MX2015004763A - Anticuerpos contra el beta-amiloide. - Google Patents
Anticuerpos contra el beta-amiloide.Info
- Publication number
- MX2015004763A MX2015004763A MX2015004763A MX2015004763A MX2015004763A MX 2015004763 A MX2015004763 A MX 2015004763A MX 2015004763 A MX2015004763 A MX 2015004763A MX 2015004763 A MX2015004763 A MX 2015004763A MX 2015004763 A MX2015004763 A MX 2015004763A
- Authority
- MX
- Mexico
- Prior art keywords
- amyloid beta
- antibodies
- peptide
- antibody
- human amyloid
- Prior art date
Links
- 108010090849 Amyloid beta-Peptides Proteins 0.000 title abstract 2
- 102000013455 Amyloid beta-Peptides Human genes 0.000 title abstract 2
- 108010064539 amyloid beta-protein (1-42) Proteins 0.000 abstract 3
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 108010064397 amyloid beta-protein (1-40) Proteins 0.000 abstract 1
- 206010002022 amyloidosis Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A61K38/1716—Amyloid plaque core protein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Endocrinology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Anticuerpo contra el beta-amiloide humano Anticuerpo que se une selectivamente al péptido beta-amiloide 42 humano respecto al péptido beta-amiloide 40 humano. Anticuerpos específicos contra el beta-amiloide 42 como agentes terapéuticos para unirse al péptido beta-amiloide 42 y tratar afecciones asociadas con la amiloidosis, tal como la enfermedad de Alzheimer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261713996P | 2012-10-15 | 2012-10-15 | |
PCT/EP2013/071567 WO2014060444A1 (en) | 2012-10-15 | 2013-10-15 | Antibodies to amyloid beta |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2015004763A true MX2015004763A (es) | 2016-01-08 |
MX370725B MX370725B (es) | 2019-12-20 |
Family
ID=49765450
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015004763A MX370725B (es) | 2012-10-15 | 2013-10-15 | Anticuerpos contra el beta-amiloide. |
MX2019015602A MX2019015602A (es) | 2012-10-15 | 2015-04-15 | Anticuerpos contra el beta-amiloide. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019015602A MX2019015602A (es) | 2012-10-15 | 2015-04-15 | Anticuerpos contra el beta-amiloide. |
Country Status (23)
Country | Link |
---|---|
US (4) | US9834598B2 (es) |
EP (2) | EP3721942A1 (es) |
JP (5) | JP6343615B2 (es) |
KR (2) | KR102450670B1 (es) |
CN (2) | CN105164156B (es) |
AU (2) | AU2013333948B2 (es) |
BR (1) | BR112015008347B1 (es) |
CA (1) | CA2888322A1 (es) |
CY (1) | CY1122987T1 (es) |
DK (1) | DK2906597T3 (es) |
ES (1) | ES2802873T3 (es) |
HK (1) | HK1213906A1 (es) |
HR (1) | HRP20200936T1 (es) |
HU (1) | HUE051127T2 (es) |
LT (1) | LT2906597T (es) |
ME (1) | ME03751B (es) |
MX (2) | MX370725B (es) |
PL (1) | PL2906597T3 (es) |
PT (1) | PT2906597T (es) |
RS (1) | RS60388B1 (es) |
RU (2) | RU2689674C2 (es) |
SI (1) | SI2906597T1 (es) |
WO (1) | WO2014060444A1 (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK2906597T3 (da) * | 2012-10-15 | 2020-07-13 | Medimmune Ltd | Antistoffer mod beta-amyloid |
WO2016120843A1 (en) * | 2015-01-29 | 2016-08-04 | Technophage, Investigação E Desenvolvimento Em Biotecnologia, Sa | Antibody molecules and peptide delivery systems for use in alzheimer's disease and related disorders |
US10618952B2 (en) | 2015-10-30 | 2020-04-14 | Medimmune Limited | Prevention of N-terminal truncation in IgG light chains |
JP2019511500A (ja) * | 2016-03-15 | 2019-04-25 | アストラゼネカ・アクチエボラーグAstrazeneca Aktiebolag | アミロイドベータの蓄積に関連する障害の処置のためのbace阻害剤と抗体または抗原結合性断片との組合せ |
BR112018075300A2 (pt) * | 2016-06-07 | 2019-04-30 | Biogen International Neuroscience Gmbh | métodos para tratamento do mal de alzheimer |
EP3819311A4 (en) * | 2018-07-17 | 2022-08-17 | Jiangsu Hengrui Medicine Co., Ltd. | ANTI-ABETA ANTIBODY, ANTIGEN-BINDING FRAGMENT THEREOF AND APPLICATION THEREOF |
CN111454980A (zh) * | 2020-04-14 | 2020-07-28 | 郑州师范学院 | 重组载体的构建方法及其构建的重组载体及应用 |
IL299215A (en) | 2020-06-25 | 2023-02-01 | Medimmune Ltd | Prevention of axonal damage through binding of an antibody to amyloid beta 1-42 |
TW202300517A (zh) | 2021-03-12 | 2023-01-01 | 美商美國禮來大藥廠 | 抗類澱粉β抗體及其用途 |
WO2022251048A1 (en) | 2021-05-24 | 2022-12-01 | Eli Lilly And Company | Anti-amyloid beta antibodies and uses thereof |
KR102565470B1 (ko) * | 2022-08-04 | 2023-08-10 | 가천대학교 산학협력단 | 아밀로이드 베타 특이적 펩타이드 sma_04088-2 및 이를 포함하는 알츠하이머병 치료용 조성물 |
KR102565471B1 (ko) * | 2022-08-04 | 2023-08-10 | 가천대학교 산학협력단 | 아밀로이드 베타 특이적 펩타이드 cbrv1-04369 및 이를 포함하는 알츠하이머병 치료용 조성물 |
WO2024086796A1 (en) | 2022-10-20 | 2024-04-25 | Alector Llc | Anti-ms4a4a antibodies with amyloid-beta therapies |
CN116716351B (zh) * | 2023-03-30 | 2024-02-23 | 湖北天勤生物技术研究院有限公司 | 用于构建食蟹猴阿尔兹海默症模型的组合物及其应用和构建方法 |
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GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
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JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
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ATE311444T1 (de) | 2000-03-31 | 2005-12-15 | Cambridge Antibody Tech | Verbesserungen in bezug auf ribosom-komplexe als selektionspartikel |
EP2298809A3 (en) | 2001-07-12 | 2012-02-15 | FOOTE, Jefferson | Super humanized antibodies |
WO2003015691A2 (en) * | 2001-08-17 | 2003-02-27 | Eli Lilly And Company | RAPID IMPROVEMENT OF COGNITION IN CONDITIONS RELATED TO A$g(b) |
EP2330113B1 (en) * | 2002-04-19 | 2016-06-29 | The Governing Council Of The University Of Toronto | Immunological methods and compositions for the treatment of Alzheimer's disease |
WO2005080435A1 (ja) * | 2004-02-20 | 2005-09-01 | Immuno-Biological Laboratories Co., Ltd. | モノクローナル抗体およびその利用 |
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ES2318918B1 (es) * | 2005-04-01 | 2010-02-16 | Biotherapix Molecular Medicines, S.L.U. | Anticuerpos humanos con capacidad de union al peptido beta-amiloide y sus aplicaciones. |
TW200815469A (en) * | 2006-06-23 | 2008-04-01 | Astrazeneca Ab | Compounds |
CA2657681C (en) * | 2006-07-14 | 2019-03-19 | Ac Immune S.A. | Humanized antibodies against beta amyloid protein |
US20090232801A1 (en) * | 2007-05-30 | 2009-09-17 | Abbot Laboratories | Humanized Antibodies Which Bind To AB (1-42) Globulomer And Uses Thereof |
US20090175847A1 (en) * | 2007-05-30 | 2009-07-09 | Abbott Laboratories | Humanized antibodies to ab (20-42) globulomer and uses thereof |
WO2009057664A1 (ja) * | 2007-10-29 | 2009-05-07 | Mitsubishi Chemical Corporation | 抗体及びその利用 |
WO2009075084A1 (ja) * | 2007-12-12 | 2009-06-18 | Immuno-Biological Laboratories Co., Ltd. | アルツハイマー病の存在又は傾向の診断薬及び診断方法 |
EP2072527A1 (en) * | 2007-12-21 | 2009-06-24 | Altonabiotec AG | Fusion polypeptides comprising a SHBG dimerization component and uses thereof |
WO2009085200A2 (en) * | 2007-12-21 | 2009-07-09 | Amgen Inc. | Anti-amyloid antibodies and uses thereof |
US8298533B2 (en) * | 2008-11-07 | 2012-10-30 | Medimmune Limited | Antibodies to IL-1R1 |
DK2906597T3 (da) * | 2012-10-15 | 2020-07-13 | Medimmune Ltd | Antistoffer mod beta-amyloid |
US9209965B2 (en) | 2014-01-14 | 2015-12-08 | Microsemi Semiconductor Ulc | Network interface with clock recovery module on line card |
JP2019511500A (ja) | 2016-03-15 | 2019-04-25 | アストラゼネカ・アクチエボラーグAstrazeneca Aktiebolag | アミロイドベータの蓄積に関連する障害の処置のためのbace阻害剤と抗体または抗原結合性断片との組合せ |
TW201740944A (zh) | 2016-03-15 | 2017-12-01 | 美國禮來大藥廠 | 組合療法 |
-
2013
- 2013-10-15 DK DK13805277.4T patent/DK2906597T3/da active
- 2013-10-15 RS RS20200694A patent/RS60388B1/sr unknown
- 2013-10-15 EP EP20160286.9A patent/EP3721942A1/en active Pending
- 2013-10-15 CN CN201380053909.7A patent/CN105164156B/zh active Active
- 2013-10-15 SI SI201331737T patent/SI2906597T1/sl unknown
- 2013-10-15 US US14/435,520 patent/US9834598B2/en active Active
- 2013-10-15 KR KR1020217031163A patent/KR102450670B1/ko active IP Right Grant
- 2013-10-15 CN CN201910295599.9A patent/CN110294804B/zh active Active
- 2013-10-15 KR KR1020157012631A patent/KR102308915B1/ko active IP Right Grant
- 2013-10-15 PL PL13805277T patent/PL2906597T3/pl unknown
- 2013-10-15 JP JP2015536189A patent/JP6343615B2/ja active Active
- 2013-10-15 RU RU2018110064A patent/RU2689674C2/ru active
- 2013-10-15 CA CA2888322A patent/CA2888322A1/en active Pending
- 2013-10-15 ES ES13805277T patent/ES2802873T3/es active Active
- 2013-10-15 ME MEP-2020-119A patent/ME03751B/me unknown
- 2013-10-15 HU HUE13805277A patent/HUE051127T2/hu unknown
- 2013-10-15 AU AU2013333948A patent/AU2013333948B2/en active Active
- 2013-10-15 EP EP13805277.4A patent/EP2906597B1/en active Active
- 2013-10-15 WO PCT/EP2013/071567 patent/WO2014060444A1/en active Application Filing
- 2013-10-15 BR BR112015008347-1A patent/BR112015008347B1/pt active IP Right Grant
- 2013-10-15 PT PT138052774T patent/PT2906597T/pt unknown
- 2013-10-15 RU RU2015118180A patent/RU2651486C2/ru active
- 2013-10-15 MX MX2015004763A patent/MX370725B/es active IP Right Grant
- 2013-10-15 LT LTEP13805277.4T patent/LT2906597T/lt unknown
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2015
- 2015-04-15 MX MX2019015602A patent/MX2019015602A/es unknown
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2016
- 2016-02-17 HK HK16101678.9A patent/HK1213906A1/zh unknown
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2017
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