HUP9800112A2 - Ciánamido-szulfonil-bifonil-metil-helyettesített imidazolszármazékok, alkalmazésuk gyógyszerkészítmények előállítására, valamint a vegyületeket tartalmazó gyógyszerkészítmények - Google Patents

Ciánamido-szulfonil-bifonil-metil-helyettesített imidazolszármazékok, alkalmazésuk gyógyszerkészítmények előállítására, valamint a vegyületeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP9800112A2
HUP9800112A2 HU9800112A HUP9800112A HUP9800112A2 HU P9800112 A2 HUP9800112 A2 HU P9800112A2 HU 9800112 A HU9800112 A HU 9800112A HU P9800112 A HUP9800112 A HU P9800112A HU P9800112 A2 HUP9800112 A2 HU P9800112A2
Authority
HU
Hungary
Prior art keywords
pipe powder
alkyl
hydrogen atom
pharmaceutical compositions
powder
Prior art date
Application number
HU9800112A
Other languages
English (en)
Inventor
Sabine Faber
Hans-Willi Jansen
Heinz-Werner Kleemann
Hans Jochen Lang
Jan-Robert Schwark
Andreas Weichert
Original Assignee
Hoechst Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19702045A external-priority patent/DE19702045A1/de
Priority claimed from DE19731328A external-priority patent/DE19731328A1/de
Priority claimed from DE1997141636 external-priority patent/DE19741636A1/de
Application filed by Hoechst Ag. filed Critical Hoechst Ag.
Publication of HU9800112D0 publication Critical patent/HU9800112D0/hu
Publication of HUP9800112A2 publication Critical patent/HUP9800112A2/hu
Publication of HUP9800112A3 publication Critical patent/HUP9800112A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/68—Halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/70—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Wood Science & Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Dentistry (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

A találmány új antiarritmiás hatású heterőciklűsős vegyületekrevőnatkőzik, amelyek az (I) általánős képletnek felelnek meg. Az (I)általánős képletben R1 jelentése hidrőgénatőm, alkilcsőpőrt vagy -CaH2a-fenilcsőpőrt,amely adőtt esetben szűbsztitűált, a értéke 0, 1 vagy 2; vagy R1 jelentése -CbH2b-(C1-C9)-heterőarilcsőpőrt, vagy R1 -CdH2d-(C3-C7)-ciklőalkilcsőpőrtőt jelent, amelyekben b és d értéke0, 1 vagy 2; R2 és R3 jelentése egymástól függetlenül hidrőgénatőm, flűőr-, klór-,bróm-, jódatőm, -C186N, -NO2-, -CH2OR17, -CO-R6 vagy -OR7 képletűcsőpőrt, ahől R17 jelentése hidrőgénatőm vagy alkilcsőpőrt, R6 jelentése hidrőgénatőm, 1-8 szénatőmős alkilcsőpőrt, -OR30 csőpőrtvagy fenilcsőpőrt, vagy R2 és R3 jelentése alkilcsőpőrt, ciklőalkilcsőpőrt vagy -CgH2g-fenilcsőpőrt, vagy R2 és R3 jelentése egymástól függetlenül -ClH2l-(C1-C9)-heterőarilcsőpőrt, R4 és R5 jelentése egymástól függetlenül hidrőgénatőm, alkilcsőpőrt,halőgénatőm, triflűőrmetilcsőpőrt, -C186N, -NO2, SOp-R16, -CO-R23 vagy-O-R24 képletű csőpőrt, ahől g, l és p értéke 0, 1 vagy 2, R16 jelentése alkilcsőpőrt vagy fenilcsőpőrt, R23 jelentése hidrőgénatőm, alkilcsőpőrt vagy -OR25 csőpőrt, ahőlR25 jelentése hidrőgénatőm alkilcsőpőrt; R24 jelentése hidrőgénatőm, alkilcsőpőrt vagy fenilcsőpőrt,valamint e vegyületek fiziőlógiailag elfőgadható sói. ŕ
HU9800112A 1997-01-22 1998-01-22 Cyanamido sulfonyl biphenyl methyl substituted imidazole derivatives, their use for producing pharmaceutical compositions, and pharmaceutical compositions containing these compounds HUP9800112A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19702045A DE19702045A1 (de) 1997-01-22 1997-01-22 Imidazol-Derivae mit Biphenylsulfonylcyanamid-Seitenkette, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19731328A DE19731328A1 (de) 1997-07-22 1997-07-22 Imidazol-Derivate mit Biphenylsulfonylcyanamid-Seitenkette, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament
DE1997141636 DE19741636A1 (de) 1997-09-22 1997-09-22 Fünfgliedrige Heterocyclen mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Publications (3)

Publication Number Publication Date
HU9800112D0 HU9800112D0 (en) 1998-03-30
HUP9800112A2 true HUP9800112A2 (hu) 1998-08-28
HUP9800112A3 HUP9800112A3 (en) 2001-07-30

Family

ID=27217050

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9800112A HUP9800112A3 (en) 1997-01-22 1998-01-22 Cyanamido sulfonyl biphenyl methyl substituted imidazole derivatives, their use for producing pharmaceutical compositions, and pharmaceutical compositions containing these compounds

Country Status (22)

Country Link
US (2) US6335451B1 (hu)
EP (1) EP0855392A3 (hu)
JP (1) JPH10204064A (hu)
KR (1) KR100529479B1 (hu)
CN (1) CN1176911C (hu)
AR (1) AR011082A1 (hu)
AU (1) AU738676B2 (hu)
BR (1) BR9800436A (hu)
CA (1) CA2227112A1 (hu)
CZ (1) CZ18598A3 (hu)
HK (1) HK1009814A1 (hu)
HR (1) HRP980025A2 (hu)
HU (1) HUP9800112A3 (hu)
ID (1) ID19574A (hu)
IL (1) IL123013A (hu)
MY (1) MY121708A (hu)
NO (1) NO311570B1 (hu)
NZ (1) NZ329606A (hu)
PL (1) PL191575B1 (hu)
SK (1) SK284126B6 (hu)
TR (1) TR199800084A2 (hu)
TW (1) TW593283B (hu)

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EP0855392A3 (de) 1997-01-22 2000-01-05 Hoechst Aktiengesellschaft Fünfgliedrige Heterocyclen mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19741635A1 (de) * 1997-09-22 1999-03-25 Hoechst Marion Roussel De Gmbh Biphenylsulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament
PL193215B1 (pl) * 1997-10-17 2007-01-31 Eurogene Ltd Zastosowanie lipofilnych inhibitorów układu renina-angiotensyna
DE19802969A1 (de) 1998-01-27 1999-07-29 Hoechst Marion Roussel De Gmbh Verfahren zur Herstellung von S-Alkyl(Aryl)-substituierten Imidazol-Derivaten
DE19804251A1 (de) 1998-02-04 1999-08-05 Hoechst Marion Roussel De Gmbh Biphenylsulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament
DE19820064A1 (de) 1998-05-06 1999-11-11 Hoechst Marion Roussel De Gmbh Substituierte Sulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament
DE19832428A1 (de) 1998-07-18 2000-01-20 Hoechst Marion Roussel De Gmbh Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19832429A1 (de) * 1998-07-18 2000-01-20 Hoechst Marion Roussel De Gmbh Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
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ES2582945T3 (es) * 2005-04-12 2016-09-16 Vicore Pharma Ab Nuevos agonistas bicíclicos de angiotensina II
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CN101193886B (zh) * 2005-04-12 2014-08-27 维科尔药物公司 三环的血管紧张素ii激动剂
US10517839B2 (en) 2008-06-09 2019-12-31 Cornell University Mast cell inhibition in diseases of the retina and vitreous
WO2010029576A2 (en) 2008-09-02 2010-03-18 Elder Pharmaceuticals Ltd. Anti inflammatory compounds
CN103992276B (zh) * 2014-06-03 2016-08-24 吉林省药物研究院 4’-{[(2,4,5-三取代苯基)-1h-咪唑-1-基]甲基}联苯-2-甲酸衍生物
NZ727422A (en) * 2014-07-17 2023-12-22 Univ Southern California Methods, compounds, and compositions for the treatment of musculoskeletal diseases
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Also Published As

Publication number Publication date
NZ329606A (en) 1999-10-28
KR19980070682A (ko) 1998-10-26
NO311570B1 (no) 2001-12-10
US6486189B2 (en) 2002-11-26
CA2227112A1 (en) 1998-07-22
HRP980025A2 (en) 1998-10-31
CN1188760A (zh) 1998-07-29
AU5215998A (en) 1998-07-30
PL324418A1 (en) 1998-08-03
AR011082A1 (es) 2000-08-02
KR100529479B1 (ko) 2006-10-19
MX9800611A (es) 1998-10-31
TR199800084A3 (tr) 1998-08-21
CZ18598A3 (cs) 1998-08-12
HK1009814A1 (en) 1999-06-11
TW593283B (en) 2004-06-21
SK7798A3 (en) 1998-08-05
EP0855392A2 (de) 1998-07-29
ID19574A (id) 1998-07-23
JPH10204064A (ja) 1998-08-04
MY121708A (en) 2006-02-28
AU738676B2 (en) 2001-09-20
PL191575B1 (pl) 2006-06-30
EP0855392A3 (de) 2000-01-05
CN1176911C (zh) 2004-11-24
NO980273D0 (no) 1998-01-21
HU9800112D0 (en) 1998-03-30
HUP9800112A3 (en) 2001-07-30
BR9800436A (pt) 1999-09-08
IL123013A0 (en) 1998-09-24
US6335451B1 (en) 2002-01-01
SK284126B6 (sk) 2004-09-08
IL123013A (en) 2003-02-12
US20020045761A1 (en) 2002-04-18
NO980273L (no) 1998-07-23
TR199800084A2 (xx) 1998-08-21

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