RS60388B1 - Antitela usmerena na beta-amiloid - Google Patents

Antitela usmerena na beta-amiloid

Info

Publication number
RS60388B1
RS60388B1 RS20200694A RSP20200694A RS60388B1 RS 60388 B1 RS60388 B1 RS 60388B1 RS 20200694 A RS20200694 A RS 20200694A RS P20200694 A RSP20200694 A RS P20200694A RS 60388 B1 RS60388 B1 RS 60388B1
Authority
RS
Serbia
Prior art keywords
antibodies
amyloid beta
amyloid
beta
Prior art date
Application number
RS20200694A
Other languages
English (en)
Inventor
Maria Groves
Suzanne Gustavsson
Kina Höglund
David Lowne
Chris Lloyd
Adrian Nickson
Camilla Niva
Sylvia Simon
Original Assignee
Medimmune Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49765450&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RS60388(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Medimmune Ltd filed Critical Medimmune Ltd
Publication of RS60388B1 publication Critical patent/RS60388B1/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A61K38/1716—Amyloid plaque core protein
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
RS20200694A 2012-10-15 2013-10-15 Antitela usmerena na beta-amiloid RS60388B1 (sr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261713996P 2012-10-15 2012-10-15
PCT/EP2013/071567 WO2014060444A1 (en) 2012-10-15 2013-10-15 Antibodies to amyloid beta
EP13805277.4A EP2906597B1 (en) 2012-10-15 2013-10-15 Antibodies to amyloid beta

Publications (1)

Publication Number Publication Date
RS60388B1 true RS60388B1 (sr) 2020-07-31

Family

ID=49765450

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20200694A RS60388B1 (sr) 2012-10-15 2013-10-15 Antitela usmerena na beta-amiloid

Country Status (23)

Country Link
US (5) US9834598B2 (sr)
EP (2) EP2906597B1 (sr)
JP (5) JP6343615B2 (sr)
KR (2) KR102450670B1 (sr)
CN (2) CN110294804B (sr)
AU (3) AU2013333948B2 (sr)
BR (1) BR112015008347B1 (sr)
CA (1) CA2888322A1 (sr)
CY (1) CY1122987T1 (sr)
DK (1) DK2906597T3 (sr)
ES (1) ES2802873T3 (sr)
HK (1) HK1213906A1 (sr)
HR (1) HRP20200936T1 (sr)
HU (1) HUE051127T2 (sr)
LT (1) LT2906597T (sr)
ME (1) ME03751B (sr)
MX (2) MX370725B (sr)
PL (1) PL2906597T3 (sr)
PT (1) PT2906597T (sr)
RS (1) RS60388B1 (sr)
RU (2) RU2651486C2 (sr)
SI (1) SI2906597T1 (sr)
WO (1) WO2014060444A1 (sr)

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DK2906597T3 (da) * 2012-10-15 2020-07-13 Medimmune Ltd Antistoffer mod beta-amyloid
CN107531781B (zh) * 2015-01-29 2021-12-07 抗菌技术,生物技术研究与发展股份有限公司 用于阿尔茨海默病和相关紊乱的抗体分子和肽递送系统
WO2017072310A1 (en) 2015-10-30 2017-05-04 Medimmune Limited Prevention of n-terminal truncation in igg light chains
US20190262327A1 (en) * 2016-03-15 2019-08-29 Astrazeneca Ab Combination of a bace inhibitor and an antibody or antigen-binding fragment for the treatment of a disorder associated with the accumulation of amyloid beta
BR112018075300A2 (pt) * 2016-06-07 2019-04-30 Biogen International Neuroscience Gmbh métodos para tratamento do mal de alzheimer
JP7436449B2 (ja) * 2018-07-17 2024-02-21 ジエンス ヘンルイ メデイシンカンパニー リミテッド 抗ａベータ抗体、その抗原結合フラグメントおよびそれらの用途
EP3999532A2 (en) * 2019-07-16 2022-05-25 Sanofi Neutralizing anti-amyloid beta antibodies for the treatment of alzheimer's disease
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CA3187785A1 (en) 2020-06-25 2021-12-30 Medimmune Limited Prevention of axonal damage using antibody binding to amyloid beta 1-42
TW202300517A (zh) 2021-03-12 2023-01-01 美商美國禮來大藥廠 抗類澱粉β抗體及其用途
WO2022251048A1 (en) 2021-05-24 2022-12-01 Eli Lilly And Company Anti-amyloid beta antibodies and uses thereof
KR102565470B1 (ko) * 2022-08-04 2023-08-10 가천대학교 산학협력단 아밀로이드 베타 특이적 펩타이드 sma_04088-2 및 이를 포함하는 알츠하이머병 치료용 조성물
KR102565471B1 (ko) * 2022-08-04 2023-08-10 가천대학교 산학협력단 아밀로이드 베타 특이적 펩타이드 cbrv1-04369 및 이를 포함하는 알츠하이머병 치료용 조성물
WO2024086796A1 (en) 2022-10-20 2024-04-25 Alector Llc Anti-ms4a4a antibodies with amyloid-beta therapies
CN116716351B (zh) * 2023-03-30 2024-02-23 湖北天勤生物技术研究院有限公司 用于构建食蟹猴阿尔兹海默症模型的组合物及其应用和构建方法

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Also Published As

Publication number Publication date
JP6669805B2 (ja) 2020-03-18
MX2015004763A (es) 2016-01-08
US20220251181A1 (en) 2022-08-11
ES2802873T3 (es) 2021-01-21
HRP20200936T1 (hr) 2020-09-18
EP2906597A1 (en) 2015-08-19
JP6959377B2 (ja) 2021-11-02
CN110294804A (zh) 2019-10-01
JP2023116770A (ja) 2023-08-22
JP7301924B2 (ja) 2023-07-03
AU2018256498C1 (en) 2024-06-20
AU2020256414A1 (en) 2020-11-12
LT2906597T (lt) 2020-07-10
RU2015118180A (ru) 2016-12-10
US9834598B2 (en) 2017-12-05
PL2906597T3 (pl) 2020-09-21
SI2906597T1 (sl) 2020-08-31
WO2014060444A1 (en) 2014-04-24
US11286297B2 (en) 2022-03-29
RU2651486C2 (ru) 2018-04-19
MX2019015602A (es) 2020-02-26
JP2022025078A (ja) 2022-02-09
CN105164156B (zh) 2019-04-02
JP2015536645A (ja) 2015-12-24
EP2906597B1 (en) 2020-04-08
AU2013333948B2 (en) 2018-08-02
US20210009665A1 (en) 2021-01-14
JP2018150346A (ja) 2018-09-27
RU2689674C2 (ru) 2019-05-28
AU2018256498A1 (en) 2018-11-22
HK1213906A1 (zh) 2016-07-15
US20240294619A1 (en) 2024-09-05
KR102450670B1 (ko) 2022-10-04
KR20150066593A (ko) 2015-06-16
CY1122987T1 (el) 2021-10-29
HUE051127T2 (hu) 2021-03-01
BR112015008347A2 (pt) 2017-12-05
BR112015008347B1 (pt) 2023-12-26
CN105164156A (zh) 2015-12-16
EP3721942A1 (en) 2020-10-14
ME03751B (me) 2021-04-20
US10662239B2 (en) 2020-05-26
CA2888322A1 (en) 2014-04-24
AU2013333948A1 (en) 2015-05-14
US12098191B2 (en) 2024-09-24
US20150299299A1 (en) 2015-10-22
JP6343615B2 (ja) 2018-06-20
JP2020099340A (ja) 2020-07-02
RU2018110064A3 (sr) 2019-02-28
KR20210125587A (ko) 2021-10-18
AU2018256498B2 (en) 2020-07-23
AU2020256414B2 (en) 2024-01-25
CN110294804B (zh) 2023-07-14
MX370725B (es) 2019-12-20
KR102308915B1 (ko) 2021-10-06
DK2906597T3 (da) 2020-07-13
PT2906597T (pt) 2020-06-18
RU2018110064A (ru) 2019-02-28
US20180105585A1 (en) 2018-04-19

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