RU96123410A - Моногидрат гидрохлорида 1-циклопропил-7-([s,s]-2,8-диазабицикло[4.3.0] нон-8-ил)- 6-фтор-1,4-дигидро-8-метокси-4-оксо-3-хинолинкарбоновой кислоты и фармацевтическая композиция с антибактериальной активностью - Google Patents
Моногидрат гидрохлорида 1-циклопропил-7-([s,s]-2,8-диазабицикло[4.3.0] нон-8-ил)- 6-фтор-1,4-дигидро-8-метокси-4-оксо-3-хинолинкарбоновой кислоты и фармацевтическая композиция с антибактериальной активностьюInfo
- Publication number
- RU96123410A RU96123410A RU96123410/04A RU96123410A RU96123410A RU 96123410 A RU96123410 A RU 96123410A RU 96123410/04 A RU96123410/04 A RU 96123410/04A RU 96123410 A RU96123410 A RU 96123410A RU 96123410 A RU96123410 A RU 96123410A
- Authority
- RU
- Russia
- Prior art keywords
- monohydrate
- diazabicyclo
- dihydro
- oxo
- fluoro
- Prior art date
Links
- 150000004682 monohydrates Chemical class 0.000 title claims 4
- 239000008194 pharmaceutical composition Substances 0.000 title claims 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N HCl Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 title claims 2
- 230000000844 anti-bacterial Effects 0.000 title claims 2
- -1 [S, S] -2,8-diazabicyclo [4.3.0] non 8-yl Chemical group 0.000 claims 2
- 238000001460 carbon-13 nuclear magnetic resonance spectrum Methods 0.000 claims 2
- SPLNGOFULBNITO-UHFFFAOYSA-N O=C1C(C(O)=O)C=NC2=C1C=CC=C2OC Chemical compound O=C1C(C(O)=O)C=NC2=C1C=CC=C2OC SPLNGOFULBNITO-UHFFFAOYSA-N 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
Claims (4)
1. Моногидрат гидрохлорида 1-циклопропил-7-([S, S] -2,8-диазабицикло[4.3.0] нон-8-ил)-6-фтор- 1,4-дигидро-8-метокси-4-оксо-3-хинолинкарбоновой кислоты формулы
в 13С-ЯМР-спектре которого имеется характеристический пик при 168,1 м.д. и на рентгеновской дифрактограмме имеется линия при угле 2Θ = 26,7.
в 13С-ЯМР-спектре которого имеется характеристический пик при 168,1 м.д. и на рентгеновской дифрактограмме имеется линия при угле 2Θ = 26,7.
2. Моногидрат по п. 1 в кристаллической форме в виде призм.
3. Фармацевтическая композиция с антибактериальной активностью, содержащая гидрохлорид 1-циклопропил-7-([S,S]-2,8-диазабицикло[4.3.0]нон-8-ил)-6-фтор-1,4- дигидро-8-метокси-4-оксо-3-хинолинкарбоновой кислоты в качестве действующего начала и по крайней мере один фармацевтически приемлемый носитель, отличающаяся тем, что в качестве действующего начала она содержит в эффективном количестве моногидрат указанного гидрохлорида формулы
в 13C-ЯМР-спектре которого имеется характеристический пик при 168,1 м.д. и на рентгеновской дифрактограмме имеется линия при угле 2Θ = 26,7.
в 13C-ЯМР-спектре которого имеется характеристический пик при 168,1 м.д. и на рентгеновской дифрактограмме имеется линия при угле 2Θ = 26,7.
4. Фармацевтическая композиция по п. 1, отличающаяся тем, что она содержит моногидрат в кристаллической форме в виде призм.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19546249A DE19546249A1 (de) | 1995-12-12 | 1995-12-12 | Neue Kristallmodifikation des 1-Cyclopropyl-7-([S,S]-2,8-diazabicyclo[4,3,0]non-8-yl)-6-fluor-1,4-dihydro-8-methoxy-4-oxo-3-chinolincarbonsäure Hydrochlorid (CDCH), Verfahren zu dessen Herstellung und diese enthaltende pharmazeutische Zubereitungen |
| DE19546249.1 | 1995-12-12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU96123410A true RU96123410A (ru) | 1999-02-10 |
| RU2162468C2 RU2162468C2 (ru) | 2001-01-27 |
Family
ID=7779831
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU96123410/04A RU2162468C2 (ru) | 1995-12-12 | 1996-12-11 | Моногидрат гидрохлорида 1-циклопропил-7-([s,s]-2,8-диазабицикло[4.3.0]нон-8-ил)-6-фтор-1,4-дигидро -8-метокси-4-оксо-3-хинолинкарбоновой кислоты и фармацевтическая композиция с антибактериальной активностью |
Country Status (42)
| Country | Link |
|---|---|
| US (1) | US5849752A (ru) |
| EP (1) | EP0780390B1 (ru) |
| JP (1) | JP4104687B2 (ru) |
| KR (1) | KR100525146B1 (ru) |
| CN (1) | CN1061348C (ru) |
| AR (1) | AR005009A1 (ru) |
| AT (1) | ATE221531T1 (ru) |
| AU (1) | AU708006B2 (ru) |
| BG (1) | BG62258B1 (ru) |
| BR (1) | BR9605968A (ru) |
| CA (1) | CA2192418C (ru) |
| CO (1) | CO4480105A1 (ru) |
| CU (1) | CU22774A3 (ru) |
| CZ (1) | CZ288657B6 (ru) |
| DE (2) | DE19546249A1 (ru) |
| DK (1) | DK0780390T3 (ru) |
| EE (1) | EE03474B1 (ru) |
| ES (1) | ES2179910T3 (ru) |
| HR (1) | HRP960558B1 (ru) |
| HU (1) | HU226521B1 (ru) |
| ID (1) | ID22625A (ru) |
| IL (1) | IL119795A (ru) |
| IN (1) | IN185805B (ru) |
| MA (1) | MA24342A1 (ru) |
| MY (1) | MY117492A (ru) |
| NL (1) | NL300109I1 (ru) |
| NO (1) | NO306725B1 (ru) |
| NZ (1) | NZ299905A (ru) |
| PL (1) | PL184885B1 (ru) |
| PT (1) | PT780390E (ru) |
| RO (1) | RO119782B1 (ru) |
| RU (1) | RU2162468C2 (ru) |
| SA (1) | SA96170492B1 (ru) |
| SG (1) | SG47201A1 (ru) |
| SI (1) | SI0780390T1 (ru) |
| SK (1) | SK282805B6 (ru) |
| SV (1) | SV1996000109A (ru) |
| TR (1) | TR199600970A2 (ru) |
| TW (1) | TW411340B (ru) |
| UA (1) | UA35638C2 (ru) |
| YU (1) | YU49485B (ru) |
| ZA (1) | ZA9610405B (ru) |
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| AU731693B2 (en) * | 1997-09-25 | 2001-04-05 | Bayer Intellectual Property Gmbh | Drug formulation having controlled release of active compound |
| DE19751948A1 (de) | 1997-11-24 | 1999-05-27 | Bayer Ag | Verfahren zur Herstellung von 8-Methoxy-Chinoloncarbonsäuren |
| US6509327B1 (en) | 1998-09-30 | 2003-01-21 | Alcon Manufacturing, Ltd. | Compositions and methods for treating otic, ophthalmic and nasal infections |
| US6395746B1 (en) | 1998-09-30 | 2002-05-28 | Alcon Manufacturing, Ltd. | Methods of treating ophthalmic, otic and nasal infections and attendant inflammation |
| US6716830B2 (en) | 1998-09-30 | 2004-04-06 | Alcon, Inc. | Ophthalmic antibiotic compositions containing moxifloxacin |
| TR200101310T2 (tr) * | 1998-11-10 | 2001-10-22 | Bayer Aktiengesellschaft | Farmasötik moksifloksasin preparatı. |
| DE19854355A1 (de) * | 1998-11-25 | 2000-05-31 | Bayer Ag | Kristallmodifikation B von 8-Cyan-1-cyclopropyl-7-(1S, 6S-2,8-diazabicyclo-/4.3.O/nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure |
| DE19854357A1 (de) * | 1998-11-25 | 2000-05-31 | Bayer Ag | Semi-Hydrochlorid von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo/4.3.0/ -nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure |
| DE19854356A1 (de) * | 1998-11-25 | 2000-05-31 | Bayer Ag | Kristallmodifikation A von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo-/4.3.0/nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure |
| DE19908449A1 (de) * | 1999-02-26 | 2000-08-31 | Bayer Ag | Kristallmodifikation C von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicylo-[4.3.0]nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chino/incarbonsäure |
| WO2004039804A1 (en) * | 2002-10-31 | 2004-05-13 | Ranbaxy Laboratories Limited | Amorphous moxifloxacin hydrochloride |
| DE602004022646D1 (de) * | 2003-04-09 | 2009-10-01 | Reddys Lab Ltd Dr | Kristalline form iii von wasserfreiem moxifloxacin-hydrochlorid und ein verfahren zu seiner herstellung |
| EP1651630A1 (en) * | 2003-08-05 | 2006-05-03 | Matrix Laboratories Ltd | An improved process for the preparation of moxifloxacin hydrochloride |
| EP1685130B1 (en) * | 2003-11-20 | 2008-12-10 | CHEMI S.p.A. | Polymorphs of 1-cyclopropyl-7-([s,s] - 2,8-diazadicyclo [4.3.0] non-8-yl) -6-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid hydrochloride and methods for the preparation thereof |
| ITMI20032259A1 (it) | 2003-11-20 | 2005-05-21 | Chemi Spa | Nuovo polimorfo dell'acido 1-ciclopropil-7-(s,s-2,8-diazabciclo-4.3.0-non-8-il)-6-fluoro-1,4-diidro-8-metossi-4-oxo-chinolin carbossilico cloridrato e metodi per la sua preparazione |
| US7491725B2 (en) | 2004-02-06 | 2009-02-17 | Bristol-Myers Squibb Company | Process for preparing 2-aminothiazole-5-aromatic carboxamides as kinase inhibitors |
| DE102004063347A1 (de) * | 2004-12-23 | 2006-07-13 | Stada Arzneimittel Ag | Gebrauchsfertige Gemcitabinlösungen und Gemcitabinlösungskonzentrate |
| WO2007033515A1 (fr) * | 2005-09-21 | 2007-03-29 | Shenzhen Tys R & D Co., Ltd. | Formulation orale contenant de la moxifloxacine et son procédé de préparation |
| GB0612422D0 (en) * | 2006-06-23 | 2006-08-02 | Generics Uk Ltd | Novel hydrate form |
| SI2032521T1 (sl) | 2006-06-27 | 2010-02-26 | Sandoz Ag | Nov postopek za pripravo soli |
| ES2303768B1 (es) * | 2006-09-08 | 2009-06-05 | Quimica Sintetica, S.A. | Nueva forma cristalina de moxifloxacino clorhidrato. |
| NZ576929A (en) * | 2006-11-13 | 2012-07-27 | Cipla Ltd | Crystalline anhydrous form C of moxifloxacin hydrochloride |
| EP1992626A1 (en) * | 2007-05-10 | 2008-11-19 | Sandoz AG | Process for the preparation of moxifloxacin hydrochloride |
| EP2083010A1 (en) * | 2008-01-08 | 2009-07-29 | Chemo Ibérica, S.A. | Polymorphic Forms of Moxifloxacin hydrochloride and processes for preparation thereof |
| EP2154137A1 (en) | 2008-08-04 | 2010-02-17 | Chemo Ibérica, S.A. | Crystalline form of moxifloxacin base |
| WO2010041100A1 (en) * | 2008-10-09 | 2010-04-15 | Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi | Using of organic solvents in wet granulation of moxifloxacin |
| WO2010052726A1 (en) * | 2008-11-06 | 2010-05-14 | Hetero Research Foundation | Novel polymorph of moxifloxacin hydrochloride |
| EP2364141B2 (de) | 2008-12-08 | 2017-08-02 | ratiopharm GmbH | Kompaktiertes moxifloxacin |
| CA2762022A1 (en) | 2009-05-15 | 2010-11-18 | Redx Pharma Limited | Redox drug derivatives |
| WO2011121596A2 (en) * | 2010-04-01 | 2011-10-06 | Neuland Laboratories Ltd. | Crystal modification of moxifloxacin hydrochloride |
| BRPI1106900A2 (pt) | 2011-12-26 | 2013-11-05 | Ems Sa | Composição farmacêutica sólida compreendendo antibótico da familia das quinolonas e processo de sua obtenção |
| FR2992218B1 (fr) | 2012-06-22 | 2015-01-23 | Rivopharm Sa | Composition pharmaceutique de chlorhydrate de moxifloxacine et procede de preparation |
| CN102924449B (zh) * | 2012-10-30 | 2015-08-12 | 重庆福安药业集团庆余堂制药有限公司 | 盐酸莫西沙星h晶型及其制备方法和药物组合物 |
| US9388178B2 (en) | 2012-12-04 | 2016-07-12 | Mankind Research Centre | Process for the preparation of moxifloxacin hydrochloride |
| RU2561037C2 (ru) * | 2013-02-07 | 2015-08-20 | Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН") | Антибактериальная фармацевтическая композиция и способ ее получения |
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| DE3601567A1 (de) * | 1986-01-21 | 1987-07-23 | Bayer Ag | 7-(azabicycloalkyl)-chinoloncarbonsaeure- und -naphthyridon-carbonsaeure-derivate |
| NO871333L (no) * | 1986-03-31 | 1987-10-01 | Sankyo Co | Kinolin-3-karboksylsyrederivater, fremgangsmaate til fremstilling og anvendelse derav. |
| AU609974B2 (en) * | 1988-05-18 | 1991-05-09 | Warner-Lambert Company | Improved process for the preparation of 5-amino-7- (substituted amino)-quinoline-3-carboxylic acids |
| DE3910663A1 (de) * | 1989-04-03 | 1990-10-04 | Bayer Ag | 5-alkylchinoloncarbonsaeuren |
| TW209865B (ru) | 1992-01-10 | 1993-07-21 | Bayer Ag | |
| ATE207479T1 (de) * | 1992-01-31 | 2001-11-15 | Chugai Pharmaceutical Co Ltd | Kristalle von derivaten von chinozon carbonsäure- hydraten |
| DE4234078A1 (de) * | 1992-10-09 | 1994-04-14 | Bayer Ag | Chinoloncarbonsäuren |
| CA2112165C (en) * | 1992-12-25 | 2003-04-08 | Makoto Takemura | Bicyclic amine derivatives |
| ZA946853B (en) * | 1993-09-10 | 1995-04-24 | Daiichi Seiyaku Co | Crystals of antimicrobial compound. |
| ATE170400T1 (de) * | 1994-04-07 | 1998-09-15 | Pfizer | Verwendung von trovafloxacin oder dessen derivaten zur herstellung eines arzneimittels zur behandlung von h.pylori infektionen |
-
1995
- 1995-12-12 DE DE19546249A patent/DE19546249A1/de not_active Withdrawn
-
1996
- 1996-11-22 MA MA24398A patent/MA24342A1/fr unknown
- 1996-11-25 RO RO96-02223A patent/RO119782B1/ro unknown
- 1996-11-25 HR HR960558A patent/HRP960558B1/xx not_active IP Right Cessation
- 1996-11-27 CU CU1996111A patent/CU22774A3/es not_active IP Right Cessation
- 1996-11-29 SI SI9630468T patent/SI0780390T1/xx unknown
- 1996-11-29 DK DK96119134T patent/DK0780390T3/da active
- 1996-11-29 ES ES96119134T patent/ES2179910T3/es not_active Expired - Lifetime
- 1996-11-29 DE DE59609501T patent/DE59609501D1/de not_active Expired - Lifetime
- 1996-11-29 PT PT96119134T patent/PT780390E/pt unknown
- 1996-11-29 AT AT96119134T patent/ATE221531T1/de active
- 1996-11-29 EP EP96119134A patent/EP0780390B1/de not_active Expired - Lifetime
- 1996-12-05 US US08/760,543 patent/US5849752A/en not_active Expired - Lifetime
- 1996-12-05 TR TR96/00970A patent/TR199600970A2/xx unknown
- 1996-12-06 YU YU65096A patent/YU49485B/sh unknown
- 1996-12-06 IN IN2723DE1996 patent/IN185805B/en unknown
- 1996-12-06 AU AU74216/96A patent/AU708006B2/en not_active Expired
- 1996-12-06 TW TW085115048A patent/TW411340B/zh not_active IP Right Cessation
- 1996-12-09 NZ NZ299905A patent/NZ299905A/en not_active IP Right Cessation
- 1996-12-09 AR ARP960105569A patent/AR005009A1/es active IP Right Grant
- 1996-12-09 CA CA002192418A patent/CA2192418C/en not_active Expired - Lifetime
- 1996-12-10 BG BG101043A patent/BG62258B1/bg unknown
- 1996-12-10 CO CO96064770A patent/CO4480105A1/es unknown
- 1996-12-10 ID IDP963684A patent/ID22625A/id unknown
- 1996-12-10 JP JP34450296A patent/JP4104687B2/ja not_active Expired - Lifetime
- 1996-12-10 SG SG1996011612A patent/SG47201A1/en unknown
- 1996-12-10 IL IL11979596A patent/IL119795A/en not_active IP Right Cessation
- 1996-12-10 PL PL96317415A patent/PL184885B1/pl unknown
- 1996-12-11 BR BR9605968A patent/BR9605968A/pt not_active IP Right Cessation
- 1996-12-11 SK SK1591-96A patent/SK282805B6/sk not_active IP Right Cessation
- 1996-12-11 EE EE9600201A patent/EE03474B1/xx unknown
- 1996-12-11 KR KR1019960064345A patent/KR100525146B1/ko not_active IP Right Cessation
- 1996-12-11 MY MYPI96005214A patent/MY117492A/en unknown
- 1996-12-11 NO NO19965298A patent/NO306725B1/no not_active IP Right Cessation
- 1996-12-11 CZ CZ19963646A patent/CZ288657B6/cs not_active IP Right Cessation
- 1996-12-11 RU RU96123410/04A patent/RU2162468C2/ru active
- 1996-12-11 SA SA96170492A patent/SA96170492B1/ar unknown
- 1996-12-11 UA UA96124628A patent/UA35638C2/ru unknown
- 1996-12-11 ZA ZA9610405A patent/ZA9610405B/xx unknown
- 1996-12-12 CN CN96123220A patent/CN1061348C/zh not_active Expired - Lifetime
- 1996-12-12 SV SV1996000109A patent/SV1996000109A/es active IP Right Grant
- 1996-12-12 HU HU9603428A patent/HU226521B1/hu unknown
-
2002
- 2002-12-05 NL NL300109C patent/NL300109I1/nl unknown
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