SG11201706024YA - Multivalent molecules comprising dr5-binding domains - Google Patents

Multivalent molecules comprising dr5-binding domains

Info

Publication number
SG11201706024YA
SG11201706024YA SG11201706024YA SG11201706024YA SG11201706024YA SG 11201706024Y A SG11201706024Y A SG 11201706024YA SG 11201706024Y A SG11201706024Y A SG 11201706024YA SG 11201706024Y A SG11201706024Y A SG 11201706024YA SG 11201706024Y A SG11201706024Y A SG 11201706024YA
Authority
SG
Singapore
Prior art keywords
binding domains
multivalent molecules
multivalent
molecules
domains
Prior art date
Application number
SG11201706024YA
Other languages
English (en)
Inventor
Paul A Moore
Leslie S Johnson
Jonathan C Li
Kalpana Shah
Original Assignee
Macrogenics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Macrogenics Inc filed Critical Macrogenics Inc
Publication of SG11201706024YA publication Critical patent/SG11201706024YA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SG11201706024YA 2015-01-26 2015-05-29 Multivalent molecules comprising dr5-binding domains SG11201706024YA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562107871P 2015-01-26 2015-01-26
US201562149139P 2015-04-17 2015-04-17
PCT/US2015/033099 WO2016122702A1 (en) 2015-01-26 2015-05-29 Multivalent molecules comprising dr5-binding domains

Publications (1)

Publication Number Publication Date
SG11201706024YA true SG11201706024YA (en) 2017-08-30

Family

ID=56544108

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201706024YA SG11201706024YA (en) 2015-01-26 2015-05-29 Multivalent molecules comprising dr5-binding domains

Country Status (13)

Country Link
US (1) US10501552B2 (OSRAM)
EP (1) EP3250601A4 (OSRAM)
JP (1) JP6602875B2 (OSRAM)
KR (1) KR20170105622A (OSRAM)
CN (1) CN107250161A (OSRAM)
AU (1) AU2015380455A1 (OSRAM)
CA (1) CA2974807A1 (OSRAM)
HK (1) HK1247215A1 (OSRAM)
IL (1) IL253668A0 (OSRAM)
RU (1) RU2017129236A (OSRAM)
SG (1) SG11201706024YA (OSRAM)
TW (1) TWI688572B (OSRAM)
WO (1) WO2016122702A1 (OSRAM)

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DK3247728T3 (da) 2015-01-20 2020-07-13 Igm Biosciences Inc Tumornekrosefaktor-(tnf)-superfamiliereceptorbindende molekyler og anvendelser deraf
EP3112381A1 (en) * 2015-07-01 2017-01-04 FONDAZIONE IRCCS Istituto Nazionale dei Tumori Bispecific antibodies for use in cancer immunotherapy
IL295423B2 (en) * 2015-10-01 2023-11-01 Heat Biologics Inc Compounds and methods for joining extracellular complexes of type 1 and 2 as heterologous chimeric proteins
KR102791773B1 (ko) * 2015-10-30 2025-04-03 갤럭시 바이오테크, 엘엘씨 사멸 수용체 4 및 사멸 수용체 5에 결합하는 매우 강력한 항체
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KR101926834B1 (ko) 2017-03-21 2018-12-07 동아에스티 주식회사 항-dr5 항체 및 그의 용도
CN111164101B (zh) * 2017-10-04 2025-04-25 安进公司 甲状腺素视黄质运载蛋白免疫球蛋白融合体
KR102194026B1 (ko) * 2017-12-15 2020-12-22 경북대학교 산학협력단 Trail 수용체에 결합하는 펩타이드 및 이의 용도
JP2021526026A (ja) * 2018-06-08 2021-09-30 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 翻訳後修飾が低減したペプチドリンカー
CA3106829A1 (en) 2018-08-03 2020-02-06 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule containing two antigen-binding domains that are linked to each other
US12331320B2 (en) 2018-10-10 2025-06-17 The Research Foundation For The State University Of New York Genome edited cancer cell vaccines
WO2021178569A2 (en) * 2020-03-04 2021-09-10 Regents Of The University Of Minnesota Anti-dr5 polypeptides and methods of use thereof
WO2022241034A1 (en) * 2021-05-12 2022-11-17 BioLegend, Inc. Anti-ccr8 antibodies, antigen-binding fragments thereof, and agents and compositions and methods for making and using the same
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RU2017129236A (ru) 2019-03-07
JP2018507188A (ja) 2018-03-15
US10501552B2 (en) 2019-12-10
IL253668A0 (en) 2017-09-28
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US20180016344A1 (en) 2018-01-18
JP6602875B2 (ja) 2019-11-06

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