RU2193033C2 - Замещенные гуанидиды тиофенилалкенилкарбоновой кислоты и лекарственное средство - Google Patents

Замещенные гуанидиды тиофенилалкенилкарбоновой кислоты и лекарственное средство Download PDF

Info

Publication number
RU2193033C2
RU2193033C2 RU97102136/04A RU97102136A RU2193033C2 RU 2193033 C2 RU2193033 C2 RU 2193033C2 RU 97102136/04 A RU97102136/04 A RU 97102136/04A RU 97102136 A RU97102136 A RU 97102136A RU 2193033 C2 RU2193033 C2 RU 2193033C2
Authority
RU
Russia
Prior art keywords
compounds
acid
formula
guanidides
methyl
Prior art date
Application number
RU97102136/04A
Other languages
English (en)
Russian (ru)
Other versions
RU97102136A (ru
Inventor
Ян-Роберт ШВАРК (DE)
Ян-Роберт Шварк
Йоахим БРЕНДЕЛЬ (DE)
Йоахим Брендель
Хайнц-Вернер КЛЕЕМАНН (DE)
Хайнц-Вернер КЛЕЕМАНН
Ханс Йохен ЛАНГ (DE)
Ханс Йохен Ланг
Андреас ВАЙХЕРТ (DE)
Андреас Вайхерт
Удо АЛЬБУС (DE)
Удо АЛЬБУС
Вольфганг ШОЛЬЦ (DE)
Вольфганг Шольц
Original Assignee
Хехст АГ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Хехст АГ filed Critical Хехст АГ
Publication of RU97102136A publication Critical patent/RU97102136A/ru
Application granted granted Critical
Publication of RU2193033C2 publication Critical patent/RU2193033C2/ru

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/28—Halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
RU97102136/04A 1996-02-15 1997-02-14 Замещенные гуанидиды тиофенилалкенилкарбоновой кислоты и лекарственное средство RU2193033C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19605610A DE19605610A1 (de) 1996-02-15 1996-02-15 Substituierte Thiophenylalkenylcarbonsäureguanidide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19605610.1 1996-02-15

Publications (2)

Publication Number Publication Date
RU97102136A RU97102136A (ru) 1999-02-27
RU2193033C2 true RU2193033C2 (ru) 2002-11-20

Family

ID=7785491

Family Applications (1)

Application Number Title Priority Date Filing Date
RU97102136/04A RU2193033C2 (ru) 1996-02-15 1997-02-14 Замещенные гуанидиды тиофенилалкенилкарбоновой кислоты и лекарственное средство

Country Status (29)

Country Link
US (1) US5756535A (enExample)
EP (1) EP0790245B1 (enExample)
JP (1) JP4402747B2 (enExample)
KR (1) KR970061887A (enExample)
AR (1) AR005812A1 (enExample)
AT (1) ATE202096T1 (enExample)
AU (1) AU706554B2 (enExample)
BR (1) BR9700990A (enExample)
CA (1) CA2197628C (enExample)
CZ (1) CZ45597A3 (enExample)
DE (2) DE19605610A1 (enExample)
DK (1) DK0790245T3 (enExample)
ES (1) ES2158383T3 (enExample)
GR (1) GR3036122T3 (enExample)
HR (1) HRP970081B1 (enExample)
HU (1) HUP9700437A3 (enExample)
ID (1) ID15889A (enExample)
IL (1) IL120214A (enExample)
MX (1) MX9701163A (enExample)
NO (1) NO315424B1 (enExample)
NZ (1) NZ314230A (enExample)
PL (1) PL318412A1 (enExample)
PT (1) PT790245E (enExample)
RU (1) RU2193033C2 (enExample)
SI (1) SI0790245T1 (enExample)
SK (1) SK282440B6 (enExample)
TR (1) TR199700109A2 (enExample)
TW (1) TW445261B (enExample)
ZA (1) ZA971260B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19634229A1 (de) * 1996-08-23 1998-02-26 Basf Ag Photostabile UV-A-Filter enthaltende kosmetische Zubereitungen
US6011059A (en) * 1997-12-24 2000-01-04 Bristol-Myers Squibb Company Acyl guanidine sodium/proton exchange inhibitors and method
US6160134A (en) * 1997-12-24 2000-12-12 Bristol-Myers Squibb Co. Process for preparing chiral cyclopropane carboxylic acids and acyl guanidines
AU4360200A (en) 1999-04-23 2000-11-10 Bristol-Myers Squibb Company Bicyclic acyl guanidine sodium/proton exchange inhibitors and method
PL217872B1 (pl) 2001-10-19 2014-08-29 Toyama Chemical Co Ltd Pochodna eteru alkilowego lub jej sól, stanowiąca 1-{3-[2-(1-benzotiofen-5-ylo)etoksy]propylo}-3-azetydynol lub jego sól

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0459748A2 (en) * 1990-06-01 1991-12-04 Lilly Industries Limited Thien-2-yl methylurea derivatives as leukotriene inhibitors
EP0666252A1 (de) * 1994-01-25 1995-08-09 Hoechst Aktiengesellschaft Perfluoralkylgruppen tragende phenyl-substituierte Alkylcarbonsäure-guanidide, Vefahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2734904A (en) * 1956-02-14 Xcxnhxc-nh
US4544670A (en) * 1982-08-24 1985-10-01 William H. Rorer, Inc. Method of treating coccidiosis with acyl guanidines
DE4402057A1 (de) * 1994-01-25 1995-08-03 Hoechst Ag Perfluoralkylgruppen tragende phenyl-substituierte Alkylcarbonsäure-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4412334A1 (de) * 1994-04-11 1995-10-19 Hoechst Ag Substituierte N-Heteroaroylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4421536A1 (de) * 1994-06-20 1995-12-21 Hoechst Ag Perfluoralkylgruppen tragende phenylsubstituierte Alkenylcarbonsäure-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0459748A2 (en) * 1990-06-01 1991-12-04 Lilly Industries Limited Thien-2-yl methylurea derivatives as leukotriene inhibitors
EP0666252A1 (de) * 1994-01-25 1995-08-09 Hoechst Aktiengesellschaft Perfluoralkylgruppen tragende phenyl-substituierte Alkylcarbonsäure-guanidide, Vefahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Also Published As

Publication number Publication date
TR199700109A2 (tr) 1997-09-21
HUP9700437A3 (en) 2000-03-28
JP4402747B2 (ja) 2010-01-20
SI0790245T1 (en) 2001-08-31
PL318412A1 (en) 1997-08-18
PT790245E (pt) 2001-10-30
SK282440B6 (sk) 2002-02-05
AR005812A1 (es) 1999-07-14
EP0790245B1 (de) 2001-06-13
US5756535A (en) 1998-05-26
JPH09249660A (ja) 1997-09-22
SK21397A3 (en) 1997-09-10
DK0790245T3 (da) 2001-09-03
GR3036122T3 (en) 2001-09-28
ATE202096T1 (de) 2001-06-15
BR9700990A (pt) 1998-09-01
AU1265997A (en) 1997-08-21
EP0790245A1 (de) 1997-08-20
HRP970081B1 (en) 2003-04-30
IL120214A (en) 2000-08-31
HU9700437D0 (en) 1997-04-28
NO970697L (no) 1997-08-18
CZ45597A3 (en) 1997-09-17
NZ314230A (en) 1997-12-19
CA2197628A1 (en) 1997-08-16
HUP9700437A2 (hu) 1998-08-28
KR970061887A (ko) 1997-09-12
ID15889A (id) 1997-08-14
MX9701163A (es) 1997-08-30
NO315424B1 (no) 2003-09-01
ZA971260B (en) 1997-08-15
CA2197628C (en) 2006-05-16
IL120214A0 (en) 1997-06-10
HRP970081A2 (en) 1998-04-30
DE19605610A1 (de) 1997-08-21
TW445261B (en) 2001-07-11
DE59703746D1 (de) 2001-07-19
ES2158383T3 (es) 2001-09-01
NO970697D0 (no) 1997-02-14
AU706554B2 (en) 1999-06-17

Similar Documents

Publication Publication Date Title
JP3490739B2 (ja) ３，４，５−置換ベンゾイルグアニジン、それらの製法ならびにそれらを含有する医薬
KR100360127B1 (ko) 치환된1-옥소-1,2-디하이드로이소퀴놀리노일구아니딘,1,1-디옥소-2h-1,2-벤조티아지노일구아니딘및이들을함유하는약제
KR100368513B1 (ko) 퍼플루오로알킬그룹을갖는페닐-치환된알케닐카보구아니디드,이의제조방법및이를함유하는약제학적조성물
CZ403392A3 (en) Amino-substituted benzylguanidines, process of their preparation, their use as medicaments and a medicament containing thereof
RU2164913C2 (ru) Гуанидиды алкенилкарбоновых кислот, способ их получения, способ ингибирования клеточного na+/h+-обмена и фармацевтическая композиция
RU2154055C2 (ru) Замещенные аминокислотой бензоилгуанидины, способ их получения, способ ингибирования целлюлярного na+/н+-ионообмена и лекарственное средство
RU2190601C2 (ru) Замещенные гуанидиды коричной кислоты, способ их получения и фармацевтическая композиция
RU2160727C2 (ru) Бензоилгуанидины, способ их получения, промежуточное соединение для их получения, способ ингибирования и лекарственное средство
US6632840B1 (en) Monoacyl-substituted guanidines, a process for their preparation, their use as a medicament or diagnostic aid, and pharmaceutical compositions containing them
JP3718250B2 (ja) パーフルオロアルキル基を有するフェニル置換アルキルカルボグアニジドおよびその調製方法
RU2165412C2 (ru) Бензоилгуанидины, способ их получения, способ ингибирования, фармацевтический состав и способ его получения
RU2193033C2 (ru) Замещенные гуанидиды тиофенилалкенилкарбоновой кислоты и лекарственное средство
JP4101904B2 (ja) オルト−置換されたベンゾイルグアニジン、その製法、医薬または診断剤としてのその使用およびそれを含有する医薬
RU2159762C2 (ru) Замещенные бензоилгуанидины, способ их получения, способ ингибирования и фармацевтический препарат
RU2182901C2 (ru) Замещенные 1-нафтоилгуанидины и лекарственное средство на их основе
RU2193025C2 (ru) Ортозамещенные бензоилгуанидины и лекарственное средство на их основе
MXPA97001163A (en) Guidelines of substitute thiophenyl alcoholic substitute acids, procedure for its preparation, its employment as a medicine or diagnostic agent, as well as a medication that contains them
RU2212400C2 (ru) Орто-замещенные бензоилгуанидины и содержащие их лекарственные средства
MXPA97001323A (en) Benzoilguanidinas replaced in orthodous position, a procedure for its preparation, its use as a diagnostic medicine or agent, so i composed that conti
MXPA97001619A (es) Benzoilguanidinas sustituidas en posicion orto, procedimiento para su preparacion, su utilizacion como medicamento o agente de diagnostico, asi como medicamento que las contiene
MXPA96005675A (en) Diguanididas of bencenodicarboxilicos substitute acids, procedure for its preparation, its employment as a diagnostic medicine or agent, as well as a medication that the
MXPA97001618A (en) Benzoilguanidinas replaced in orthodous position, procedure for its preparation, its use as a diagnostic medicine or agent, as well as a medication that conti
MXPA94006545A (en) Ortho-substituted benzoylguanidines, a process for their preparation, their use as a medicament or diagnostic agent, and a medicament comprising them

Legal Events

Date Code Title Description
MM4A The patent is invalid due to non-payment of fees

Effective date: 20040215