RU2018110064A3 - - Google Patents
Info
- Publication number
- RU2018110064A3 RU2018110064A3 RU2018110064A RU2018110064A RU2018110064A3 RU 2018110064 A3 RU2018110064 A3 RU 2018110064A3 RU 2018110064 A RU2018110064 A RU 2018110064A RU 2018110064 A RU2018110064 A RU 2018110064A RU 2018110064 A3 RU2018110064 A3 RU 2018110064A3
- Authority
- RU
- Russia
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A61K38/1716—Amyloid plaque core protein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Endocrinology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261713996P | 2012-10-15 | 2012-10-15 | |
US61/713,996 | 2012-10-15 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2015118180A Division RU2651486C2 (ru) | 2012-10-15 | 2013-10-15 | Антитела к бета-амилоиду |
Publications (3)
Publication Number | Publication Date |
---|---|
RU2018110064A3 true RU2018110064A3 (ru) | 2019-02-28 |
RU2018110064A RU2018110064A (ru) | 2019-02-28 |
RU2689674C2 RU2689674C2 (ru) | 2019-05-28 |
Family
ID=49765450
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2018110064A RU2689674C2 (ru) | 2012-10-15 | 2013-10-15 | Антитела к бета-амилоиду |
RU2015118180A RU2651486C2 (ru) | 2012-10-15 | 2013-10-15 | Антитела к бета-амилоиду |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2015118180A RU2651486C2 (ru) | 2012-10-15 | 2013-10-15 | Антитела к бета-амилоиду |
Country Status (23)
Country | Link |
---|---|
US (4) | US9834598B2 (ru) |
EP (2) | EP2906597B1 (ru) |
JP (5) | JP6343615B2 (ru) |
KR (2) | KR102450670B1 (ru) |
CN (2) | CN105164156B (ru) |
AU (2) | AU2013333948B2 (ru) |
BR (1) | BR112015008347B1 (ru) |
CA (1) | CA2888322A1 (ru) |
CY (1) | CY1122987T1 (ru) |
DK (1) | DK2906597T3 (ru) |
ES (1) | ES2802873T3 (ru) |
HK (1) | HK1213906A1 (ru) |
HR (1) | HRP20200936T1 (ru) |
HU (1) | HUE051127T2 (ru) |
LT (1) | LT2906597T (ru) |
ME (1) | ME03751B (ru) |
MX (2) | MX370725B (ru) |
PL (1) | PL2906597T3 (ru) |
PT (1) | PT2906597T (ru) |
RS (1) | RS60388B1 (ru) |
RU (2) | RU2689674C2 (ru) |
SI (1) | SI2906597T1 (ru) |
WO (1) | WO2014060444A1 (ru) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT2906597T (pt) * | 2012-10-15 | 2020-06-18 | Medimmune Ltd | Anticorpos para amilóide beta |
WO2016120843A1 (en) * | 2015-01-29 | 2016-08-04 | Technophage, Investigação E Desenvolvimento Em Biotecnologia, Sa | Antibody molecules and peptide delivery systems for use in alzheimer's disease and related disorders |
EP3368561A1 (en) | 2015-10-30 | 2018-09-05 | Medimmune Limited | Prevention of n-terminal truncation in igg light chains |
KR20180119670A (ko) | 2016-03-15 | 2018-11-02 | 아스트라제네카 아베 | 아밀로이드 베타의 축적과 관련된 질환의 치료를 위한 bace 억제제와 항체 또는 항원 결합 단편의 조합 |
CN114931635A (zh) * | 2016-06-07 | 2022-08-23 | 生物基因国际神经科学有限责任公司 | 治疗阿尔茨海默病的方法 |
BR112020027055A2 (pt) * | 2018-07-17 | 2021-04-06 | Jiangsu Hengrui Medicine Co., Ltd. | Anticorpo anti-abeta, fragmento de ligação ao antígeno do mesmo e aplicação dos mesmos |
CN111454980A (zh) * | 2020-04-14 | 2020-07-28 | 郑州师范学院 | 重组载体的构建方法及其构建的重组载体及应用 |
JP2023531069A (ja) | 2020-06-25 | 2023-07-20 | メディミューン リミテッド | アミロイドβ1-42に結合する抗体を使用する軸索損傷の予防 |
TW202300517A (zh) | 2021-03-12 | 2023-01-01 | 美商美國禮來大藥廠 | 抗類澱粉β抗體及其用途 |
WO2022251048A1 (en) | 2021-05-24 | 2022-12-01 | Eli Lilly And Company | Anti-amyloid beta antibodies and uses thereof |
KR102565471B1 (ko) * | 2022-08-04 | 2023-08-10 | 가천대학교 산학협력단 | 아밀로이드 베타 특이적 펩타이드 cbrv1-04369 및 이를 포함하는 알츠하이머병 치료용 조성물 |
KR102565470B1 (ko) * | 2022-08-04 | 2023-08-10 | 가천대학교 산학협력단 | 아밀로이드 베타 특이적 펩타이드 sma_04088-2 및 이를 포함하는 알츠하이머병 치료용 조성물 |
WO2024086796A1 (en) | 2022-10-20 | 2024-04-25 | Alector Llc | Anti-ms4a4a antibodies with amyloid-beta therapies |
CN116716351B (zh) * | 2023-03-30 | 2024-02-23 | 湖北天勤生物技术研究院有限公司 | 用于构建食蟹猴阿尔兹海默症模型的组合物及其应用和构建方法 |
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US565332A (en) | 1896-08-04 | Toy for making soap-bubbles | ||
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US4479930A (en) | 1982-07-26 | 1984-10-30 | Trustees Of The University Of Massachusetts | Amines coupled wth dicyclic dianhydrides capable of being radiolabeled product |
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JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
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US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
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US6172197B1 (en) | 1991-07-10 | 2001-01-09 | Medical Research Council | Methods for producing members of specific binding pairs |
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US5858657A (en) | 1992-05-15 | 1999-01-12 | Medical Research Council | Methods for producing members of specific binding pairs |
US5871907A (en) | 1991-05-15 | 1999-02-16 | Medical Research Council | Methods for producing members of specific binding pairs |
US5962255A (en) | 1992-03-24 | 1999-10-05 | Cambridge Antibody Technology Limited | Methods for producing recombinant vectors |
US6225447B1 (en) | 1991-05-15 | 2001-05-01 | Cambridge Antibody Technology Ltd. | Methods for producing members of specific binding pairs |
US5565332A (en) | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
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WO2003089460A1 (en) * | 2002-04-19 | 2003-10-30 | The Governing Council Of The University Of Toronto | Immunological methods and compositions for the treatment of alzheimer's disease |
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US20090232801A1 (en) * | 2007-05-30 | 2009-09-17 | Abbot Laboratories | Humanized Antibodies Which Bind To AB (1-42) Globulomer And Uses Thereof |
US20090175847A1 (en) * | 2007-05-30 | 2009-07-09 | Abbott Laboratories | Humanized antibodies to ab (20-42) globulomer and uses thereof |
CN101878301B (zh) * | 2007-10-29 | 2014-08-20 | 道健康生活医药株式会社 | 抗体及其应用 |
WO2009075084A1 (ja) * | 2007-12-12 | 2009-06-18 | Immuno-Biological Laboratories Co., Ltd. | アルツハイマー病の存在又は傾向の診断薬及び診断方法 |
CA2709354C (en) * | 2007-12-21 | 2014-06-17 | Amgen Inc. | Anti-amyloid antibodies and uses thereof |
EP2072527A1 (en) * | 2007-12-21 | 2009-06-24 | Altonabiotec AG | Fusion polypeptides comprising a SHBG dimerization component and uses thereof |
US8298533B2 (en) * | 2008-11-07 | 2012-10-30 | Medimmune Limited | Antibodies to IL-1R1 |
PT2906597T (pt) * | 2012-10-15 | 2020-06-18 | Medimmune Ltd | Anticorpos para amilóide beta |
US9209965B2 (en) | 2014-01-14 | 2015-12-08 | Microsemi Semiconductor Ulc | Network interface with clock recovery module on line card |
AR107783A1 (es) | 2016-03-15 | 2018-06-06 | Lilly Co Eli | Terapia de combinación |
KR20180119670A (ko) | 2016-03-15 | 2018-11-02 | 아스트라제네카 아베 | 아밀로이드 베타의 축적과 관련된 질환의 치료를 위한 bace 억제제와 항체 또는 항원 결합 단편의 조합 |
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2013
- 2013-10-15 PT PT138052774T patent/PT2906597T/pt unknown
- 2013-10-15 BR BR112015008347-1A patent/BR112015008347B1/pt active IP Right Grant
- 2013-10-15 JP JP2015536189A patent/JP6343615B2/ja active Active
- 2013-10-15 CA CA2888322A patent/CA2888322A1/en active Pending
- 2013-10-15 RS RS20200694A patent/RS60388B1/sr unknown
- 2013-10-15 WO PCT/EP2013/071567 patent/WO2014060444A1/en active Application Filing
- 2013-10-15 KR KR1020217031163A patent/KR102450670B1/ko active IP Right Grant
- 2013-10-15 CN CN201380053909.7A patent/CN105164156B/zh active Active
- 2013-10-15 RU RU2018110064A patent/RU2689674C2/ru active
- 2013-10-15 EP EP13805277.4A patent/EP2906597B1/en active Active
- 2013-10-15 RU RU2015118180A patent/RU2651486C2/ru active
- 2013-10-15 US US14/435,520 patent/US9834598B2/en active Active
- 2013-10-15 SI SI201331737T patent/SI2906597T1/sl unknown
- 2013-10-15 HU HUE13805277A patent/HUE051127T2/hu unknown
- 2013-10-15 ME MEP-2020-119A patent/ME03751B/me unknown
- 2013-10-15 PL PL13805277T patent/PL2906597T3/pl unknown
- 2013-10-15 CN CN201910295599.9A patent/CN110294804B/zh active Active
- 2013-10-15 AU AU2013333948A patent/AU2013333948B2/en active Active
- 2013-10-15 EP EP20160286.9A patent/EP3721942A1/en active Pending
- 2013-10-15 ES ES13805277T patent/ES2802873T3/es active Active
- 2013-10-15 LT LTEP13805277.4T patent/LT2906597T/lt unknown
- 2013-10-15 MX MX2015004763A patent/MX370725B/es active IP Right Grant
- 2013-10-15 KR KR1020157012631A patent/KR102308915B1/ko active IP Right Grant
- 2013-10-15 DK DK13805277.4T patent/DK2906597T3/da active
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2015
- 2015-04-15 MX MX2019015602A patent/MX2019015602A/es unknown
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2016
- 2016-02-17 HK HK16101678.9A patent/HK1213906A1/zh unknown
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2017
- 2017-10-25 US US15/793,510 patent/US10662239B2/en active Active
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2018
- 2018-05-21 JP JP2018096788A patent/JP6669805B2/ja active Active
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2020
- 2020-02-27 JP JP2020031419A patent/JP6959377B2/ja active Active
- 2020-05-01 US US16/864,439 patent/US11286297B2/en active Active
- 2020-06-10 HR HRP20200936TT patent/HRP20200936T1/hr unknown
- 2020-06-11 CY CY20201100538T patent/CY1122987T1/el unknown
- 2020-10-16 AU AU2020256414A patent/AU2020256414B2/en active Active
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2021
- 2021-10-07 JP JP2021165338A patent/JP7301924B2/ja active Active
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2022
- 2022-02-16 US US17/673,449 patent/US20220251181A1/en active Pending
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2023
- 2023-06-21 JP JP2023101375A patent/JP2023116770A/ja active Pending