BR112012006326A2 - anticorpo biespecífico, composição farmacêutica, sequência de ácidos nucleicos, vetor de expressão, célula hospedeira procariótica ou eucariótica e invenção - Google Patents

anticorpo biespecífico, composição farmacêutica, sequência de ácidos nucleicos, vetor de expressão, célula hospedeira procariótica ou eucariótica e invenção

Info

Publication number
BR112012006326A2
BR112012006326A2 BR112012006326A BR112012006326A BR112012006326A2 BR 112012006326 A2 BR112012006326 A2 BR 112012006326A2 BR 112012006326 A BR112012006326 A BR 112012006326A BR 112012006326 A BR112012006326 A BR 112012006326A BR 112012006326 A2 BR112012006326 A2 BR 112012006326A2
Authority
BR
Brazil
Prior art keywords
prokaryotic
nucleic acid
acid sequence
pharmaceutical composition
host cell
Prior art date
Application number
BR112012006326A
Other languages
English (en)
Inventor
Christoph Lampert
Claudia Ferrara Koller
Ekkehard Moessner
Inja Waldhauer
Pablo Umana
Peter Bruenker
Sandra Grau
Sylvia Herter
Original Assignee
Roche Glycart Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Glycart Ag filed Critical Roche Glycart Ag
Publication of BR112012006326A2 publication Critical patent/BR112012006326A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3007—Carcino-embryonic Antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
BR112012006326A 2009-09-29 2010-09-27 anticorpo biespecífico, composição farmacêutica, sequência de ácidos nucleicos, vetor de expressão, célula hospedeira procariótica ou eucariótica e invenção BR112012006326A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09171659 2009-09-29
PCT/EP2010/064209 WO2011039126A1 (en) 2009-09-29 2010-09-27 Bispecific death receptor agonistic antibodies

Publications (1)

Publication Number Publication Date
BR112012006326A2 true BR112012006326A2 (pt) 2016-11-16

Family

ID=43086853

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012006326A BR112012006326A2 (pt) 2009-09-29 2010-09-27 anticorpo biespecífico, composição farmacêutica, sequência de ácidos nucleicos, vetor de expressão, célula hospedeira procariótica ou eucariótica e invenção

Country Status (19)

Country Link
US (1) US9481730B2 (pt)
EP (1) EP2483310B1 (pt)
JP (1) JP5695059B2 (pt)
KR (1) KR101508043B1 (pt)
CN (1) CN102574921B (pt)
AU (1) AU2010303142B2 (pt)
BR (1) BR112012006326A2 (pt)
CA (1) CA2773515C (pt)
CY (1) CY1115639T1 (pt)
DK (1) DK2483310T3 (pt)
ES (1) ES2505269T3 (pt)
HK (1) HK1169132A1 (pt)
HR (1) HRP20141032T1 (pt)
IL (1) IL218437A (pt)
MX (1) MX2012003598A (pt)
PL (1) PL2483310T3 (pt)
PT (1) PT2483310E (pt)
SI (1) SI2483310T1 (pt)
WO (1) WO2011039126A1 (pt)

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JP6779873B2 (ja) * 2014-11-12 2020-11-04 メモリアル スローン ケタリング キャンサー センター 抗コンドロイチン硫酸プロテオグリカン４抗体およびその使用
HUE049982T2 (hu) 2014-11-14 2020-11-30 Hoffmann La Roche TNF-családba tartozó ligandum-trimert tartalmazó antigénkötõ molekulák
US11566082B2 (en) 2014-11-17 2023-01-31 Cytiva Bioprocess R&D Ab Mutated immunoglobulin-binding polypeptides
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US20170369588A1 (en) * 2014-12-23 2017-12-28 Universita' Degli Studi Di Parma Pro-apoptotic anti-ng2/cspg4 antibodies and their uses for disease therapy
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CN104818295A (zh) * 2015-02-03 2015-08-05 武汉友芝友生物制药有限公司 制备和筛选表达双特异性抗体细胞株的方法
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Also Published As

Publication number Publication date
EP2483310A1 (en) 2012-08-08
MX2012003598A (es) 2012-04-20
IL218437A0 (en) 2012-04-30
DK2483310T3 (da) 2014-09-01
WO2011039126A1 (en) 2011-04-07
CN102574921B (zh) 2016-05-04
HK1169132A1 (zh) 2013-01-18
AU2010303142B2 (en) 2013-05-09
CY1115639T1 (el) 2017-01-04
PT2483310E (pt) 2014-10-07
SI2483310T1 (sl) 2014-12-31
ES2505269T3 (es) 2014-10-09
IL218437A (en) 2017-04-30
KR101508043B1 (ko) 2015-04-06
US20120184718A1 (en) 2012-07-19
CN102574921A (zh) 2012-07-11
CA2773515A1 (en) 2011-04-07
JP5695059B2 (ja) 2015-04-01
PL2483310T3 (pl) 2015-01-30
CA2773515C (en) 2015-04-28
KR20120056857A (ko) 2012-06-04
AU2010303142A1 (en) 2012-03-15
HRP20141032T1 (hr) 2015-01-30
JP2013505732A (ja) 2013-02-21
EP2483310B1 (en) 2014-08-13
US9481730B2 (en) 2016-11-01

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