IE780631L - Azabicycloheptenes - Google Patents

Azabicycloheptenes

Info

Publication number
IE780631L
IE780631L IE780631A IE63178A IE780631L IE 780631 L IE780631 L IE 780631L IE 780631 A IE780631 A IE 780631A IE 63178 A IE63178 A IE 63178A IE 780631 L IE780631 L IE 780631L
Authority
IE
Ireland
Prior art keywords
compound
formula
acceptable salts
pharmacologically acceptable
gram
Prior art date
Application number
IE780631A
Other versions
IE47043B1 (en
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of IE780631L publication Critical patent/IE780631L/en
Publication of IE47043B1 publication Critical patent/IE47043B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The compound of the formula I and its pharmacologically acceptable salts are described. They can be obtained by reduction of the compound of the formula (III) in which R and R' have the meaning given in Claim 4. The compound (I) and its pharmacologically acceptable salts are effective antibiotics against Gram-positive and Gram-negative bacteria and can therefore be used as active compounds in medicaments, animal feed additives, preservatives for foodstuffs and in disinfectants. <IMAGE> [GB1595267A]
IE631/78A 1977-04-08 1978-03-30 Azabicycloheptenes IE47043B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78581177A 1977-04-08 1977-04-08
US86123077A 1977-12-16 1977-12-16

Publications (2)

Publication Number Publication Date
IE780631L true IE780631L (en) 1978-10-08
IE47043B1 IE47043B1 (en) 1983-12-14

Family

ID=27120448

Family Applications (1)

Application Number Title Priority Date Filing Date
IE631/78A IE47043B1 (en) 1977-04-08 1978-03-30 Azabicycloheptenes

Country Status (11)

Country Link
JP (1) JPS53127491A (en)
CH (1) CH640236A5 (en)
DE (1) DE2815157A1 (en)
DK (1) DK123578A (en)
FR (1) FR2386545A1 (en)
GB (1) GB1595267A (en)
IE (1) IE47043B1 (en)
IT (1) IT1102456B (en)
LU (1) LU79403A1 (en)
NL (1) NL7802826A (en)
SE (1) SE7803173L (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR62185B (en) * 1977-03-31 1979-03-02 Panlabs Inc Preparation process of an antibiotic ps-5 and its derivatives with inhibitory activity of b-lactamase
JPS5473788A (en) * 1977-11-17 1979-06-13 Sanraku Inc Antibiotic n-desacetyl ps-5
EP0005349A1 (en) * 1978-05-06 1979-11-14 Beecham Group Plc Alkylcarbapenems, their preparation, use in pharmaceutical compositions and intermediates
JPS5572191A (en) * 1978-11-22 1980-05-30 Sanraku Inc Antibiotic n-desacetyl ps-5
JPS55136282A (en) * 1979-04-06 1980-10-23 Shionogi & Co Ltd Novel antibiotic pa-31088-4
US4235922A (en) * 1979-06-15 1980-11-25 Merck & Co., Inc. 3-(2-Aminoethylthio)-6-ethyl-7-oxo-1-azabicyclo [3.2.0]hept-2-ene-2-carboxylic acid
EP0024832B1 (en) * 1979-08-10 1985-03-13 Beecham Group Plc Beta-lactam antibiotics, their preparation, pharmaceutical compositions containing them and their preparation
JPS5683489A (en) * 1979-12-12 1981-07-08 Shionogi & Co Ltd New antibiotic pa-39504-x1 and it preparation
JPS5764693A (en) * 1980-10-07 1982-04-19 Kowa Co Novel carbapenem compound and its preparation

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3950357A (en) * 1974-11-25 1976-04-13 Merck & Co., Inc. Antibiotics

Also Published As

Publication number Publication date
DE2815157A1 (en) 1978-10-19
IT7848747A0 (en) 1978-04-05
IE47043B1 (en) 1983-12-14
GB1595267A (en) 1981-08-12
FR2386545A1 (en) 1978-11-03
FR2386545B1 (en) 1980-08-01
SE7803173L (en) 1978-10-09
JPS53127491A (en) 1978-11-07
CH640236A5 (en) 1983-12-30
DK123578A (en) 1978-10-09
LU79403A1 (en) 1978-11-27
IT1102456B (en) 1985-10-07
NL7802826A (en) 1978-10-10

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