TW359672B - Thienopyrimidines ad phosphodiesterase V antagonists, process for the production thereof and pharmaceutical compositions containing the same - Google Patents

Thienopyrimidines ad phosphodiesterase V antagonists, process for the production thereof and pharmaceutical compositions containing the same

Info

Publication number
TW359672B
TW359672B TW086111481A TW86111481A TW359672B TW 359672 B TW359672 B TW 359672B TW 086111481 A TW086111481 A TW 086111481A TW 86111481 A TW86111481 A TW 86111481A TW 359672 B TW359672 B TW 359672B
Authority
TW
Taiwan
Prior art keywords
thienopyrimidines
phosphodiesterase
hal
antagonists
production
Prior art date
Application number
TW086111481A
Other languages
English (en)
Inventor
Jonas Rochus
Pierre Schelling
Franz-Werner Kluxen
Maria Christadler
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Application granted granted Critical
Publication of TW359672B publication Critical patent/TW359672B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW086111481A 1996-08-12 1997-08-11 Thienopyrimidines ad phosphodiesterase V antagonists, process for the production thereof and pharmaceutical compositions containing the same TW359672B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19632423A DE19632423A1 (de) 1996-08-12 1996-08-12 Thienopyrimidine

Publications (1)

Publication Number Publication Date
TW359672B true TW359672B (en) 1999-06-01

Family

ID=7802392

Family Applications (1)

Application Number Title Priority Date Filing Date
TW086111481A TW359672B (en) 1996-08-12 1997-08-11 Thienopyrimidines ad phosphodiesterase V antagonists, process for the production thereof and pharmaceutical compositions containing the same

Country Status (29)

Country Link
US (1) US6110920A (zh)
EP (1) EP0920431B1 (zh)
JP (1) JP4405593B2 (zh)
KR (1) KR100502271B1 (zh)
CN (1) CN1081638C (zh)
AR (1) AR009052A1 (zh)
AT (1) ATE233265T1 (zh)
AU (1) AU725227B2 (zh)
BR (1) BR9711062A (zh)
CA (1) CA2263561C (zh)
CZ (1) CZ287772B6 (zh)
DE (2) DE19632423A1 (zh)
DK (1) DK0920431T3 (zh)
ES (1) ES2191192T3 (zh)
HK (1) HK1021731A1 (zh)
HU (1) HUP0001607A3 (zh)
IL (1) IL128504A (zh)
NO (1) NO990643D0 (zh)
NZ (1) NZ334600A (zh)
PL (1) PL190174B1 (zh)
PT (1) PT920431E (zh)
RU (1) RU2199541C2 (zh)
SI (1) SI0920431T1 (zh)
SK (1) SK282823B6 (zh)
TR (1) TR199900308T2 (zh)
TW (1) TW359672B (zh)
UA (1) UA55421C2 (zh)
WO (1) WO1998006722A1 (zh)
ZA (1) ZA977156B (zh)

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US6476078B2 (en) 1999-08-11 2002-11-05 Sepracor, Inc. Methods of using sibutramine metabolites in combination with a phosphodiesterase inhibitor to treat sexual dysfunction
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US6399826B1 (en) 1999-08-11 2002-06-04 Sepracor Inc. Salts of sibutramine metabolites, methods of making sibutramine metabolites and intermediates useful in the same, and methods of treating pain
DE10031585A1 (de) * 2000-06-29 2002-01-10 Merck Patent Gmbh 2-Aminoalkyl-thieno[2,3-d]pyrimidine
EP1329454A1 (en) * 2000-09-29 2003-07-23 Nippon Soda Co., Ltd. Thienopyrimidine compounds and their salts and process for preparation of both
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WO2002083631A1 (en) 2001-04-13 2002-10-24 Sepracor Inc. Methods of preparing didesmethylsibutramine and other sibutramine derivatives
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JPWO2003035653A1 (ja) * 2001-10-26 2005-02-10 日本曹達株式会社 ピリドチエノピリミジン化合物およびその塩
US7153412B2 (en) 2001-12-28 2006-12-26 Kabushiki Kaisha Toyota Chuo Kenkyusho Electrodes, electrochemical elements, gas sensors, and gas measurement methods
US7208516B2 (en) 2002-03-20 2007-04-24 Celgene Corporation Methods of the treatment of psoriatic arthritis using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
US7276529B2 (en) 2002-03-20 2007-10-02 Celgene Corporation Methods of the treatment or prevention of exercise-induced asthma using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
US6962940B2 (en) 2002-03-20 2005-11-08 Celgene Corporation (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof
US7893101B2 (en) 2002-03-20 2011-02-22 Celgene Corporation Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof
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US9603848B2 (en) 2007-06-08 2017-03-28 Senomyx, Inc. Modulation of chemosensory receptors and ligands associated therewith
BRPI0816767B8 (pt) * 2007-09-14 2021-05-25 Addex Pharmaceuticals Sa composto 4-fenil-3,4,5,6-tetra-hidro-2h,1'h-[1,4']bipiridi¬nil-2'-onas 1',3'-dissubstituídas, composição farmacêutica e uso dos mesmos
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AU2008297876B2 (en) 2007-09-14 2011-07-07 Addex Pharma S.A. 1,3-disubstituted 4-(aryl-x-phenyl)-1h-pyridin-2-ones
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US20150119399A1 (en) 2012-01-10 2015-04-30 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
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Also Published As

Publication number Publication date
SI0920431T1 (en) 2003-08-31
CA2263561C (en) 2007-02-20
US6110920A (en) 2000-08-29
UA55421C2 (uk) 2003-04-15
ES2191192T3 (es) 2003-09-01
EP0920431A1 (de) 1999-06-09
HUP0001607A2 (hu) 2000-10-28
AR009052A1 (es) 2000-03-08
AU4203597A (en) 1998-03-06
ATE233265T1 (de) 2003-03-15
NZ334600A (en) 2000-07-28
PL331538A1 (en) 1999-07-19
TR199900308T2 (xx) 1999-04-21
CA2263561A1 (en) 1998-02-19
HUP0001607A3 (en) 2002-09-30
DE19632423A1 (de) 1998-02-19
CN1081638C (zh) 2002-03-27
AU725227B2 (en) 2000-10-12
PT920431E (pt) 2003-07-31
CZ287772B6 (en) 2001-01-17
NO990643L (no) 1999-02-11
PL190174B1 (pl) 2005-11-30
JP2000516223A (ja) 2000-12-05
BR9711062A (pt) 1999-08-17
WO1998006722A1 (de) 1998-02-19
KR100502271B1 (ko) 2005-07-22
SK16499A3 (en) 1999-06-11
CZ44899A3 (cs) 1999-05-12
ZA977156B (en) 1998-02-19
CN1227560A (zh) 1999-09-01
NO990643D0 (no) 1999-02-11
DK0920431T3 (da) 2003-06-02
RU2199541C2 (ru) 2003-02-27
JP4405593B2 (ja) 2010-01-27
DE59709404D1 (en) 2003-04-03
IL128504A0 (en) 2000-01-31
SK282823B6 (sk) 2002-12-03
IL128504A (en) 2003-01-12
HK1021731A1 (en) 2000-06-30
KR20000029932A (ko) 2000-05-25
EP0920431B1 (de) 2003-02-26

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