JP2014532718A5 - - Google Patents
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- JP2014532718A5 JP2014532718A5 JP2014540118A JP2014540118A JP2014532718A5 JP 2014532718 A5 JP2014532718 A5 JP 2014532718A5 JP 2014540118 A JP2014540118 A JP 2014540118A JP 2014540118 A JP2014540118 A JP 2014540118A JP 2014532718 A5 JP2014532718 A5 JP 2014532718A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- conductivity
- elution buffer
- buffer
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161554898P | 2011-11-02 | 2011-11-02 | |
| US61/554,898 | 2011-11-02 | ||
| PCT/US2012/063242 WO2013067301A1 (en) | 2011-11-02 | 2012-11-02 | Overload and elute chromatography |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018113263A Division JP2018184405A (ja) | 2011-11-02 | 2018-06-14 | オーバーロード／溶出クロマトグラフィー |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014532718A JP2014532718A (ja) | 2014-12-08 |
| JP2014532718A5 true JP2014532718A5 (cg-RX-API-DMAC7.html) | 2015-12-24 |
| JP6356607B2 JP6356607B2 (ja) | 2018-07-11 |
Family
ID=48192803
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014540118A Active JP6356607B2 (ja) | 2011-11-02 | 2012-11-02 | オーバーロード／溶出クロマトグラフィー |
| JP2018113263A Pending JP2018184405A (ja) | 2011-11-02 | 2018-06-14 | オーバーロード／溶出クロマトグラフィー |
| JP2019209674A Active JP6979442B2 (ja) | 2011-11-02 | 2019-11-20 | オーバーロード／溶出クロマトグラフィー |
| JP2021185350A Active JP7203928B2 (ja) | 2011-11-02 | 2021-11-15 | オーバーロード／溶出クロマトグラフィー |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018113263A Pending JP2018184405A (ja) | 2011-11-02 | 2018-06-14 | オーバーロード／溶出クロマトグラフィー |
| JP2019209674A Active JP6979442B2 (ja) | 2011-11-02 | 2019-11-20 | オーバーロード／溶出クロマトグラフィー |
| JP2021185350A Active JP7203928B2 (ja) | 2011-11-02 | 2021-11-15 | オーバーロード／溶出クロマトグラフィー |
Country Status (25)
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108404453B (zh) | 2010-07-30 | 2021-01-05 | Emd密理博公司 | 层析介质和方法 |
| EP2702077A2 (en) | 2011-04-27 | 2014-03-05 | AbbVie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
| RS58472B2 (sr) | 2011-11-02 | 2024-10-31 | Hoffmann La Roche | Hromatografija preopterećenja i eluata |
| US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
| US9181572B2 (en) | 2012-04-20 | 2015-11-10 | Abbvie, Inc. | Methods to modulate lysine variant distribution |
| US9334319B2 (en) | 2012-04-20 | 2016-05-10 | Abbvie Inc. | Low acidic species compositions |
| WO2013176754A1 (en) * | 2012-05-24 | 2013-11-28 | Abbvie Inc. | Novel purification of antibodies using hydrophobic interaction chromatography |
| US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
| MX379269B (es) * | 2012-10-24 | 2025-03-11 | Genzyme Corp | Elucion de biomoleculas de resinas multimodales utilizando mes y mops como modificadores de fase movil. |
| EP2830651A4 (en) | 2013-03-12 | 2015-09-02 | Abbvie Inc | HUMAN ANTIBODIES THAT BIND TNF-ALPHA AND PREPARATION METHODS |
| US10023608B1 (en) | 2013-03-13 | 2018-07-17 | Amgen Inc. | Protein purification methods to remove impurities |
| US9499614B2 (en) | 2013-03-14 | 2016-11-22 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides |
| US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
| WO2015051293A2 (en) | 2013-10-04 | 2015-04-09 | Abbvie, Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
| US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
| US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
| US20150139988A1 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
| WO2015088677A1 (en) | 2013-12-12 | 2015-06-18 | Emd Millipore Corporation | Protein separations using an acrylamide containing filter |
| EP3079722B1 (en) * | 2013-12-13 | 2021-03-24 | Novo Nordisk Health Care AG | Method for thioether conjugation of proteins |
| KR20150083689A (ko) * | 2014-01-10 | 2015-07-20 | 삼성전자주식회사 | 항 c-Met 항체 정제 방법 |
| CN106103465B (zh) | 2014-03-10 | 2021-01-08 | 吉瑞工厂 | 使用预清洗步骤的免疫球蛋白纯化 |
| CN106460027B (zh) * | 2014-03-24 | 2020-07-31 | 日东纺绩株式会社 | 使用阳离子性接枝聚合物的目标物分离浓缩方法 |
| SG11201609908VA (en) * | 2014-05-28 | 2016-12-29 | Agency Science Tech & Res | Virus reduction method |
| JP2017519838A (ja) * | 2014-06-25 | 2017-07-20 | ジェイエイチエル バイオテック インコーポレイテッド | タンパク質の精製のための方法及び試薬 |
| CN104208719B (zh) * | 2014-09-24 | 2017-05-03 | 北京天广实生物技术股份有限公司 | 一种抗体偶联药物的阳离子交换层析纯化方法 |
| CA2966515C (en) * | 2014-12-08 | 2021-04-27 | Emd Millipore Corporation | Mixed bed ion exchange adsorber |
| KR20170122216A (ko) * | 2015-03-06 | 2017-11-03 | 제넨테크, 인크. | 초순수화 dsba 및 dsbc와 이를 제조하고 사용하는 방법 |
| CN106290591B (zh) * | 2015-05-14 | 2019-07-26 | 上海医药工业研究院 | 一种庆大霉素C1a的检测方法 |
| GB2539420B (en) * | 2015-06-16 | 2021-01-13 | Cytiva Sweden Ab | Determination of chromatography conditions |
| CN107849122B (zh) * | 2015-08-21 | 2022-01-25 | 豪夫迈·罗氏有限公司 | 用低电导率洗涤缓冲液进行亲和层析纯化 |
| KR102691585B1 (ko) | 2015-08-21 | 2024-08-05 | 에프. 호프만-라 로슈 아게 | 친화성 크로마토그래피에서의 숙주 세포 단백질 감소 방법 |
| KR102617148B1 (ko) * | 2016-08-15 | 2023-12-26 | 제넨테크, 인크. | 비이온성 계면활성제 및 폴리펩티드를 포함하는 조성물에서 비이온성 계면활성제를 정량화하기 위한 크로마토그래피 방법 |
| GB201702856D0 (en) * | 2017-02-22 | 2017-04-05 | Ge Healthcare Bio Sciences Ab | Method in continuous chromatography |
| US11339377B2 (en) * | 2017-11-08 | 2022-05-24 | Bluesky Immunotherapies Gmbh | SO3 chromatography for use in a method for virus purification |
| CN112384615A (zh) * | 2018-07-04 | 2021-02-19 | 普罗拜奥根股份公司 | 用于纯化包膜病毒的方法 |
| US12306152B2 (en) * | 2018-12-21 | 2025-05-20 | Solventum Intellectual Properties Company | Method for testing a chromatography device used for ion exchange |
| WO2020172658A1 (en) | 2019-02-24 | 2020-08-27 | Bristol-Myers Squibb Company | Methods of isolating a protein |
| AR119264A1 (es) * | 2019-06-05 | 2021-12-09 | Genentech Inc | Método para reutilización de cromatografía |
| CN111351876A (zh) * | 2020-04-01 | 2020-06-30 | 上海中科新生命生物科技有限公司 | 一种抗体药中宿主细胞蛋白半绝对定量检测方法 |
| US11379651B1 (en) * | 2020-07-06 | 2022-07-05 | Turtl Surf & Immerse Limited | Methods and systems for interactive content creation |
| JP2023542924A (ja) * | 2020-09-22 | 2023-10-12 | ブリストル－マイヤーズ スクイブ カンパニー | 治療タンパク質を生産するための方法 |
| JP7620456B2 (ja) * | 2021-03-15 | 2025-01-23 | 株式会社カネカ | κ鎖を含む抗体の製造方法 |
| EP4408856A4 (en) * | 2021-09-28 | 2025-11-12 | Kashiv Biosciences Llc | IMPROVED PROCESS FOR PROTEIN PURIFICATION |
| CA3236213A1 (en) * | 2021-10-27 | 2023-05-04 | Eugene ZURLO | Compositions and methods for isolating proteins |
Family Cites Families (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2413974A1 (fr) | 1978-01-06 | 1979-08-03 | David Bernard | Sechoir pour feuilles imprimees par serigraphie |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| US5567610A (en) | 1986-09-04 | 1996-10-22 | Bioinvent International Ab | Method of producing human monoclonal antibodies and kit therefor |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
| EP0402226A1 (en) | 1989-06-06 | 1990-12-12 | Institut National De La Recherche Agronomique | Transformation vectors for yeast yarrowia |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| AU641673B2 (en) | 1989-06-29 | 1993-09-30 | Medarex, Inc. | Bispecific reagents for aids therapy |
| US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| US5229275A (en) | 1990-04-26 | 1993-07-20 | Akzo N.V. | In-vitro method for producing antigen-specific human monoclonal antibodies |
| AU8295491A (en) | 1990-06-29 | 1992-01-23 | Biosource Technologies Incorporated | Melanin production by transformed microorganisms |
| US5571894A (en) | 1991-02-05 | 1996-11-05 | Ciba-Geigy Corporation | Recombinant antibodies specific for a growth factor receptor |
| CA2102511A1 (en) | 1991-05-14 | 1992-11-15 | Paul J. Higgins | Heteroconjugate antibodies for treatment of hiv infection |
| CA2103059C (en) | 1991-06-14 | 2005-03-22 | Paul J. Carter | Method for making humanized antibodies |
| IE922437A1 (en) | 1991-07-25 | 1993-01-27 | Idec Pharma Corp | Recombinant antibodies for human therapy |
| US5565332A (en) | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
| FI941572L (fi) | 1991-10-07 | 1994-05-27 | Oncologix Inc | Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenetelmä |
| WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
| DK1136556T3 (da) | 1991-11-25 | 2005-10-03 | Enzon Inc | Fremgangsmåde til fremstilling af multivalente antigen-bindende proteiner |
| DE69333807T2 (de) | 1992-02-06 | 2006-02-02 | Chiron Corp., Emeryville | Marker für krebs und biosynthetisches bindeprotein dafür |
| JP3571337B2 (ja) | 1992-02-11 | 2004-09-29 | セル ジェネシス，インコーポレーテッド | 遺伝子標的現象による同型遺伝子接合 |
| US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
| CA2140280A1 (en) | 1992-08-17 | 1994-03-03 | Avi J. Ashkenazi | Bispecific immunoadhesins |
| DE69329503T2 (de) | 1992-11-13 | 2001-05-03 | Idec Pharma Corp | Therapeutische Verwendung von chimerischen und markierten Antikörpern, die gegen ein Differenzierung-Antigen gerichtet sind, dessen Expression auf menschliche B Lymphozyt beschränkt ist, für die Behandlung von B-Zell-Lymphoma |
| CA2106612C (en) | 1993-09-21 | 2001-02-06 | Diana Pliura | Displacement chromatography process |
| US5534615A (en) | 1994-04-25 | 1996-07-09 | Genentech, Inc. | Cardiac hypertrophy factor and uses therefor |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
| US5712374A (en) | 1995-06-07 | 1998-01-27 | American Cyanamid Company | Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates |
| DK1538202T3 (en) * | 1996-09-13 | 2014-03-24 | Shire Human Genetic Therapies | PREPARATION OF HUMANT ALPHA-GALACTOSIDASE A |
| SI0950067T1 (sl) * | 1996-11-27 | 2007-12-31 | Genentech Inc | Afinitetno čiščenje polipeptida na proteinskemA matriksu |
| DE69907439T3 (de) * | 1998-05-06 | 2014-01-02 | Genentech, Inc. | Reinigung von proteinen durch ionenaustauschchromatographie |
| IL127127A0 (en) | 1998-11-18 | 1999-09-22 | Peptor Ltd | Small functional units of antibody heavy chain variable regions |
| EP1345967B1 (en) | 2000-12-22 | 2011-08-10 | Grad, Carole, Legal representative of Kaplan, Howard | Phage display libraries of human v h fragments |
| EA009771B1 (ru) * | 2001-02-01 | 2008-04-28 | Байоджен Айдек Ма, Инк. | Полипептид нейбластина, способы его получения и применения |
| JP2005289809A (ja) | 2001-10-24 | 2005-10-20 | Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) | 突然変異重鎖抗体 |
| US20070261962A1 (en) * | 2002-04-02 | 2007-11-15 | Ryszard Gajek | Separation Systems with Charge Mosaic Membrane |
| US7459085B2 (en) * | 2002-10-18 | 2008-12-02 | Asahi Kasei Medical Co., Ltd. | Microporous hydrophilic membrane |
| AU2004220325B2 (en) | 2003-06-30 | 2011-05-12 | Domantis Limited | Polypeptides |
| WO2006031370A2 (en) | 2004-08-19 | 2006-03-23 | Genentech, Inc. | Polypeptide variants with altered effector function |
| CN101065151B (zh) | 2004-09-23 | 2014-12-10 | 健泰科生物技术公司 | 半胱氨酸改造的抗体和偶联物 |
| CN104610422A (zh) * | 2005-03-11 | 2015-05-13 | 惠氏公司 | 弱分配层析的方法 |
| GB2439875B (en) | 2005-04-22 | 2010-10-20 | Waters Investments Ltd | Apparatus and methods for mass spectrometric directed purification of biopolymers |
| ZA200900836B (en) * | 2006-08-28 | 2010-05-26 | Ares Trading Sa | Process for the purification of FC-fusion proteins |
| BRPI0716382B8 (pt) * | 2006-08-28 | 2021-05-25 | Ares Trading Sa | método para reduzir o teor de porções de fc livres em um fluido compreendendo uma proteína contendo fc, e uso de cromatografia de troca catiônica |
| ES2449148T5 (es) | 2007-06-01 | 2023-06-14 | Hoffmann La Roche | Purificación de inmunoglobulinas |
| DE102009005479A1 (de) * | 2009-01-21 | 2010-07-22 | Sartorius Stedim Biotech Gmbh | Vorrichtung und Verfahren für die Stofftrennung |
| JP5614936B2 (ja) * | 2009-02-19 | 2014-10-29 | 旭化成ケミカルズ株式会社 | アニオン交換基が固定された多孔膜を用いた核酸の精製方法 |
| KR101415660B1 (ko) * | 2009-08-07 | 2014-07-16 | 이엠디 밀리포어 코포레이션 | 샘플 중의 1 이상의 불순물로부터 표적 단백질을 정제하는 방법 |
| WO2011035282A1 (en) * | 2009-09-21 | 2011-03-24 | Ge Healthcare Bio-Sciences Ab | Dual capture separation |
| CN102094034A (zh) * | 2009-12-09 | 2011-06-15 | 泰州新生源生物医药有限公司 | 一种重组人Fc融合长效干扰素的纯化工艺 |
| WO2012030512A1 (en) * | 2010-09-03 | 2012-03-08 | Percivia Llc. | Flow-through protein purification process |
| US20130331554A1 (en) * | 2010-11-15 | 2013-12-12 | Biogen Idec Inc. | Enrichment and concentration of select product isoforms by overloaded bind and elute chromatography |
| RS58472B2 (sr) | 2011-11-02 | 2024-10-31 | Hoffmann La Roche | Hromatografija preopterećenja i eluata |
-
2012
- 2012-11-02 RS RS20190358A patent/RS58472B2/sr unknown
- 2012-11-02 AU AU2012323995A patent/AU2012323995B2/en active Active
- 2012-11-02 HU HUE12845437A patent/HUE035685T2/en unknown
- 2012-11-02 RU RU2014121884/10A patent/RU2014121884A/ru not_active Application Discontinuation
- 2012-11-02 CA CA2854330A patent/CA2854330A1/en not_active Abandoned
- 2012-11-02 PT PT17157670T patent/PT3257564T/pt unknown
- 2012-11-02 EP EP17157670.5A patent/EP3257564B2/en active Active
- 2012-11-02 KR KR1020147014357A patent/KR20140091721A/ko not_active Withdrawn
- 2012-11-02 ES ES12845437T patent/ES2637423T5/es active Active
- 2012-11-02 JP JP2014540118A patent/JP6356607B2/ja active Active
- 2012-11-02 HR HRP20190485TT patent/HRP20190485T4/hr unknown
- 2012-11-02 SI SI201231031T patent/SI2773438T2/sl unknown
- 2012-11-02 EP EP12845437.8A patent/EP2773438B2/en active Active
- 2012-11-02 SG SG11201402019TA patent/SG11201402019TA/en unknown
- 2012-11-02 DK DK12845437.8T patent/DK2773438T4/da active
- 2012-11-02 WO PCT/US2012/063242 patent/WO2013067301A1/en not_active Ceased
- 2012-11-02 PL PL12845437T patent/PL2773438T5/pl unknown
- 2012-11-02 CN CN201280065729.6A patent/CN104023804B/zh active Active
- 2012-11-02 SI SI201231562T patent/SI3257564T2/sl unknown
- 2012-11-02 TR TR2019/03707T patent/TR201903707T4/tr unknown
- 2012-11-02 CN CN201710173196.8A patent/CN107163101B/zh active Active
- 2012-11-02 US US14/355,818 patent/US20140301977A1/en not_active Abandoned
- 2012-11-02 MX MX2014005330A patent/MX2014005330A/es unknown
- 2012-11-02 DK DK17157670.5T patent/DK3257564T4/da active
- 2012-11-02 HU HUE17157670A patent/HUE043755T2/hu unknown
- 2012-11-02 BR BR112014010406A patent/BR112014010406A2/pt not_active Application Discontinuation
- 2012-11-02 PL PL17157670.5T patent/PL3257564T5/pl unknown
- 2012-11-02 ES ES17157670T patent/ES2717536T5/es active Active
- 2012-11-02 EP EP18206718.1A patent/EP3527274B1/en active Active
- 2012-11-02 FI FIEP17157670.5T patent/FI3257564T4/fi active
- 2012-11-02 LT LTEP17157670.5T patent/LT3257564T/lt unknown
-
2014
- 2014-04-22 IL IL232146A patent/IL232146A0/en unknown
- 2014-04-23 ZA ZA2014/02932A patent/ZA201402932B/en unknown
-
2018
- 2018-04-18 US US15/956,635 patent/US20190023768A1/en not_active Abandoned
- 2018-06-14 JP JP2018113263A patent/JP2018184405A/ja active Pending
-
2019
- 2019-11-20 JP JP2019209674A patent/JP6979442B2/ja active Active
-
2020
- 2020-10-20 US US17/075,238 patent/US20210206836A1/en active Pending
-
2021
- 2021-11-15 JP JP2021185350A patent/JP7203928B2/ja active Active
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