UA35638C2 - Моногідрат гідрохлориду 1-циклопропіл-7-([s,s]-2,8-діазабіцикло[4.3.0]нон-8-іл)- 6-фтор-1,4-дигідро-8-метокси-4-оксо-3-хінолінкарбонової кислоти та фармацевтична композиція з антибактеріальною активністю - Google Patents

Моногідрат гідрохлориду 1-циклопропіл-7-([s,s]-2,8-діазабіцикло[4.3.0]нон-8-іл)- 6-фтор-1,4-дигідро-8-метокси-4-оксо-3-хінолінкарбонової кислоти та фармацевтична композиція з антибактеріальною активністю

Info

Publication number
UA35638C2
UA35638C2 UA96124628A UA96124628A UA35638C2 UA 35638 C2 UA35638 C2 UA 35638C2 UA 96124628 A UA96124628 A UA 96124628A UA 96124628 A UA96124628 A UA 96124628A UA 35638 C2 UA35638 C2 UA 35638C2
Authority
UA
Ukraine
Prior art keywords
quinolinecarboxylic acid
diazabicyclo
monohydrate
cyclopropyl
dihydro
Prior art date
Application number
UA96124628A
Other languages
English (en)
Russian (ru)
Inventor
Альфонс Груненберг
Патрік Боше
Патрик Боше
Original Assignee
Баєр Акціенгезельшафт
Байер Акциенгезельшафт
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7779831&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA35638(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Баєр Акціенгезельшафт, Байер Акциенгезельшафт filed Critical Баєр Акціенгезельшафт
Publication of UA35638C2 publication Critical patent/UA35638C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Винахід стосується нового похідного хінолінонкарбонової кислоти з антибактеріальною активністю. Моногідрат гідрохлориду 1-циклопропіл-7-([S,S]-2,8- діазабіцикло[4.3.0]нон-8-іл)-6-фтор-1,4-дигідро-8-метокси-4-оксо-3-хінолінкарбонової кислоти формули у 13С-ЯМР спектрі якого є характеристичний пік при 168,1 м.ч. і на рентгенівській дифрактограмі є лінія під кутом 2Θ = 26,7.
UA96124628A 1995-12-12 1996-12-11 Моногідрат гідрохлориду 1-циклопропіл-7-([s,s]-2,8-діазабіцикло[4.3.0]нон-8-іл)- 6-фтор-1,4-дигідро-8-метокси-4-оксо-3-хінолінкарбонової кислоти та фармацевтична композиція з антибактеріальною активністю UA35638C2 (uk)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19546249A DE19546249A1 (de) 1995-12-12 1995-12-12 Neue Kristallmodifikation des 1-Cyclopropyl-7-([S,S]-2,8-diazabicyclo[4,3,0]non-8-yl)-6-fluor-1,4-dihydro-8-methoxy-4-oxo-3-chinolincarbonsäure Hydrochlorid (CDCH), Verfahren zu dessen Herstellung und diese enthaltende pharmazeutische Zubereitungen

Publications (1)

Publication Number Publication Date
UA35638C2 true UA35638C2 (uk) 2001-04-16

Family

ID=7779831

Family Applications (1)

Application Number Title Priority Date Filing Date
UA96124628A UA35638C2 (uk) 1995-12-12 1996-12-11 Моногідрат гідрохлориду 1-циклопропіл-7-([s,s]-2,8-діазабіцикло[4.3.0]нон-8-іл)- 6-фтор-1,4-дигідро-8-метокси-4-оксо-3-хінолінкарбонової кислоти та фармацевтична композиція з антибактеріальною активністю

Country Status (42)

Country Link
US (1) US5849752A (uk)
EP (1) EP0780390B1 (uk)
JP (1) JP4104687B2 (uk)
KR (1) KR100525146B1 (uk)
CN (1) CN1061348C (uk)
AR (1) AR005009A1 (uk)
AT (1) ATE221531T1 (uk)
AU (1) AU708006B2 (uk)
BG (1) BG62258B1 (uk)
BR (1) BR9605968A (uk)
CA (1) CA2192418C (uk)
CO (1) CO4480105A1 (uk)
CU (1) CU22774A3 (uk)
CZ (1) CZ288657B6 (uk)
DE (2) DE19546249A1 (uk)
DK (1) DK0780390T3 (uk)
EE (1) EE03474B1 (uk)
ES (1) ES2179910T3 (uk)
HR (1) HRP960558B1 (uk)
HU (1) HU226521B1 (uk)
ID (1) ID22625A (uk)
IL (1) IL119795A (uk)
IN (1) IN185805B (uk)
MA (1) MA24342A1 (uk)
MY (1) MY117492A (uk)
NL (1) NL300109I1 (uk)
NO (1) NO306725B1 (uk)
NZ (1) NZ299905A (uk)
PL (1) PL184885B1 (uk)
PT (1) PT780390E (uk)
RO (1) RO119782B1 (uk)
RU (1) RU2162468C2 (uk)
SA (1) SA96170492B1 (uk)
SG (1) SG47201A1 (uk)
SI (1) SI0780390T1 (uk)
SK (1) SK282805B6 (uk)
SV (1) SV1996000109A (uk)
TR (1) TR199600970A2 (uk)
TW (1) TW411340B (uk)
UA (1) UA35638C2 (uk)
YU (1) YU49485B (uk)
ZA (1) ZA9610405B (uk)

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US6509327B1 (en) 1998-09-30 2003-01-21 Alcon Manufacturing, Ltd. Compositions and methods for treating otic, ophthalmic and nasal infections
US6395746B1 (en) 1998-09-30 2002-05-28 Alcon Manufacturing, Ltd. Methods of treating ophthalmic, otic and nasal infections and attendant inflammation
KR100650489B1 (ko) * 1998-11-10 2006-11-28 바이엘 헬스케어 아게 목시플록사신 제약 제제
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DE19854356A1 (de) * 1998-11-25 2000-05-31 Bayer Ag Kristallmodifikation A von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo-/4.3.0/nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure
DE19908449A1 (de) * 1999-02-26 2000-08-31 Bayer Ag Kristallmodifikation C von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicylo-[4.3.0]nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chino/incarbonsäure
EP1562942A1 (en) * 2002-10-31 2005-08-17 Ranbaxy Laboratories, Ltd. Amorphous moxifloxacin hydrochloride
ATE439840T1 (de) * 2003-04-09 2009-09-15 Reddys Lab Ltd Dr Kristalline form iii von wasserfreiem moxifloxacin-hydrochlorid und ein verfahren zu seiner herstellung
US20060264635A1 (en) * 2003-08-05 2006-11-23 Chava Satyanarayana Process for the preparation of moxifloxacin hydrochloride
WO2005054240A1 (en) * 2003-11-20 2005-06-16 Chemi Spa Polymorphs of 1-cyclopropyl-7-([s,s]-2,8-diazadicyclo[4.3.0]non-8-yl)-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid hydrochloride and methods for the preparation thereof
ITMI20032259A1 (it) 2003-11-20 2005-05-21 Chemi Spa Nuovo polimorfo dell'acido 1-ciclopropil-7-(s,s-2,8-diazabciclo-4.3.0-non-8-il)-6-fluoro-1,4-diidro-8-metossi-4-oxo-chinolin carbossilico cloridrato e metodi per la sua preparazione
US7491725B2 (en) 2004-02-06 2009-02-17 Bristol-Myers Squibb Company Process for preparing 2-aminothiazole-5-aromatic carboxamides as kinase inhibitors
DE102004063347A1 (de) * 2004-12-23 2006-07-13 Stada Arzneimittel Ag Gebrauchsfertige Gemcitabinlösungen und Gemcitabinlösungskonzentrate
WO2007033515A1 (fr) * 2005-09-21 2007-03-29 Shenzhen Tys R & D Co., Ltd. Formulation orale contenant de la moxifloxacine et son procédé de préparation
GB0612422D0 (en) * 2006-06-23 2006-08-02 Generics Uk Ltd Novel hydrate form
EP2032521B1 (en) 2006-06-27 2009-10-28 Sandoz AG New method for salt preparation
ES2303768B1 (es) * 2006-09-08 2009-06-05 Quimica Sintetica, S.A. Nueva forma cristalina de moxifloxacino clorhidrato.
WO2008059223A2 (en) * 2006-11-13 2008-05-22 Cipla Limited Process for the synthesis of moxifloxacin hydrochloride
EP1992626A1 (en) * 2007-05-10 2008-11-19 Sandoz AG Process for the preparation of moxifloxacin hydrochloride
EP2083010A1 (en) * 2008-01-08 2009-07-29 Chemo Ibérica, S.A. Polymorphic Forms of Moxifloxacin hydrochloride and processes for preparation thereof
EP2154137A1 (en) 2008-08-04 2010-02-17 Chemo Ibérica, S.A. Crystalline form of moxifloxacin base
ES2391132T3 (es) * 2008-10-09 2012-11-21 Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi Uso de disolventes orgánicos en la granulación húmeda de moxifloxacino
WO2010052726A1 (en) * 2008-11-06 2010-05-14 Hetero Research Foundation Novel polymorph of moxifloxacin hydrochloride
ES2467105T5 (es) 2008-12-08 2017-12-05 Ratiopharm Gmbh Moxifloxacino compactado
AU2010247141A1 (en) 2009-05-15 2011-12-15 Redx Pharma Plc Redox drug derivatives
WO2011121596A2 (en) * 2010-04-01 2011-10-06 Neuland Laboratories Ltd. Crystal modification of moxifloxacin hydrochloride
BRPI1106900A2 (pt) 2011-12-26 2013-11-05 Ems Sa Composição farmacêutica sólida compreendendo antibótico da familia das quinolonas e processo de sua obtenção
FR2992218B1 (fr) 2012-06-22 2015-01-23 Rivopharm Sa Composition pharmaceutique de chlorhydrate de moxifloxacine et procede de preparation
CN102924449B (zh) * 2012-10-30 2015-08-12 重庆福安药业集团庆余堂制药有限公司 盐酸莫西沙星h晶型及其制备方法和药物组合物
CA2893534A1 (en) 2012-12-04 2014-06-12 Mankind Research Centre An improved process for the preparation of moxifloxacin hydrochloride
RU2561037C2 (ru) * 2013-02-07 2015-08-20 Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН") Антибактериальная фармацевтическая композиция и способ ее получения

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Also Published As

Publication number Publication date
HU226521B1 (en) 2009-03-30
NO965298D0 (no) 1996-12-11
DE19546249A1 (de) 1997-06-19
PL184885B1 (pl) 2003-01-31
HRP960558B1 (en) 2002-04-30
HUP9603428A3 (en) 1997-10-28
IL119795A0 (en) 1997-03-18
YU49485B (sh) 2006-08-17
AR005009A1 (es) 1999-04-07
CA2192418A1 (en) 1997-06-13
CN1061348C (zh) 2001-01-31
PT780390E (pt) 2002-11-29
TW411340B (en) 2000-11-11
SK159196A3 (en) 1997-10-08
MA24342A1 (fr) 1998-07-01
JPH09169757A (ja) 1997-06-30
JP4104687B2 (ja) 2008-06-18
YU65096A (sh) 1998-12-23
ES2179910T3 (es) 2003-02-01
RO119782B1 (ro) 2005-03-30
SV1996000109A (es) 1997-10-23
HUP9603428A2 (en) 1997-08-28
CN1160052A (zh) 1997-09-24
NO965298L (no) 1997-06-13
SK282805B6 (sk) 2002-12-03
CU22774A3 (es) 2002-07-24
EE03474B1 (et) 2001-08-15
BR9605968A (pt) 1998-08-18
BG101043A (en) 1998-04-30
SG47201A1 (en) 1998-03-20
SI0780390T1 (en) 2002-10-31
CZ364696A3 (en) 1997-07-16
RU2162468C2 (ru) 2001-01-27
MY117492A (en) 2004-07-31
DE59609501D1 (de) 2002-09-05
CZ288657B6 (cs) 2001-08-15
ID22625A (id) 1999-12-02
AU7421696A (en) 1997-06-19
ZA9610405B (en) 1997-06-23
TR199600970A2 (tr) 1997-06-21
NZ299905A (en) 1998-09-24
PL317415A1 (en) 1997-06-23
US5849752A (en) 1998-12-15
CA2192418C (en) 2001-06-12
KR970042550A (ko) 1997-07-24
NO306725B1 (no) 1999-12-13
HRP960558A2 (en) 1998-02-28
BG62258B1 (bg) 1999-06-30
SA96170492B1 (ar) 2006-05-23
HU9603428D0 (en) 1997-01-28
MX9606325A (es) 1997-10-31
CO4480105A1 (es) 1997-07-09
ATE221531T1 (de) 2002-08-15
IN185805B (uk) 2001-05-05
EP0780390A1 (de) 1997-06-25
IL119795A (en) 1998-12-27
KR100525146B1 (ko) 2006-01-27
EP0780390B1 (de) 2002-07-31
AU708006B2 (en) 1999-07-29
EE9600201A (et) 1997-06-16
DK0780390T3 (da) 2002-11-11
NL300109I1 (nl) 2003-02-03

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