RU2014121884A - Хроматография перегрузки и элюирования - Google Patents
Хроматография перегрузки и элюирования Download PDFInfo
- Publication number
- RU2014121884A RU2014121884A RU2014121884/10A RU2014121884A RU2014121884A RU 2014121884 A RU2014121884 A RU 2014121884A RU 2014121884/10 A RU2014121884/10 A RU 2014121884/10A RU 2014121884 A RU2014121884 A RU 2014121884A RU 2014121884 A RU2014121884 A RU 2014121884A
- Authority
- RU
- Russia
- Prior art keywords
- polypeptide
- antibody
- specified
- buffer
- conductivity
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/14—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the introduction of the feed to the apparatus
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
- B01D15/424—Elution mode
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/32—Bonded phase chromatography
- B01D15/325—Reversed phase
- B01D15/327—Reversed phase with hydrophobic interaction
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
- B01D15/361—Ion-exchange
- B01D15/363—Anion-exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
- B01D15/3804—Affinity chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
- B01D15/3847—Multimodal interactions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161554898P | 2011-11-02 | 2011-11-02 | |
| US61/554,898 | 2011-11-02 | ||
| PCT/US2012/063242 WO2013067301A1 (en) | 2011-11-02 | 2012-11-02 | Overload and elute chromatography |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2014121884A true RU2014121884A (ru) | 2015-12-10 |
Family
ID=48192803
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014121884/10A RU2014121884A (ru) | 2011-11-02 | 2012-11-02 | Хроматография перегрузки и элюирования |
Country Status (25)
Families Citing this family (44)
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| CN108404453B (zh) | 2010-07-30 | 2021-01-05 | Emd密理博公司 | 层析介质和方法 |
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| RS58472B2 (sr) | 2011-11-02 | 2024-10-31 | Hoffmann La Roche | Hromatografija preopterećenja i eluata |
| US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
| US9181572B2 (en) | 2012-04-20 | 2015-11-10 | Abbvie, Inc. | Methods to modulate lysine variant distribution |
| US9334319B2 (en) | 2012-04-20 | 2016-05-10 | Abbvie Inc. | Low acidic species compositions |
| WO2013176754A1 (en) * | 2012-05-24 | 2013-11-28 | Abbvie Inc. | Novel purification of antibodies using hydrophobic interaction chromatography |
| US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
| MX379269B (es) * | 2012-10-24 | 2025-03-11 | Genzyme Corp | Elucion de biomoleculas de resinas multimodales utilizando mes y mops como modificadores de fase movil. |
| EP2830651A4 (en) | 2013-03-12 | 2015-09-02 | Abbvie Inc | HUMAN ANTIBODIES THAT BIND TNF-ALPHA AND PREPARATION METHODS |
| US10023608B1 (en) | 2013-03-13 | 2018-07-17 | Amgen Inc. | Protein purification methods to remove impurities |
| US9499614B2 (en) | 2013-03-14 | 2016-11-22 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides |
| US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
| WO2015051293A2 (en) | 2013-10-04 | 2015-04-09 | Abbvie, Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
| US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
| US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
| US20150139988A1 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
| WO2015088677A1 (en) | 2013-12-12 | 2015-06-18 | Emd Millipore Corporation | Protein separations using an acrylamide containing filter |
| EP3079722B1 (en) * | 2013-12-13 | 2021-03-24 | Novo Nordisk Health Care AG | Method for thioether conjugation of proteins |
| KR20150083689A (ko) * | 2014-01-10 | 2015-07-20 | 삼성전자주식회사 | 항 c-Met 항체 정제 방법 |
| CN106103465B (zh) | 2014-03-10 | 2021-01-08 | 吉瑞工厂 | 使用预清洗步骤的免疫球蛋白纯化 |
| CN106460027B (zh) * | 2014-03-24 | 2020-07-31 | 日东纺绩株式会社 | 使用阳离子性接枝聚合物的目标物分离浓缩方法 |
| SG11201609908VA (en) * | 2014-05-28 | 2016-12-29 | Agency Science Tech & Res | Virus reduction method |
| JP2017519838A (ja) * | 2014-06-25 | 2017-07-20 | ジェイエイチエル バイオテック インコーポレイテッド | タンパク質の精製のための方法及び試薬 |
| CN104208719B (zh) * | 2014-09-24 | 2017-05-03 | 北京天广实生物技术股份有限公司 | 一种抗体偶联药物的阳离子交换层析纯化方法 |
| CA2966515C (en) * | 2014-12-08 | 2021-04-27 | Emd Millipore Corporation | Mixed bed ion exchange adsorber |
| KR20170122216A (ko) * | 2015-03-06 | 2017-11-03 | 제넨테크, 인크. | 초순수화 dsba 및 dsbc와 이를 제조하고 사용하는 방법 |
| CN106290591B (zh) * | 2015-05-14 | 2019-07-26 | 上海医药工业研究院 | 一种庆大霉素C1a的检测方法 |
| GB2539420B (en) * | 2015-06-16 | 2021-01-13 | Cytiva Sweden Ab | Determination of chromatography conditions |
| CN107849122B (zh) * | 2015-08-21 | 2022-01-25 | 豪夫迈·罗氏有限公司 | 用低电导率洗涤缓冲液进行亲和层析纯化 |
| KR102691585B1 (ko) | 2015-08-21 | 2024-08-05 | 에프. 호프만-라 로슈 아게 | 친화성 크로마토그래피에서의 숙주 세포 단백질 감소 방법 |
| KR102617148B1 (ko) * | 2016-08-15 | 2023-12-26 | 제넨테크, 인크. | 비이온성 계면활성제 및 폴리펩티드를 포함하는 조성물에서 비이온성 계면활성제를 정량화하기 위한 크로마토그래피 방법 |
| GB201702856D0 (en) * | 2017-02-22 | 2017-04-05 | Ge Healthcare Bio Sciences Ab | Method in continuous chromatography |
| US11339377B2 (en) * | 2017-11-08 | 2022-05-24 | Bluesky Immunotherapies Gmbh | SO3 chromatography for use in a method for virus purification |
| CN112384615A (zh) * | 2018-07-04 | 2021-02-19 | 普罗拜奥根股份公司 | 用于纯化包膜病毒的方法 |
| US12306152B2 (en) * | 2018-12-21 | 2025-05-20 | Solventum Intellectual Properties Company | Method for testing a chromatography device used for ion exchange |
| WO2020172658A1 (en) | 2019-02-24 | 2020-08-27 | Bristol-Myers Squibb Company | Methods of isolating a protein |
| AR119264A1 (es) * | 2019-06-05 | 2021-12-09 | Genentech Inc | Método para reutilización de cromatografía |
| CN111351876A (zh) * | 2020-04-01 | 2020-06-30 | 上海中科新生命生物科技有限公司 | 一种抗体药中宿主细胞蛋白半绝对定量检测方法 |
| US11379651B1 (en) * | 2020-07-06 | 2022-07-05 | Turtl Surf & Immerse Limited | Methods and systems for interactive content creation |
| JP2023542924A (ja) * | 2020-09-22 | 2023-10-12 | ブリストル－マイヤーズ スクイブ カンパニー | 治療タンパク質を生産するための方法 |
| JP7620456B2 (ja) * | 2021-03-15 | 2025-01-23 | 株式会社カネカ | κ鎖を含む抗体の製造方法 |
| EP4408856A4 (en) * | 2021-09-28 | 2025-11-12 | Kashiv Biosciences Llc | IMPROVED PROCESS FOR PROTEIN PURIFICATION |
| CA3236213A1 (en) * | 2021-10-27 | 2023-05-04 | Eugene ZURLO | Compositions and methods for isolating proteins |
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-
2012
- 2012-11-02 RS RS20190358A patent/RS58472B2/sr unknown
- 2012-11-02 AU AU2012323995A patent/AU2012323995B2/en active Active
- 2012-11-02 HU HUE12845437A patent/HUE035685T2/en unknown
- 2012-11-02 RU RU2014121884/10A patent/RU2014121884A/ru not_active Application Discontinuation
- 2012-11-02 CA CA2854330A patent/CA2854330A1/en not_active Abandoned
- 2012-11-02 PT PT17157670T patent/PT3257564T/pt unknown
- 2012-11-02 EP EP17157670.5A patent/EP3257564B2/en active Active
- 2012-11-02 KR KR1020147014357A patent/KR20140091721A/ko not_active Withdrawn
- 2012-11-02 ES ES12845437T patent/ES2637423T5/es active Active
- 2012-11-02 JP JP2014540118A patent/JP6356607B2/ja active Active
- 2012-11-02 HR HRP20190485TT patent/HRP20190485T4/hr unknown
- 2012-11-02 SI SI201231031T patent/SI2773438T2/sl unknown
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