RU2138253C1 - Лекарственное средство с замедленным высвобождением активнодействующего вещества - Google Patents

Лекарственное средство с замедленным высвобождением активнодействующего вещества Download PDF

Info

Publication number
RU2138253C1
RU2138253C1 RU94032150A RU94032150A RU2138253C1 RU 2138253 C1 RU2138253 C1 RU 2138253C1 RU 94032150 A RU94032150 A RU 94032150A RU 94032150 A RU94032150 A RU 94032150A RU 2138253 C1 RU2138253 C1 RU 2138253C1
Authority
RU
Russia
Prior art keywords
active substance
cellulose
release
pharmaceutically acceptable
biologically active
Prior art date
Application number
RU94032150A
Other languages
English (en)
Russian (ru)
Other versions
RU94032150A (ru
Inventor
Хайнрих Антониус Бартоломойс Иоханес
Original Assignee
Грюненталь Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6496771&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RU2138253(C1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Грюненталь Гмбх filed Critical Грюненталь Гмбх
Publication of RU94032150A publication Critical patent/RU94032150A/ru
Application granted granted Critical
Publication of RU2138253C1 publication Critical patent/RU2138253C1/ru

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/2853—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU94032150A 1993-09-03 1994-09-01 Лекарственное средство с замедленным высвобождением активнодействующего вещества RU2138253C1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP4329794.3 1993-09-03
DE4329794A DE4329794C2 (de) 1993-09-03 1993-09-03 Tramadolsalz enthaltende Arzneimittel mit verzögerter Wirkstofffreisetzung

Publications (2)

Publication Number Publication Date
RU94032150A RU94032150A (ru) 1996-11-10
RU2138253C1 true RU2138253C1 (ru) 1999-09-27

Family

ID=6496771

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94032150A RU2138253C1 (ru) 1993-09-03 1994-09-01 Лекарственное средство с замедленным высвобождением активнодействующего вещества

Country Status (27)

Country Link
US (1) US5601842A (enExample)
EP (1) EP0642788B1 (enExample)
JP (1) JP3954117B2 (enExample)
KR (1) KR100325494B1 (enExample)
CN (1) CN1092956C (enExample)
AT (1) ATE166575T1 (enExample)
AU (1) AU671384B2 (enExample)
BR (1) BR9403030A (enExample)
CA (1) CA2131350C (enExample)
CO (1) CO4290295A1 (enExample)
CZ (1) CZ288832B6 (enExample)
DE (2) DE4329794C2 (enExample)
DK (1) DK0642788T3 (enExample)
EC (1) ECSP941148A (enExample)
ES (1) ES2119034T3 (enExample)
FI (1) FI113336B (enExample)
HU (1) HU215955B (enExample)
IL (1) IL109800A (enExample)
LT (1) LT3664B (enExample)
MY (1) MY111754A (enExample)
PE (1) PE10195A1 (enExample)
PL (1) PL177315B1 (enExample)
RU (1) RU2138253C1 (enExample)
SI (1) SI0642788T1 (enExample)
UA (1) UA26455C2 (enExample)
UY (1) UY23804A1 (enExample)
ZA (1) ZA946775B (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2174836C1 (ru) * 2000-12-15 2001-10-20 Открытое акционерное общество "Химико-фармацевтический комбинат "Акрихин" Фармацевтическая композиция, обладающая анальгезирующим действием
RU2201223C2 (ru) * 1996-07-25 2003-03-27 Виатрис Гмбх Унд Ко. Кг Фармацевтическая композиция из множества субъединиц и способ ее получения
RU2285519C2 (ru) * 2000-09-29 2006-10-20 Солвей Фармасьютикалс Б.В. Фармацевтическая композиция с пролонгированным высвобождением, независимым от ионной силы
RU2423107C2 (ru) * 2005-03-11 2011-07-10 Пх Энд Т С.П.А. Составы с контролируемым высвобождением альфузозина
RU2445081C2 (ru) * 2005-09-15 2012-03-20 Грюненталь Гмбх Дюрантная лекарственная форма, содержащая 3-(2-диметиламинометилциклогексил)фенол

Families Citing this family (105)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5266331A (en) * 1991-11-27 1993-11-30 Euroceltique, S.A. Controlled release oxycodone compositions
US5968551A (en) 1991-12-24 1999-10-19 Purdue Pharma L.P. Orally administrable opioid formulations having extended duration of effect
US5958459A (en) * 1991-12-24 1999-09-28 Purdue Pharma L.P. Opioid formulations having extended controlled released
US5478577A (en) * 1993-11-23 1995-12-26 Euroceltique, S.A. Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
US20080075781A1 (en) * 1992-11-25 2008-03-27 Purdue Pharma Lp Controlled release oxycodone compositions
NZ260408A (en) 1993-05-10 1996-05-28 Euro Celtique Sa Controlled release preparation comprising tramadol
US20070275062A1 (en) * 1993-06-18 2007-11-29 Benjamin Oshlack Controlled release oxycodone compositions
US7740881B1 (en) 1993-07-01 2010-06-22 Purdue Pharma Lp Method of treating humans with opioid formulations having extended controlled release
IL110014A (en) * 1993-07-01 1999-11-30 Euro Celtique Sa Solid controlled-release oral dosage forms of opioid analgesics
US5879705A (en) * 1993-07-27 1999-03-09 Euro-Celtique S.A. Sustained release compositions of morphine and a method of preparing pharmaceutical compositions
KR100354702B1 (ko) 1993-11-23 2002-12-28 유로-셀티크 소시에떼 아노뉨 약학조성물의제조방법및서방형조성물
US5891471A (en) 1993-11-23 1999-04-06 Euro-Celtique, S.A. Pharmaceutical multiparticulates
US5843480A (en) 1994-03-14 1998-12-01 Euro-Celtique, S.A. Controlled release diamorphine formulation
GB9422154D0 (en) 1994-11-03 1994-12-21 Euro Celtique Sa Pharmaceutical compositions and method of producing the same
US5965161A (en) 1994-11-04 1999-10-12 Euro-Celtique, S.A. Extruded multi-particulates
DE19530575A1 (de) * 1995-08-19 1997-02-20 Gruenenthal Gmbh Schnell zerfallende Arzneiform von Tramadol oder einem Tramadolsalz
GB9519363D0 (en) 1995-09-22 1995-11-22 Euro Celtique Sa Pharmaceutical formulation
CN100475210C (zh) * 1996-03-08 2009-04-08 尼科梅德丹麦有限公司 改进释放的多单位剂量组合物
DE19712398A1 (de) * 1997-03-25 1998-10-01 Gruenenthal Gmbh Orale Anwendung von (+)-0-Demethyltramadol als Schmerzmittel
ATE322892T1 (de) * 1997-07-02 2006-04-15 Euro Celtique Sa Stabilisierte tramadol formulierungen mit verzögerter freisetzung
US6156342A (en) * 1998-05-26 2000-12-05 Andex Pharmaceuticals, Inc. Controlled release oral dosage form
US6806294B2 (en) 1998-10-15 2004-10-19 Euro-Celtique S.A. Opioid analgesic
DE29818454U1 (de) * 1998-10-15 1999-01-14 Euroceltique S.A., Luxemburg/Luxembourg Opioid-Analgetikum
WO2000040205A2 (en) * 1999-01-05 2000-07-13 Copley Pharmaceutical Inc. Sustained release formulation with reduced moisture sensitivity
DE19901692C2 (de) * 1999-01-18 2002-06-20 Gruenenthal Gmbh Verfahren zur Herstellung von Pellets mit einem Gehalt von bis zu 90 Gew.% eines pharmazeutischen Wirkstoffes
DE19901686A1 (de) * 1999-01-18 2000-07-20 Gruenenthal Gmbh Retardierte Tramadolzubereitungen mit einem lagerstabilen Freisetzungsprofil und Verfahren zu deren Herstellung
DE19918325A1 (de) 1999-04-22 2000-10-26 Euro Celtique Sa Verfahren zur Herstellung von Arzneiformen mit regulierter Wirkstofffreisetzung mittels Extrusion
MXPA02002193A (es) * 1999-08-31 2002-09-30 Gr Nenthal Gmbh Forma de administracion de accion retardada que contiene sacarinato de tramadol.
US10179130B2 (en) 1999-10-29 2019-01-15 Purdue Pharma L.P. Controlled release hydrocodone formulations
KR100889069B1 (ko) 1999-10-29 2009-03-17 유로-셀티크 소시에떼 아노뉨 서방성 하이드로코돈 제형
SK285128B6 (sk) * 1999-12-28 2006-07-07 Zentiva, A. S. Liečivý prípravok s riadeným uvoľňovaním obsahujúci tramadol hydrochlorid a spôsob jeho prípravy
RU2165922C1 (ru) * 2000-07-19 2001-04-27 Государственный научно-исследовательский институт органической химии и технологии Способ получения трамадола
ES2228789T3 (es) * 2000-09-22 2005-04-16 Smb Technology Composicion oral de tramadol en forma de granulados para tomar una vez por dia.
HU230686B1 (en) 2000-10-30 2017-08-28 Euro Celtique Sa Controlled release hydrocodone compositions
DE10108122A1 (de) 2001-02-21 2002-10-02 Gruenenthal Gmbh Arzneimittel auf Basis von Tramadol
US6974839B2 (en) 2001-03-16 2005-12-13 Dmi Biosciences, Inc. Method of delaying ejaculation
US20110104214A1 (en) 2004-04-15 2011-05-05 Purdue Pharma L.P. Once-a-day oxycodone formulations
UA81224C2 (uk) 2001-05-02 2007-12-25 Euro Celtic S A Дозована форма оксикодону та її застосування
PE20030527A1 (es) 2001-10-24 2003-07-26 Gruenenthal Chemie Formulacion farmaceutica con liberacion retardada que contiene 3-(3-dimetilamino-1-etil-2-metil-propil) fenol o una sal farmaceuticamente aceptable del mismo y tabletas para administracion oral que la contienen
US8128957B1 (en) * 2002-02-21 2012-03-06 Valeant International (Barbados) Srl Modified release compositions of at least one form of tramadol
US20060099249A1 (en) * 2002-02-21 2006-05-11 Pawan Seth Modified release formulations of at least one form of tramadol
CA2479350A1 (en) * 2002-03-15 2003-09-25 Cypress Bioscience, Inc. Ne and 5-ht reuptake inhibitors for treating visceral pain syndromes
AU2003215671A1 (en) * 2002-03-22 2003-10-08 Cilag Ag Sustained release formulation of tramadol
US7410965B2 (en) 2002-05-29 2008-08-12 Gruenenthal Gmbh Delayed release pharmaceutical composition containing 1-dimethyl-amino-3-(3-methoxyphenyl)-2-methyl-pentan-3-ol
DE10224108A1 (de) * 2002-05-29 2004-01-29 Grünenthal GmbH 1-Dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol enthaltendes Arzneimiitel mit verzögerter Wirkstofffreisetzung
US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
CA2498798A1 (en) * 2002-09-20 2004-04-01 Alpharma, Inc. Sustained-release opioid formulations and methods of use
US8487002B2 (en) 2002-10-25 2013-07-16 Paladin Labs Inc. Controlled-release compositions
US20060003004A1 (en) * 2002-10-25 2006-01-05 Collegium Pharmaceutical, Inc. Pulsatile release compositions of milnacipran
US20040132826A1 (en) * 2002-10-25 2004-07-08 Collegium Pharmaceutical, Inc. Modified release compositions of milnacipran
TWI319713B (en) 2002-10-25 2010-01-21 Sustained-release tramadol formulations with 24-hour efficacy
WO2004067039A1 (en) * 2003-01-28 2004-08-12 Collegium Pharmaceutical, Inc. Multiparticulate compositions of milnacipran for oral administration
DE10333835A1 (de) * 2003-07-24 2005-03-10 Gruenenthal Gmbh 6-Dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexane-1,3-diol enthaltendes Arzneimittel mit verzögerter Wirkstofffreisetzung
DE10336400A1 (de) 2003-08-06 2005-03-24 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
EP1658054B1 (de) * 2003-08-06 2007-06-27 Grünenthal GmbH Gegen missbrauch gesicherte darreichungsform
DE102005005446A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
DE102004020220A1 (de) * 2004-04-22 2005-11-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform
US20070048228A1 (en) * 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
DE10361596A1 (de) 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
US8075872B2 (en) 2003-08-06 2011-12-13 Gruenenthal Gmbh Abuse-proofed dosage form
DE102004032051A1 (de) * 2004-07-01 2006-01-19 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform
US20060172006A1 (en) * 2003-10-10 2006-08-03 Vincent Lenaerts Sustained-release tramadol formulations with 24-hour clinical efficacy
US20050089558A1 (en) * 2003-10-28 2005-04-28 Alamo Pharmaceuticals, Llc Compositions and methods for the co-formulation and administration of tramadol and propoxyphene
DE102004032103A1 (de) * 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
DE102004032049A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
DE102005005449A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
RU2008104638A (ru) * 2005-07-07 2009-08-20 Фарнэм Компаниз, Инк. (Us) Фармацевтические композиции хорошо растворимых в воде лекарственных средств, обеспечивающих их замедленное высвобождение
CA2616416A1 (en) 2005-09-09 2007-05-03 Labopharm, Inc. Trazodone composition for once a day adminisitiation
CN101242856A (zh) 2005-09-09 2008-08-13 莱博法姆公司 持续药物释放的组合物
US8691272B2 (en) * 2005-12-30 2014-04-08 Intelgenx Corp. Multilayer tablet
US20070190141A1 (en) * 2006-02-16 2007-08-16 Aaron Dely Extended release opiate composition
AU2007275034A1 (en) * 2006-07-21 2008-01-24 Lab International Srl Hydrophilic abuse deterrent delivery system
DE102006044694A1 (de) * 2006-09-22 2008-03-27 Krewel Meuselbach Gmbh Perorale feste Schmerzmittelzubereitung
PL2114147T3 (pl) 2007-02-12 2012-10-31 Vyrix Pharmaceuticals Inc Zmniejszanie skutków ubocznych tramadolu
NZ579169A (en) * 2007-02-12 2012-05-25 Dmi Biosciences Inc Treatment of comorbid premature ejaculation and erectile dysfunction using tramadol and a phosphodiesterase (pde) inhibitor
DE102007011485A1 (de) * 2007-03-07 2008-09-11 Grünenthal GmbH Darreichungsform mit erschwertem Missbrauch
RU2469718C2 (ru) * 2007-10-16 2012-12-20 Лабофарм Инк. Двухслойная композиция для непрерывного высвобождения ацетаминофена и трамадола
CA2707980C (en) 2007-12-17 2015-05-12 Labopharm Inc. Misuse preventative, controlled release formulation
WO2009092601A1 (en) * 2008-01-25 2009-07-30 Grünenthal GmbH Pharmaceutical dosage form
NZ588863A (en) * 2008-05-09 2012-08-31 Gruenenthal Chemie Process for the preparation of an intermediate powder formulation and a final solid dosage form under usage of a spray congealing step
US20100003322A1 (en) * 2008-07-03 2010-01-07 Lai Felix S Enteric coated hydrophobic matrix formulation
JP5667575B2 (ja) 2008-12-16 2015-02-12 パラディン ラブス インコーポレーテッド 誤用を防止する放出制御製剤
JP5667183B2 (ja) 2009-07-22 2015-02-12 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 加熱溶融押出成型した制御放出性投与剤型
ES2718688T3 (es) 2009-07-22 2019-07-03 Gruenenthal Gmbh Forma de dosificación resistente a la manipulación para opioides sensibles a la oxidación
US10610528B2 (en) 2009-12-08 2020-04-07 Intelgenx Corp. Solid oral film dosage forms and methods for making same
US20110136815A1 (en) 2009-12-08 2011-06-09 Horst Zerbe Solid oral film dosage forms and methods for making same
CN102821757B (zh) * 2010-02-03 2016-01-20 格吕伦塔尔有限公司 通过挤出机制备粉末状药物组合物
US9993433B2 (en) 2010-05-10 2018-06-12 Euro-Celtique S.A. Manufacturing of active-free granules and tablets comprising the same
CA2801620A1 (en) 2010-07-06 2012-01-12 Gruenenthal Gmbh Novel gastro-retentive dosage forms comprising a gaba analog and an opioid
US9636303B2 (en) 2010-09-02 2017-05-02 Gruenenthal Gmbh Tamper resistant dosage form comprising an anionic polymer
CN103269688A (zh) 2010-09-02 2013-08-28 格吕伦塔尔有限公司 包含无机盐的抗破碎剂型
US20120202838A1 (en) * 2010-11-04 2012-08-09 Abbott Laboratories Drug formulations
EP2736495B1 (en) 2011-07-29 2017-08-23 Grünenthal GmbH Tamper-resistant tablet providing immediate drug release
NO2736497T3 (enExample) 2011-07-29 2018-01-20
MX356421B (es) 2012-02-28 2018-05-29 Gruenenthal Gmbh Forma de dosificacion resistente a la manipulacion indebida que comprende un compuesto farmacologicamente activo y un polimero anionico.
TR201815502T4 (tr) 2012-04-18 2018-11-21 Gruenenthal Gmbh Kurcalama veya dirençli ve doz boşalımına dirençli farmasötik dozaj formu.
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
US10154966B2 (en) 2013-05-29 2018-12-18 Grünenthal GmbH Tamper-resistant dosage form containing one or more particles
MX2015016254A (es) 2013-05-29 2016-04-20 Gruenenthal Gmbh Forma de dosificacion resistente al uso indebido con perfil de liberacion bimodal.
CN105682643B (zh) 2013-07-12 2019-12-13 格吕伦塔尔有限公司 含有乙烯-醋酸乙烯酯聚合物的防篡改剂型
JP6480936B2 (ja) 2013-11-26 2019-03-13 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング クライオミリングによる粉末状医薬組成物の調製
EP3142646A1 (en) 2014-05-12 2017-03-22 Grünenthal GmbH Tamper resistant immediate release capsule formulation comprising tapentadol
JP2017516789A (ja) 2014-05-26 2017-06-22 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング エタノール過量放出に対して防護されている多粒子
HK1246173A1 (zh) 2015-04-24 2018-09-07 Grünenthal GmbH 具有立即释放和对溶剂萃取的抗性的抗篡改剂型
US10842750B2 (en) 2015-09-10 2020-11-24 Grünenthal GmbH Protecting oral overdose with abuse deterrent immediate release formulations

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4389393A (en) * 1982-03-26 1983-06-21 Forest Laboratories, Inc. Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3065143A (en) 1960-04-19 1962-11-20 Richardson Merrell Inc Sustained release tablet
JPS5492631A (en) * 1977-12-27 1979-07-23 Kowa Co Analgestic
US4259314A (en) * 1979-12-10 1981-03-31 Hans Lowey Method and composition for the preparation of controlled long-acting pharmaceuticals
EP0147780A3 (en) * 1984-01-03 1987-03-11 Merck & Co. Inc. Drug delivery device
US4968508A (en) * 1987-02-27 1990-11-06 Eli Lilly And Company Sustained release matrix
FR2618073B1 (fr) * 1987-07-16 1990-09-07 Pf Medicament Comprimes de type a matrice hydrophile a base de salbutamol et leur procede de preparation
DE3830353A1 (de) * 1988-09-07 1990-03-15 Basf Ag Verfahren zur kontinuierlichen herstellung von festen pharmazeutischen formen
US5126145A (en) * 1989-04-13 1992-06-30 Upsher Smith Laboratories Inc Controlled release tablet containing water soluble medicament
US5268181A (en) * 1989-04-13 1993-12-07 Upsher-Smith Laboratories, Inc. Method of using niacin to control nocturnal cholesterol synthesis
JPH04217925A (ja) * 1990-03-27 1992-08-07 Nippon Saafuakutanto Kogyo Kk 新規な解熱消炎鎮痛剤組成物
DE4315525B4 (de) * 1993-05-10 2010-04-15 Euro-Celtique S.A. Pharmazeutische Zusammensetzung
NZ260408A (en) * 1993-05-10 1996-05-28 Euro Celtique Sa Controlled release preparation comprising tramadol

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4389393A (en) * 1982-03-26 1983-06-21 Forest Laboratories, Inc. Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose
US4389393B1 (enExample) * 1982-03-26 1985-10-22

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2201223C2 (ru) * 1996-07-25 2003-03-27 Виатрис Гмбх Унд Ко. Кг Фармацевтическая композиция из множества субъединиц и способ ее получения
RU2285519C2 (ru) * 2000-09-29 2006-10-20 Солвей Фармасьютикалс Б.В. Фармацевтическая композиция с пролонгированным высвобождением, независимым от ионной силы
RU2174836C1 (ru) * 2000-12-15 2001-10-20 Открытое акционерное общество "Химико-фармацевтический комбинат "Акрихин" Фармацевтическая композиция, обладающая анальгезирующим действием
RU2423107C2 (ru) * 2005-03-11 2011-07-10 Пх Энд Т С.П.А. Составы с контролируемым высвобождением альфузозина
RU2445081C2 (ru) * 2005-09-15 2012-03-20 Грюненталь Гмбх Дюрантная лекарственная форма, содержащая 3-(2-диметиламинометилциклогексил)фенол

Also Published As

Publication number Publication date
PE10195A1 (es) 1995-03-31
DE4329794A1 (de) 1995-03-09
US5601842A (en) 1997-02-11
CN1092956C (zh) 2002-10-23
DE4329794C2 (de) 1997-09-18
HU215955B (hu) 1999-03-29
ES2119034T3 (es) 1998-10-01
CO4290295A1 (es) 1996-04-17
EP0642788A2 (de) 1995-03-15
UA26455C2 (uk) 1999-08-30
KR100325494B1 (ko) 2002-06-22
JP3954117B2 (ja) 2007-08-08
AU7280394A (en) 1995-03-16
HU9402478D0 (en) 1994-10-28
PL177315B1 (pl) 1999-10-29
ZA946775B (en) 1995-04-21
DK0642788T3 (da) 1999-01-18
FI113336B (fi) 2004-04-15
EP0642788B1 (de) 1998-05-27
LTIP2033A (en) 1995-03-27
CA2131350C (en) 2005-08-16
HUT70438A (en) 1995-10-30
BR9403030A (pt) 1995-05-02
HK1010447A1 (en) 1999-06-17
ECSP941148A (es) 1995-01-16
RU94032150A (ru) 1996-11-10
SI0642788T1 (en) 1998-08-31
UY23804A1 (es) 1994-07-22
CZ214094A3 (en) 1995-03-15
FI944035L (fi) 1995-03-04
FI944035A0 (fi) 1994-09-02
IL109800A (en) 2000-06-01
EP0642788A3 (enExample) 1995-04-12
CA2131350A1 (en) 1995-03-04
MY111754A (en) 2000-12-30
JPH07196482A (ja) 1995-08-01
LT3664B (en) 1996-01-25
CZ288832B6 (cs) 2001-09-12
IL109800A0 (en) 1994-08-26
ATE166575T1 (de) 1998-06-15
DE59406075D1 (de) 1998-07-02
PL304860A1 (en) 1995-03-06
KR950007841A (ko) 1995-04-15
CN1106656A (zh) 1995-08-16
AU671384B2 (en) 1996-08-22

Similar Documents

Publication Publication Date Title
RU2138253C1 (ru) Лекарственное средство с замедленным высвобождением активнодействующего вещества
US11007156B2 (en) Prolonged release pharmaceutical composition containing 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol
AU2002322964B2 (en) Dosage forms having prolonged active ingredient release
HUP0103883A2 (hu) Új, késleltetett felszabadulású, orális készítmények
US20100196473A1 (en) Pharmaceutical Composition Containing 6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol with Delayed Active Ingredient Release
AU2002322964A1 (en) Dosage forms having prolonged active ingredient release
US20030099710A1 (en) Granule modulating hydrogel system
JP5420126B2 (ja) ｐＨ非依存延長放出性医薬組成物
JP2007530670A (ja) メトホルミンの経口投与用徐放性製剤
KR20050100710A (ko) 경구 제어 방출 제제
AU2006291422B2 (en) 3-(2-dimethylaminomethyl cyclohexyl) phenol retard formulation
CN1172429A (zh) 使用从高等植物中可得到的粉末状水解胶体树胶的持续释放药物运送体系
CA2739611C (en) Pharmaceutical containing 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol and providing delayed release of the active ingredient
JP4696210B2 (ja) イソソルビド‐５‐モノニトレートを有効成分とする徐放性錠剤及びその製造方法
IE883894L (en) Synergistic combination of decarboxylase inhibitors and L-dopa pellets
US20040228918A1 (en) Granule modulating hydrogel system
AU8919898A (en) Timed release tablet comprising naproxen and pseudoephedrine
HK1010447B (en) Tramadol salt containing medicaments with sustained release of the active ingredient
WO2008038106A1 (en) Venlafaxine extended release formulations
US20090162431A1 (en) Sustained release formulations containing acetaminophen and tramadol
HK1068539B (en) Pharmaceutical containing 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol and providing delayed release of the active ingredient