RU2017129236A - Мультивалентные молекулы, содержащие dr5-связывающие домены - Google Patents

Мультивалентные молекулы, содержащие dr5-связывающие домены Download PDF

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Publication number
RU2017129236A
RU2017129236A RU2017129236A RU2017129236A RU2017129236A RU 2017129236 A RU2017129236 A RU 2017129236A RU 2017129236 A RU2017129236 A RU 2017129236A RU 2017129236 A RU2017129236 A RU 2017129236A RU 2017129236 A RU2017129236 A RU 2017129236A
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seq
domain
cdr
amino acid
acid sequence
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RU2017129236A
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English (en)
Russian (ru)
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RU2017129236A3 (OSRAM
Inventor
Пол А. Мур
Лесли С. Джонсон
Джонатан С. ЛИ
Калпана ШАН
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Макродженикс, Инк.
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Publication of RU2017129236A publication Critical patent/RU2017129236A/ru
Publication of RU2017129236A3 publication Critical patent/RU2017129236A3/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2017129236A 2015-01-26 2015-05-29 Мультивалентные молекулы, содержащие dr5-связывающие домены RU2017129236A (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562107871P 2015-01-26 2015-01-26
US62/107,871 2015-01-26
US201562149139P 2015-04-17 2015-04-17
US62/149,139 2015-04-17
PCT/US2015/033099 WO2016122702A1 (en) 2015-01-26 2015-05-29 Multivalent molecules comprising dr5-binding domains

Publications (2)

Publication Number Publication Date
RU2017129236A true RU2017129236A (ru) 2019-03-07
RU2017129236A3 RU2017129236A3 (OSRAM) 2019-03-07

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
RU2017129236A RU2017129236A (ru) 2015-01-26 2015-05-29 Мультивалентные молекулы, содержащие dr5-связывающие домены

Country Status (13)

Country Link
US (1) US10501552B2 (OSRAM)
EP (1) EP3250601A4 (OSRAM)
JP (1) JP6602875B2 (OSRAM)
KR (1) KR20170105622A (OSRAM)
CN (1) CN107250161A (OSRAM)
AU (1) AU2015380455A1 (OSRAM)
CA (1) CA2974807A1 (OSRAM)
HK (1) HK1247215A1 (OSRAM)
IL (1) IL253668A0 (OSRAM)
RU (1) RU2017129236A (OSRAM)
SG (1) SG11201706024YA (OSRAM)
TW (1) TWI688572B (OSRAM)
WO (1) WO2016122702A1 (OSRAM)

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RU2766200C1 (ru) * 2015-10-01 2022-02-09 Хит Байолоджикс, Инк. Композиции и способы для соединения внеклеточных доменов типа i и типа ii в качестве гетерологичных химерных белков
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KR101926834B1 (ko) * 2017-03-21 2018-12-07 동아에스티 주식회사 항-dr5 항체 및 그의 용도
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CN117597364A (zh) * 2021-05-12 2024-02-23 百进生物科技公司 抗ccr8抗体、其抗原结合片段、以及试剂和组合物及其制备和使用方法
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KR20170105622A (ko) 2017-09-19
US10501552B2 (en) 2019-12-10
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US20180016344A1 (en) 2018-01-18
SG11201706024YA (en) 2017-08-30
TW201627323A (zh) 2016-08-01
TWI688572B (zh) 2020-03-21
JP2018507188A (ja) 2018-03-15
EP3250601A1 (en) 2017-12-06
RU2017129236A3 (OSRAM) 2019-03-07
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WO2016122702A1 (en) 2016-08-04
HK1247215A1 (zh) 2018-09-21

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