HUP9700437A2 - Szubsztituált tiofén-alkenilkarbonsav guanidinoszármazékai, előállításuk valamint e vegyületeket tartalmazó gyógyszerkészítmények - Google Patents
Szubsztituált tiofén-alkenilkarbonsav guanidinoszármazékai, előállításuk valamint e vegyületeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP9700437A2 HUP9700437A2 HU9700437A HUP9700437A HUP9700437A2 HU P9700437 A2 HUP9700437 A2 HU P9700437A2 HU 9700437 A HU9700437 A HU 9700437A HU P9700437 A HUP9700437 A HU P9700437A HU P9700437 A2 HUP9700437 A2 HU P9700437A2
- Authority
- HU
- Hungary
- Prior art keywords
- stemmed
- carbon
- alkyl
- atom
- ring
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 229910052799 carbon Inorganic materials 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 229910052794 bromium Inorganic materials 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- 239000000460 chlorine Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000000428 dust Substances 0.000 abstract 2
- 229910052731 fluorine Inorganic materials 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 229910052740 iodine Inorganic materials 0.000 abstract 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- 206010002383 Angina Pectoris Diseases 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 206010003119 arrhythmia Diseases 0.000 abstract 1
- 230000006793 arrhythmia Effects 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 150000001721 carbon Chemical group 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 230000000302 ischemic effect Effects 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 125000005010 perfluoroalkyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/28—Halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
A találmány (I) általánős képletű tienil-alkenil-karbőnsav-gűanidid-származékőkra és e vegyületek fiziőlógiailag elfőgadható sóiravőnatkőzik. Az (I) általánős képletben R(1), R(2) és R(3) közül legalább egynek a jelentése -Op-(CH2)s-CqF2q+1 képletű csőpőrt, R(40)CO- vagy R(31)SOk-, ahől p értéke 0 vagy 1, s értéke 0, 1, 2, 3 vagy 4, q értéke 1, 2, 3, 4, 5, 6, 7 vagy 8, k értéke 0, 1 vagy 2, és R(40)1-8 szénatőmős alkilcsőpőrtőt, 1-8 szénatőmős perflűőr-alkilcsőpőrtőt, 3-8 szénatőmős ciklőalkilcsőpőrtőt vagy adőtt esetbenszűbsztitűált fenilcsőpőrtőt jelent, R(31) 1-8 szénatőmős alkilcsőpőrtőt, 1-8 szénatőmős perflűőr-alkilcsőpőrtőt, 3-8 szénatőmős ciklőalkilcsőpőrtőt vagy fenilcsőpőrtőtjelent, R(31) -NR(41)R(42) képletű csőpőrtőt jelent, mely csőpőrtban R(41) ésR(42) egymástól függetlenül hidrőgénatőm, 1-4 szénatőmős alkilcsőpőrtvagy 1-4 szénatőmős perflűőralkilcsőpőrt lehet, vagy R(41) és R(42)együttesen 4 vagy 5 metiléncsőpőrtőt alkőt, e közül egyik -O-, -S-, -NH-, -N(CH3)- vagy -N(benzil)-csőpőrttal lehet helyettesítve, és az R(1), R(2) és R(3) közül maradó két másik szűbsztitűensjelentése egymástól függetlenül H, F, Cl, Br, I, CN, -OnaCmaH2ma+1 vagy -OgaCraH2raR(10), ahől na értéke 0 vagy 1, ma értéke 0, 1, 2, 3, 4, 5, 6, 7 vagy 8, ga értéke 0 vagy 1, ra értéke 0, 1, 2, 3 vagy 4 és R(10)jelentése 3-8 szénatőmős ciklőalkilcsőpőrt vagy fenilcsőpőrt; R(4) és R(5) jelentése egymástól függetlenül hidrőgénatőm, flűőr-,klór-, bróm-, jódatőm, 1-8 szénatőmős alkilcsőpőrt, 1-8 szénatőmősperflűőralkilcsőpőrt 3-8 szénatőmős ciklőalkilcsőpőrt vagy adőttesetben szűbsztitűált fenilcsőpőrt. Fenti vegyületek ischemiásállapőtők, szív aritmia és angina pectőris kezelésére alkalmasak. ŕ
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19605610A DE19605610A1 (de) | 1996-02-15 | 1996-02-15 | Substituierte Thiophenylalkenylcarbonsäureguanidide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HU9700437D0 HU9700437D0 (en) | 1997-04-28 |
| HUP9700437A2 true HUP9700437A2 (hu) | 1998-08-28 |
| HUP9700437A3 HUP9700437A3 (en) | 2000-03-28 |
Family
ID=7785491
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9700437A HUP9700437A3 (en) | 1996-02-15 | 1997-02-13 | Guanidino-derivatives of substituted thienyl-alkenyl-carboxylic-acids, their production, and pharmaceutical compositions containing them |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US5756535A (hu) |
| EP (1) | EP0790245B1 (hu) |
| JP (1) | JP4402747B2 (hu) |
| KR (1) | KR970061887A (hu) |
| AR (1) | AR005812A1 (hu) |
| AT (1) | ATE202096T1 (hu) |
| AU (1) | AU706554B2 (hu) |
| BR (1) | BR9700990A (hu) |
| CA (1) | CA2197628C (hu) |
| CZ (1) | CZ45597A3 (hu) |
| DE (2) | DE19605610A1 (hu) |
| DK (1) | DK0790245T3 (hu) |
| ES (1) | ES2158383T3 (hu) |
| GR (1) | GR3036122T3 (hu) |
| HR (1) | HRP970081B1 (hu) |
| HU (1) | HUP9700437A3 (hu) |
| ID (1) | ID15889A (hu) |
| IL (1) | IL120214A (hu) |
| MX (1) | MX9701163A (hu) |
| NO (1) | NO315424B1 (hu) |
| NZ (1) | NZ314230A (hu) |
| PL (1) | PL318412A1 (hu) |
| PT (1) | PT790245E (hu) |
| RU (1) | RU2193033C2 (hu) |
| SI (1) | SI0790245T1 (hu) |
| SK (1) | SK282440B6 (hu) |
| TR (1) | TR199700109A2 (hu) |
| TW (1) | TW445261B (hu) |
| ZA (1) | ZA971260B (hu) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19634229A1 (de) * | 1996-08-23 | 1998-02-26 | Basf Ag | Photostabile UV-A-Filter enthaltende kosmetische Zubereitungen |
| US6011059A (en) * | 1997-12-24 | 2000-01-04 | Bristol-Myers Squibb Company | Acyl guanidine sodium/proton exchange inhibitors and method |
| US6160134A (en) * | 1997-12-24 | 2000-12-12 | Bristol-Myers Squibb Co. | Process for preparing chiral cyclopropane carboxylic acids and acyl guanidines |
| CA2370607A1 (en) | 1999-04-23 | 2000-11-02 | Bristol-Myers Squibb Company | Bicyclic acyl guanidine sodium/proton exchange inhibitors and method |
| BRPI0213393B8 (pt) | 2001-10-19 | 2021-05-25 | Fujifilm Toyama Chemical Co Ltd | derivados de éter alquílico, ou um de seus sais, processo para produzir um derivado de éter alquílico, derivado de alquil-amida, ou um de seus sais, e, composição farmacêutica |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2734904A (en) * | 1956-02-14 | Xcxnhxc-nh | ||
| US4544670A (en) * | 1982-08-24 | 1985-10-01 | William H. Rorer, Inc. | Method of treating coccidiosis with acyl guanidines |
| DE4402057A1 (de) * | 1994-01-25 | 1995-08-03 | Hoechst Ag | Perfluoralkylgruppen tragende phenyl-substituierte Alkylcarbonsäure-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| TW415937B (en) * | 1994-01-25 | 2000-12-21 | Hoechst Ag | Phenyl-substituted alkylcarboxylic acid guanidides bearing perfluoroalkyl groups, process for their preparation, their use as a medicament or diagnostic, and medicament containing them |
| DE4412334A1 (de) * | 1994-04-11 | 1995-10-19 | Hoechst Ag | Substituierte N-Heteroaroylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE4421536A1 (de) * | 1994-06-20 | 1995-12-21 | Hoechst Ag | Perfluoralkylgruppen tragende phenylsubstituierte Alkenylcarbonsäure-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
-
1996
- 1996-02-15 DE DE19605610A patent/DE19605610A1/de not_active Withdrawn
-
1997
- 1997-02-03 DK DK97101597T patent/DK0790245T3/da active
- 1997-02-03 DE DE59703746T patent/DE59703746D1/de not_active Expired - Lifetime
- 1997-02-03 SI SI9730146T patent/SI0790245T1/xx unknown
- 1997-02-03 ES ES97101597T patent/ES2158383T3/es not_active Expired - Lifetime
- 1997-02-03 AT AT97101597T patent/ATE202096T1/de not_active IP Right Cessation
- 1997-02-03 EP EP97101597A patent/EP0790245B1/de not_active Expired - Lifetime
- 1997-02-03 PT PT97101597T patent/PT790245E/pt unknown
- 1997-02-05 ID IDP970354A patent/ID15889A/id unknown
- 1997-02-10 PL PL97318412A patent/PL318412A1/xx unknown
- 1997-02-11 US US08/798,259 patent/US5756535A/en not_active Expired - Lifetime
- 1997-02-13 CZ CZ97455A patent/CZ45597A3/cs unknown
- 1997-02-13 AU AU12659/97A patent/AU706554B2/en not_active Ceased
- 1997-02-13 TW TW086101574A patent/TW445261B/zh active
- 1997-02-13 HR HR970081A patent/HRP970081B1/xx not_active IP Right Cessation
- 1997-02-13 AR ARP970100577A patent/AR005812A1/es unknown
- 1997-02-13 IL IL12021497A patent/IL120214A/xx not_active IP Right Cessation
- 1997-02-13 SK SK213-97A patent/SK282440B6/sk unknown
- 1997-02-13 NZ NZ314230A patent/NZ314230A/en unknown
- 1997-02-13 TR TR97/00109A patent/TR199700109A2/xx unknown
- 1997-02-13 HU HU9700437A patent/HUP9700437A3/hu unknown
- 1997-02-14 KR KR1019970004337A patent/KR970061887A/ko not_active Application Discontinuation
- 1997-02-14 BR BR9700990A patent/BR9700990A/pt active Search and Examination
- 1997-02-14 MX MX9701163A patent/MX9701163A/es unknown
- 1997-02-14 NO NO19970697A patent/NO315424B1/no not_active IP Right Cessation
- 1997-02-14 CA CA002197628A patent/CA2197628C/en not_active Expired - Fee Related
- 1997-02-14 ZA ZA9701260A patent/ZA971260B/xx unknown
- 1997-02-14 RU RU97102136/04A patent/RU2193033C2/ru not_active IP Right Cessation
- 1997-02-14 JP JP02949597A patent/JP4402747B2/ja not_active Expired - Fee Related
-
2001
- 2001-06-27 GR GR20010400975T patent/GR3036122T3/el not_active IP Right Cessation
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