MA41052A - Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii - Google Patents

Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii

Info

Publication number
MA41052A
MA41052A MA041052A MA41052A MA41052A MA 41052 A MA41052 A MA 41052A MA 041052 A MA041052 A MA 041052A MA 41052 A MA41052 A MA 41052A MA 41052 A MA41052 A MA 41052A
Authority
MA
Morocco
Prior art keywords
treatment
cardiovascular disease
actrii ligand
ligand traps
traps
Prior art date
Application number
MA041052A
Other languages
English (en)
French (fr)
Inventor
Nianhang Chen
Yifu Fang
Keith Hruska
William Smith
Original Assignee
Celgene Corp
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp, Univ Washington filed Critical Celgene Corp
Publication of MA41052A publication Critical patent/MA41052A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
MA041052A 2014-10-09 2015-10-07 Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii MA41052A (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462062021P 2014-10-09 2014-10-09
US201462078321P 2014-11-11 2014-11-11
US201562103515P 2015-01-14 2015-01-14
US201562167052P 2015-05-27 2015-05-27
US201562170015P 2015-06-02 2015-06-02

Publications (1)

Publication Number Publication Date
MA41052A true MA41052A (fr) 2017-08-15

Family

ID=55858162

Family Applications (1)

Application Number Title Priority Date Filing Date
MA041052A MA41052A (fr) 2014-10-09 2015-10-07 Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii

Country Status (15)

Country Link
US (1) US11813308B2 (enExample)
EP (1) EP3204118B8 (enExample)
JP (2) JP2017533191A (enExample)
KR (1) KR20170088836A (enExample)
CN (1) CN107206255A (enExample)
AU (2) AU2015339786B2 (enExample)
CA (1) CA2964129A1 (enExample)
ES (1) ES2978963T3 (enExample)
HK (1) HK1244741A1 (enExample)
IL (1) IL251649B (enExample)
MA (1) MA41052A (enExample)
MX (1) MX392749B (enExample)
RU (1) RU2017115720A (enExample)
TW (2) TW202300170A (enExample)
WO (1) WO2016069234A1 (enExample)

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RU2018145985A (ru) 2012-11-02 2019-02-18 Селджин Корпорейшн Антагонисты активина-actrii и их применение для лечения нарушений костной ткани и других нарушений
MA41052A (fr) 2014-10-09 2017-08-15 Celgene Corp Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii
DK3227675T3 (da) 2014-12-03 2023-05-30 Celgene Corp Activin-actrii-antagonister og anvendelser til behandling af myelodysplastisk syndrom
CN108350057A (zh) 2015-05-20 2018-07-31 细胞基因公司 使用II型活化素受体配体阱的用于β-地中海贫血的体外细胞培养方法
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CN110461359B (zh) * 2017-03-24 2025-01-21 诺华股份有限公司 用于预防和治疗心脏病的方法
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EP4121088A4 (en) 2020-03-20 2024-07-03 Keros Therapeutics, Inc. Methods of using activin receptor type iib variants
KR20230004515A (ko) 2020-03-20 2023-01-06 케로스 테라퓨틱스, 인크. 액티빈 수용체 유형 ii 키메라 및 이의 사용 방법
CN111474369A (zh) * 2020-04-22 2020-07-31 河北医科大学 一种平滑肌蛋白SM22α作为检测心血管疾病标志物的应用
US20230226146A1 (en) * 2020-06-23 2023-07-20 Acceleron Pharma Inc. Actrii proteins for the treatment of pulmonary arterial hypertension (pah)
CN111870685B (zh) * 2020-07-16 2022-11-29 上海市同仁医院 运动相关多肽在制备防治缺血性心脏病药物中的应用
US12186370B1 (en) 2020-11-05 2025-01-07 Celgene Corporation ACTRIIB ligand trap compositions and uses thereof
KR20250155050A (ko) * 2023-03-09 2025-10-29 머크 샤프 앤드 돔 엘엘씨 ActRIIa 단백질 변이체를 포함하는 제제
PE20260259A1 (es) * 2023-03-09 2026-01-30 Merck Sharp And Dohme Llc Formulaciones que comprenden variantes polipeptidicas de actriia
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