RU2018110064A - Антитела к бета-амилоиду - Google Patents
Антитела к бета-амилоиду Download PDFInfo
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- RU2018110064A RU2018110064A RU2018110064A RU2018110064A RU2018110064A RU 2018110064 A RU2018110064 A RU 2018110064A RU 2018110064 A RU2018110064 A RU 2018110064A RU 2018110064 A RU2018110064 A RU 2018110064A RU 2018110064 A RU2018110064 A RU 2018110064A
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- Prior art keywords
- antibody molecule
- seq
- human
- molecule according
- selected antibody
- Prior art date
Links
- 102000013455 Amyloid beta-Peptides Human genes 0.000 title 1
- 108010090849 Amyloid beta-Peptides Proteins 0.000 title 1
- 108010064397 amyloid beta-protein (1-40) Proteins 0.000 claims 4
- 108010064539 amyloid beta-protein (1-42) Proteins 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 150000001413 amino acids Chemical group 0.000 claims 2
- 206010002022 amyloidosis Diseases 0.000 claims 2
- 238000010494 dissociation reaction Methods 0.000 claims 2
- 230000005593 dissociations Effects 0.000 claims 2
- 239000004475 Arginine Substances 0.000 claims 1
- 201000010374 Down Syndrome Diseases 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 1
- 239000004473 Threonine Substances 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- 230000003930 cognitive ability Effects 0.000 claims 1
- 230000003931 cognitive performance Effects 0.000 claims 1
- 208000002780 macular degeneration Diseases 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A61K38/1716—Amyloid plaque core protein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Endocrinology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Claims (20)
1. Выделенная молекула антитела, которая является селективной в отношении связывания человеческого бета-амилоидного 1-42 пептида (Aβ1-42), а не человеческого бета-амилоидного 1-40 пептида (Aβ1-40), где молекула антитела содержит:
(i) VH-домен, содержащий следующие HCDR:
HCDR1 SEQ ID NO: 525,
HCDR2 SEQ ID NO: 526 и
HCDR3 SEQ ID NO: 527; и
(ii) VL-домен, содержащий следующие LCDR:
LCDR1 SEQ ID NO: 534
LCDR2 SEQ ID NO: 535 и
LCDR3 SEQ ID NO: 536;
и где VL-домен имеет треонин в аминокислотном положении, соответствующем положению 81 в SEQ ID NO: 29.
2. Выделенная молекула антитела по п. 1, где VH-домен имеет аргинин в аминокислотном положении, соответствующем положению 43 в SEQ ID NO: 20.
3. Выделенная молекула антитела по п.1 или 2, где молекула антитела способна связывать растворимый мономерный человеческий Aβ1-42 с константой диссоциации (KD) 500 Пм.
4. Выделенная молекула антитела по любому из пп.1-3, где молекула антитела способна связывать n-олигомер с небольшим количеством звеньев (до пентамера) человеческого Aβ1-42 с константой диссоциации (KD) 500 Пм.
5. Выделенная молекула антитела по любому из пп.1-4, где молекула антитела либо не связывает Aβ1-40, либо связывает Aβ1-40 с KD более, чем 1 мМ.
6. Выделенная молекула антитела по любому из пп.1-5, где молекула антитела представляет собой моноклональное антитело.
7. Выделенная молекула антитела по любому из пп.1-5, где молекула антитела представляет собой scFv.
8. Выделенная молекула антитела по любому из пп.1-5, где молекула антитела представляет собой Fab.
9. Способ лечения человека или животного, нуждающегося в этом, включающий введение указанному субъекту антитела по любому из пп.1-8.
10. Способ по п.9, где лечение по меньшей мере снижает амилоидоз, лечит болезнь Альцгеймера, улучшает когнитивную деятельность или замедляет снижение когнитивных способностей у пациента, страдающего болезнью Альцгеймера или синдромом Дауна, и/или лечит макулярную дегенерацию.
11. Способ по п.9, где способ снижает амилоидоз.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261713996P | 2012-10-15 | 2012-10-15 | |
| US61/713,996 | 2012-10-15 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015118180A Division RU2651486C2 (ru) | 2012-10-15 | 2013-10-15 | Антитела к бета-амилоиду |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2018110064A3 RU2018110064A3 (ru) | 2019-02-28 |
| RU2018110064A true RU2018110064A (ru) | 2019-02-28 |
| RU2689674C2 RU2689674C2 (ru) | 2019-05-28 |
Family
ID=49765450
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018110064A RU2689674C2 (ru) | 2012-10-15 | 2013-10-15 | Антитела к бета-амилоиду |
| RU2015118180A RU2651486C2 (ru) | 2012-10-15 | 2013-10-15 | Антитела к бета-амилоиду |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015118180A RU2651486C2 (ru) | 2012-10-15 | 2013-10-15 | Антитела к бета-амилоиду |
Country Status (23)
| Country | Link |
|---|---|
| US (4) | US9834598B2 (ru) |
| EP (2) | EP3721942A1 (ru) |
| JP (5) | JP6343615B2 (ru) |
| KR (2) | KR102308915B1 (ru) |
| CN (2) | CN105164156B (ru) |
| AU (3) | AU2013333948B2 (ru) |
| BR (1) | BR112015008347B1 (ru) |
| CA (1) | CA2888322A1 (ru) |
| CY (1) | CY1122987T1 (ru) |
| DK (1) | DK2906597T3 (ru) |
| ES (1) | ES2802873T3 (ru) |
| HK (1) | HK1213906A1 (ru) |
| HR (1) | HRP20200936T1 (ru) |
| HU (1) | HUE051127T2 (ru) |
| LT (1) | LT2906597T (ru) |
| ME (1) | ME03751B (ru) |
| MX (2) | MX370725B (ru) |
| PL (1) | PL2906597T3 (ru) |
| PT (1) | PT2906597T (ru) |
| RS (1) | RS60388B1 (ru) |
| RU (2) | RU2689674C2 (ru) |
| SI (1) | SI2906597T1 (ru) |
| WO (1) | WO2014060444A1 (ru) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9834598B2 (en) * | 2012-10-15 | 2017-12-05 | Medimmune Limited | Antibodies to amyloid beta |
| EP3250595B1 (en) * | 2015-01-29 | 2024-04-24 | Technophage, Investigação E Desenvolvimento Em Biotecnologia, SA | Antibody molecules and peptide delivery systems for use in alzheimer's disease and related disorders |
| JP6920293B2 (ja) | 2015-10-30 | 2021-08-18 | メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ | ＩｇＧ軽鎖におけるＮ末端切断の防止 |
| CN109195630A (zh) * | 2016-03-15 | 2019-01-11 | 阿斯利康(瑞典)有限公司 | 用于治疗与淀粉样蛋白β累积相关的病症的BACE抑制剂和抗体或抗原结合片段的组合 |
| US20200308259A1 (en) * | 2016-06-07 | 2020-10-01 | Biogen International Neuroscience Gmbh | Methods for treating alzheimer's disease |
| AU2019304384A1 (en) * | 2018-07-17 | 2021-01-28 | Jiangsu Hengrui Medicine Co., Ltd. | Anti-abeta antibody, antigen-binding fragment thereof and application thereof |
| CN111454980A (zh) * | 2020-04-14 | 2020-07-28 | 郑州师范学院 | 重组载体的构建方法及其构建的重组载体及应用 |
| WO2021260193A1 (en) | 2020-06-25 | 2021-12-30 | Medimmune Limited | Prevention of axonal damage using antibody binding to amyloid beta 1-42 |
| TW202300517A (zh) | 2021-03-12 | 2023-01-01 | 美商美國禮來大藥廠 | 抗類澱粉β抗體及其用途 |
| WO2022251048A1 (en) | 2021-05-24 | 2022-12-01 | Eli Lilly And Company | Anti-amyloid beta antibodies and uses thereof |
| KR102565470B1 (ko) * | 2022-08-04 | 2023-08-10 | 가천대학교 산학협력단 | 아밀로이드 베타 특이적 펩타이드 sma_04088-2 및 이를 포함하는 알츠하이머병 치료용 조성물 |
| KR102565471B1 (ko) * | 2022-08-04 | 2023-08-10 | 가천대학교 산학협력단 | 아밀로이드 베타 특이적 펩타이드 cbrv1-04369 및 이를 포함하는 알츠하이머병 치료용 조성물 |
| WO2024086796A1 (en) | 2022-10-20 | 2024-04-25 | Alector Llc | Anti-ms4a4a antibodies with amyloid-beta therapies |
| CN116716351B (zh) * | 2023-03-30 | 2024-02-23 | 湖北天勤生物技术研究院有限公司 | 用于构建食蟹猴阿尔兹海默症模型的组合物及其应用和构建方法 |
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