RU2014104693A - Система связи, помещенная в заглатываемый продукт - Google Patents

Система связи, помещенная в заглатываемый продукт Download PDF

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RU2014104693A
RU2014104693A RU2014104693/14A RU2014104693A RU2014104693A RU 2014104693 A RU2014104693 A RU 2014104693A RU 2014104693/14 A RU2014104693/14 A RU 2014104693/14A RU 2014104693 A RU2014104693 A RU 2014104693A RU 2014104693 A RU2014104693 A RU 2014104693A
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Хуман ХАФЕЗИ
Дэвид О'РЕЙЛИ
Захедех ХАТАМКХАНИ
Тимоти Робертсон
Патриша ДЖОНСОН
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Протеус Диджитал Хелс, Инк.
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/07Endoradiosondes
    • A61B5/073Intestinal transmitters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14539Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring pH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1468Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1473Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/48Other medical applications
    • A61B5/4836Diagnosis combined with treatment in closed-loop systems or methods
    • A61B5/4839Diagnosis combined with treatment in closed-loop systems or methods combined with drug delivery
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/68Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/68Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/6861Capsules, e.g. for swallowing or implanting
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/007Marking tablets or the like
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01QANTENNAS, i.e. RADIO AERIALS
    • H01Q1/00Details of, or arrangements associated with, antennas
    • H01Q1/27Adaptation for use in or on movable bodies
    • H01Q1/273Adaptation for carrying or wearing by persons or animals

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  • Health & Medical Sciences (AREA)
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  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Medical Informatics (AREA)
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  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Instruments For Viewing The Inside Of Hollow Bodies (AREA)
  • Endoscopes (AREA)
  • Medicinal Preparation (AREA)

Abstract

1. Прибор для связи с использованием тела пользователя, содержащий следующие элементы:проглатываемый ингредиент ипроглатываемое устройство, для обмена информацией, связанное с ингредиентом, причем проглатываемое устройство содержит::несущую структуру;первый материал, физически связанный с несущей структурой; ивторой материал, физически связанный с несущей структурой, расположенный отлично от расположения первого материала, также как и то, что первый материал и второй материал электрически изолированы друг от друга и способны генерировать электрический потенциал при контакте с проводящей жидкостью,при этом несущая структура содержит модуль управления для регулирования проводимости между первым материалом и вторым материалом; апроглатываемое устройство активируется, вступая в контакт с проводящей жидкостью, в результате чего возникает кодированная токовая последовательность, содержащая информацию, кодируемую с использованием модуля управления.2. Прибор по п.1, отличающийся тем, что проглатываемым ингредиентом является пищевой материал.3. Прибор по п.1, отличающийся тем, что проглатываемый ингредиент прикреплен к заглатываемому устройству.4. Прибор по п.1, отличающийся тем, что заглатываемое устройство способно осуществлять связь с детектором, связанным с телом пользователя, и, при этом детектор принимает и декодирует информацию, производимую заглатываемым устройством.5. Прибор по п.1, дополнительно содержащий материал покрытия, обволакивающий заглатываемое устройство6. Прибор по п.5, отличающийся тем, что материал покрытия разрушается на части при жевании пользователем.7. Прибор по п.5, отличающийся т

Claims (24)

1. Прибор для связи с использованием тела пользователя, содержащий следующие элементы:
проглатываемый ингредиент и
проглатываемое устройство, для обмена информацией, связанное с ингредиентом, причем проглатываемое устройство содержит::
несущую структуру;
первый материал, физически связанный с несущей структурой; и
второй материал, физически связанный с несущей структурой, расположенный отлично от расположения первого материала, также как и то, что первый материал и второй материал электрически изолированы друг от друга и способны генерировать электрический потенциал при контакте с проводящей жидкостью,
при этом несущая структура содержит модуль управления для регулирования проводимости между первым материалом и вторым материалом; а
проглатываемое устройство активируется, вступая в контакт с проводящей жидкостью, в результате чего возникает кодированная токовая последовательность, содержащая информацию, кодируемую с использованием модуля управления.
2. Прибор по п.1, отличающийся тем, что проглатываемым ингредиентом является пищевой материал.
3. Прибор по п.1, отличающийся тем, что проглатываемый ингредиент прикреплен к заглатываемому устройству.
4. Прибор по п.1, отличающийся тем, что заглатываемое устройство способно осуществлять связь с детектором, связанным с телом пользователя, и, при этом детектор принимает и декодирует информацию, производимую заглатываемым устройством.
5. Прибор по п.1, дополнительно содержащий материал покрытия, обволакивающий заглатываемое устройство
6. Прибор по п.5, отличающийся тем, что материал покрытия разрушается на части при жевании пользователем.
7. Прибор по п.5, отличающийся тем, что материал покрытия растворяется, вступая в контакт с физиологической жидкостью.
8. Прибор по п.1, отливающийся тем, что прибор настроен с возможностью осуществлять связь с приемником, прикрепленным к коже пользователя.
9. Прибор поп.1, дополнительно содержащий датчик, находящийся в коммуникации с/и электрически подключенный к заглатываемому устройству, причем датчик определяет уровни рН среды, окружающей заглатываемое устройство, и посылает сигнал модулю управления.
10. Прибор по п.2, отличающийся тем, что укомплектован таким образом, что вследствии потребления пищевого материала пользователем, происходит активация заглатываемого устройства для выработки информации, которая указывает, что пищевой материал употреблен.
11. Прибор по п.2, дополнительно содержащий:
корпус, определяющий полость, причем пищевой материал является жидкостью, хранящейся внутри полости корпуса;
материал покрытия, обволакивающий заглатываемое устройство, хранящееся внутри корпуса таким образом, чтобы материал покрытия изолировал заглатываемое устройство от жидкости, пока покрытие не растворится пищеварительной системой пользователя.
12. Прибор по п.1, где заглатываемое устройство дополнительно содержит непроводящую мембрану, прикрепленную к несущей структуре и расположенную относительно первого и второго материалов, таким образом, чтобы облегчить удлинение электрического пути между первым и вторым материалом, когда они находятся в контакте с проводящей жидкостью.
13. Прибор по п.2, дополнительно содержащий фармацевтический продукт в форме, предназначенной для орального приема и связанный с, по крайней мере, одним заглатываемым устройством и пищевым материалом таким образом, чтобы заглатывание также доставляло лекарство.
14. Взаимодействующий пищевой продукт для потребления пользователем, содержащий: корпус, определяющий полость, причем корпус может быть прожеван пользователем, заглатываемое устройство для передачи информации через тело пользователя располагается внутри полости, причем заглатываемое устройство содержит:
несущую структуру;
первый материал, физически связанный с несущей структурой;
второй материал, физически связанный с несущей структурой, расположенный отлично от расположения первого материала, при том, что первый материал и второй материал электрически изолированы друг от друга и способны генерировать электрический потенциал при контакте с проводящей жидкостью,
при этом несущая структура содержит модуль управления для регулирования проводимости между первым материалом и вторым материалом; а
заглатываемое устройство активируется, вступая в контакт с проводящей жидкостью, образуя кодированную токовую последовательность, содержащую информацию, кодируемую с использованием модуля управления.
15. Продукт по п.14, дополнительно содержащий:
покрытие, обволакивающее заглатываемое устройство; и
перевариваемый ингредиент, расположенный внутри полости в корпусе,
причем покрытие изолирует перевариваемый ингредиент от заглатываемого устройства.
16. Продукт по п.15, отличающийся тем, что корпус является гибким, выполненный с возможностью оказывать сопротивление давлению при жевании и разлагаться в желудке пользователя.
17. Продукт по п.15, отливающийся тем, что корпус распадается на части при жевании и освобождает заглатываемое устройство.
18. Продукт по п.15, отличающийся тем, что перевариваемым ингредиентом является жидкость.
19. Продукт по п.14, дополнительно содержащий датчик, находящийся в коммуникации с/и электрически подключенный к заглатываемому устройству, причем датчик определяет уровни рН среды, окружающей заглатываемое устройство, и посылает сигнал модулю управления на активацию коммуникации заглатываемого устройства.
20. Сигнал, вызванный пищевым продуктом, представляющий: перевариваемый материал; совокупность коммуникационных устройств, при том, что каждое коммуникационное устройство содержит:
первый материал, физически связанный с несущей структурой; и
второй материал, физически связанный с несущей структурой, расположенный отлично от расположения первого материала,
причем первый материал и второй материал электрически изолированы друг от друга и представляют электрический потенциал для питания коммуникационного устройства при контакте с проводящей жидкостью,
а несущая структура содержит модуль управления для регулирования проводимости между первым материалом и вторым материалом,
и, по крайней мере, одно коммуникационное устройство расположено внутри полости, определенной корпусом, который растворяется в желудке пользователя, предотвращая активацию коммуникационного устройства и производство сигнала пока пользователь жует пищевой продукт, и
по крайней мере, одно коммуникационное устройство из совокупности коммуникационных устройств имеет покрытие и покрытие разрушается, когда пользователь жует продукт, тем самым активизируя коммуникационное устройство во рту пользователя.
21. Прибор, содержащий:
пищевой продукт;
проглатываемый медикамент, находящийся в пищевом продукте;
множество заглатываемых устройств, находящихся внутри пищевого продукта; и
материал покрытия, обволакивающий каждое заглатываемое устройство из множества заглатываемых устройств, причем материал покрытия подготовлен так, чтобы изолировать каждое заглатываемое устройство из множества заглатываемых устройств в проглатываемом медикаменте, когда материал покрытия не находится в контакте с электропроводящей жидкостью,
пищевой продукт подготовлен так, чтобы высвободить по крайней мере одно заглатываемое устройство из множества заглатываемых устройств во время жевания пищевого продукта, причем по крайней мере одно заглатываемое устройство во время контакта с электропроводящей жидкостью, настроено на генерацию характерного тока, связанного с проглатываемым медикаментом.
22. Прибор, содержащий:
корпус, определяющий полость, причем корпус является гибким, чтобы противостоять давлению жевания, причем корпус растворяется электропроводящей жидкостью;
проглатываемый медикамент, содержащийся внутри полости в корпусе; и
заглатываемое устройство, находящееся внутри полости в корпусе, причем заглатываемое устройство связанно с проглатываемым медикаментом,
корпус, подготовленный для высвобождения заглатываемого устройства во время растворения электропроводящей жидкостью,
заглатываемое устройство, настроенное на генерацию характерного тока, связанного с проглатываемым медикаментом, во время контакта с электропроводящей жидкостью.
23. Прибор по п.22, дополнительно содержащий: пищевой продукт, причем корпус содержится внутри пищевого продукта.
24. Прибор, содержащий:
пищевой продукт;
проглатываемый медикамент, находящийся внутри пищевого продукта; и
заглатываемое устройство, находящееся внутри пищевого продукта, причем заглатываемое устройство включает защитный слой, и заглатываемое устройство связано с проглатываемым медикаментом,
пищевой продукт, подготовленный для высвобождения заглатываемого устройства во время жевания пищевого продукта пользователем, причем защитный слой подготовлен для сохранения заглатываемого устройства по существу неповрежденным во время жевания пользователем, причем защитный слой подготовлен, чтобы быть растворенным желудочным соком пользователя,
заглатываемое устройство, во время контакта с желудочным соком, после растворения рН-чувствительного слоя, настроено на генерацию характерного тока, который заключает в себе кодированную информацию, связанную с проглатываемым медикаментом.
RU2014104693/14A 2011-07-11 2012-07-10 Система связи, помещенная в заглатываемый продукт RU2572017C2 (ru)

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US13/180,507 US8836513B2 (en) 2006-04-28 2011-07-11 Communication system incorporated in an ingestible product
US13/180,507 2011-07-11
PCT/US2012/046126 WO2013009788A2 (en) 2011-07-11 2012-07-10 Communication system incorporated in an ingestible product

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EP (1) EP2731496B1 (ru)
JP (1) JP5805315B2 (ru)
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US8836513B2 (en) 2014-09-16
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