йонас Рохус
Пьер ШЕЛЛИНГ
Франц-Вернер КЛУКСЕН
Мария Кристадлер
Original Assignee
Мерк Патент Гмбх
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Publication of RU99104796A publication Critical patent/RU99104796A/ru
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
RU99104796/04A 1996-08-12 1997-07-30 Тиенопиримидины, способ их получения (варианты), фармацевтическая композиция и способ ее получения RU2199541C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19632423A DE19632423A1 (de) 1996-08-12 1996-08-12 Thienopyrimidine
DE19632423.8 1996-08-12

Publications (2)

Publication Number Publication Date
RU99104796A RU99104796A (ru) 2001-01-20
RU2199541C2 true RU2199541C2 (ru) 2003-02-27

Family

ID=7802392

Family Applications (1)

Application Number Title Priority Date Filing Date
RU99104796/04A RU2199541C2 (ru) 1996-08-12 1997-07-30 Тиенопиримидины, способ их получения (варианты), фармацевтическая композиция и способ ее получения

Country Status (28)

Country Link
US (1) US6110920A (Direct)
EP (1) EP0920431B1 (Direct)
JP (1) JP4405593B2 (Direct)
KR (1) KR100502271B1 (Direct)
CN (1) CN1081638C (Direct)
AR (1) AR009052A1 (Direct)
AT (1) ATE233265T1 (Direct)
AU (1) AU725227B2 (Direct)
BR (1) BR9711062A (Direct)
CA (1) CA2263561C (Direct)
CZ (1) CZ287772B6 (Direct)
DE (2) DE19632423A1 (Direct)
DK (1) DK0920431T3 (Direct)
ES (1) ES2191192T3 (Direct)
HU (1) HUP0001607A3 (Direct)
IL (1) IL128504A (Direct)
NO (1) NO990643D0 (Direct)
NZ (1) NZ334600A (Direct)
PL (1) PL190174B1 (Direct)
PT (1) PT920431E (Direct)
RU (1) RU2199541C2 (Direct)
SI (1) SI0920431T1 (Direct)
SK (1) SK282823B6 (Direct)
TR (1) TR199900308T2 (Direct)
TW (1) TW359672B (Direct)
UA (1) UA55421C2 (Direct)
WO (1) WO1998006722A1 (Direct)
ZA (1) ZA977156B (Direct)

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US6339106B1 (en) 1999-08-11 2002-01-15 Sepracor, Inc. Methods and compositions for the treatment and prevention of sexual dysfunction
US6974838B2 (en) 1998-08-24 2005-12-13 Sepracor Inc. Methods of treating or preventing pain using sibutramine metabolites
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US6399826B1 (en) 1999-08-11 2002-06-04 Sepracor Inc. Salts of sibutramine metabolites, methods of making sibutramine metabolites and intermediates useful in the same, and methods of treating pain
DE19950647A1 (de) * 1999-10-21 2001-04-26 Merck Patent Gmbh Imidazolderivate als Phosphodiesterase VII-Hemmer
DE10031585A1 (de) * 2000-06-29 2002-01-10 Merck Patent Gmbh 2-Aminoalkyl-thieno[2,3-d]pyrimidine
CN1458933A (zh) * 2000-09-29 2003-11-26 日本曹达株式会社 噻吩并嘧啶化合物及其盐以及其制备方法
BR0206853A (pt) * 2001-02-02 2004-01-13 Merck Patent Ges Mit Beschroen Formulação farmacêutica compreendendo pirazolo[4,3-d]pirimidinas e antagonistas de receptor de endotelina ou tienopirimidinas e antagonistas de receptor de endotelina
US6610887B2 (en) 2001-04-13 2003-08-26 Sepracor Inc. Methods of preparing didesmethylsibutramine and other sibutramine derivatives
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US7375109B2 (en) * 2001-09-04 2008-05-20 N.V. Organon Glycine-substituted thieno[2,3-d]pyrimidines with combined LH and FSH agonistic activity
WO2003035653A1 (en) * 2001-10-26 2003-05-01 Nippon Soda Co.,Ltd. Pyridothienopyrimidine compound and salt thereof
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US7208516B2 (en) 2002-03-20 2007-04-24 Celgene Corporation Methods of the treatment of psoriatic arthritis using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
US6962940B2 (en) 2002-03-20 2005-11-08 Celgene Corporation (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof
US7893101B2 (en) 2002-03-20 2011-02-22 Celgene Corporation Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof
US7276529B2 (en) 2002-03-20 2007-10-02 Celgene Corporation Methods of the treatment or prevention of exercise-induced asthma using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
TW200410975A (en) * 2002-09-26 2004-07-01 Nihon Nohyaku Co Ltd New pesticide and method for using it, new substituted thienopyrimidine derivative, its intermediate, and method for producing it
GB0320300D0 (en) * 2003-08-29 2003-10-01 Cancer Rec Tech Ltd Pyrimidothiophene compounds
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WO1995019774A1 (en) * 1994-01-25 1995-07-27 Warner-Lambert Company Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family

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Patent Citations (2)

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US4196207A (en) * 1977-05-23 1980-04-01 Ici Australia Limited Process for controlling eradicating or preventing infestations of animals by Ixodid ticks
WO1995019774A1 (en) * 1994-01-25 1995-07-27 Warner-Lambert Company Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family

Also Published As

Publication number Publication date
TW359672B (en) 1999-06-01
ATE233265T1 (de) 2003-03-15
SK16499A3 (en) 1999-06-11
UA55421C2 (uk) 2003-04-15
CZ287772B6 (en) 2001-01-17
DE59709404D1 (en) 2003-04-03
KR20000029932A (ko) 2000-05-25
AU725227B2 (en) 2000-10-12
DK0920431T3 (da) 2003-06-02
JP4405593B2 (ja) 2010-01-27
HK1021731A1 (en) 2000-06-30
US6110920A (en) 2000-08-29
CN1081638C (zh) 2002-03-27
CN1227560A (zh) 1999-09-01
SK282823B6 (sk) 2002-12-03
WO1998006722A1 (de) 1998-02-19
NO990643L (no) 1999-02-11
BR9711062A (pt) 1999-08-17
DE19632423A1 (de) 1998-02-19
HUP0001607A3 (en) 2002-09-30
CA2263561C (en) 2007-02-20
HUP0001607A2 (hu) 2000-10-28
NZ334600A (en) 2000-07-28
PL331538A1 (en) 1999-07-19
IL128504A0 (en) 2000-01-31
IL128504A (en) 2003-01-12
CA2263561A1 (en) 1998-02-19
AU4203597A (en) 1998-03-06
CZ44899A3 (cs) 1999-05-12
JP2000516223A (ja) 2000-12-05
SI0920431T1 (en) 2003-08-31
PL190174B1 (pl) 2005-11-30
AR009052A1 (es) 2000-03-08
EP0920431B1 (de) 2003-02-26
ZA977156B (en) 1998-02-19
TR199900308T2 (xx) 1999-04-21
PT920431E (pt) 2003-07-31
EP0920431A1 (de) 1999-06-09
KR100502271B1 (ko) 2005-07-22
NO990643D0 (no) 1999-02-11
ES2191192T3 (es) 2003-09-01

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Effective date: 20060731