RU2162468C2 - Моногидрат гидрохлорида 1-циклопропил-7-([s,s]-2,8-диазабицикло[4.3.0]нон-8-ил)-6-фтор-1,4-дигидро -8-метокси-4-оксо-3-хинолинкарбоновой кислоты и фармацевтическая композиция с антибактериальной активностью - Google Patents

Моногидрат гидрохлорида 1-циклопропил-7-([s,s]-2,8-диазабицикло[4.3.0]нон-8-ил)-6-фтор-1,4-дигидро -8-метокси-4-оксо-3-хинолинкарбоновой кислоты и фармацевтическая композиция с антибактериальной активностью Download PDF

Info

Publication number
RU2162468C2
RU2162468C2 RU96123410/04A RU96123410A RU2162468C2 RU 2162468 C2 RU2162468 C2 RU 2162468C2 RU 96123410/04 A RU96123410/04 A RU 96123410/04A RU 96123410 A RU96123410 A RU 96123410A RU 2162468 C2 RU2162468 C2 RU 2162468C2
Authority
RU
Russia
Prior art keywords
monohydrate
diazabicyclo
cyclopropyl
dihydro
oxo
Prior art date
Application number
RU96123410/04A
Other languages
English (en)
Russian (ru)
Other versions
RU96123410A (ru
Inventor
ГРУНЕНБЕРГ Альфонс (DE)
Груненберг Альфонс
БОШЕ Патрик (DE)
Боше Патрик
Original Assignee
Байер Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7779831&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RU2162468(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Байер Аг filed Critical Байер Аг
Publication of RU96123410A publication Critical patent/RU96123410A/ru
Application granted granted Critical
Publication of RU2162468C2 publication Critical patent/RU2162468C2/ru

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
RU96123410/04A 1995-12-12 1996-12-11 Моногидрат гидрохлорида 1-циклопропил-7-([s,s]-2,8-диазабицикло[4.3.0]нон-8-ил)-6-фтор-1,4-дигидро -8-метокси-4-оксо-3-хинолинкарбоновой кислоты и фармацевтическая композиция с антибактериальной активностью RU2162468C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19546249.1 1995-12-12
DE19546249A DE19546249A1 (de) 1995-12-12 1995-12-12 Neue Kristallmodifikation des 1-Cyclopropyl-7-([S,S]-2,8-diazabicyclo[4,3,0]non-8-yl)-6-fluor-1,4-dihydro-8-methoxy-4-oxo-3-chinolincarbonsäure Hydrochlorid (CDCH), Verfahren zu dessen Herstellung und diese enthaltende pharmazeutische Zubereitungen

Publications (2)

Publication Number Publication Date
RU96123410A RU96123410A (ru) 1999-02-10
RU2162468C2 true RU2162468C2 (ru) 2001-01-27

Family

ID=7779831

Family Applications (1)

Application Number Title Priority Date Filing Date
RU96123410/04A RU2162468C2 (ru) 1995-12-12 1996-12-11 Моногидрат гидрохлорида 1-циклопропил-7-([s,s]-2,8-диазабицикло[4.3.0]нон-8-ил)-6-фтор-1,4-дигидро -8-метокси-4-оксо-3-хинолинкарбоновой кислоты и фармацевтическая композиция с антибактериальной активностью

Country Status (42)

Country Link
US (1) US5849752A (forum.php)
EP (1) EP0780390B1 (forum.php)
JP (1) JP4104687B2 (forum.php)
KR (1) KR100525146B1 (forum.php)
CN (1) CN1061348C (forum.php)
AR (1) AR005009A1 (forum.php)
AT (1) ATE221531T1 (forum.php)
AU (1) AU708006B2 (forum.php)
BG (1) BG62258B1 (forum.php)
BR (1) BR9605968A (forum.php)
CA (1) CA2192418C (forum.php)
CO (1) CO4480105A1 (forum.php)
CU (1) CU22774A3 (forum.php)
CZ (1) CZ288657B6 (forum.php)
DE (2) DE19546249A1 (forum.php)
DK (1) DK0780390T3 (forum.php)
EE (1) EE03474B1 (forum.php)
ES (1) ES2179910T3 (forum.php)
HR (1) HRP960558B1 (forum.php)
HU (1) HU226521B1 (forum.php)
ID (1) ID22625A (forum.php)
IL (1) IL119795A (forum.php)
IN (1) IN185805B (forum.php)
MA (1) MA24342A1 (forum.php)
MY (1) MY117492A (forum.php)
NL (1) NL300109I1 (forum.php)
NO (1) NO306725B1 (forum.php)
NZ (1) NZ299905A (forum.php)
PL (1) PL184885B1 (forum.php)
PT (1) PT780390E (forum.php)
RO (1) RO119782B1 (forum.php)
RU (1) RU2162468C2 (forum.php)
SA (1) SA96170492B1 (forum.php)
SG (1) SG47201A1 (forum.php)
SI (1) SI0780390T1 (forum.php)
SK (1) SK282805B6 (forum.php)
SV (1) SV1996000109A (forum.php)
TR (1) TR199600970A2 (forum.php)
TW (1) TW411340B (forum.php)
UA (1) UA35638C2 (forum.php)
YU (1) YU49485B (forum.php)
ZA (1) ZA9610405B (forum.php)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2383543C2 (ru) * 2004-04-01 2010-03-10 Байер Энимэл Хельс ГмбХ Тригидрат 8-циано-1-циклопропил-7-(1s, 6s-2,8-диазабицикло-[4.3.0]нонан-8-ил)-6-фтор-1, 4-дигидро-4-оксо-3-хинолинкарбоновой кислоты
RU2561037C2 (ru) * 2013-02-07 2015-08-20 Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН") Антибактериальная фармацевтическая композиция и способ ее получения

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1017392T1 (en) * 1997-09-25 2002-12-31 Bayer Aktiengesellschaft Medicament formulation with a controlled release of an active agent
DE19751948A1 (de) 1997-11-24 1999-05-27 Bayer Ag Verfahren zur Herstellung von 8-Methoxy-Chinoloncarbonsäuren
US6716830B2 (en) 1998-09-30 2004-04-06 Alcon, Inc. Ophthalmic antibiotic compositions containing moxifloxacin
US6509327B1 (en) 1998-09-30 2003-01-21 Alcon Manufacturing, Ltd. Compositions and methods for treating otic, ophthalmic and nasal infections
US6395746B1 (en) 1998-09-30 2002-05-28 Alcon Manufacturing, Ltd. Methods of treating ophthalmic, otic and nasal infections and attendant inflammation
WO2000027398A1 (de) 1998-11-10 2000-05-18 Bayer Aktiengesellschaft Pharmazeutische zubereitung von moxifloxacin
DE19854357A1 (de) * 1998-11-25 2000-05-31 Bayer Ag Semi-Hydrochlorid von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo/4.3.0/ -nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure
DE19854355A1 (de) * 1998-11-25 2000-05-31 Bayer Ag Kristallmodifikation B von 8-Cyan-1-cyclopropyl-7-(1S, 6S-2,8-diazabicyclo-/4.3.O/nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure
DE19854356A1 (de) * 1998-11-25 2000-05-31 Bayer Ag Kristallmodifikation A von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo-/4.3.0/nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure
DE19908449A1 (de) * 1999-02-26 2000-08-31 Bayer Ag Kristallmodifikation C von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicylo-[4.3.0]nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chino/incarbonsäure
WO2004039804A1 (en) * 2002-10-31 2004-05-13 Ranbaxy Laboratories Limited Amorphous moxifloxacin hydrochloride
CA2521398C (en) * 2003-04-09 2011-03-22 Dr. Reddy's Laboratories Limited A crystalline form iii of anhydrous moxifloxacin hydrochloride and a process for preparation thereof
EP1651630A1 (en) * 2003-08-05 2006-05-03 Matrix Laboratories Ltd An improved process for the preparation of moxifloxacin hydrochloride
ITMI20032259A1 (it) 2003-11-20 2005-05-21 Chemi Spa Nuovo polimorfo dell'acido 1-ciclopropil-7-(s,s-2,8-diazabciclo-4.3.0-non-8-il)-6-fluoro-1,4-diidro-8-metossi-4-oxo-chinolin carbossilico cloridrato e metodi per la sua preparazione
WO2005054240A1 (en) * 2003-11-20 2005-06-16 Chemi Spa Polymorphs of 1-cyclopropyl-7-([s,s]-2,8-diazadicyclo[4.3.0]non-8-yl)-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid hydrochloride and methods for the preparation thereof
US7491725B2 (en) 2004-02-06 2009-02-17 Bristol-Myers Squibb Company Process for preparing 2-aminothiazole-5-aromatic carboxamides as kinase inhibitors
DE102004063347A1 (de) * 2004-12-23 2006-07-13 Stada Arzneimittel Ag Gebrauchsfertige Gemcitabinlösungen und Gemcitabinlösungskonzentrate
WO2007033515A1 (fr) * 2005-09-21 2007-03-29 Shenzhen Tys R & D Co., Ltd. Formulation orale contenant de la moxifloxacine et son procédé de préparation
GB0612422D0 (en) * 2006-06-23 2006-08-02 Generics Uk Ltd Novel hydrate form
SI2032521T1 (sl) 2006-06-27 2010-02-26 Sandoz Ag Nov postopek za pripravo soli
ES2303768B1 (es) * 2006-09-08 2009-06-05 Quimica Sintetica, S.A. Nueva forma cristalina de moxifloxacino clorhidrato.
AU2007320997B2 (en) * 2006-11-13 2012-11-08 Cipla Limited Process for the synthesis of moxifloxacin hydrochloride
EP1992626A1 (en) * 2007-05-10 2008-11-19 Sandoz AG Process for the preparation of moxifloxacin hydrochloride
EP2083010A1 (en) * 2008-01-08 2009-07-29 Chemo Ibérica, S.A. Polymorphic Forms of Moxifloxacin hydrochloride and processes for preparation thereof
EP2154137A1 (en) 2008-08-04 2010-02-17 Chemo Ibérica, S.A. Crystalline form of moxifloxacin base
BRPI0823092A2 (pt) * 2008-10-09 2015-09-29 Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi método de granulação úmida de moxifloxacin anídrico ou seus sais
EP2342204A1 (en) * 2008-11-06 2011-07-13 Hetero Research Foundation Novel polymorph of moxifloxacin hydrochloride
ES2467105T5 (es) 2008-12-08 2017-12-05 Ratiopharm Gmbh Moxifloxacino compactado
NZ596492A (en) 2009-05-15 2013-08-30 Redx Pharma Ltd Redox drug derivatives
WO2011121596A2 (en) * 2010-04-01 2011-10-06 Neuland Laboratories Ltd. Crystal modification of moxifloxacin hydrochloride
BRPI1106900A2 (pt) 2011-12-26 2013-11-05 Ems Sa Composição farmacêutica sólida compreendendo antibótico da familia das quinolonas e processo de sua obtenção
FR2992218B1 (fr) 2012-06-22 2015-01-23 Rivopharm Sa Composition pharmaceutique de chlorhydrate de moxifloxacine et procede de preparation
CN102924449B (zh) * 2012-10-30 2015-08-12 重庆福安药业集团庆余堂制药有限公司 盐酸莫西沙星h晶型及其制备方法和药物组合物
US9388178B2 (en) 2012-12-04 2016-07-12 Mankind Research Centre Process for the preparation of moxifloxacin hydrochloride
US12036219B2 (en) 2013-03-15 2024-07-16 Melinta Subsidiary Corp. Methods of treating infections in overweight and obese patients using antibiotics

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0550903A1 (de) * 1992-01-10 1993-07-14 Bayer Ag Chinolon- und Naphthyridon-Carbonsäurederivate als antibakterielles Mittel
RU2047613C1 (ru) * 1989-10-30 1995-11-10 Лаборатуар Роже Беллон Производные 1,8-бензо(b)нафтиридина и фармацевтическая композиция на их основе

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3601567A1 (de) * 1986-01-21 1987-07-23 Bayer Ag 7-(azabicycloalkyl)-chinoloncarbonsaeure- und -naphthyridon-carbonsaeure-derivate
CN1019114B (zh) * 1986-03-31 1992-11-18 三共株式会社 喹啉-3-羟酸衍生物的制备方法
AU609974B2 (en) * 1988-05-18 1991-05-09 Warner-Lambert Company Improved process for the preparation of 5-amino-7- (substituted amino)-quinoline-3-carboxylic acids
DE3910663A1 (de) * 1989-04-03 1990-10-04 Bayer Ag 5-alkylchinoloncarbonsaeuren
ES2167329T3 (es) * 1992-01-31 2002-05-16 Chugai Pharmaceutical Co Ltd Cristal de hidrato de derivado de acido quinolonacarboxilico.
DE4234078A1 (de) * 1992-10-09 1994-04-14 Bayer Ag Chinoloncarbonsäuren
NO301165B1 (no) * 1992-12-25 1997-09-22 Daiichi Seiyaku Co Bicykliske aminderivater og antibakterielle midler inneholdende disse
ZA946853B (en) * 1993-09-10 1995-04-24 Daiichi Seiyaku Co Crystals of antimicrobial compound.
EP0676199B1 (en) * 1994-04-07 1998-09-02 Pfizer Inc. Use of trovafloxacin or derivatives thereof for the manufacture of a medicament for the treatment of H. pylori infections

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2047613C1 (ru) * 1989-10-30 1995-11-10 Лаборатуар Роже Беллон Производные 1,8-бензо(b)нафтиридина и фармацевтическая композиция на их основе
EP0550903A1 (de) * 1992-01-10 1993-07-14 Bayer Ag Chinolon- und Naphthyridon-Carbonsäurederivate als antibakterielles Mittel

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2383543C2 (ru) * 2004-04-01 2010-03-10 Байер Энимэл Хельс ГмбХ Тригидрат 8-циано-1-циклопропил-7-(1s, 6s-2,8-диазабицикло-[4.3.0]нонан-8-ил)-6-фтор-1, 4-дигидро-4-оксо-3-хинолинкарбоновой кислоты
RU2561037C2 (ru) * 2013-02-07 2015-08-20 Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН") Антибактериальная фармацевтическая композиция и способ ее получения

Also Published As

Publication number Publication date
MA24342A1 (fr) 1998-07-01
CN1160052A (zh) 1997-09-24
HU9603428D0 (en) 1997-01-28
KR970042550A (ko) 1997-07-24
JPH09169757A (ja) 1997-06-30
SV1996000109A (es) 1997-10-23
NL300109I1 (nl) 2003-02-03
ZA9610405B (en) 1997-06-23
JP4104687B2 (ja) 2008-06-18
NO965298D0 (no) 1996-12-11
PL184885B1 (pl) 2003-01-31
PT780390E (pt) 2002-11-29
SA96170492B1 (ar) 2006-05-23
CU22774A3 (es) 2002-07-24
MX9606325A (es) 1997-10-31
NO965298L (no) 1997-06-13
SG47201A1 (en) 1998-03-20
EP0780390B1 (de) 2002-07-31
EP0780390A1 (de) 1997-06-25
MY117492A (en) 2004-07-31
RO119782B1 (ro) 2005-03-30
AU708006B2 (en) 1999-07-29
EE03474B1 (et) 2001-08-15
TR199600970A2 (tr) 1997-06-21
HRP960558A2 (en) 1998-02-28
HU226521B1 (en) 2009-03-30
IL119795A (en) 1998-12-27
YU49485B (sh) 2006-08-17
PL317415A1 (en) 1997-06-23
US5849752A (en) 1998-12-15
KR100525146B1 (ko) 2006-01-27
CZ288657B6 (cs) 2001-08-15
NO306725B1 (no) 1999-12-13
BG101043A (en) 1998-04-30
SI0780390T1 (en) 2002-10-31
HUP9603428A2 (en) 1997-08-28
AU7421696A (en) 1997-06-19
SK159196A3 (en) 1997-10-08
YU65096A (sh) 1998-12-23
UA35638C2 (uk) 2001-04-16
NZ299905A (en) 1998-09-24
DE59609501D1 (de) 2002-09-05
DK0780390T3 (da) 2002-11-11
HUP9603428A3 (en) 1997-10-28
HRP960558B1 (en) 2002-04-30
CN1061348C (zh) 2001-01-31
DE19546249A1 (de) 1997-06-19
CO4480105A1 (es) 1997-07-09
EE9600201A (et) 1997-06-16
ATE221531T1 (de) 2002-08-15
IL119795A0 (en) 1997-03-18
CA2192418A1 (en) 1997-06-13
CZ364696A3 (en) 1997-07-16
IN185805B (forum.php) 2001-05-05
SK282805B6 (sk) 2002-12-03
BR9605968A (pt) 1998-08-18
AR005009A1 (es) 1999-04-07
TW411340B (en) 2000-11-11
ID22625A (id) 1999-12-02
ES2179910T3 (es) 2003-02-01
BG62258B1 (bg) 1999-06-30
CA2192418C (en) 2001-06-12

Similar Documents

Publication Publication Date Title
RU2162468C2 (ru) Моногидрат гидрохлорида 1-циклопропил-7-([s,s]-2,8-диазабицикло[4.3.0]нон-8-ил)-6-фтор-1,4-дигидро -8-метокси-4-оксо-3-хинолинкарбоновой кислоты и фармацевтическая композиция с антибактериальной активностью
ES3025633T3 (en) New crystalline forms of n-(3-(2-(2-hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methvlphenyl)-2(trifluoromethyl)isonicotinamide as raf inhibitors for the treatment of cancer
US10385008B2 (en) Polymorphic forms of RAD1901-2HCL
KR20210013554A (ko) Tlr7/tlr8 억제제의 결정질 형태
KR20010074472A (ko) 신규의 결정질 형태의 항바이러스성 벤즈이미다졸 화합물
US11643385B2 (en) Polymorphic forms of RAD1901-2HCl
KR101153606B1 (ko) 아타자나비르 비술페이트 및 신규 형태의 제조 방법
WO2021044437A1 (en) Olaparib co-crystals and process of preparation thereof
WO2023064519A1 (en) Solid state forms of elacestrant and processes for preparation thereof
AU2022201921B2 (en) Crystalline forms of a LTA4H inhibitor
PL194752B1 (pl) Krystaliczna postać VI 5,6-dichloro-2-(izopropyloamino)-1-(ß-L-rybofuranozylo)-1H-benzimidazolu, sposób jej wytwarzania, kompozycja farmaceutyczna zawierająca krystaliczną postać i zastosowanie krystalicznej postaci
JP2018515477A (ja) 免疫調節薬の新規な結晶形
MXPA96006325A (en) New variante cristalina del cdch, procedure for its production and pharmaceutical preparations that contains it
WO2022224269A1 (en) Co-crystals, salts and solid forms of niraparib
HK1002006B (en) Crystalline modification of cdch, process for its preparation and pharmaceutical compositions containing it
HK1002006A (en) Crystalline modification of cdch, process for its preparation and pharmaceutical compositions containing it

Legal Events

Date Code Title Description
PC4A Invention patent assignment

Effective date: 20050120

HK4A Changes in a published invention
PD4A Correction of name of patent owner
PC41 Official registration of the transfer of exclusive right

Effective date: 20130806