RU2017115720A - Лечение сердечно-сосудистого заболевания при помощи лигандных ловушек на основе actrii - Google Patents

Лечение сердечно-сосудистого заболевания при помощи лигандных ловушек на основе actrii Download PDF

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RU2017115720A
RU2017115720A RU2017115720A RU2017115720A RU2017115720A RU 2017115720 A RU2017115720 A RU 2017115720A RU 2017115720 A RU2017115720 A RU 2017115720A RU 2017115720 A RU2017115720 A RU 2017115720A RU 2017115720 A RU2017115720 A RU 2017115720A
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RU2017115720A
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RU2017115720A3 (enExample
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Кейт ХРУСКА
Ифу ФАН
Уилльям СМИТ
Няньхан ЧЭНЬ
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Селджин Корпорейшн
Вашингтон Юниверсити
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Publication of RU2017115720A3 publication Critical patent/RU2017115720A3/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
RU2017115720A 2014-10-09 2015-10-08 Лечение сердечно-сосудистого заболевания при помощи лигандных ловушек на основе actrii RU2017115720A (ru)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201462062021P 2014-10-09 2014-10-09
US62/062,021 2014-10-09
US201462078321P 2014-11-11 2014-11-11
US62/078,321 2014-11-11
US201562103515P 2015-01-14 2015-01-14
US62/103,515 2015-01-14
US201562167052P 2015-05-27 2015-05-27
US62/167,052 2015-05-27
US201562170015P 2015-06-02 2015-06-02
US62/170,015 2015-06-02
PCT/US2015/054674 WO2016069234A1 (en) 2014-10-09 2015-10-08 Treatment of cardiovascular disease using actrii ligand traps

Related Child Applications (1)

Application Number Title Priority Date Filing Date
RU2022108605A Division RU2022108605A (ru) 2014-10-09 2015-10-08 ЛЕЧЕНИЕ СЕРДЕЧНО-СОСУДИСТОГО ЗАБОЛЕВАНИЯ ПРИ ПОМОЩИ ЛИГАНДНЫХ ЛОВУШЕК НА ОСНОВЕ ActRII

Publications (2)

Publication Number Publication Date
RU2017115720A true RU2017115720A (ru) 2018-11-15
RU2017115720A3 RU2017115720A3 (enExample) 2019-05-08

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RU2017115720A RU2017115720A (ru) 2014-10-09 2015-10-08 Лечение сердечно-сосудистого заболевания при помощи лигандных ловушек на основе actrii

Country Status (15)

Country Link
US (1) US11813308B2 (enExample)
EP (1) EP3204118B8 (enExample)
JP (2) JP2017533191A (enExample)
KR (1) KR20170088836A (enExample)
CN (1) CN107206255A (enExample)
AU (2) AU2015339786B2 (enExample)
CA (1) CA2964129A1 (enExample)
ES (1) ES2978963T3 (enExample)
HK (1) HK1244741A1 (enExample)
IL (1) IL251649B (enExample)
MA (1) MA41052A (enExample)
MX (1) MX392749B (enExample)
RU (1) RU2017115720A (enExample)
TW (2) TW202300170A (enExample)
WO (1) WO2016069234A1 (enExample)

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RU2678117C2 (ru) 2012-11-02 2019-01-23 Селджин Корпорейшн Антагонисты активина-actrii и их применение для лечения нарушений костной ткани и других нарушений
MA41052A (fr) 2014-10-09 2017-08-15 Celgene Corp Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii
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EP3298034A4 (en) 2015-05-20 2019-02-13 Celgene Corporation IN VITRO CELL CULTURE PROCEDURE FOR BETA THALASSEMIA BY MEANS OF ACTIVIN TYPE II RECEPTOR LIGANDS
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KR102628323B1 (ko) * 2017-03-24 2024-01-22 노바르티스 아게 심장질환 예방 및 치료 방법
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IL278546B2 (en) * 2018-05-09 2026-03-01 Keros Therapeutics Inc Activin receptor type IIA variants and methods of using them
KR20220054608A (ko) 2019-09-03 2022-05-03 노파르티스 아게 ActRII 수용체 길항제를 포함하는 간 질환 또는 장애 치료제
EP4121088A4 (en) 2020-03-20 2024-07-03 Keros Therapeutics, Inc. Methods of using activin receptor type iib variants
EP4121078A4 (en) 2020-03-20 2024-08-14 Keros Therapeutics, Inc. ACTIVIN RECEPTOR TYPE II CHIMERAS AND METHODS OF USE THEREOF
CN111474369A (zh) * 2020-04-22 2020-07-31 河北医科大学 一种平滑肌蛋白SM22α作为检测心血管疾病标志物的应用
US20230174620A1 (en) 2020-04-28 2023-06-08 Acceleron Pharma Inc. Actrii proteins and use in treating post-capillary pulmonary hypertension
KR20230026435A (ko) * 2020-06-23 2023-02-24 악셀레론 파마 인코포레이티드 Actrii 단백질 및 이의 용도
CN111870685B (zh) * 2020-07-16 2022-11-29 上海市同仁医院 运动相关多肽在制备防治缺血性心脏病药物中的应用
EP4674480A3 (en) * 2020-10-02 2026-04-08 Keros Therapeutics, Inc. Methods of using activin receptor type ii variants
US12186370B1 (en) 2020-11-05 2025-01-07 Celgene Corporation ACTRIIB ligand trap compositions and uses thereof
CR20250375A (es) * 2023-03-09 2025-10-07 Merck Sharp & Dohme Llc Formulaciones que comprenden variantes de la proteína actriia
AU2024231427A1 (en) * 2023-03-09 2025-09-04 Merck Sharp & Dohme Llc Formulations comprising actriia polypeptide variants
WO2024238920A1 (en) * 2023-05-18 2024-11-21 Keros Therapeutics, Inc. Methods of using activin receptor type ii variants
CN121344183B (zh) * 2025-12-18 2026-03-27 成都医学院 检测ACVR2b的试剂在制备慢性肾脏病血管钙化诊断试剂盒中的用途

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