MX2017004675A - Tratamiento de enfermedad cardiovascular usando trampas de ligando actrii. - Google Patents

Tratamiento de enfermedad cardiovascular usando trampas de ligando actrii.

Info

Publication number
MX2017004675A
MX2017004675A MX2017004675A MX2017004675A MX2017004675A MX 2017004675 A MX2017004675 A MX 2017004675A MX 2017004675 A MX2017004675 A MX 2017004675A MX 2017004675 A MX2017004675 A MX 2017004675A MX 2017004675 A MX2017004675 A MX 2017004675A
Authority
MX
Mexico
Prior art keywords
treatment
alpha
activin
type
protein
Prior art date
Application number
MX2017004675A
Other languages
English (en)
Inventor
Hruska Keith
Smith William
Fang Yifu
Chen Nianhang
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of MX2017004675A publication Critical patent/MX2017004675A/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Se proporcionan en la presente métodos para tratar enfermedades asociadas con calcificación vascular y/o enfermedad cardiovascular y/o resorción ósea en un sujeto, al usar el nivel de un biomarcador, en particular, homólogo de snai 1 I (Snai1), fosfosmad2, fosfosmad3, proteína urinaria, homólogo dickkopf 1 (Dkk1), colágeno tipo 1 alfa 1 (Colla1), activina (es decir, activina libre), factor de transcripción relacionado con runt (Runx2), fosfatasa alcalina (Alp), fosfatasa alcalina específica de hueso (BSAP), telopéptido de colágeno tipo 1 C-terminal (CTX), osterix, Klotho, actina de músculo suave alfa (alfa-SMA), miocardina (MYOCD), receptor de activina tipo 2A (ActRllA), proteína de inhibición de eje 2 (Axin2) y/o proteína de músculo suave 22-alfa (Sm22-alfa), como un indicador o indicadores de sensibilidad del sujeto al tratamiento, eficacia del tratamiento o dosificación apropiada para el tratamiento con un inhibidor de señalización de receptor de activina tipo II.
MX2017004675A 2014-10-09 2015-10-08 Tratamiento de enfermedad cardiovascular usando trampas de ligando actrii. MX2017004675A (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201462062021P 2014-10-09 2014-10-09
US201462078321P 2014-11-11 2014-11-11
US201562103515P 2015-01-14 2015-01-14
US201562167052P 2015-05-27 2015-05-27
US201562170015P 2015-06-02 2015-06-02
PCT/US2015/054674 WO2016069234A1 (en) 2014-10-09 2015-10-08 Treatment of cardiovascular disease using actrii ligand traps

Publications (1)

Publication Number Publication Date
MX2017004675A true MX2017004675A (es) 2018-06-12

Family

ID=55858162

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017004675A MX2017004675A (es) 2014-10-09 2015-10-08 Tratamiento de enfermedad cardiovascular usando trampas de ligando actrii.

Country Status (14)

Country Link
US (1) US11813308B2 (es)
EP (1) EP3204118B8 (es)
JP (2) JP2017533191A (es)
KR (1) KR20170088836A (es)
CN (1) CN107206255A (es)
AU (2) AU2015339786B2 (es)
CA (1) CA2964129A1 (es)
HK (1) HK1244741A1 (es)
IL (1) IL251649B (es)
MA (1) MA41052A (es)
MX (1) MX2017004675A (es)
RU (1) RU2017115720A (es)
TW (2) TW201625288A (es)
WO (1) WO2016069234A1 (es)

Families Citing this family (12)

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KR102279522B1 (ko) 2012-11-02 2021-07-19 셀진 코포레이션 골 및 다른 장애를 치료하기 위한 액티빈-actrii 길항제 및 용도
MA41052A (fr) 2014-10-09 2017-08-15 Celgene Corp Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii
RS64214B1 (sr) 2014-12-03 2023-06-30 Celgene Corp Antagonisti aktivin-actrii i njihova primena u lečenju mijelodisplastičnog sindroma
EP3298034A4 (en) 2015-05-20 2019-02-13 Celgene Corporation IN VITRO CELL CULTURE PROCEDURE FOR BETA THALASSEMIA BY MEANS OF ACTIVIN TYPE II RECEPTOR LIGANDS
CN116650622A (zh) * 2016-10-05 2023-08-29 艾科赛扬制药股份有限公司 用于治疗肾脏疾病的组合物和方法
ES2914308T3 (es) 2017-02-28 2022-06-09 Univ Berlin Charite Uromodulina para su uso en la prevención y terapia de calcificación vascular o inflamación vascular
KR102628323B1 (ko) * 2017-03-24 2024-01-22 노바르티스 아게 심장질환 예방 및 치료 방법
JP7194172B2 (ja) * 2018-03-30 2022-12-21 日立Astemo株式会社 電動パーキングブレーキ装置
EP3790572A4 (en) * 2018-05-09 2022-03-16 Keros Therapeutics, Inc. TYPE IIA ACTIVIN RECEPTOR VARIANTS AND METHODS OF USE THEREOF
MX2022002636A (es) 2019-09-03 2022-03-25 Novartis Ag Tratamiento de la enfermedad o trastorno hepatico que comprende los antagonistas del receptor de actrii.
CN111474369A (zh) * 2020-04-22 2020-07-31 河北医科大学 一种平滑肌蛋白SM22α作为检测心血管疾病标志物的应用
CN111870685B (zh) * 2020-07-16 2022-11-29 上海市同仁医院 运动相关多肽在制备防治缺血性心脏病药物中的应用

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