TW201320963A - 組入於可攝取式產品之通訊系統 - Google Patents

組入於可攝取式產品之通訊系統 Download PDF

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TW201320963A
TW201320963A TW101124936A TW101124936A TW201320963A TW 201320963 A TW201320963 A TW 201320963A TW 101124936 A TW101124936 A TW 101124936A TW 101124936 A TW101124936 A TW 101124936A TW 201320963 A TW201320963 A TW 201320963A
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Hooman Hafezi
David O'reilly
Patricia Johnson
Zahedeh Hatamkhany
Timothy Robertson
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Proteus Digital Health Inc
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Abstract

本發明的系統包括傳導元件、電子組件以及不同形式之異質材料的部分電源。與導電流體接觸時，產生電位且完成電源，如此便啟動系統。電子組件控制異質材料間的傳導率以產生獨特的電流特徵。系統亦能與食品結合並傳遞關於食品材料之攝取的資料。

Description

組入於可攝取式產品之通訊系統
本發明關於偵測一事件之通訊系統。更精確而言，本發明揭示包括一種包括具有不同電源及通訊方案的裝置。
包括電子電路可攝取裝置已被提出用於種種不同的醫療應用，包括診斷及治療應用。此等裝置典型需要操作用的內部電源。此等可攝取裝置是可攝取電子囊劑，其於通過人體時收集資料，並傳送該資料到外部接收器系統。此類型電子囊劑的一個例子是在生物體內進行的攝影機。可吞嚥囊劑包括攝影機系統及用以將關注的區域成像於攝影機系統的光學系統。發射器傳送攝影機系統的視頻輸出而接收系統接收被傳送的視頻輸出。其他的例子包括可攝取成像裝置，其具有內部及機內的電源，其獲取來自身體內膣或體腔內部的影像。此裝置的電子電路組件被一在身體內部通過的不活潑的可攝取外殼(例如玻璃外殼)所包圍。其他的例子包括可攝取資料記錄器囊劑醫療裝置。所揭示之裝置(例如感測器、記錄器、電池等)的電子電路是包在不活潑材質組成的囊劑中。
在其他的例子中，易脆的射頻識別(RFID)標籤被用於藥品攝取監控應用方面。為使RFID標籤運作，每個需要內部電源。RFID標籤是被配置來穿過身體傳送射頻信號的天線結構。
此等現存裝置呈現的問題在於電源在裝置內部且此種電源生產成本高且倘若電源洩露或受損則對周圍環境有潛在危害。此外，當裝置用在生物體內時，天線自裝置伸出對於天線受損或造成問題而言是需要擔心的事。
本發明揭露一種用以產生會指示事件發生的獨特特徵的系統。此系統包括能被置於含有導電流體之特定環境內的電路及組件。此一環境的例子是在容置導電流體的容器內部，諸如包括靜脈注射袋的具有溶液之密封袋。一例子是在諸如動物或人類的活機體的身體內部。此種系統是可攝取且/或可消化或部分可消化的。此種系統包括異質材料，產生電位差。此電位差因而電壓是用於電力開啟置於該架構內部之控制邏輯。離子或電流經由控制邏輯從第一異質材料流到第二異質材料且接著透過導電流體以完成一電路。控制邏輯控制二異質材料之間的傳導率且因而控制或調整傳導率。
因為該可攝取電路以可攝取且甚至可消化的組件所組成，即使在用於慢性情況時，該可攝取電路會導致不想要的負作用(若有的話)。可含有的組件的範圍的例子為：邏輯及/或記憶體元件；反器；信號傳輸元件；以及諸如電阻器或電感器的被動元件。在支架表面上之一或多個組件可以以任何方便的組態置放。在固態支架表面上有二或多個組件的地方可設有互連。可攝取電路之所有組件及支架 是可攝取的，且在某些例子中是可消化或部分可消化的。
本揭露包括用以指示事件發生的多種態樣。如以下更詳細說明者，本發明的系統係與導電流體共用以藉由接觸導電流體與系統之間來指示被標記的事件。例如，本揭露的系統可以與醫藥製品共用且被指示出的事件是當該製品被服用或攝取時。名詞「被攝取」或「攝取或「攝取中」被瞭解係指任何身體內部的系統的引入。舉例來說，攝取中單純指將系統置入口中直到降結腸。因此，此攝取中一詞意指當系統被引入含有導電流體之環境時的時間上任何瞬間。另一例子是當非導電流體與導電流體混合時的情況。在此一情況中，系統會在非導電流體中且當兩液體混合時，系統與導電流體接觸且系統被啟動。又另一例子是當所需之特定液體的存在要被偵測時的情況。在此等例子中，在導電流體內之被啟動之系統的存在可被偵測到，且因而個別液體的存在會被偵測到。
現再度參照系統與被攝取進活機體的製品共用的例子，當包括該系統的製品被服用或攝取時，裝置與身體的導電流體相接觸。當本發明的系統與體液相接觸時，產生電位且系統被啟動。一部分電源是由裝置提供，而另一部分的電位係由導電流體提供，此於下文詳述。
現參照圖1，包含本發明系統之可攝取囊劑14顯示於身體內部。囊劑14被配置為以口攝取的藥丸或囊劑形式 的醫藥配方。於攝取之際，囊劑14移至胃。到達胃之際，囊劑14與胃液18接觸並經歷與胃液18中諸如氫氯酸及其他消化器官的不同材料的化學反應。本發明系統係參照醫藥環境加以討論。然而，本發明的範圍不侷限於此。本發明能用於任何環境，例如，有導電流體或透過混合兩種或多種形成導電流體之成分而變成有導電流體處。
現參照圖2A，類似圖1之囊劑14的醫藥製品10係與諸如可攝取事件標記裝置或離子發射模組的系統12共同顯示。本發明範圍不侷限於製品10的形狀或種類。例如，熟於此技之人士會明白製品10可以是囊劑、限時釋放口服劑量、錠劑、膠囊、舌下錠、或任何可以與系統結合的口服劑量製品。
此外，本發明的系統12可被攝取而不用經由載體囊劑的醫藥製品，其僅包括系統而沒有其他活性劑。根據本發明一態樣，系統12可用作為食品或食品中的成分。例如，系統12塗覆以如以下詳述的塗層。系統12接著包含在該食品中，類似任何的成分。因此，該食品的攝取可被自動追蹤，其通常在需要設定知悉實際服用的食品及攝取時間方面是有用的，例如，當某人有特殊飲食或正在醫院以病人或住院病人身分接受照顧時。
根據本發明另一例子，系統12可與一般用於製作食品的成分結合。例如，系統12可依類似於系統12固定於醫藥製品的方式來固定於鹽。接著當該成分與系統混入食品時，食品將包含該系統，其會於攝取時變成啟動的。
根據本發明的種種態樣，當系統12與食品結合且被攝取時，有多種不同的方法啟動系統12。根據本發明一態樣，系統12被塗覆以於食品正被咀嚼(例如嚼或壓碎)時會破裂及釋放系統12的材料。根據本發明另一態樣，塗層材料可對唾液起反應且當與唾液相接觸時會溶解或崩解而釋放系統12。與唾液結合的導電流體可啟動系統12。根據本發明另一態樣，塗層材料於與胃液接觸之際可對胃酸起反應且溶解或崩解以釋放系統12。根據本發明另一態樣，該塗層材料於被咀嚼或曝露於唾液時可以以抗破裂或溶解的材料製成，像是在飲料中找到的珠粒。根據本發明另一態樣，該塗層材料於分佈或混入食品內時可被故意毀壞或破壞，像是當混合麵包及製備食品(例如比薩餅麵團)時。
繼續參照圖2A，在所顯示的態樣中，製品10使用將微裝置固定於醫藥製品、或可攝取成分(例如食品或食品的成分)外部的習知方法使系統固定在外部。將微裝置固定於醫藥製品外部的習知方法係揭示於2009年1月1日申請之第61/142,849之名為「HIGH-THROUGHPUT PRODUCTION OF INGESTIBLE EVENT MARKERS」的美國專利臨時申請案，以及2009年5月12日申請之第61/177,611號之名為「IGESTIBLE EVENT MARKERS COMPRISING AN IDENTIFIER AND AN INGESTIBLE COMPONENT」的美國專利臨時申請案，其各整體揭露內容於此併入參考。一旦被攝取，系統12便與體液接觸而系統12被啟動。系統12利用電位差來電力開啟且之後調節傳導率以產生獨特且可識別的電 流特徵。於啟動之際，系統12控制傳導率且因而電流以產生電流特徵。
有種種延遲系統I2啟動的原因。為延遲系統12的啟動，系統12可塗覆以遮罩材料或保護層。該層經過一段時間會溶解，從而允許系統12於製品10已到達目標位置時被啟動。
現參照圖2B，類似圖1之囊劑14的可攝取製品/成分20係與諸如可攝取事件標記裝置或可識別發射模組的系統22共同顯示。本發明範圍不侷限於製品10的形狀或種類系統22被引入環境。例如，系統22可被包在醫藥製品以外服用的囊劑內。該囊劑可以僅是系統22的載具且不包含任何製品。再者，本發明範圍不侷限於製品20的形狀或種類。例如，熟於此技之人士會明白製品20可以是食品或食品成分、囊劑、限時釋放口服劑量、錠劑、膠囊、舌下錠、或任何可以與系統結合的口服劑量製品。在參照的態樣中，製品20使系統22放置在製品20的內部或固定在製品的內部。在一態樣中，系統22被固定製品20的內壁。當系統22設置於膠囊內部時，膠囊的內容物是非導電膠液。另一方面，倘若膠囊的內容物是非導電流體，則於另一態樣中，系統22被塗覆以護套以防止不想要之由膠囊內容物的啟動。倘若囊劑內容物是乾粉或微球粒，則系統22被設置或置於囊劑內部。倘若製品20是錠劑或硬藥丸，則系統22被保持在錠劑內固設置。一旦被攝取，含有系統22的製品20被崩解或溶解。系統22與體液 接觸且系統22被啟動。取決於製品20，系統22可以設置於接近中心或接近邊緣位置，端視初始攝取時間與系統22啟動之間所想要的啟動延遲而定。例如，系統22的中心位置表示系統22要較長的時間才會與導電流體接觸，且因而系統22要較長時間被啟動。因此，要花較長時間才會偵測到事件的發生。
現參照圖3，在一態樣中，圖2A及2B的系統11及系統22分別較詳細顯示為系統30。如上述，系統30與任何醫藥製品聯合使用，以決定病人何時服用醫藥製品。如上所指出者，本發明範圍不受限於環境及與系統30供用的製品。例如，系統30可置於囊劑內且囊劑置於導電流體中。囊劑接著經過一段時間溶解並系統30釋放進導電流體。因此，在一態樣中，囊劑會含有系統30而無製品。此種囊劑可接著用於任何有導電流體以及與任何製品共用。例如，囊劑可以滴進充填有航空燃油、鹽水、蕃茄醬、機油、或任何類似製品的容器。此外，含有系統30的囊劑可以在任何醫藥製品被攝取的相同時間被攝取，以便記錄諸如製品何時被服用的事件的發生。
在系統30與醫藥製品結合的特定例子中，當製品或藥丸被攝取時，系統30被啟動。系統30控制傳導率以產生要被偵測到的獨特電流特徵，從而表示該醫藥製品已被服用。系統30包括架構32。架構32係系統30的框架且多種組件附接到、沈積於或固定在架構32。在系統30的此一態樣中，可消化的材料34與架構32實體結合。材料 34可化學沈積於、蒸發到、固定在、或建構於架構32。材料34被沈積於架構32的一側。所關注之可用作為材料34的材料包括但不侷限於：Cu或CuI。材料34的沈積在協定之中可藉由物理氣相沈積、電沈積或電漿沈積。材料34可從0.05到約500μm厚，像是從約5到約100μm厚。形狀係由遮罩沈積、或光刻及蝕刻所控制。此外，即使只有顯示一用以沈積該材料的區域，但每一系統30可包含二或多個可以沈積材料34的電獨特區域，如所想要的。
在圖3所示之相反側的一不同側，沈積另一可消化材料36，使得材料34及36為異質。雖未顯示，但所之不同側可以是針對材料34所選之側的緊鄰側。本發明範圍不侷限於所選的側且「不同側」一詞可以指任何與首先選擇側相異的多個側。再者，即使系統的形狀顯示為正方形，但形狀可以是任何幾何上適合的形狀。材料34及36被選擇使得其當系統30與是體液的導電流體相接觸時產生電位差。所關注之材料36的材料可以包括但不侷限於Mg、Zn或其他負電性金屬。如上述關於材料34所指出者，材料36可化學沈積於、蒸發到、固定在、或建構於架構。而且，可要黏合層來幫助材料36(以及材料34，有需要時)黏到架構32。材料36的典型黏合層是Ti、TiW、Cr或類似材料。陽極材料及黏合層的沈積可以藉由物理氣相沈積、電沈積或電漿沈積。材料36可從0.05到約500μm厚，像是從約5到約100μm厚。然而，本發明範圍不侷限於該厚度或任何材料或是任何用來沈積或固定材料到架構32 的方法種類。
根據所述的揭露內容，材料34及36可以是任何具有不同電化電位的材料對。此外，在系統30係用於生物體內的態樣中，材料34及36能以任何兩種適合系統30將運作的環境之材料組成。例如，當與可攝取製品共用時，材料34及36係任何具有不同電化電位之可攝取的材料對。說明例包括當系統30與諸如胃液的離子溶液成接觸時的例子。適合的材料並不侷限於金屬，且在某些態樣中，該成對材料係選自金屬及非金屬，例如一對由金屬(諸如Mg)與鹽(諸如CuCl或CuI)所組成。對於活性電極材料而言，任何成對的材料-金屬、鹽、或插層化合物-具有適當不同電化電位(電壓)及低介面阻力者係合適合的。
所關注之材質及配對包括但不侷限於以下表1所報告者。在一態樣中，該等金屬的一或二者可以被摻雜例如非金屬，以強化當其導電流體相接觸時產生於材質間的電位。在某些態樣中可用作為摻雜劑的非金屬包括但不侷限於：硫、碘及其類似物。在另一態樣中，材質為碘化銅(CuI)作為陽極而鎂(Mg)作為陰極。本發明的態樣所使用的電極材料對人體無害。
因此，當系統30與導電流體相接觸時，電流路徑，如圖5所示的例子者，係透過材料34與36間的導電流體形成。控制裝置38固定於架構32且電耦合到材料34與36。控制裝置38包括電子電路，例如能夠控制及改變材料34與36間之傳導率的控制邏輯。
產生於材料34與36間的電位提供用以操作系統的電力以及產生經過導電流體及系統的電流。在一態樣中，系統操作於直流模式。在一替代態樣中，系統控制電流的方向，使得電流方向以類似交流電的周期方式反向。當系統抵達流體或電解液成分係由例如胃酸的生理流體所提供的導電流體或電解液處時，在材料34與36間的電流路徑便在系統30外部完成。經過系統30的電流路徑受控於控制裝置38。電流路徑的完成可讓電流流動，且接收器(未顯示)能偵測電流的存在並辨識出系統30已被啟動且想要的 事件正發生或已發生。此等接收器的說明例進一步參照圖7至12說明於下文。
在一態樣中，兩材料34與36在功能方面類似諸如電池之直流電源所需的兩電極。導電流體作用為完成電源所的電解液。所述之完成的電源可以被視為一種利用離子或諸如胃液、血、或其他體液及組織的導電溶液中的電化傳導率的電源。
此外，環境可以是有別於身體的環境，且液體可以是任何導電液體。例如，導電流體可以是鹽水或金屬為基礎的顏料。
在特定的態樣中，此兩種材料以附加的材質層遮罩免於周圍環境傷害。當遮罩溶解而該兩種異質材料曝露於目標位置時，電位於是產生。
在某些態樣中，完成的電源或電源供應係由活性電極材料、電解液、及非活性材料，諸如受電器、包裝等所組成。活性材料係任何具有不同電化電位的材料對。適合的材料不限於金屬，且在某些態樣中，成對的材料係選自金屬及非金屬，例如以金屬(諸如Mg)與鹽(諸如CuI)組成的一對。對於活性電極材料而言，任何成對的材料-金屬、鹽、或插層化合物-具有適當不同電化電位(電壓)及低介面阻力者係合適合的。
多種不同材料可被用作為形成電極的材料。在某些態樣中，電極材料被選擇於與例如胃的目標生理位置接觸之際提供電壓，其足夠驅動識別器的系統。在某些態樣中， 於電源之金屬與目標生理位置接觸之際由電極所提供的電壓係等於或高於0.001 V，包括等於或高於0.01 V，諸如等於或高於0.1 V，例如等於或高於0.3 V，包括等於或高於0.5 V，且含等於或高於1.0 V，其中在某些態樣中，電壓範圍從約0.001到約10伏特，諸如從約0.01到約10 V。
現參照圖3，材料34與36提供電位元來啟動控制裝置38。一旦控制裝置38被啟動或被電力開啟，控制裝置38可以以獨特方式改變材料34與36間的傳導率。藉改變材料34與36間的傳導率，控制裝置38能夠控制經過圍繞系統30之導電流體的電流大小。此產生能被接收器(未顯示)所偵測及測量之獨特的電流特徵。接收器的說明例進一步參照圖7至12說明於下文。除了控制材料間電流路徑的大小以外，非導電材料、膜、或「裙部(skirt)」係用來增加電流路徑的「長度」，因此，作為增加傳導路徑之用，如揭露於2008年9月25日申請之序號第12/238,345且於2009年3月6日公開為第2009-0082645 A1號之名為「In-Body Device with Virtual Dipole Signal Amplification」的美國專利申請案，其整體內容於此併入參考。或者，此處通篇揭露內容中，名詞「非導電材料」、「膜」、及「裙部」可以與「電流路徑延伸器」互換而不影響此處本態樣及申請專利範圍的範疇。在35及37處所顯示之部位的裙部分別可以例如固定於架構32而與架構32結合。裙部的種種形狀及配置係在本發明範圍內。例如，系統30可以整個或部分被裙部包圍，且裙部可以 沿著系統30的中心軸線或對中心軸線偏心的方式設置。因此，此處本發明的範圍不侷限於裙部的形狀或尺寸。再者，在其他態樣中，材料34與36可被一裙部隔開設置於材料34與36間任何界定區域中的裙部所隔開。
現參照圖4，在另一態樣中，圖2A及2B的系統12及22分別更詳細顯示為系統40。系統40包括架構42。架構42類似圖3之架構32。在系統40的態樣中，可消化或可溶解材料44被沈積在架構42的一部位上。架構42的相同側的不同部位處沈積另一可消化材料46。更精確而言，材料44與46被選取使得當他們與諸如體液的導電液體接觸時形成一電位差。因此，當系統40與導電液體相接觸或部分接觸時，接著電流路徑，圖5所示的例子，透材料44與46間的導電液體形成。控制裝置48固定於架構42且電耦合到材料44與46。控制裝置48包括能夠控制材料44與46間的部分傳導路徑。材料44與46被非導電裙部49隔開。裙部49的種種例子揭露於2009年4月28日申請為美國專利臨時申請案第61/173,511號之名為「HIGHLY RELIABLE INGESTIBLE EVENT MAKERS AND METHODS OF USING SAME」的申請案，以及於2009年4月28日申請為美國專利臨時申請案第61/173,564號之名為「INGESTIBLE EVENT MARKERS HAVING SIGNAL AMPLIFIERS THAT COMPRISE AN ACTIVE AGENT」的申請案，以及於2008年9月25日申請為美國專利申請案第12/238,345號之名為「IN-BODY DEVICE WITH VIRTUAL DIPOLE AMPLIFICATION」的申請案；其等整體內容分別於此併入參考。
一旦控制裝置48被啟動或動力開啟，控制裝置48能改變材料44與46間的傳導率。因此，控制裝置48能夠控制經過圍繞系統40之導電液體的電流的大小。如上參照系統30所述，與系統40相關聯之獨特電流特徵能被接收器(未顯示)偵測到以標記系統40的啟動。說明例可見於下文描述的圖7至12的接收器的例子。為增加電流路徑的「長度」，裙部49的尺寸被改變。電流路徑愈長，則接收器愈容易偵測到電流。
現參照圖5，顯示圖3的系統30於啟動狀態且與導電流體相接觸。系統30透過接地點52接地。例如，當系統30與導電流體相接觸時，導電流體提供接地。系統30亦包括感測器模組74，其會參照圖6詳述。離子或電流路徑50形成於材料34與36間且透過導電流體與系統30相接觸。產生於材料34與36間的電位係透材料34/36與導電流體間的化學反應而產生。
系統30亦包括單元75。單元75包括致能通訊功能的態樣且依據本發明種種態樣能作用為以下任一者：接收器、發射器、或收發器。因此，在系統30外部的另一裝置，諸如行動電話、植入裝置、附接於使用者身體的裝置、或任何置於使用者皮膚下的裝置，透過單元75，例如可與系統30通訊。單元75亦電連接到材料34與36。根據本發明一態樣，任何在系統30外部的裝置可使用流經圍繞 系統30之環境與單元75或控制模組38通訊。例如，附接於使用者身體的補片或接收器、行動電話或由使用者手持的裝置、或植入裝置，其等任一者能透過使用者身體產生電流特徵。電流特徵能包括在其內編碼的資訊。使用單元75或控制模組38，電流特徵被系統30偵測，且被解碼以允許從系統30外部之裝置到系統30的通訊。於是，該外部裝置能以無線或透過傳導傳送一信號到單元75，其控制系統30的啟動。
倘若環境的條件改變以變成利於通訊，如環境之測量所決定者，則單元75傳送一信號到控制裝置38來改變材料34與36間的傳導率以允許使用系統30的電流特徵的通訊。因此，倘若系統30已被停用且倘若環境的阻抗適於通訊，則系統30能再度被啟動。
現參照圖5A，此顯示材料34的表面的分解圖。在一態樣中，材料34的表面並不平坦，但反而像是不規則表面。該不規則表面增加材料之表面區域，且因而，該區域與導電流體相接觸。在一態樣中，在材料34的表面處，在材料34與周圍導電流體之間有電化學反應，使得質量與導電流體互換。此處使用的名詞「質量」包括任何可以被加或移除自導電流體之作為發生於材料34之電化反應的一部分之離子或非離子物種。一例子包括材料是CuCl且當與導電流體相接觸時的例子，CuCl被轉換成Cu金屬(固體)且Cl-被釋放進溶液。正離子的流進導電流體係電流路徑50來繪示。負離子以反方向流動。依類似方式， 有涉及材料36的電化反應導致離子自導電流體釋放或移除。於此例子中，在材料34負離子的釋放及由材料36正離子的釋放透過控制裝置38控制之電流係彼此有關。反應速率及因此的離子發射速率或電流係受控於控制裝置38。控制裝置38能藉由改變其內部傳導率而增加或減少離子流的速率，其改變阻抗，且因此在材料34與36的電流及反應速率。透過控制反應速率，系統30能編碼在離子流中的資訊。因此，系統30使用子發射或流來編碼資訊。
控制裝置38可以改變離子流或電流的期間而同時保持電流或離子流大小接近常數，類似當頻率被調變且大小是常數時。而且，控制裝置38能改變離子流速率或電流的大小而同時保持期間接近常數。因此，使用種種在期間方面的變化的組合及改變速率或大小，控制裝置38編碼或離子流中資訊。例如，控制裝置38可使用但不侷限於以下技術的任一者，包括二元相位移鍵控(PSK)、調頻、調幅、開關按鍵、及利用開關按鍵的PSK。
如上所示，此處揭露的種種態樣，諸如圖3及48分別所示之系統30及40，包括作為控制裝置38或控制裝置48部分的電子組件。可存在的組組件包括但不侷限於：邏輯及/或記憶體元件、積體電路、電感器、電阻器、及用以測量種種參數的感測器。各個組值可以固定於架構及/或另一組件。在支之表面上的組件可以以任何方便的組態配置。在固體支架的表面上有二或多個組件之處可提供互連。
如上所示，諸如控制裝置30及40的系統，控制異質材料間的傳導率且因而，離子流或電流的速率。透過依特定方式改變傳導率，系統能夠編碼離子流中的資訊及電流特徵。離子流或電流特徵係用來獨特地辨識特定系統。此外，系統30及40能夠產生種種不同的獨特模式或特徵，且因而提供額外資訊。例如，基於第二傳導率模式的第二電流特徵可用以提供額外資訊，該資訊可關於實體環境。為進一步說明，第一電流特徵可以是維持晶片上的振盪器的非常低的電流狀態，第二電流特徵可以是至少較與第一電流特徵相關聯之電流狀態高十的因數的電流狀態。
現參照圖6，顯示表示控制裝置38之方塊圖。控制裝置30包括控制模組62、計數器或時脈64、以及記憶體66。此外，裝置38顯示包括感測器模組72以及於圖5參照過的感測器模組74。控制模組62具有電耦合到材料34的輸入68以及電耦合到材料36的輸出70。控制模組62、時脈64、記憶體66以及感測器模組72/74亦具有電力輸入(有些未顯示)。每一個此等組件的電力係當系統30與導電流體相接觸時由材料34及36與導電流體間的化學反應所產生的電位所提供。控制模組62透過會改變系統30之全部阻抗的邏輯來控制傳導率。控制模組62電耦合到時脈64。時脈64供時脈週期給控制模組62。基於控制模組62的經編程特性，當經設定之數目的時脈週期已經過時，控制模組62改變材料34與36的傳導率特性。此週期重覆且因此控制裝置38產生一獨特的電流特徵特性。控制 模組62亦電耦合到記憶體66。時脈64及記憶體66係由材料34與36間所產生的電位來提供電力。
控制模組62亦電耦合到並與感測器模組72與74通訊。在所示的態樣中，感測器模組72是控制裝置38的一部分而感測器模組74是獨立的組件。於替代態樣中，可使用感測器模組72與74二者中的任一者而不用另一者，且本發明範圍並不侷限於感測器模組72或74的結構或功能位置。此外，系統30的任何組件可功能上或結構上移動、結合或復位而不會限制本發明所主張的範圍。因此，有可能具有一例如處理器的單一結構，其設計來執行以下有模組的功能：控制模組62、計數器或時脈64、記憶體66及感測器模組72或74。另一方面，亦可在本發明範圍內使此等功能組件的每一者位於電力鏈結且能構通訊的獨立結構中。
現再度參照圖6，感測器模組72或74能包括以下感測器的任一者：溫度、壓力、pH值水準及傳導率。在一態樣中，感測器模組72或74集結來自環境的資訊並將該類比資訊傳遞到控制模組62。控制模組接著將該類比資訊轉換成數位資訊，而該數位資訊以電流或產生離子流的質量傳送的速率編碼。在另一態樣中，感測器模組72或74集結來自環境的資訊並將該類比資訊轉換成數位資訊且接著將該數位資訊傳遞到控制模組62。在圖5所示的態樣中，顯示感測器模組74電耦合到材料34與36以及控制模組38。在圖6所示的另一態樣中，感測器模組74在接點 78電耦合到控制裝置38。接點78同時作為感測器模組74的電源以及感測器模組74與控制裝置38間的通訊通道二者。
現參照圖5B，系統30包括連接到根據要執行之感測功能的特定型態所選擇的材料39的pH值感測器模組76。pH值感測器模組76亦連接到控制裝置38。材料39以非導電阻隔件55而與材料34電隔離。在一態樣中，材料39是鉑。在操作方面，pH值感測器模組76使用材料34與36間的電位差。pH值感測器模組76測量材料34與材料39間的電位差並將該直記錄供以後比較之用。pH值感測器模組76亦測量材料39與材料36間的電位差並將該直記錄供以後比較之用。pH值感測器模組76使用該等電位值記算周圍環境之pH水準。pH值感測器模組76提供該資訊給控制裝置38。控制裝置38改變產生離子傳送的質量傳送的速率及電流以將與離子傳送中之pH水準有關的資訊編碼，其可被接收器(未顯示)所偵測。接收器的說明例進一步參照圖7至12說明於下文。因此，系統30可以決定並提供有關pH水準的資訊給環境的外源。
如上所示，控制裝置38能事先被編程以輸出一預先界定之電流特徵。在另一態樣中，系統能包括接收器系統，其能當系統被啟動時接收編程資訊。在未顯示的另一態樣中，開關64及記憶體66能結合成一個裝置。
除上述組件以外，系統30亦可包括一或其他電子組件。所注之電子組件包括但不侷限於：例如以積體電路形 式的附加邏輯及/或記憶體元件；電力調節裝置，例如電池、燃料電池或電容器；感測器、刺激器等；被動元件，例如電感器、電阻器等。
在某些態樣中，可攝取電路包括塗層。此塗層的目的能改變，例如，於處理期間、於儲存期間或甚至於攝取期間保護電路、晶片及/或電池或任何組件。在此等例子中，可包括在該電路頂面上的塗層。同樣關注的塗層是設計來於儲存期間保護該可攝取電路，但於使用期間馬上溶解。例如，塗層於與諸如胃液的水性流體或如上述的導電流體相接觸之際溶解。同樣關注的是保護處理塗層，其被用來允許使用在其他方面損害裝置的特定組值的處理步驟。例如，在產生具異質材料沈積在頂面及底面的晶片的態樣中，製品需要被切丁。然而，切丁程式會刮掉異質材料，而且還可能有關液體會致異質材料排出或溶解。在此等例子中，亦可利用在材料上的保護塗層防止與組件於處理期間的機械或液體接觸。可溶解塗層的另一目的可用以延遲裝置的啟動。例如，可利用置放在異質材料上且花一段例如五分鐘與接觸胃液時溶解的塗層。該塗層亦能是對環境敏感的塗層，例如，溫度或pH敏感塗層，或是其他化學敏感塗層，以一受控的方式溶解且允許吾人於想要時啟動該裝置。可在胃部存活但在小腸溶解的塗層亦是受到關注的，例如，吾人想要延遲啟動直到該裝置離開胃部為止時。此種塗層的一個例子是聚合物，其在低pH值不溶，但在較高pH值時變成可溶。此外所關注的是醫藥配方保護 塗層，例如膠囊液體保護塗層，其防止電路被膠囊的液體啟動。
受關注的識別器包括二異質材料，其作用類似電源的電極(例如陽極及陰極)。此處提到電極或陽極或陰極僅是為了作為說明例。本發明範圍並不侷限於所使用的標籤且包括於二異質材料間產生電位的態樣。因此，當提及電極、陽極、或陰極時，其係為了二異質材料間產生電位的參照。
當材料曝露且與諸如胃液或其他種類的流體(獨自或與乾燥傳導介質先質結合)的體液相接觸時，電位差，亦即電壓，產生於電極間作為發生在該二電極材料之個別氧化及還原反應的結果。於是，在本發明態樣中，配置此種電源使得當二異質材料曝露到例如胃、消化道等目標位置時，產生電壓。
在某些態樣中，一或二金屬可被摻雜非金屬，例如，以強化電池的電壓輸出。在某些態樣中可用作為摻雜劑的非金屬包括但不侷限於：硫、碘及其類似者。
根據本發明種種態樣，本發明系統可在特定食品(例如格蘭諾拉麥片棒(granola bar))內部，其中一被編碼並被系統傳遞的資料是食品的大蒜內容或其他相關飲食資訊，例如，纖維糖含量、脂肪類型及含量等。此可幫助進行特別飲食的人監控他們的每日攝取量、因保持特別飲食而得到獎勵等等。此外，該系統係與食品共同攝取的，使用機上感測來測被釋放進胃中的食品，例如脂肪含量。種種態 樣可包括工具杯，其偵測本發明系統何時已掉入該杯以及使用者或人體是否喝了飲料(例如類似於2011年4月11日申請之第PCT/US11/3196號PCT申請案中描述的吸入器產品，其整體內容於此併入參考)、以及喝了多少。本發明此態樣的優點於對於服用飲用之前與水混合之呈粉或其他形式的規律補充品的人而言可以是有用的。
根據本發明的其他態樣，化學製品指示器能將特定指示器種類結合到食品(例如鹽、低或高pH值、蛋白質、及油脂)。當被攝取時，指示器種類被釋放進胃部環境。利用感測能力，本發明的系統偵測在表面上的化學結合受體或藉由在與化學活性塗層(例如諸如只允許想要的指示器種類穿過的特殊離子導電玻璃膜)反應的該系統上塗層。在種種態樣中，可攝取或咀嚼的系統能包含能夠測量心內膜的偵測器，例如敘述於DiPatrizio等人之名為「Endocannabinoid signal in the gut controls dietary fat intake」的出版物，其整體內容於此併入參考)。當偵到信號時，例如，已發生攝取高脂肪食品的跡象，使用者或病人透過電話訊息或其他通訊而受到指示服用處方(亦可為遠端安裝服務(RIS)的)來中斷該心內膜信號，因而減少渴望更高脂肪食品。
根據本發明另一態樣，該系統於裙部消失時可被偵測到。根據本發明另一態樣，例如藉薄化矽膠。該系統咬食安全。根據本發明一態樣，本發明的數個系統係置於食品中，故倘若一些可攝取裝置於咀嚼期間損害，仍然有功能性的裝置在。因此，該系統可分佈於整個食品，所以被偵 測到的系統數給予所消耗食品量的指示。此外，本發明另一態樣教示本發明系統能以膠黏物質環繞且來層疊於在低pH值下而非中性pH值(唾液)可溶的聚合物層。再者，根據本發明另一態樣，藉反向塗層，得到相反的效果。首先以pH值敏感的聚合物塗層/疊層本發明系統，接著將其插入例如軟糖(gummy bites)之小又膠性的粒子內部，有助其在口中倖存。因此，本發明的系統位在像幹貝熊軟糖(gummy-bear)的保護層內部，且可在尺寸方面縮減，諸如無裙部或可撓式裙部。該保護層可以由多層構成或是可具有密度溶解性梯度使得最接近系統之材料只是緩慢可溶且由於其滑溜的表面、圓的形狀及非常小的尺寸而可能被吞嚥。根據本發明另一態樣，系統除了探測及局部阻抗以外，還會有一電路修改，其於局部阻抗高時有反饋以延後啟動。此讓剩餘的層有時間溶解。一旦液體穿過系統馬上被啟動或開啟，但無法傳送充分的信號強度供偵測，高電流及電池耗盡延後直到阻抗充分降為止。因此，根據本發明此一態樣的系統被放進預量的餐及點心類型以讀出何者被消耗。
為說明之目的，種種接收器可與本發明的種種態樣共用。在有時於本文稱為「信號接收器」的接收器的一個例子中，可使用二或多個不同解調協定來解碼一給定的接收信號。在某些例子中，可使用同調解調協定及差分同調解調協定。圖7提供根據本發明一態樣接收器如何可實施一同調解調協定的功能方塊圖。應注意圖7只顯示一部分的 接收器。圖7顯示一旦決定載波頻率(以及載波信號向下混合成載波偏移)，將信號向下混合成基頻的程式。載波信號2221與第二載波信號2222在混合器2223混合。窄低通濾波器2220被施以適合的頻寬以減少界外雜訊的影響。根據本發明的同調解調方案解調在方塊2225發生。複合信號的展開相位2230被決定。可施加任選的第三混合器階級，其中使用相位展開來估計計算出與實際載波頻率間的頻率差動。接著在方塊2240利用封包的結構來決BPSK信號之FM編碼區域的開始。主要地，作為該複合解調信號之中的FM沿的同步標頭的存在係用以決定封包的起始界。一旦決定了封包的起始點，信號便在IQ平面上的方塊2250旋轉而在方塊2260標準位元識別且最後被解碼。
除了解調以外，穿體通訊模組可包括前向偵錯模組，該模組可提供額外增益來對抗來自不需要之信號及雜訊的幹擾。所關注之前向偵錯模組包括描述於序號PCT/US2007/024225且公開為WO 2008/063626的PCT申請案中，其內容於此併入參考。在某些例子中，前向偵錯模組可利用任何方便的協定，諸如裏憄索羅門校正碼(Reed-Solomon)、高利(Golay)、漢明(Hamming)、BCH以及渦輪(Turbo)協定，來識別並校正(界內)解碼錯誤。
在另一例子中，接收器包括如圖8所示之功能方塊圖口中的信標。圖8簡圖中的方案概括一種用以識別有效信標的技術。進入信號2360呈現被電極接收、經一高頻信 號鏈(包括該載波頻率)帶通濾波(諸如從10 KHz至34KHz)、以及從類比轉換成數位的信號。信號2360接著在方塊2361被抽取並在混合器2362以正常驅動頻率(諸如12.5 KHz、20 HHz等)被混合。結果信號在方塊2364被抽取並在方塊2365被低通濾波(諸如5 KHz BW)以產生被向下混合成載波偏移的載波信號2369。信號2369進一步被方塊2367處理(快速傅立葉轉換且接著二最強峰值偵測)以提供正真實的載波頻率信號2368。此一協定準確決定被傳送信標之載波頻率。
圖9提供根據本發明一態樣之信號接收器的積體電路組件的方塊功能圖。在圖9中，接收器2700包括電極輸入2710。電耦合到電極輸入2710的是2720及2730。在一態樣中，穿體傳導通訊模組2720係實施為低頻(LF)信號鏈。同樣所顯示的是CMOS溫度感測模組2740(用以偵測周圍溫度)及三軸加速計2750。接收器2700亦包括處理引擎2760(例如微處理器及數位信號處理器)、非揮發性記憶體2770(用於資料儲存)及無線通訊模組2780(用於資料傳輸到另一裝置，例如於資料上傳的動作中)。
圖10提供根據本發明一態樣配置以實施圖9描述之接收器的功能方塊圖之電路的更詳細的方塊圖。在圖10中，接收器2800包括電極e1、e2及e3(2811、2812及2813)，其等例如接收由所關注之整合環境模型(IEM)及/或感測生理參數或生物指標傳導傳送的信號。被電極2811、2812及2813接收的該等信號被電耦合到該等電極的多工 器2820多工處理。
多工器2820電耦合到高帶通濾波器2830及低帶通濾波器2840二者。高及低頻信號鏈提供可編程增益以涵蓋想要的位準或範圍。在此特定態樣中，高帶通濾波器2830通過在10 KHz到34 KHz頻帶中的頻率而過濾除來自帶外頻率的雜訊。此高頻帶可改變且可包括，例如，3 KHz到300 KHz的範圍。通過的頻率接著在被轉換器2834轉換成數位信號之前被放大器2832放大，用以輸入進高功率處理器2880(顯示為DSP)，其電耦合到高頻信號鏈。
低功率處理器2840顯示通過在0.5 Hz到150 Hz範圍的低頻，而濾除界外頻率。頻帶可改變且可包括例如，小於300 Hz的頻率，諸如小於200 Hz，包括小於150 Hz。通過頻率信號被放大器2842放大。同樣顯示的是電耦合到第二多工器2860的加速計2850。多工器2860將來自加速計的信號與來自放大器2842的放大信號多工處理。經多工處理的信號接著被亦電耦合到低功率處理器2870的轉換器2864轉換成數位信號。
在一態樣中，數位元加速計(諸如由Analog Devices製造者)，可以取代加速計2850來實施。藉使用數位元加速計可得到種種優點。例如，因為數位元加速計會產生的信號已經是數位元格式，數位元加速計會旁通轉換器2864且電耦合到低功率微控制器2870，於該情形中不再需要多工器2860。而且，該數位信號可被組態而當偵測到動作時將自己開啟，進一步保存電力。此外，可實施連續步級計 數。數位元加速計可包括FIFO緩衝器以幫助控制被傳送到低功率處理器2870之資料流。例如，資料可在FIFO內緩衝直到滿為止，在該時處理器可被觸發而從閒置狀態被喚醒且接收該資料。
低功率處理器2870可以例如是德州儀器(Texas Instruments)的MSP430微控制器。接收器2800的低功率處理器2870保持閒置狀態，其如前述，需要最小電流引出，例如等於或小於10.mu.A，或等於或小於1.mu.A。
高功率處理器2880可以例如是德州儀器(Texas Instruments)的VC5509數位信號處理器。高功率處理器2880於現用狀態期間執行信號處理動作。此等動作，如前述，比閒置狀態需要更大量電流，例如，等於或大於30.mu.A，諸如等於或大於50.mu.A的電流，且可包括，例如，諸如掃瞄傳導傳送的信號、接收時傳導處理傳送的信號、獲得及/或處理生理資料等。
亦顯示於圖10的是電耦合到高功率處理器2880的快閃記憶體2890。在一態樣中，快閃記憶體2890可電耦合到低功率處理器2870，其提供較佳的功率效率。
無線通訊元件2895係顯示電耦合到高功率處理器2880且可包括例如藍牙無線通訊收發器。在一態樣中，無線通訊元件2895係電耦合到高功率處理器2880。在另一態樣中，無線通訊元件2895係電耦合到高功率處理器2880及低功率處理器2870。再者，可實施無線通訊元件2895具有其自己的電源使得其可獨立於接收器的其他組件 被例如微處理器開啟及關閉。
考慮到閒置狀態，以下段落提供根據本發明一態樣顯示於圖10之接收器組件於種種拉收器狀態的範例配置。應了解到替代組態可依據想要的應用加以實施。
例如，在一閒置狀態中，接收器引出最小電流。接收器2880被配置使得低功率處理器2870係處於不活動狀態(諸如閒置狀態)而高功率處理器2880係處於不活動狀態(諸如閒置狀態)，且有關周邊電路的電路方塊及其所需電源於種種現用狀態期間保持關閉(例如，無線通訊模組2895及類比前端)。例如，低功率處理器可具有32 KHz的振盪器活動的且可消耗一些等於或小於.mu.A電流。在閒置狀態中，低功率處理器2870可例如，等待一信號以便轉移到現用狀態。該信號可以是外部的，諸如一個中斷或由諸如計時器的周邊裝置其中之一者由內部產生。於高功率處理器的閒置狀態期間，高功率處理器可例如運作32 KHz的鐘錶石英。高功率處理器可例如，等待一信號以便轉移到現用狀態。
當接收器處於側錄(sniff)狀態時，低功率處理器2870係處於閒置狀態且該側錄功能所需之包括A/C轉換器的類比前端是開啟的(換言之，高頻信號鏈)。如前述，信標信號模組可實施種種類型的側錄信號以達到低功率效率。
於偵測一被傳送信號之際，可進入到高功率解調及解碼狀態。當接收器係處於解調及解碼狀態時，低功率處理器2870係處於活動狀態且高功率處理器2880係處於活動 狀態。高功率處理器2880可以例如從12 MHz或接近具可給予裝置108 MHz時脈速度之PLL為基礎的時脈倍頻器(clock multiplier)的鐘錶石英振盪器運行。低功率處理器2870可例如於活動狀態期間以1 MHz到20 MHz的範圍運作內部R-C振盪器以及以每MHz 250至300 uA範圍的時脈速度消耗功率。活動狀態允許接下來的任何傳輸。所需的傳輸可觸發無線通訊模組關閉循環到開啟。
當接收器於收集心電圖(ECG)及加速計狀態時，有關加速計及/或ECG信號調節鏈的電路方塊開啟。高功率處理器2880於收集期間係處於閒置狀態，而於理及傳輸期間係處於活動狀態(例如，從12 MHz或接近具可給予裝置108 MHz時脈速度之PLL為基礎的時脈倍頻器的鐘錶石英振盪器運行)。低功率處理器2870於此狀態期間係處於活動狀態且可以1 MHz到20 MHz的範圍運作內部R-C振盪器以及以每MHz 250至300 uA範圍的時脈速度消耗功率。
圖11提供根據本發明一態樣之接收器有關高頻信號鏈的接收器中硬體的方塊圖。於圖11中，接收器2900包括電耦合到多工器2920的接收器探針(例如以電極2911、2912及2913的形式)。同樣顯示的高通濾波器2930及低通濾波器2940，提供帶通濾波器用來消除任何界外頻率。在所示的態樣中，提供10 KHz到34 KHz的帶通來通過落在該頻帶以內的載波信號。載波頻率的例子可包括但不侷限於12.5 KHz及20 KHz。可以有一或多個載波存在。此外，接收器2900包括類比數位轉換器2950，例如，在 500 KHz取樣。該數位信號之後被DSP處理。顯示於此態樣中的是DMA到DSP單元2960，其傳送該數位信號到DSP的專用記憶體。直接記憶體存取提供允許DSP的其餘部分保持在低功率模式的好處。
包括一接收器之系統的一個例子係顯示於圖12。在圖12中，系統3500包括醫藥組成物3510，其包含諸如可攝取事件指示器的可攝取裝置「IEM」。同樣存在於系統3500中是信號接收器3520。信號接收器3520被配置以偵測從IEM 3510發射的信號。信號接收器3520亦包括生理感測能力，諸如ECG及運動感測能力。信號接收器3520被配置以傳送資料到一外部裝置或個人數位助理(PDA)3530(諸如智慧型電話或其他無線通訊致能裝置)，其接著將該資料傳送到伺服器3540。伺服器3540可依所需配置，例如，用以提供病人導向的許可。例如，伺服器3540可配置來例如，經由介面(諸如網路介面)允許家屬看護3550參與病人的治療方案，該介面允許家屬看護3550監控由伺服器3540所產生之警示及趨勢，並提供支援回到病人，如箭號3560所示者。伺服器3540亦可配置來直接提供回應給病人，例如，以病人警示、病人誘因等形式，如箭號3565所示者，其經由PDA 3530中繼到病人。伺服器亦可與健康中心專業人員(例如註冊護士、醫師)3555互動，其能使用資料處理演繹法來得到病人健康、用藥意願的測量，例如健全指示摘要、警示、跨病人基準等，並提供通知的臨床通訊及支援回到病人，如箭號3580所示 者。##
應了解到本發明不侷限於此處描述的特定實施例或態樣，且因此可以改變。亦應了解到此處使用的專有名詞僅是為了說明特定態樣之目的，且不是為了限制，因為本發明範圍僅受到附加之申請專利範圍的限制。
應了解到有提供值的範圍處，除非上下文清楚指示，否則每一仲介值到下限的單位的十分位，在該範圍上限與下限之間，且任何其他敘述或在該敘述範圍中的仲介值，係包含在本發明以內。此等小範圍之上及下限可獨立包括於小範圍且亦包含在本發明以內，受到該敘述範圍中任何特別排除的限制。所敘述的範圍該等限制的一或二者，排除所包括之限制的任一或二者的範圍亦包含在本發明內。
除非特別界定，否則此處使用的所有技術及科學名詞與熟於本發明所屬之此技術之人士一般所了解者相同。雖然類似或等同此處所描述之任何方法及材料亦能用於本發明的實施及測試，但現將描述呈現性的說明方法及材料。
於本說明書引用的所用公開案及專利於此併入參考如同每一個別公開案或專利被特別及個別指出要被併入參考，且於此併入參考以揭示及說明與所引用之該等公開案有關的方法及/或材料。任何公開案的引用係針對在申請日前的其揭示且不應解釋為許可本發明係無權由於習知發明而早於此公開案。再者，所提供之公開案的日期可能與實際公開日不同，可能需要個別確認。
應注意，當使用於本文中及所附之申請專利範圍時， 單數形式「一」、「一個」及「該」包括複數的意涵，除非內文中有清楚地作出相反的表示。應進一步指出的是，申請專利範圍可被撰寫成排除任何非必要的元件。因此，此陳述是要為使用像是「唯一」、「僅」及其它類似排除性術語來作為請求元件的限制或「負面」限制提供先行詞基礎。
僅管有申請專利範圍，本發明亦指以下條款：
1.一種經使用者身體通訊用可攝取式通訊器設備，該設備包含：可攝取成分；以及傳遞資訊的可攝取裝置，該裝置與該成分結合，其中該裝置包含：支撐結構；第一材料，與該支撐結構實體結合；以及第二材料，在一有別於該第一材料之位置處與該支撐結構實體結合，使得該第一材料與該第二材料彼此電隔離以及呈現一電壓電位；以及非導電膜，固定於該支撐結構且相對該第一材料與該第二材料設置，以有助於該第一材料與該第二材料間之電流路徑的延伸，其中，該支撐結構包括一控制模組，用以控制該第一材料與該第二材料間之傳導率；其中，該裝置於與導電流體相接觸時被啟動且導致電流特徵，該電流特徵包括使用該控制模組編碼於內的資訊。
2.如條款1之設備，其中，該可攝取成分係食品材料。
3.如條款1或2之設備，其中該可攝取成分係固定於該可攝取裝置。
4.如條款1至3中的任一條款之設備，其中，該可攝取裝置能夠與與使用者身體結合之偵測器通訊，且其中，該偵測器接收並解碼由該可攝取裝置所產生之資訊。
5.如條款1至4中的任一條款之設備，其中，進一步包含與該設備結合的塗層材料。
6.如條款5之設備，其中，該塗層材料於被使用者咀嚼時破裂。
7.如條款5或6之設備，其中，該塗層材料於與生理流體相接觸時溶解。
8.如條款1至7中的任一條款之設備，其中，該設備能夠與固定於使用者皮膚之接收器通訊。
9.如條款1至8中的任一條款之設備，進一步包含可植入式裝置，其提供治療並解碼於該電流特徵內的資訊。
10.如條款1至9中的任一條款之設備，其中，該設備被包裝使得使用者的食品的消耗導致該可攝取裝置的啟動，以產生指出該食品已被消耗的資訊。
11.如條款1至10中的任一條款之設備，其中，該資訊包括該可攝取裝置的識別。
12.如條款1至11中的任一條款之設備，其中，該資訊包括該裝置的啟動時間。
13.如條款1至12中的任一條款之設備，其中，進一 步包含醫藥製品，其係以可攝取形式且與該裝置結合，使得該食品的攝取亦遞送藥物。
14.一種系統，包含如前述任一條款之設備以及可配置於使用者皮膚上的接收器。
於本說明書引用的所用公開案及專利於此併入參考如同每一個別公開案或專利被特別及個別指出要被併入參考，且於此併入參考以揭示及說明與所引用之該等公開案有關的方法及/或材料。任何公開案的引用係針對在申請日前的其揭示且不應解釋為許可本發明係無權由於習知發明而早於此公開案。再者，所提供之公開案的日期可能與實際公開日不同，可能需要個別確認。
應注意，當使用於本文中及所附之申請專利範圍時，單數形式「一」、「一個」及「該」包括複數的意涵，除非內文中有清楚地作出相反的表示。應進一步指出的是，申請專利範圍可被撰寫成排除任何非必要的元件。因此，此陳述是要為使用像是「唯一」、「僅」及其它類似排除性術語來作為請求元件的限制或「負面」限制提供先行詞基礎。
在閱讀此揭露內容時將會變得很清楚的是，描述及例示於本文中的各實施例具有分離的構件及特徵，它們可以很輕易地與其他數個實施例中的任何一者的特徵分開或結合而不偏離本發明的範圍或精神。任何被描述的方法可依照所描述的事件順序或依照邏輯上可能的任何其他順序來實施。
雖然上述的發明已藉由為了清楚瞭解的目的以例示的方式予以詳細地描述，在發明的教導下對於在此技藝中具有一般技術者而言很明顯的是，一些改變及修改可在不偏離本案申請專利範圍的精神與範圍為被達成。
因此，上文只是例示本發明的原理。將可被瞭解的是，熟習此技藝者將能夠達成各種配置，它們雖然沒有被明確地描述或顯示於本文中，但仍體現發明的原理且亦被包括在本發明的精神與範圍內。再者，描述於本文中的所有例子及條件式語言原則上都是要用來幫助讀者瞭解本發明的原理及本案發明人對於推進此技藝所貢獻的概念，且應被解讀為不受限於被特定地描述的例子及條件。再者，本文中描述本發明的原理、態樣及實施例的所有陳述以及其特定的例子都是要用來涵蓋本發明在結構及功能上的等效物。此外，這些等效物包括目前已知的等效物及在未來發展出來的等效物，即實施相同的功能而不論其結構之開發出來的任何元件。因此，本發明的範圍並不侷限於本文中所示及描述的示範性實施例。相反地，本發明的範圍及精神是由所附的申請專利範圍來體現。
10‧‧‧醫藥製品
11‧‧‧囊劑
11a‧‧‧凹穴
12‧‧‧系統
12a‧‧‧系統
12b‧‧‧單元
12c‧‧‧凹穴
13‧‧‧材料
14‧‧‧囊劑
20‧‧‧醫藥製品
22‧‧‧系統
30‧‧‧系統
32‧‧‧架構
34‧‧‧材料
35‧‧‧裙部
36‧‧‧材料
37‧‧‧裙部
38‧‧‧控制裝置材料
39‧‧‧材料
40‧‧‧系統
42‧‧‧架構
44‧‧‧材料
46‧‧‧材料
48‧‧‧控制裝置
49‧‧‧裙部
50‧‧‧電流路徑
52‧‧‧接地點
55‧‧‧控制模組
62‧‧‧控制模組
64‧‧‧時脈
66‧‧‧記憶體
68‧‧‧輸入
70‧‧‧輸出
72‧‧‧感測器模組
74‧‧‧感測器模組
75‧‧‧單元
75a‧‧‧單元
76‧‧‧pH值感測器模組
78‧‧‧接點
2220‧‧‧窄低通濾波器
2221‧‧‧載波信號
2222‧‧‧載波信號
2223‧‧‧複合混合器
2225‧‧‧方塊
2230‧‧‧展開相位
2240‧‧‧封包尋檢器
2250‧‧‧相位旋轉器
2260‧‧‧資料解碼器
2360‧‧‧信號
2361‧‧‧抽取
2262‧‧‧複合混合器
2364‧‧‧CIC抽取
2365‧‧‧寬有限脈衝響應濾波器(FIR LPF)
2367‧‧‧方塊
2368‧‧‧載波頻率信號
2369‧‧‧信號
2700‧‧‧接收器
2710‧‧‧電極輸入
2720‧‧‧穿體傳導通訊模組
2730‧‧‧生理感測模組
2740‧‧‧溫度感測模組
2750‧‧‧加速計
2760‧‧‧處理引擎
2770‧‧‧記憶體
2780‧‧‧無線通訊模組
2800‧‧‧接收器
2811‧‧‧電極
2812‧‧‧電極
2813‧‧‧電極
2820‧‧‧多工器
2830‧‧‧高帶通濾波器
2840‧‧‧低帶通濾波器
2842‧‧‧放大器
2850‧‧‧加速計
2860‧‧‧多工器
2864‧‧‧轉換器
2870‧‧‧低功率處理器
2880‧‧‧高功率處理器(DSP)
2890‧‧‧快閃記憶體
2895‧‧‧無線通訊元件
2900‧‧‧接收器
2911‧‧‧電極(探針)
2912‧‧‧電極
2913‧‧‧電極
2920‧‧‧多工器
2930‧‧‧高通濾波器
2940‧‧‧低通濾波器
2950‧‧‧類比數位轉換器
2960‧‧‧DMA到DSP單元
3500‧‧‧系統
3510‧‧‧醫藥組成物
3520‧‧‧信號接收器
3530‧‧‧個人數位助理(PDA)
3540‧‧‧伺服器
3550‧‧‧家屬看護
3555‧‧‧健康中心專業人員
3560‧‧‧箭號
3565‧‧‧箭號
3580‧‧‧箭號
圖1顯示根據本發明教示之事件指示器系統與可植入式裝置通訊。
圖2A顯示圖1之醫藥製品，該事件指示器系統在該醫藥製品的外部。
圖2B顯示圖圖1之醫藥製品，該事件指示器系統位在該醫藥製品的內部。
圖3是方塊圖，表示具有置於相反端之異質材料的事件指示器系統的一態樣。
圖4是方塊圖，表示具有置於相同端且被非導電材料隔開之異質材料的事件指示器系統的另一態樣。
圖5顯示當圖3之事件指示器系統與導電流體接觸而成活性狀態時透過導電流體的離子轉移或電流路徑。
圖5A顯示圖5之異質材料之表面的分解圖。
圖5B顯示具有pH值感測器單元之圖5之事件指示器系統之異質材料。
圖6是一用於圖3及圖4之系統中之控制裝置之一態樣的方塊圖。
圖7是一解調電路的功能方塊圖，其根據本發明一態樣實施可在接收器中的同調解調。
圖8繪示根據本發明一態樣之用於接收器內部之信標模組的功能方塊圖。
圖9是根據本發明之可在接收器中之不同功能樣組的方塊圖。
圖10是一根據本發明一態樣之接收器的方塊圖。
圖11提供一根據本發明一態樣之接收器中高頻信號鏈的方塊圖。
圖12提供一如何使用根據本發明一態樣之包括信號接收器及可攝取事件製造器之系統的圖。
2700‧‧‧接收器
2710‧‧‧電極輸入
2720‧‧‧穿體傳導通訊模組
2730‧‧‧生理感測模組
2740‧‧‧溫度感測模組
2750‧‧‧加速計
2760‧‧‧處理引擎
2770‧‧‧記憶體
2780‧‧‧無線通訊模組

Claims (20)

  1. 一種利用使用者身體之通訊設備，該設備包含：可攝取成分；以及傳遞資訊的可攝取裝置，該可攝取裝置係與該成分結合，其中該可攝取裝置包含：支撐結構；第一材料，係與該支撐結構實體結合；以及第二材料，係在一有別於該第一材料之位置處與該支撐結構實體結合，使得該第一材料與該第二材料彼此電隔離以及能夠於與導電流體相接觸時產生一電位差，其中，該支撐結構包括一控制模組，用以控制該第一材料與該第二材料間之傳導率；以及其中，該可攝取裝置於與該導電流體相接觸時被啟動且該接觸導致電流特徵，該電流特徵包括使用該控制模組編碼於內的資訊。
  2. 如申請專利範圍第1項之設備，其中，該可攝取成分為食品材料。
  3. 如申請專利範圍第1項之設備，其中該可攝取成分係固定於該可攝取裝置。
  4. 如申請專利範圍第1項之設備，其中，該可攝取裝置正與和使用者身體結合之偵測器通訊，且其中，該偵測器接收並解碼由該可攝取裝置所產生之資訊。
  5. 如申請專利範圍第1項之設備，其中，進一步包含圍繞該可攝取裝置的塗層材料。
  6. 如申請專利範圍第5項之設備，其中，該塗層材料於被使用者咀嚼時破裂。
  7. 如申請專利範圍第5項之設備，其中，該塗層材料於與生理流體相接觸時溶解。
  8. 如申請專利範圍第1項之設備，其中，該設備被配置成與固定於使用者皮膚之接收器相通訊。
  9. 如申請專利範圍第1項之設備，進一步包含係與該可攝取裝置相通訊且電連接到該可攝取裝置的感測器，其中，該感測器偵測圍繞該可攝取裝置之環境的pH值水準並傳送信號到該控制模組。
  10. 如申請專利範圍第2項之設備，其中，該設備被包裝而使得使用者的食品材料的消耗導致該可攝取裝置的啟動，以產生指出該食品材料已被消耗的資訊。
  11. 如申請專利範圍第2項之設備，進一步包含：界定一凹穴的外殼單元，其中該食品材料係儲存於該外殼單元之該凹穴內部的液體；圍繞該可攝取裝置的塗層材料，其儲存於該外殼單元內，使得該塗層材料使該可攝取裝置與該液體隔離直到該塗層被使用者的消化系統溶解為止。
  12. 如申請專利範圍第1項之設備，其中，該可攝取裝置進一步包含非導電膜，其係固定於該支撐結構且相對該第一材料與該第二材料設置，以有助於當與導電流體相接觸時該第一材料與該第二材料間之電流路徑的延伸。
  13. 如申請專利範圍第2項之設備，其中，進一步包 含醫藥製品，其係以可攝取形式且與該可攝取裝置及該食品材料的至少其中之一者結合，使得該攝取亦遞送藥物。
  14. 一種供使用者消耗的通訊食品產物，該產物包含：界定一凹穴的外殼，其中該外殼能被使用者咀嚼；可攝取裝置，用以經由使用者身體傳遞資訊，該可攝取裝置係設置於該凹穴內部，其中該可攝取裝置包含：支撐結構；第一材料，係與該支撐結構實體結合；以及第二材料，係在一有別於該第一材料之位置處與該支撐結構實體結合，使得該第一材料與該第二材料彼此電隔離以及能夠於與導電流體相接觸時產生一電壓電位，其中，該支撐結構包括一控制模組，用以控制該第一材料與該第二材料間之傳導率；以及其中，該可攝取裝置於與該導電流體相接觸時被啟動且導致電流特徵，該電流特徵包括使用該控制模組編碼於內的資訊。
  15. 如申請專利範圍第14項之產物，進一步包含：圍繞該可攝取裝置之塗層；以及可消化成分，係載於該外殼的該凹穴內部，其中，該塗層將該可消化成分與該可攝取裝置隔離。
  16. 如申請專利範圍第15項之產物，其中，該外殼係可撓式以耐受咀嚼壓力，且其中，該外殼在使用者胃部崩解。
  17. 如申請專利範圍第15項之產物，其中，該外殼於 咀嚼時破裂並釋放該可攝取裝置。
  18. 如申請專利範圍第15項之產物，其中，該可消化成分為液體。
  19. 如申請專利範圍第14項之產物，進一步包含感測器，其係與該可攝取裝置通訊且電連接到該可攝取裝置，其中，該感測器偵測圍繞該可攝取裝置之環境的pH值水準，並傳送控制信號到該控制模組用以啟動該可攝取裝置的通訊。
  20. 一種信號產生食品產物，包含：可消化材料；多數個通訊裝置，其中各通訊裝置包含：第一材料，係與一支撐結構實體結合；以及第二材料，係在一有別於該第一材料之位置處與該支撐結構實體結合，其中，該第一材料與該第二材料彼此電隔離以及能夠於與導電流體相接觸時呈現一電壓電位以供電給該通訊裝置，其中，該支撐結構包括一控制模組，用以控制該第一材料與該第二材料間之傳導率，其中，至少一通訊裝置係設置於由一外殼所界定之一凹穴內部，該外殼在使用者胃中溶解，且該外殼防止當使用者咀嚼該信號產生食品產物時該通訊裝置的啟動，且其中，該多數個通訊裝置中的至少一個通訊裝置被塗層，且該塗層於該使用者咀嚼該產物時破裂，從而啟動在 該使用者嘴中的該通訊裝置。
TW101124936A 2011-07-11 2012-07-11 組入於可攝取式產品之通訊系統 TW201320963A (zh)

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Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9198608B2 (en) 2005-04-28 2015-12-01 Proteus Digital Health, Inc. Communication system incorporated in a container
US8912908B2 (en) 2005-04-28 2014-12-16 Proteus Digital Health, Inc. Communication system with remote activation
EP2392258B1 (en) 2005-04-28 2014-10-08 Proteus Digital Health, Inc. Pharma-informatics system
US8802183B2 (en) 2005-04-28 2014-08-12 Proteus Digital Health, Inc. Communication system with enhanced partial power source and method of manufacturing same
US8836513B2 (en) 2006-04-28 2014-09-16 Proteus Digital Health, Inc. Communication system incorporated in an ingestible product
US8730031B2 (en) 2005-04-28 2014-05-20 Proteus Digital Health, Inc. Communication system using an implantable device
KR101568660B1 (ko) 2006-05-02 2015-11-12 프로테우스 디지털 헬스, 인코포레이티드 환자 주문형 치료법
EP2083680B1 (en) 2006-10-25 2016-08-10 Proteus Digital Health, Inc. Controlled activation ingestible identifier
EP2069004A4 (en) 2006-11-20 2014-07-09 Proteus Digital Health Inc PERSONAL HEALTH SIGNAL RECEIVERS WITH ACTIVE SIGNAL PROCESSING
US8858432B2 (en) 2007-02-01 2014-10-14 Proteus Digital Health, Inc. Ingestible event marker systems
EP2111661B1 (en) 2007-02-14 2017-04-12 Proteus Digital Health, Inc. In-body power source having high surface area electrode
WO2008112578A1 (en) 2007-03-09 2008-09-18 Proteus Biomedical, Inc. In-body device having a deployable antenna
US8540632B2 (en) 2007-05-24 2013-09-24 Proteus Digital Health, Inc. Low profile antenna for in body device
ES2928197T3 (es) 2007-09-25 2022-11-16 Otsuka Pharma Co Ltd Dispositivo intracorpóreo con amplificación de señal de dipolo virtual
JP2011513865A (ja) 2008-03-05 2011-04-28 プロテウス バイオメディカル インコーポレイテッド マルチモード通信の摂取可能なイベントマーカーおよびシステム、ならびにそれを使用する方法
ES2696984T3 (es) 2008-07-08 2019-01-21 Proteus Digital Health Inc Infraestructura de datos de marcadores de eventos de ingestión
EP3173125B1 (en) 2008-07-30 2019-03-27 Ecole Polytechnique Fédérale de Lausanne Apparatus for optimized stimulation of a neurological target
AU2009281876B2 (en) 2008-08-13 2014-05-22 Proteus Digital Health, Inc. Ingestible circuitry
EP2382008B1 (en) 2008-11-12 2015-04-29 Ecole Polytechnique Federale De Lausanne Microfabricated neurostimulation device
US9439566B2 (en) 2008-12-15 2016-09-13 Proteus Digital Health, Inc. Re-wearable wireless device
US9659423B2 (en) 2008-12-15 2017-05-23 Proteus Digital Health, Inc. Personal authentication apparatus system and method
SG196787A1 (en) 2009-01-06 2014-02-13 Proteus Digital Health Inc Ingestion-related biofeedback and personalized medical therapy method and system
US8540664B2 (en) 2009-03-25 2013-09-24 Proteus Digital Health, Inc. Probablistic pharmacokinetic and pharmacodynamic modeling
SG10201810784SA (en) 2009-04-28 2018-12-28 Proteus Digital Health Inc Highly Reliable Ingestible Event Markers And Methods For Using The Same
TWI517050B (zh) 2009-11-04 2016-01-11 普羅托斯數位健康公司 供應鏈管理之系統
CA2782710C (en) 2009-12-01 2019-01-22 Ecole Polytechnique Federale De Lausanne Microfabricated neurostimulation device and methods of making and using the same
MX2012008922A (es) 2010-02-01 2012-10-05 Proteus Digital Health Inc Sistema de recoleccion de datos.
US9549708B2 (en) 2010-04-01 2017-01-24 Ecole Polytechnique Federale De Lausanne Device for interacting with neurological tissue and methods of making and using the same
BR112012025650A2 (pt) 2010-04-07 2020-08-18 Proteus Digital Health, Inc. dispositivo ingerível miniatura
TWI557672B (zh) 2010-05-19 2016-11-11 波提亞斯數位康健公司 用於從製造商跟蹤藥物直到患者之電腦系統及電腦實施之方法、用於確認將藥物給予患者的設備及方法、患者介面裝置
EP2642983A4 (en) 2010-11-22 2014-03-12 Proteus Digital Health Inc DEVICE INGREABLE WITH PHARMACEUTICAL PRODUCT
US9439599B2 (en) 2011-03-11 2016-09-13 Proteus Digital Health, Inc. Wearable personal body associated device with various physical configurations
WO2015112603A1 (en) * 2014-01-21 2015-07-30 Proteus Digital Health, Inc. Masticable ingestible product and communication system therefor
US9756874B2 (en) 2011-07-11 2017-09-12 Proteus Digital Health, Inc. Masticable ingestible product and communication system therefor
UA118745C2 (uk) 2011-07-21 2019-03-11 Протеус Діджитал Хелс, Інк. Пристрій, система та спосіб мобільного зв'язку
US8695884B2 (en) 2011-08-25 2014-04-15 Michael H. Baym Systems, devices, admixtures, and methods including transponders for indication of food attributes
US20130049932A1 (en) * 2011-08-25 2013-02-28 Elwha LLC, a limited liability company of the State of Delaware Systems, devices, methods, and admixtures of transponders and food products for indication of food attributes
US20130049934A1 (en) * 2011-08-25 2013-02-28 Elwha LLC, a limited liability company of the State of Delaware Systems, devices, methods, and admixtures including interrogators and interrogation of tags for indication of food attributes
KR20150038038A (ko) 2012-07-23 2015-04-08 프로테우스 디지털 헬스, 인코포레이티드 섭취 가능한 부품을 포함하는 섭취 가능한 이벤트 마커를 제조하기 위한 기술
KR101565013B1 (ko) 2012-10-18 2015-11-02 프로테우스 디지털 헬스, 인코포레이티드 통신 디바이스를 위한 전원에서 전력 소비 및 브로드캐스트 전력을 적응적으로 최적화시키는 장치, 시스템 및 방법
JP2016508529A (ja) 2013-01-29 2016-03-22 プロテウス デジタル ヘルス， インコーポレイテッド 高度に膨張可能なポリマーフィルムおよびこれを含む組成物
US11744481B2 (en) 2013-03-15 2023-09-05 Otsuka Pharmaceutical Co., Ltd. System, apparatus and methods for data collection and assessing outcomes
WO2014151929A1 (en) 2013-03-15 2014-09-25 Proteus Digital Health, Inc. Personal authentication apparatus system and method
US10175376B2 (en) 2013-03-15 2019-01-08 Proteus Digital Health, Inc. Metal detector apparatus, system, and method
US9796576B2 (en) 2013-08-30 2017-10-24 Proteus Digital Health, Inc. Container with electronically controlled interlock
CA2965941C (en) 2013-09-20 2020-01-28 Proteus Digital Health, Inc. Methods, devices and systems for receiving and decoding a signal in the presence of noise using slices and warping
WO2015044722A1 (en) 2013-09-24 2015-04-02 Proteus Digital Health, Inc. Method and apparatus for use with received electromagnetic signal at a frequency not known exactly in advance
JP6248326B2 (ja) * 2013-10-18 2017-12-20 国立大学法人東北大学 食事型センサ、及びセンシング方法
US10084880B2 (en) 2013-11-04 2018-09-25 Proteus Digital Health, Inc. Social media networking based on physiologic information
WO2015085011A1 (en) 2013-12-04 2015-06-11 Obalon Therapeutics , Inc. Systems and methods for locating and/or characterizing intragastric devices
JP6354143B2 (ja) 2013-12-10 2018-07-11 Tdk株式会社 情報提供システム、電子機器、方法及びプログラム
US10127361B2 (en) 2014-03-31 2018-11-13 Elwha Llc Quantified-self machines and circuits reflexively related to kiosk systems and associated food-and-nutrition machines and circuits
US10318123B2 (en) 2014-03-31 2019-06-11 Elwha Llc Quantified-self machines, circuits and interfaces reflexively related to food fabricator machines and circuits
US20150279178A1 (en) * 2014-03-31 2015-10-01 Elwha Llc Quantified-self machines and circuits reflexively related to fabricator, big-data analytics and user interfaces, and supply machines and circuits
US9922307B2 (en) 2014-03-31 2018-03-20 Elwha Llc Quantified-self machines, circuits and interfaces reflexively related to food
US11311718B2 (en) 2014-05-16 2022-04-26 Aleva Neurotherapeutics Sa Device for interacting with neurological tissue and methods of making and using the same
WO2015173787A1 (en) 2014-05-16 2015-11-19 Aleva Neurotherapeutics Sa Device for interacting with neurological tissue and methods of making and using the same
CN104042217A (zh) * 2014-06-11 2014-09-17 高秋萍 一种消化道生理信息无创检测系统
US9474894B2 (en) 2014-08-27 2016-10-25 Aleva Neurotherapeutics Deep brain stimulation lead
US9403011B2 (en) 2014-08-27 2016-08-02 Aleva Neurotherapeutics Leadless neurostimulator
US9925376B2 (en) 2014-08-27 2018-03-27 Aleva Neurotherapeutics Treatment of autoimmune diseases with deep brain stimulation
WO2016057716A1 (en) 2014-10-09 2016-04-14 Obalon Therapeutics, Inc. Ultrasonic systems and methods for locating and /or characterizing intragastric devices
JP6410308B2 (ja) 2014-12-12 2018-10-24 国立大学法人東北大学 センサチップ、検出システム、及び、検出方法
US11051543B2 (en) 2015-07-21 2021-07-06 Otsuka Pharmaceutical Co. Ltd. Alginate on adhesive bilayer laminate film
WO2017168188A1 (en) 2016-03-29 2017-10-05 Olympus Corporation Implantable communication system starter systems and methods
US10350100B2 (en) 2016-04-12 2019-07-16 Obalon Therapeutics, Inc. System for detecting an intragastric balloon
TWI728155B (zh) 2016-07-22 2021-05-21 日商大塚製藥股份有限公司 可攝食事件標示器之電磁感測及偵測
US10617315B2 (en) 2016-09-30 2020-04-14 Microsoft Technology Licensing, Llc Detecting bipotential with an ionic varistor
US10321849B2 (en) * 2016-10-13 2019-06-18 Etectrx, Inc. System for ingestion event monitoring and method for detecting ingestion events with high accuracy
CN109963499B (zh) 2016-10-26 2022-02-25 大冢制药株式会社 用于制造具有可吸收事件标记器的胶囊的方法
KR102622953B1 (ko) 2017-04-25 2024-01-09 오츠카 세이야쿠 가부시키가이샤 섭취 가능한 이벤트 마커를 사용한 리시노프릴 조성물
WO2018207257A1 (ja) * 2017-05-09 2018-11-15 大塚製薬株式会社 包装薬剤
JP7394775B2 (ja) 2017-11-28 2023-12-08 マサチューセッツ インスティテュート オブ テクノロジー 胃滞在電子機器
US10702692B2 (en) 2018-03-02 2020-07-07 Aleva Neurotherapeutics Neurostimulation device
US11786142B2 (en) 2019-01-11 2023-10-17 Tokitae Llc Ingestible RFID tag and reader system
IT202200008993A1 (it) * 2022-05-03 2023-11-03 Fondazione St Italiano Tecnologia Dispositivo degradabile per il rilascio passivo e tracciabile di una sostanza

Family Cites Families (772)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1548459A (en) 1923-12-14 1925-08-04 Hammer Charles Metal cap
US3799802A (en) 1966-06-28 1974-03-26 F Schneble Plated through hole printed circuit boards
US3607788A (en) 1967-11-20 1971-09-21 Robert J Adolph Liquid electrode material
US3589943A (en) 1968-08-29 1971-06-29 Gen Electric Electrochemical battery
US3642008A (en) 1968-09-25 1972-02-15 Medical Plastics Inc Ground electrode and test circuit
US3679480A (en) 1969-05-08 1972-07-25 Dow Chemical Co Electrical cell assembly
US3682160A (en) 1969-10-16 1972-08-08 Matsushita Electric Ind Co Ltd Physiological signal transmitter for use inside the body
US3719183A (en) 1970-03-05 1973-03-06 H Schwartz Method for detecting blockage or insufficiency of pancreatic exocrine function
US3837339A (en) 1972-02-03 1974-09-24 Whittaker Corp Blood glucose level monitoring-alarm system and method therefor
US3828766A (en) 1972-08-14 1974-08-13 Jet Medical Prod Inc Disposable medical electrode
US3989050A (en) 1972-09-19 1976-11-02 Gilbert Buchalter Process for utilizing certain gel compositions for electrical stimulation
US3849041A (en) 1973-04-30 1974-11-19 Minnesota Mining & Mfg Apparatus for manufacturing environmental seed cells
US3944064A (en) 1973-10-26 1976-03-16 Alza Corporation Self-monitored device for releasing agent at functional rate
US4106348A (en) 1974-02-20 1978-08-15 U.S. Philips Corporation Device for examination by means of ultrasonic vibrations
US3893111A (en) 1974-03-14 1975-07-01 Albert Albert F System and method for remote monitoring of animal temperature
US3967202A (en) 1974-07-25 1976-06-29 Northern Illinois Gas Company Data transmission system including an RF transponder for generating a broad spectrum of intelligence bearing sidebands
US4077397A (en) 1974-10-07 1978-03-07 Baxter Travenol Laboratories, Inc. Diagnostic electrode assembly
ZA755785B (en) 1974-10-07 1976-08-25 Baxter Laboratories Inc Diagnostic electrode assembly
US4090752A (en) 1974-10-07 1978-05-23 Baxter Travenol Laboratories, Inc. Diagnostic electrode assembly
US4062750A (en) 1974-12-18 1977-12-13 James Francis Butler Thin film electrochemical electrode and cell
US4017856A (en) 1976-03-10 1977-04-12 Westinghouse Electric Corporation Self-calibrating microwave transponder
US4055178A (en) 1976-03-10 1977-10-25 Harrigan Roy Major Drug delivery device for preventing contact of undissolved drug with the stomach lining
US4129125A (en) 1976-12-27 1978-12-12 Camin Research Corp. Patient monitoring system
GB1594214A (en) 1977-01-21 1981-07-30 Cardio Tech Body electrodes
US4082087A (en) 1977-02-07 1978-04-04 Isis Medical Instruments Body contact electrode structure for deriving electrical signals due to physiological activity
JPS5475284A (en) 1977-11-29 1979-06-15 Asahi Chemical Ind Threeeterminal magnetic reluctance effect element
US4239046A (en) 1978-09-21 1980-12-16 Ong Lincoln T Medical electrode
US4345588A (en) 1979-04-23 1982-08-24 Northwestern University Method of delivering a therapeutic agent to a target capillary bed
US4269189A (en) 1979-07-09 1981-05-26 Consolidated Medical Equipment Inc. Skin conducting electrode assembly
DE2928477C3 (de) 1979-07-14 1982-04-15 Battelle-Institut E.V., 6000 Frankfurt Vorrichtung zur Freisetzung von Substanzen an definierten Orten des Verdauungstraktes
US4331654A (en) 1980-06-13 1982-05-25 Eli Lilly And Company Magnetically-localizable, biodegradable lipid microspheres
US4578061A (en) 1980-10-28 1986-03-25 Lemelson Jerome H Injection catheter and method
US4418697A (en) 1981-08-17 1983-12-06 Francine Tama Electrode attachment method
US4494950A (en) 1982-01-19 1985-01-22 The Johns Hopkins University Plural module medication delivery system
US4439196A (en) 1982-03-18 1984-03-27 Merck & Co., Inc. Osmotic drug delivery system
US4564363A (en) 1983-07-13 1986-01-14 Smithkline Beckman Corporation Delayed action assembly
GB8322007D0 (en) 1983-08-16 1983-09-21 Wellcome Found Pharmaceutical delivery system
US4749575A (en) 1983-10-03 1988-06-07 Bio-Dar Ltd. Microencapsulated medicament in sweet matrix
US4559950A (en) 1983-11-25 1985-12-24 Graphic Controls Corporation Disposable biomedical and diagnostic electrode
US5000957A (en) 1984-03-19 1991-03-19 Alza Corporation Dispenser comprising hydrophilic osmopolymer
GB8422876D0 (en) 1984-09-11 1984-10-17 Secr Defence Silicon implant devices
JPS6172712U (zh) 1984-10-12 1986-05-17
US4681111A (en) 1985-04-05 1987-07-21 Siemens-Pacesetter, Inc. Analog and digital telemetry system for an implantable device
US4654165A (en) 1985-04-16 1987-03-31 Micro Tracers, Inc. Microingredient containing tracer
US4767627A (en) 1985-05-29 1988-08-30 Merck & Co., Inc. Drug delivery device which can be retained in the stomach for a controlled period of time
US4763659A (en) 1985-08-21 1988-08-16 Spring Creek Institute, Inc. Dry electrode system for detection of biopotentials
US4669479A (en) 1985-08-21 1987-06-02 Spring Creek Institute, Inc. Dry electrode system for detection of biopotentials
US4635641A (en) 1985-10-16 1987-01-13 Murray Electronics Associates Limited Multi-element electrode
US4663250A (en) 1986-03-12 1987-05-05 Institute Of Gas Technology Reduction of electrode dissolution
US4725997A (en) 1986-08-22 1988-02-16 Aprex Corporation Contingent dosing device
US4784162A (en) 1986-09-23 1988-11-15 Advanced Medical Technologies Portable, multi-channel, physiological data monitoring system
US4896261A (en) 1986-11-24 1990-01-23 Motorola Inc. System for scheduling serial message transmission on a bus which is adoptable for rescheduling prioritized messages using a doubly-linked list
US4876093A (en) 1987-07-02 1989-10-24 Alza Corporation Dispenser with dispersing member for delivering beneficial agent
DE3723310A1 (de) 1987-07-15 1989-01-26 John Urquhart Pharmazeutisches praeparat und verfahren zu seiner herstellung
US5002772A (en) 1988-05-31 1991-03-26 Pfizer Inc. Gastric retention system for controlled drug release
CA1327838C (fr) 1988-06-13 1994-03-15 Fred Zacouto Dispositif implantable de protection contre les affections liees a la coagulation sanguine
US4975230A (en) 1988-06-17 1990-12-04 Vapor Technologies Inc. Method of making an open pore structure
US4844076A (en) 1988-08-26 1989-07-04 The Johns Hopkins University Ingestible size continuously transmitting temperature monitoring pill
SE466684B (sv) 1989-03-07 1992-03-23 Draco Ab Anordning vid en inhalator samt foerfarande foer att med anordningen registrera medicinering med inhalator
EP0392032B1 (de) 1989-04-10 1995-01-25 Pacesetter AB Implantierbares medizinisches Gerät mit Mitteln zum telemetrischen Übertragen von Daten
CA2016517C (en) 1989-05-11 1999-01-12 Dale R. Shackle Solid state electrochemical cell having microroughened current collector
US5281287A (en) 1989-07-21 1994-01-25 Iomed, Inc. Method of making a hydratable bioelectrode
US4987897A (en) 1989-09-18 1991-01-29 Medtronic, Inc. Body bus medical device communication system
US5110441A (en) 1989-12-14 1992-05-05 Monsanto Company Solid state ph sensor
US6749122B1 (en) 1990-05-25 2004-06-15 Broadcom Corporation Multi-level hierarchial radio-frequency system communication system
US6359872B1 (en) 1997-10-28 2002-03-19 Intermec Ip Corp. Wireless personal local area network
US5167626A (en) 1990-10-02 1992-12-01 Glaxo Inc. Medical capsule device actuated by radio-frequency (RF) signal
US5279607A (en) 1991-05-30 1994-01-18 The State University Of New York Telemetry capsule and process
US5395366A (en) 1991-05-30 1995-03-07 The State University Of New York Sampling capsule and process
GB9123638D0 (en) 1991-11-07 1992-01-02 Magill Alan R Apparel & fabric & devices suitable for health monitoring applications
US5176626A (en) 1992-01-15 1993-01-05 Wilson-Cook Medical, Inc. Indwelling stent
JPH05228128A (ja) 1992-02-25 1993-09-07 Olympus Optical Co Ltd 医療用カプセル
WO1993019667A1 (en) 1992-04-03 1993-10-14 Micromedical Industries Limited Sensor and system for physiological monitoring
US5263481A (en) 1992-05-21 1993-11-23 Jens Axelgaard Electrode system with disposable gel
US5283136A (en) 1992-06-03 1994-02-01 Ramot University Authority For Applied Research And Industrial Development Ltd. Rechargeable batteries
US5318557A (en) 1992-07-13 1994-06-07 Elan Medical Technologies Limited Medication administering device
US5261402A (en) 1992-07-20 1993-11-16 Graphic Controls Corporation Snapless, tabless, disposable medical electrode with low profile
US5338625A (en) 1992-07-29 1994-08-16 Martin Marietta Energy Systems, Inc. Thin film battery and method for making same
US7758503B2 (en) 1997-01-27 2010-07-20 Lynn Lawrence A Microprocessor system for the analysis of physiologic and financial datasets
US5757326A (en) 1993-03-29 1998-05-26 Seiko Epson Corporation Slot antenna device and wireless apparatus employing the antenna device
AU676293B2 (en) 1993-06-24 1997-03-06 Wilson Greatbatch Ltd. Electrode covering for electrochemical cells
US5394882A (en) 1993-07-21 1995-03-07 Respironics, Inc. Physiological monitoring system
US5506248A (en) 1993-08-02 1996-04-09 Bristol-Myers Squibb Company Pharmaceutical compositions having good dissolution properties
US5458141A (en) 1993-08-04 1995-10-17 Quinton Instrument Company Abrasive skin electrode
US5443461A (en) 1993-08-31 1995-08-22 Alza Corporation Segmented device for simultaneous delivery of multiple beneficial agents
DE4329898A1 (de) 1993-09-04 1995-04-06 Marcus Dr Besson Kabelloses medizinisches Diagnose- und Überwachungsgerät
US5402793A (en) 1993-11-19 1995-04-04 Advanced Technology Laboratories, Inc. Ultrasonic transesophageal probe for the imaging and diagnosis of multiple scan planes
US6390088B1 (en) 1993-12-13 2002-05-21 Boehringer Ingelheim Kg Aerosol inhaler
ATE215839T1 (de) 1994-03-21 2002-04-15 Dusa Pharmaceuticals Inc Pflaster und steuereinrichtung für photodynamische therapie von dermalen verletzungen
US5600548A (en) 1994-08-11 1997-02-04 Sundstrand Corporation DC content control for an inverter
IE70735B1 (en) 1994-08-15 1996-12-11 Elan Med Tech Orally administrable delivery device
DE9414065U1 (de) 1994-08-31 1994-11-03 Röhm GmbH & Co. KG, 64293 Darmstadt Thermoplastischer Kunststoff für darmsaftlösliche Arznei-Umhüllungen
IL111396A (en) 1994-10-25 1997-07-13 Ness Neuromuscular Electrical Stimulation Systems Ltd Electrode system
US5718098A (en) 1994-12-30 1998-02-17 Pharmagraphics L.L.C., Midwest Method for producing sample package
US5485841A (en) 1995-02-14 1996-01-23 Univ Mcgill Ultrasonic lung tissue assessment
US5778882A (en) 1995-02-24 1998-07-14 Brigham And Women's Hospital Health monitoring system
US6374670B1 (en) 1995-03-13 2002-04-23 University Of Washington Non-invasive gut motility monitor
US5845265A (en) 1995-04-26 1998-12-01 Mercexchange, L.L.C. Consignment nodes
US5645063A (en) 1995-06-05 1997-07-08 Quinton Instrument Company Skin electrode having multiple conductive center members
US5738708A (en) 1995-06-07 1998-04-14 The Regents Of The University Of California Office Of Technology Transfer Composite metal membrane
US6083248A (en) 1995-06-23 2000-07-04 Medtronic, Inc. World wide patient location and data telemetry system for implantable medical devices
US5772575A (en) 1995-09-22 1998-06-30 S. George Lesinski Implantable hearing aid
US5802467A (en) 1995-09-28 1998-09-01 Innovative Intelcom Industries Wireless and wired communications, command, control and sensing system for sound and/or data transmission and reception
US6076016A (en) 1995-10-19 2000-06-13 Feierbach; Gary F. Galvanic transdermal conduction communication system and method
GB9522872D0 (en) 1995-11-08 1996-01-10 Oxford Medical Ltd Improvements relating to physiological monitoring
US8092224B2 (en) 1995-11-22 2012-01-10 James A. Jorasch Systems and methods for improved health care compliance
SE9504258D0 (sv) 1995-11-28 1995-11-28 Pacesetter Ab Device and method for generating a synthesized ECG
US5596302A (en) 1996-01-17 1997-01-21 Lucent Technologies Inc. Ring oscillator using even numbers of differential stages with current mirrors
CN1216208A (zh) 1996-02-15 1999-05-05 阿曼德P·诺伊凯尔曼 改进的可生物相容的换能器
US5868136A (en) 1996-02-20 1999-02-09 Axelgaard Manufacturing Co. Ltd. Medical electrode
US20010044588A1 (en) 1996-02-22 2001-11-22 Mault James R. Monitoring system
US5833603A (en) 1996-03-13 1998-11-10 Lipomatrix, Inc. Implantable biosensing transponder
UA48221C2 (uk) 1996-04-01 2002-08-15 Валєрій Івановіч Кобозєв Електростимулятор шлунково-кишкового тракту
GB9608268D0 (en) 1996-04-22 1996-06-26 Robertson James L Blister pack
US5864578A (en) 1996-04-29 1999-01-26 Golden Bridge Technology, Inc. Matched filter-based handoff method and apparatus
US5800421A (en) 1996-06-12 1998-09-01 Lemelson; Jerome H. Medical devices using electrosensitive gels
US6081734A (en) 1996-08-16 2000-06-27 Roche Diagnostics Gmbh Monitoring system for the regular intake of a medicament
SI0938318T1 (en) 1996-08-29 2001-12-31 Sanofi Synthelabo Tablet with controlled release of alfuzosine chlorydrate
US5792048A (en) 1996-09-03 1998-08-11 Schaefer; Guenter Indentification pill with integrated microchip: smartpill, smartpill with integrated microchip and microprocessor for medical analyses and a smartpill, smartbox, smartplague, smartbadge or smartplate for luggage control on commercial airliners
US5963132A (en) 1996-10-11 1999-10-05 Avid Indentification Systems, Inc. Encapsulated implantable transponder
US6364834B1 (en) 1996-11-13 2002-04-02 Criticare Systems, Inc. Method and system for remotely monitoring multiple medical parameters in an integrated medical monitoring system
GB9623634D0 (en) 1996-11-13 1997-01-08 Bpsi Holdings Inc Method and apparatus for the coating of substrates for pharmaceutical use
US8734339B2 (en) 1996-12-16 2014-05-27 Ip Holdings, Inc. Electronic skin patch for real time monitoring of cardiac activity and personal health management
US5974124A (en) 1997-01-21 1999-10-26 Med Graph Method and system aiding medical diagnosis and treatment
US6122351A (en) 1997-01-21 2000-09-19 Med Graph, Inc. Method and system aiding medical diagnosis and treatment
US6317714B1 (en) 1997-02-04 2001-11-13 Microsoft Corporation Controller and associated mechanical characters operable for continuously performing received control data while engaging in bidirectional communications over a single communications channel
ATE477746T1 (de) 1997-03-17 2010-09-15 Adidas Ag Informationsrückkopplungs system für physiologische signale
WO1998043537A1 (en) 1997-03-31 1998-10-08 Telecom Medical, Inc. Patient monitoring apparatus
DE19717023C2 (de) 1997-04-23 2003-02-06 Micronas Gmbh Vorrichtung zum Behandeln von malignen, tumorösen Gewebebereichen
US5981166A (en) 1997-04-23 1999-11-09 Pharmaseq, Inc. Screening of soluble chemical compounds for their pharmacological properties utilizing transponders
US6288629B1 (en) 1997-05-23 2001-09-11 Intermec Ip Corp. Method of using write—ok flag for radio frequency (RF) transponders (RF Tags)
US5984875A (en) 1997-08-22 1999-11-16 Innotek Pet Products, Inc. Ingestible animal temperature sensor
US5862808A (en) 1997-08-26 1999-01-26 Cigar Savor Enterprises Llc Cigar punch
US5948227A (en) 1997-12-17 1999-09-07 Caliper Technologies Corp. Methods and systems for performing electrophoretic molecular separations
GB9801363D0 (en) 1998-01-22 1998-03-18 Danbiosyst Uk Novel dosage form
US6099259A (en) 1998-01-26 2000-08-08 Bristol Compressors, Inc. Variable capacity compressor
US6097927A (en) 1998-01-27 2000-08-01 Symbix, Incorporated Active symbolic self design method and apparatus
US6038464A (en) 1998-02-09 2000-03-14 Axelgaard Manufacturing Co., Ltd. Medical electrode
US7542878B2 (en) 1998-03-03 2009-06-02 Card Guard Scientific Survival Ltd. Personal health monitor and a method for health monitoring
US6141592A (en) 1998-03-06 2000-10-31 Intermedics Inc. Data transmission using a varying electric field
US6579231B1 (en) 1998-03-27 2003-06-17 Mci Communications Corporation Personal medical monitoring unit and system
US6091975A (en) 1998-04-01 2000-07-18 Alza Corporation Minimally invasive detecting device
US6949816B2 (en) 2003-04-21 2005-09-27 Motorola, Inc. Semiconductor component having first surface area for electrically coupling to a semiconductor chip and second surface area for electrically coupling to a substrate, and method of manufacturing same
US6175752B1 (en) 1998-04-30 2001-01-16 Therasense, Inc. Analyte monitoring device and methods of use
DE69910003T2 (de) 1998-05-13 2004-04-22 Cygnus, Inc., Redwood City Überwachung physiologischer analyte
WO1999059465A1 (en) 1998-05-21 1999-11-25 Telecom Medical, Inc. Patient monitoring apparatus
US6477424B1 (en) 1998-06-19 2002-11-05 Medtronic, Inc. Medical management system integrated programming apparatus for communication with an implantable medical device
US6704602B2 (en) 1998-07-02 2004-03-09 Medtronic, Inc. Implanted medical device/external medical instrument communication utilizing surface electrodes
US7209787B2 (en) 1998-08-05 2007-04-24 Bioneuronics Corporation Apparatus and method for closed-loop intracranial stimulation for optimal control of neurological disease
US7548787B2 (en) 2005-08-03 2009-06-16 Kamilo Feher Medical diagnostic and communication system
US6703047B2 (en) 2001-02-02 2004-03-09 Incept Llc Dehydrated hydrogel precursor-based, tissue adherent compositions and methods of use
US6558320B1 (en) 2000-01-20 2003-05-06 Medtronic Minimed, Inc. Handheld personal data assistant (PDA) with a medical device and method of using the same
US6333699B1 (en) 1998-08-28 2001-12-25 Marathon Oil Company Method and apparatus for determining position in a pipe
JP2002524124A (ja) 1998-09-04 2002-08-06 ウルフ リサーチ プロプライエタリー リミテッド 医療埋込みシステム
AU5651699A (en) 1998-09-18 2000-04-10 Hitachi Maxell, Ltd. Noncontact communication semiconductor device
FI116957B (fi) 1998-10-29 2006-04-13 Nokia Corp Menetelmä langattoman laitteen ja elektroniikkalaitteen välistä tiedonsiirtoa varten ja tiedonsiirtolaite
US6708060B1 (en) 1998-11-09 2004-03-16 Transpharma Ltd. Handheld apparatus and method for transdermal drug delivery and analyte extraction
AU1832800A (en) 1998-11-25 2000-06-19 Ball Semiconductor Inc. Method of and system for identifying medical products
US6217744B1 (en) 1998-12-18 2001-04-17 Peter Crosby Devices for testing fluid
WO2000037114A2 (en) 1998-12-21 2000-06-29 Sequella, Inc. Methods and compositions comprising monitoring devices
US6115636A (en) 1998-12-22 2000-09-05 Medtronic, Inc. Telemetry for implantable devices using the body as an antenna
US6269058B1 (en) 1999-01-04 2001-07-31 Texas Instruments Incorporated Wide capture range circuitry
US6358202B1 (en) 1999-01-25 2002-03-19 Sun Microsystems, Inc. Network for implanted computer devices
US8636648B2 (en) 1999-03-01 2014-01-28 West View Research, Llc Endoscopic smart probe
US6285897B1 (en) 1999-04-07 2001-09-04 Endonetics, Inc. Remote physiological monitoring system
US6494829B1 (en) 1999-04-15 2002-12-17 Nexan Limited Physiological sensor array
US6200265B1 (en) 1999-04-16 2001-03-13 Medtronic, Inc. Peripheral memory patch and access method for use with an implantable medical device
US6755783B2 (en) 1999-04-16 2004-06-29 Cardiocom Apparatus and method for two-way communication in a device for monitoring and communicating wellness parameters of ambulatory patients
US6290646B1 (en) 1999-04-16 2001-09-18 Cardiocom Apparatus and method for monitoring and communicating wellness parameters of ambulatory patients
DK1182966T3 (da) 1999-05-25 2004-04-13 Medicotest As Elektrode til påsætning på huden
EP1852836A3 (en) 1999-05-26 2011-03-30 Johnson Controls Technology Company Wireless communications system and method
US6366206B1 (en) 1999-06-02 2002-04-02 Ball Semiconductor, Inc. Method and apparatus for attaching tags to medical and non-medical devices
EP1060704A3 (en) 1999-06-18 2002-09-18 Agilent Technologies, Inc. (a Delaware corporation) Multi-parameter capability transmitter for wireless telemetry systems
JP3402267B2 (ja) 1999-06-23 2003-05-06 ソニーケミカル株式会社 電子素子の実装方法
DE19929328A1 (de) 1999-06-26 2001-01-04 Daimlerchrysler Aerospace Ag Vorrichtung zur medizinischen Langzeitüberwachung von Personen
US6287252B1 (en) 1999-06-30 2001-09-11 Monitrak Patient monitor
US6307468B1 (en) 1999-07-20 2001-10-23 Avid Identification Systems, Inc. Impedance matching network and multidimensional electromagnetic field coil for a transponder interrogator
HN2000000165A (es) 1999-08-05 2001-07-09 Dimensional Foods Corp Productos holograficos comestibles, particularmente farmaceuticos, y metodos y aparatos para producirlos.
US6428809B1 (en) 1999-08-18 2002-08-06 Microdose Technologies, Inc. Metering and packaging of controlled release medication
US6206702B1 (en) 1999-08-24 2001-03-27 Deborah A. Hayden Methods and devices for treating unilateral neglect
US6526034B1 (en) 1999-09-21 2003-02-25 Tantivy Communications, Inc. Dual mode subscriber unit for short range, high rate and long range, lower rate data communications
US6533733B1 (en) 1999-09-24 2003-03-18 Ut-Battelle, Llc Implantable device for in-vivo intracranial and cerebrospinal fluid pressure monitoring
US6990082B1 (en) 1999-11-08 2006-01-24 Intel Corporation Wireless apparatus having a transceiver equipped to support multiple wireless communication protocols
EP1089572B1 (en) 1999-09-30 2011-09-21 Sony Corporation Recording apparatus, recording method, and record medium
WO2001026232A2 (en) 1999-10-07 2001-04-12 La Mont, Llc Physiological signal monitoring apparatus and method
US6852084B1 (en) 2000-04-28 2005-02-08 Peter V. Boesen Wireless physiological pressure sensor and transmitter with capability of short range radio frequency transmissions
US6882881B1 (en) 1999-10-19 2005-04-19 The Johns Hopkins University Techniques using heat flow management, stimulation, and signal analysis to treat medical disorders
US6426863B1 (en) 1999-11-25 2002-07-30 Lithium Power Technologies, Inc. Electrochemical capacitor
US6612984B1 (en) 1999-12-03 2003-09-02 Kerr, Ii Robert A. System and method for collecting and transmitting medical data
GB9930000D0 (en) 1999-12-21 2000-02-09 Phaeton Research Ltd An ingestible device
US6294999B1 (en) 1999-12-29 2001-09-25 Becton, Dickinson And Company Systems and methods for monitoring patient compliance with medication regimens
US8002700B2 (en) 1999-12-30 2011-08-23 Medtronic, Inc. Communications system for an implantable medical device and a delivery device
US6471645B1 (en) 1999-12-30 2002-10-29 Medtronic, Inc. Communications system for an implantable device and a drug dispenser
EP1119137B1 (en) 2000-01-20 2006-08-16 Lucent Technologies Inc. Interoperability for bluetooth/IEEE 802.11
US6567685B2 (en) 2000-01-21 2003-05-20 Kabushiki Kaisha Toshiba Magnetic resonance imaging apparatus
AR026148A1 (es) 2000-01-21 2003-01-29 Osmotica Argentina S A Dispositivo osmotico con pasaje preformado que aumenta de tamano
US6368190B1 (en) 2000-01-26 2002-04-09 Agere Systems Guardian Corp. Electrochemical mechanical planarization apparatus and method
US7039453B2 (en) 2000-02-08 2006-05-02 Tarun Mullick Miniature ingestible capsule
US7177675B2 (en) 2000-02-09 2007-02-13 Cns Response, Inc Electroencephalography based systems and methods for selecting therapies and predicting outcomes
DE20122488U1 (de) 2000-03-08 2005-12-15 Given Imaging Ltd. Vorrichtung und System für In-Vivo-Bildgebung
US6526315B1 (en) 2000-03-17 2003-02-25 Tanita Corporation Portable bioelectrical impedance measuring instrument
DE10014588A1 (de) 2000-03-27 2001-10-04 Basf Ag Wirkstoffhaltige Schwimmformen enthaltend Polyvinylacetat und Polyvinylpyrrolidon, deren Verwendung und Herstellung
GB0007617D0 (en) 2000-03-29 2000-05-17 Psion Dacom Plc A short range radio transceiver device
US6757523B2 (en) 2000-03-31 2004-06-29 Zeus Wireless, Inc. Configuration of transmit/receive switching in a transceiver
US6622050B2 (en) 2000-03-31 2003-09-16 Medtronic, Inc. Variable encryption scheme for data transfer between medical devices and related data management systems
US6922592B2 (en) 2000-04-04 2005-07-26 Medtronic, Inc. Implantable medical device controlled by a non-invasive physiological data measurement device
US6654638B1 (en) 2000-04-06 2003-11-25 Cardiac Pacemakers, Inc. Ultrasonically activated electrodes
US6496705B1 (en) 2000-04-18 2002-12-17 Motorola Inc. Programmable wireless electrode system for medical monitoring
US6441747B1 (en) 2000-04-18 2002-08-27 Motorola, Inc. Wireless system protocol for telemetry monitoring
US6561975B1 (en) 2000-04-19 2003-05-13 Medtronic, Inc. Method and apparatus for communicating with medical device systems
US6836862B1 (en) 2000-04-24 2004-12-28 3Com Corporation Method of indicating wireless connection integrity
WO2001086894A2 (en) 2000-05-08 2001-11-15 Transilica, Inc. Transmit-only and receive-only bluetooth apparatus and method
US6432292B1 (en) 2000-05-16 2002-08-13 Metallic Power, Inc. Method of electrodepositing metal on electrically conducting particles
AU2001264654B2 (en) 2000-05-19 2005-06-16 Welch Allyn Protocol Inc. Patient monitoring system
US6680923B1 (en) 2000-05-23 2004-01-20 Calypso Wireless, Inc. Communication system and method
WO2001091637A1 (en) 2000-05-29 2001-12-06 Medicotest A/S An electrode for establishing electrical contact with the skin
IL143418A (en) 2000-05-31 2004-09-27 Given Imaging Ltd Measurement of electrical properties of tissue
US7689437B1 (en) 2000-06-16 2010-03-30 Bodymedia, Inc. System for monitoring health, wellness and fitness
US6605038B1 (en) 2000-06-16 2003-08-12 Bodymedia, Inc. System for monitoring health, wellness and fitness
GB0014854D0 (en) 2000-06-16 2000-08-09 Isis Innovation System and method for acquiring data
US7261690B2 (en) 2000-06-16 2007-08-28 Bodymedia, Inc. Apparatus for monitoring health, wellness and fitness
GB0014855D0 (en) 2000-06-16 2000-08-09 Isis Innovation Combining measurements from different sensors
US20060122474A1 (en) 2000-06-16 2006-06-08 Bodymedia, Inc. Apparatus for monitoring health, wellness and fitness
US7009946B1 (en) 2000-06-22 2006-03-07 Intel Corporation Method and apparatus for multi-access wireless communication
GB0016561D0 (en) 2000-07-05 2000-08-23 Rolls Royce Plc Health monitoring
WO2002005712A1 (en) 2000-07-19 2002-01-24 Medicotest A/S A skin electrode with a by-pass element
WO2002007598A1 (en) 2000-07-24 2002-01-31 Motorola, Inc. Ingestible electronic capsule
US6564079B1 (en) 2000-07-27 2003-05-13 Ckm Diagnostics, Inc. Electrode array and skin attachment system for noninvasive nerve location and imaging device
JP4428835B2 (ja) 2000-08-09 2010-03-10 昭和電工株式会社 磁気記録媒体及びその製造方法
US8036731B2 (en) 2001-01-22 2011-10-11 Spectrum Dynamics Llc Ingestible pill for diagnosing a gastrointestinal tract
WO2002018936A2 (en) 2000-08-28 2002-03-07 Cygnus, Inc. Methods of monitoring glucose levels in a subject and uses thereof
US7685005B2 (en) 2000-08-29 2010-03-23 Medtronic, Inc. Medical device systems implemented network scheme for remote patient management
DE60102331T2 (de) 2000-09-08 2005-03-17 Matsushita Electric Works, Ltd., Kadoma Datenübertragungssystem unter Verwendung eines menschlichen Körpers als Signalübertragungsweg
US6720923B1 (en) 2000-09-14 2004-04-13 Stata Labs, Llc Antenna design utilizing a cavity architecture for global positioning system (GPS) applications
US6572636B1 (en) 2000-09-19 2003-06-03 Robert Sean Hagen Pulse sensing patch and associated methods
US7460130B2 (en) 2000-09-26 2008-12-02 Advantage 3D Llc Method and system for generation, storage and distribution of omni-directional object views
AU2002224453A1 (en) 2000-10-11 2002-04-22 Microchips, Inc. Microchip reservoir devices and facilitated corrosion of electrodes
US7024248B2 (en) 2000-10-16 2006-04-04 Remon Medical Technologies Ltd Systems and methods for communicating with implantable devices
US7857626B2 (en) 2000-10-23 2010-12-28 Toly Christopher C Medical physiological simulator including a conductive elastomer layer
WO2002034331A2 (en) 2000-10-26 2002-05-02 Medtronic, Inc. Externally worn transceiver for use with an implantable medical device
US6929636B1 (en) 2000-11-08 2005-08-16 Hewlett-Packard Development Company, L.P. Internal drug dispenser capsule medical device
US6632175B1 (en) 2000-11-08 2003-10-14 Hewlett-Packard Development Company, L.P. Swallowable data recorder capsule medical device
ES2177434B1 (es) 2000-12-05 2004-10-16 Gesimpex Comercial, S.L. Procedimiento y capsula para la identificacion y seguimiento remoto de aves.
US6689117B2 (en) 2000-12-18 2004-02-10 Cardiac Pacemakers, Inc. Drug delivery system for implantable medical device
US6879810B2 (en) 2000-12-20 2005-04-12 Nokia Corporation Control of short range RF communication
TW567695B (en) 2001-01-17 2003-12-21 Ibm Digital baseband system
WO2002063260A2 (en) 2001-02-08 2002-08-15 Mini-Mitter Company, Inc. Skin patch including a temperature sensor
JP2002263185A (ja) 2001-03-12 2002-09-17 Sanyo Electric Co Ltd 投薬システム及び方法及び投薬装置
GB0107045D0 (en) 2001-03-21 2001-05-09 Pace Micro Tech Plc Control system for control of power supply for lnb in broadcast data receiving system
JP2002282219A (ja) 2001-03-22 2002-10-02 Toshio Chiba 体内カプセル
US6342774B1 (en) 2001-03-27 2002-01-29 Motorola, Inc. Battery having user charge capacity control
JP2002290212A (ja) 2001-03-27 2002-10-04 Nec Corp 電圧制御発振器
EP1383575A4 (en) 2001-03-28 2010-01-20 Televital Inc SYSTEM AND METHOD FOR REAL-TIME MONITORING, INVESTIGATION, ANALYSIS, RECOVERY AND STORAGE OF PHYSIOLOGICAL DATA OVER A WIDE-FUTURE NETWORK (WAN)
US6595929B2 (en) 2001-03-30 2003-07-22 Bodymedia, Inc. System for monitoring health, wellness and fitness having a method and apparatus for improved measurement of heat flow
JP2004527296A (ja) 2001-04-02 2004-09-09 エヌ アイ メディカル リミテッド 血行動態の測定用装置
US7407484B2 (en) 2001-04-06 2008-08-05 Medic4All Inc. Physiological monitoring system for a computational device of a human subject
GR1003802B (el) 2001-04-17 2002-02-08 Micrel �.�.�. ������� ��������� ��������������� ��������� Συστημα τηλειατρικης.
US6694161B2 (en) 2001-04-20 2004-02-17 Monsanto Technology Llc Apparatus and method for monitoring rumen pH
US6801137B2 (en) 2001-04-23 2004-10-05 Cardionet, Inc. Bidirectional communication between a sensor unit and a monitor unit in patient monitoring
US6782290B2 (en) 2001-04-27 2004-08-24 Medtronic, Inc. Implantable medical device with rechargeable thin-film microbattery power source
WO2002087681A2 (en) 2001-04-30 2002-11-07 Medtronic,Inc. Implantable medical device and patch system
EP1383425A1 (en) 2001-05-03 2004-01-28 Telzuit Technologies, Inc. Wireless medical monitoring apparatus and system
US7039033B2 (en) 2001-05-07 2006-05-02 Ixi Mobile (Israel) Ltd. System, device and computer readable medium for providing a managed wireless network using short-range radio signals
WO2002095351A2 (en) 2001-05-20 2002-11-28 Given Imaging Ltd. A floatable in vivo sensing device
GB0113212D0 (en) 2001-05-31 2001-07-25 Oxford Biosignals Ltd Patient condition display
US20020192159A1 (en) 2001-06-01 2002-12-19 Reitberg Donald P. Single-patient drug trials used with accumulated database: flowchart
US20020179921A1 (en) 2001-06-02 2002-12-05 Cohn Michael B. Compliant hermetic package
BR0210508A (pt) 2001-06-19 2006-04-04 Digital Sports Media monitoração fisiológica e sistema
US7160258B2 (en) 2001-06-26 2007-01-09 Entrack, Inc. Capsule and method for treating or diagnosing the intestinal tract
US7044911B2 (en) 2001-06-29 2006-05-16 Philometron, Inc. Gateway platform for biological monitoring and delivery of therapeutic compounds
US7083578B2 (en) 2001-07-12 2006-08-01 Given Imaging Ltd. Device and method for examining a body lumen
US20030017826A1 (en) 2001-07-17 2003-01-23 Dan Fishman Short-range wireless architecture
WO2003009920A1 (en) 2001-07-25 2003-02-06 Biosource, Inc. Electrode array for use in electrochemical cells
FR2827919B1 (fr) 2001-07-26 2004-03-05 Thermodyn Garniture d'etancheite pour compresseur et compresseur centrifuge pourvu d'une telle garniture
US6951536B2 (en) 2001-07-30 2005-10-04 Olympus Corporation Capsule-type medical device and medical system
US6747556B2 (en) 2001-07-31 2004-06-08 Medtronic Physio-Control Corp. Method and system for locating a portable medical device
US20030065536A1 (en) 2001-08-13 2003-04-03 Hansen Henrik Egesborg Portable device and method of communicating medical data information
WO2003015890A1 (en) 2001-08-20 2003-02-27 President And Fellows Of Harvard College Fluidic arrays and method of using
JP3962250B2 (ja) 2001-08-29 2007-08-22 株式会社レアメタル 生体内情報検出システム及びこれに用いるタグ装置、中継装置
US6650191B2 (en) 2001-09-07 2003-11-18 Texas Instruments Incorporated Low jitter ring oscillator architecture
US20050137480A1 (en) 2001-10-01 2005-06-23 Eckhard Alt Remote control of implantable device through medical implant communication service band
US20030062551A1 (en) 2001-10-02 2003-04-03 Jds Uniphase Corporation Electrode structure including encapsulated adhesion layer
US6840904B2 (en) 2001-10-11 2005-01-11 Jason Goldberg Medical monitoring device and system
US7357891B2 (en) 2001-10-12 2008-04-15 Monosol Rx, Llc Process for making an ingestible film
US6745082B2 (en) 2001-10-22 2004-06-01 Jens Axelgaard Current-controlling electrode with adjustable contact area
US20030152622A1 (en) 2001-10-25 2003-08-14 Jenny Louie-Helm Formulation of an erodible, gastric retentive oral diuretic
US20030083559A1 (en) 2001-10-31 2003-05-01 Thompson David L. Non-contact monitor
US6643541B2 (en) 2001-12-07 2003-11-04 Motorola, Inc Wireless electromyography sensor and system
US20030107487A1 (en) 2001-12-10 2003-06-12 Ronen Korman Method and device for measuring physiological parameters at the wrist
GB0130010D0 (en) 2001-12-14 2002-02-06 Isis Innovation Combining measurements from breathing rate sensors
US7016648B2 (en) 2001-12-18 2006-03-21 Ixi Mobile (Israel) Ltd. Method, system and computer readable medium for downloading a software component to a device in a short distance wireless network
US7729776B2 (en) 2001-12-19 2010-06-01 Cardiac Pacemakers, Inc. Implantable medical device with two or more telemetry systems
US7877273B2 (en) 2002-01-08 2011-01-25 Fredric David Abramson System and method for evaluating and providing nutrigenomic data, information and advice
AU2003205153A1 (en) 2002-01-11 2003-07-30 Hexalog Sa Systems and methods for medication monitoring
US7519416B2 (en) 2002-02-04 2009-04-14 Heartview, Llc Diagnostic method utilizing standard lead ECG signals
IL154391A (en) 2002-02-11 2009-05-04 Given Imaging Ltd Self-propelled device
FR2835730B1 (fr) 2002-02-11 2004-12-10 C T M Ct De Transfert Des Micr Dispositif pour la delivrance de substances et le prelevement intracorporel
US6935560B2 (en) 2002-02-26 2005-08-30 Safety Syringes, Inc. Systems and methods for tracking pharmaceuticals within a facility
US20030162556A1 (en) 2002-02-28 2003-08-28 Libes Michael A. Method and system for communication between two wireless-enabled devices
US7043305B2 (en) 2002-03-06 2006-05-09 Cardiac Pacemakers, Inc. Method and apparatus for establishing context among events and optimizing implanted medical device performance
US7468032B2 (en) 2002-12-18 2008-12-23 Cardiac Pacemakers, Inc. Advanced patient management for identifying, displaying and assisting with correlating health-related data
US6957107B2 (en) 2002-03-13 2005-10-18 Cardionet, Inc. Method and apparatus for monitoring and communicating with an implanted medical device
US6968153B1 (en) 2002-03-13 2005-11-22 Nokia Corporation Apparatus, method and system for a Bluetooth repeater
US7188767B2 (en) 2002-03-18 2007-03-13 Precision Dynamics Corporation Physical condition or environmental threat detection appliance system
JP3869291B2 (ja) 2002-03-25 2007-01-17 オリンパス株式会社 カプセル型医療装置
US6850788B2 (en) 2002-03-25 2005-02-01 Masimo Corporation Physiological measurement communications adapter
US7376435B2 (en) 2002-04-01 2008-05-20 Intel Corporation Transferring multiple data units over a wireless communication link
US7797033B2 (en) 2002-04-08 2010-09-14 Smart Pill Corporation Method of using, and determining location of, an ingestible capsule
US7645262B2 (en) 2002-04-11 2010-01-12 Second Sight Medical Products, Inc. Biocompatible bonding method and electronics package suitable for implantation
AU2003234159A1 (en) 2002-04-22 2003-11-03 Purdue Research Foundation Hydrogels having enhanced elasticity and mechanical strength properties
US7424268B2 (en) 2002-04-22 2008-09-09 Cisco Technology, Inc. System and method for management of a shared frequency band
IL164685A0 (en) 2002-04-22 2005-12-18 Marcio Marc Aurelio Martins Ab Apparatus and method for measuring biologic parameters
EP1356762A1 (de) 2002-04-22 2003-10-29 UbiCom Gesellschaft für Telekommunikation mbH Geräteanordnung zur Fernüberwachung von Körperfunktionen
US20030216622A1 (en) 2002-04-25 2003-11-20 Gavriel Meron Device and method for orienting a device in vivo
US7368190B2 (en) 2002-05-02 2008-05-06 Abbott Diabetes Care Inc. Miniature biological fuel cell that is operational under physiological conditions, and associated devices and methods
US7901939B2 (en) 2002-05-09 2011-03-08 University Of Chicago Method for performing crystallization and reactions in pressure-driven fluid plugs
JP2003325439A (ja) 2002-05-15 2003-11-18 Olympus Optical Co Ltd カプセル型医療装置
US20030216729A1 (en) 2002-05-20 2003-11-20 Marchitto Kevin S. Device and method for wound healing and uses therefor
US6847844B2 (en) 2002-06-06 2005-01-25 University Of Pittsburgh Of The Commonwealth System Of Higher Education Method of data communication with implanted device and associated apparatus
US6864692B1 (en) 2002-06-20 2005-03-08 Xsilogy, Inc. Sensor having improved selectivity
US8003179B2 (en) 2002-06-20 2011-08-23 Alcan Packaging Flexible France Films having a desiccant material incorporated therein and methods of use and manufacture
US20040008123A1 (en) 2002-07-15 2004-01-15 Battelle Memorial Institute System and method for tracking medical devices
US20040143182A1 (en) 2002-08-08 2004-07-22 Pavel Kucera System and method for monitoring and stimulating gastro-intestinal motility
US7619819B2 (en) 2002-08-20 2009-11-17 Illumina, Inc. Method and apparatus for drug product tracking using encoded optical identification elements
US6909878B2 (en) 2002-08-20 2005-06-21 Ixi Mobile (Israel) Ltd. Method, system and computer readable medium for providing an output signal having a theme to a device in a short distance wireless network
US7020508B2 (en) 2002-08-22 2006-03-28 Bodymedia, Inc. Apparatus for detecting human physiological and contextual information
US7294105B1 (en) 2002-09-03 2007-11-13 Cheetah Omni, Llc System and method for a wireless medical communication system
DE60305817T2 (de) 2002-09-04 2007-01-11 Broadcom Corp., Irvine System und Verfahren zur Optimierung von Stromverbrauch in einer mobilen Umgebung
US20040049245A1 (en) 2002-09-09 2004-03-11 Volker Gass Autonomous patch for communication with an implantable device, and medical kit for using said patch
US7102508B2 (en) 2002-09-09 2006-09-05 Persephone, Inc. Method and apparatus for locating and tracking persons
US7388903B2 (en) 2002-09-18 2008-06-17 Conexant, Inc. Adaptive transmission rate and fragmentation threshold mechanism for local area networks
GB2393356B (en) 2002-09-18 2006-02-01 E San Ltd Telemedicine system
US7118531B2 (en) 2002-09-24 2006-10-10 The Johns Hopkins University Ingestible medical payload carrying capsule with wireless communication
US6842636B2 (en) 2002-09-27 2005-01-11 Axelgaard Manufacturing Co., Ltd. Medical electrode
US7736309B2 (en) 2002-09-27 2010-06-15 Medtronic Minimed, Inc. Implantable sensor method and system
US7209790B2 (en) 2002-09-30 2007-04-24 Medtronic, Inc. Multi-mode programmer for medical device communication
US7686762B1 (en) 2002-10-03 2010-03-30 Integrated Sensing Systems, Inc. Wireless device and system for monitoring physiologic parameters
BR0315229A (pt) 2002-10-09 2005-08-30 Bodymedia Inc Aparelho para detectar, receber, derivar, e apresentar informação humana fisiológica e de contexto
US20040073454A1 (en) 2002-10-10 2004-04-15 John Urquhart System and method of portal-mediated, website-based analysis of medication dosing
US6959217B2 (en) 2002-10-24 2005-10-25 Alfred E. Mann Foundation For Scientific Research Multi-mode crystal oscillator system selectively configurable to minimize power consumption or noise generation
US7027871B2 (en) 2002-10-31 2006-04-11 Medtronic, Inc. Aggregation of data from external data sources within an implantable medical device
US20030126593A1 (en) 2002-11-04 2003-07-03 Mault James R. Interactive physiological monitoring system
US7232627B2 (en) 2002-11-08 2007-06-19 Honda Motor Co., Ltd. Electrode for solid polymer fuel cell
US20040092801A1 (en) 2002-11-13 2004-05-13 Budimir Drakulic System for, and method of, acquiring physiological signals of a patient
US20050288594A1 (en) 2002-11-29 2005-12-29 Shlomo Lewkowicz Methods, device and system for in vivo diagnosis
US20040115507A1 (en) 2002-12-05 2004-06-17 Potter Curtis N Monolithic fuel cell and method of manufacture
CA2508722A1 (en) 2002-12-11 2004-06-24 Pfizer Products Inc. Controlled-release of an active substance into a high fat environment
US20040167226A1 (en) 2002-12-16 2004-08-26 Serafini Tito A. Methods for the treatment of pain and traumatic injury using benzamides and compositions containing the same
JP2006509574A (ja) 2002-12-16 2006-03-23 ギブン イメージング リミテッド 生体内センサの選択的作動のための装置、システム、及び方法
US7009511B2 (en) 2002-12-17 2006-03-07 Cardiac Pacemakers, Inc. Repeater device for communications with an implantable medical device
WO2004056418A1 (en) 2002-12-19 2004-07-08 Koninklijke Philips Electronics N.V. An electrode assembly and a system with impedance control
US7127300B2 (en) 2002-12-23 2006-10-24 Cardiac Pacemakers, Inc. Method and apparatus for enabling data communication between an implantable medical device and a patient management system
US6975174B1 (en) 2002-12-31 2005-12-13 Radioframe Networks, Inc. Clock oscillator
US7396330B2 (en) 2003-01-07 2008-07-08 Triage Data Networks Wireless, internet-based medical-diagnostic system
US20060142648A1 (en) 2003-01-07 2006-06-29 Triage Data Networks Wireless, internet-based, medical diagnostic system
US7512448B2 (en) 2003-01-10 2009-03-31 Phonak Ag Electrode placement for wireless intrabody communication between components of a hearing system
KR100522132B1 (ko) 2003-01-25 2005-10-18 한국과학기술연구원 인체통신시스템에서의 데이터 수신방법 및 수신장치
KR100873683B1 (ko) * 2003-01-25 2008-12-12 한국과학기술연구원 인체통신방법, 인체통신시스템 및 이에 사용되는 캡슐형 내시경
WO2004066903A2 (en) 2003-01-29 2004-08-12 E-Pill Pharma Ltd. Active drug delivery in the gastrointestinal tract
EP2374406B1 (en) 2003-01-30 2013-06-05 Accenture Global Services Limited Event data acquisition and transmission system
US7002476B2 (en) 2003-01-30 2006-02-21 Leap Of Faith Technologies, Inc. Medication compliance system
US7149581B2 (en) 2003-01-31 2006-12-12 Medtronic, Inc. Patient monitoring device with multi-antenna receiver
US6933026B2 (en) 2003-02-06 2005-08-23 Aradgim Corporation Method to reduce damage caused by irradiation of halogenated polymers
US7215660B2 (en) 2003-02-14 2007-05-08 Rearden Llc Single transceiver architecture for a wireless network
US7392015B1 (en) 2003-02-14 2008-06-24 Calamp Corp. Calibration methods and structures in wireless communications systems
US7155232B2 (en) 2003-03-05 2006-12-26 Conexant Systems, Inc. Transmit request signaling between transceivers
US7653031B2 (en) 2003-03-05 2010-01-26 Timothy Gordon Godfrey Advance notification of transmit opportunities on a shared-communications channel
US7321920B2 (en) 2003-03-21 2008-01-22 Vocel, Inc. Interactive messaging system
AU2004224345B2 (en) 2003-03-21 2010-02-18 Welch Allyn, Inc. Personal status physiologic monitor system and architecture and related monitoring methods
DE10313005B4 (de) 2003-03-24 2007-05-03 Siemens Ag Reservebatterie und Verfahren zu deren Herstellung
US7245954B2 (en) 2003-03-27 2007-07-17 Given Imaging Ltd. Measuring a gradient in-vivo
US20040193446A1 (en) 2003-03-27 2004-09-30 Mayer Steven Lloyd System and method for managing a patient treatment program including a prescribed drug regimen
GB0308114D0 (en) 2003-04-08 2003-05-14 Glaxo Group Ltd Novel compounds
JP4593083B2 (ja) 2003-04-11 2010-12-08 オリンパス株式会社 検査データ管理方法
GB0308467D0 (en) 2003-04-11 2003-05-21 Rolls Royce Plc Method and system for analysing tachometer and vibration data from an apparatus having one or more rotary components
FI116117B (fi) 2003-04-17 2005-09-30 Polar Electro Oy Mittalaite ja menetelmä sykkeen mittaamiseksi sekä mittalaitteen valmistusmenetelmä
US7972616B2 (en) 2003-04-17 2011-07-05 Nanosys, Inc. Medical device applications of nanostructured surfaces
WO2004096023A1 (ja) 2003-04-25 2004-11-11 Olympus Corporation 無線型被検体内情報取得システムおよび被検体外部装置
US20040218683A1 (en) 2003-05-01 2004-11-04 Texas Instruments Incorporated Multi-mode wireless devices having reduced-mode receivers
US20040225199A1 (en) 2003-05-08 2004-11-11 Evanyk Shane Walter Advanced physiological monitoring systems and methods
TWI226761B (en) 2003-05-08 2005-01-11 Ind Tech Res Inst Dual band transceiver architecture for wireless application
US7031745B2 (en) 2003-05-12 2006-04-18 Shen Ein-Yiao Cellular phone combined physiological condition examination and processing device
WO2004100776A1 (ja) 2003-05-14 2004-11-25 Olympus Corporation カプセル型医療装置
KR100542101B1 (ko) 2003-06-02 2006-01-11 삼성전자주식회사 전송 파워 제어 방법 및 이를 이용한 블루투스 장치
US20040249257A1 (en) 2003-06-04 2004-12-09 Tupin Joe Paul Article of manufacture for extracting physiological data using ultra-wideband radar and improved signal processing techniques
US7313163B2 (en) 2003-06-17 2007-12-25 Motorola, Inc. Fast synchronization for half duplex digital communications
US20040260154A1 (en) 2003-06-18 2004-12-23 Boris Sidelnik Human physiological and chemical monitoring system
WO2004112592A1 (ja) 2003-06-24 2004-12-29 Olympus Corporation カプセル型医療装置通信システム、カプセル型医療装置及び生体情報受信装置
KR20060039900A (ko) 2003-07-16 2006-05-09 코닌클리케 필립스 일렉트로닉스 엔.브이. 휴대용 전자 디바이스 및 개인의 생리적인 조건을모니터하기 위해 배열된 건강 관리 시스템
WO2005007223A2 (en) 2003-07-16 2005-01-27 Sasha John Programmable medical drug delivery systems and methods for delivery of multiple fluids and concentrations
US7554452B2 (en) 2003-07-18 2009-06-30 Cary Cole Ingestible tracking and locating device
US7442164B2 (en) 2003-07-23 2008-10-28 Med-El Elektro-Medizinische Gerate Gesellschaft M.B.H. Totally implantable hearing prosthesis
US7653350B2 (en) 2003-07-24 2010-01-26 Sony Ericsson Mobile Communications Ab Wireless terminals and methods for communicating over cellular and enhanced mode bluetooth communication links
JP4038575B2 (ja) 2003-07-25 2008-01-30 独立行政法人産業技術総合研究所 バイオセンサ、バイオセンサ装置またはバイオセンサの保存方法
US7243118B2 (en) 2003-07-30 2007-07-10 Broadcom Corporation Method and apparatus for efficient derivation of modulo arithmetic for frequency selection
US20050055014A1 (en) 2003-08-04 2005-03-10 Coppeta Jonathan R. Methods for accelerated release of material from a reservoir device
US7787946B2 (en) 2003-08-18 2010-08-31 Cardiac Pacemakers, Inc. Patient monitoring, diagnosis, and/or therapy systems and methods
US20050172958A1 (en) 2003-08-20 2005-08-11 The Brigham And Women's Hospital, Inc. Inhalation device and system for the remote monitoring of drug administration
CA2539547A1 (en) 2003-08-20 2005-03-03 Philometron, Inc. Hydration monitoring
US8346482B2 (en) 2003-08-22 2013-01-01 Fernandez Dennis S Integrated biosensor and simulation system for diagnosis and therapy
JP4398204B2 (ja) 2003-08-29 2010-01-13 オリンパス株式会社 被検体内導入装置および無線型被検体内情報取得システム
JP4332152B2 (ja) 2003-09-02 2009-09-16 富士通株式会社 薬服用状況管理方法及び薬剤
JP3993546B2 (ja) * 2003-09-08 2007-10-17 オリンパス株式会社 被検体内導入装置および無線型被検体内情報取得システム
US20050062644A1 (en) 2003-09-08 2005-03-24 Leci Jonathan Ilan Capsule device to identify the location of an individual
DK1662987T3 (da) 2003-09-11 2012-02-27 Theranos Inc Medicinsk anordning til analytovervågning og lægemiddeltilførsel
US7352998B2 (en) 2003-09-12 2008-04-01 Nokia Corporation Method and system for establishing a wireless communications link
KR101084554B1 (ko) 2003-09-12 2011-11-17 보디미디어 인코퍼레이티드 심장 관련 파라미터를 측정하기 위한 방법 및 장치
US7499674B2 (en) 2003-09-12 2009-03-03 Nokia Corporation Method and system for repeat request in hybrid ultra wideband-bluetooth radio
JP4153852B2 (ja) 2003-09-18 2008-09-24 オリンパス株式会社 エネルギー供給用コイルおよびこれを用いた無線型被検体内情報取得システム
US20090157358A1 (en) 2003-09-22 2009-06-18 Hyeung-Yun Kim System for diagnosing and monitoring structural health conditions
AU2004277167A1 (en) 2003-09-22 2005-04-07 Kim Hyeung-Yun Methods for monitoring structural health conditions
US7218967B2 (en) 2003-09-26 2007-05-15 Medtronic, Inc. System and method for real-time remote monitoring of implantable medical devices
JP4503979B2 (ja) 2003-10-22 2010-07-14 オリンパス株式会社 体内装置および医療機器
US20050075145A1 (en) 2003-10-03 2005-04-07 Dvorak Joseph L. Method and system for coordinating use of objects using wireless communications
DE60305505T2 (de) 2003-10-23 2007-04-26 Sony Ericsson Mobile Communications Ab Leistungssteuerungsschaltkreis für eine mobile Endgeräteanwendung
US20050096514A1 (en) 2003-11-01 2005-05-05 Medtronic, Inc. Gastric activity notification
US6892590B1 (en) 2003-11-04 2005-05-17 Andermotion Technologies Llc Single-balanced shield electrode configuration for use in capacitive displacement sensing systems and methods
US7101343B2 (en) 2003-11-05 2006-09-05 Temple University Of The Commonwealth System Of Higher Education Implantable telemetric monitoring system, apparatus, and method
US20050101843A1 (en) 2003-11-06 2005-05-12 Welch Allyn, Inc. Wireless disposable physiological sensor
US7415242B1 (en) 2003-11-10 2008-08-19 Sprint Spectrum L.P. Method and system for proximity detection for an in-building wireless repeater
DE102004032812B4 (de) 2003-11-11 2006-07-20 Dräger Safety AG & Co. KGaA Kombinationssensor für physiologische Messgrößen
JP2005158770A (ja) 2003-11-20 2005-06-16 Matsushita Electric Ind Co Ltd 積層基板とその製造方法及び前記積層基板を用いたモジュールの製造方法とその製造装置
US6987691B2 (en) 2003-12-02 2006-01-17 International Business Machines Corporation Easy axis magnetic amplifier
US7427266B2 (en) 2003-12-15 2008-09-23 Hewlett-Packard Development Company, L.P. Method and apparatus for verification of ingestion
US8306592B2 (en) 2003-12-19 2012-11-06 Olympus Corporation Capsule medical device
JP2005185567A (ja) * 2003-12-25 2005-07-14 Olympus Corp 医療用カプセル装置
JP4198045B2 (ja) 2003-12-25 2008-12-17 オリンパス株式会社 被検体内位置検出システム
US7392091B2 (en) 2003-12-30 2008-06-24 Cochlear Limited Implanted antenna and radio communications link
JP2005192821A (ja) 2004-01-07 2005-07-21 Olympus Corp カプセル型医療装置
JP2005193535A (ja) 2004-01-07 2005-07-21 Alps Electric Co Ltd サーマルヘッド及びその製造方法、並びにサーマルヘッドのドットアスペクト比調整方法
US7176784B2 (en) 2004-01-21 2007-02-13 Battelle Memorial Institute K1-53 Multi-mode radio frequency device
US7342895B2 (en) 2004-01-30 2008-03-11 Mark Serpa Method and system for peer-to-peer wireless communication over unlicensed communication spectrum
US7647112B2 (en) 2004-02-11 2010-01-12 Ethicon, Inc. System and method for selectively stimulating different body parts
US20060154642A1 (en) 2004-02-20 2006-07-13 Scannell Robert F Jr Medication & health, environmental, and security monitoring, alert, intervention, information and network system with associated and supporting apparatuses
US20050187789A1 (en) 2004-02-25 2005-08-25 Cardiac Pacemakers, Inc. Advanced patient and medication therapy management system and method
US7904133B2 (en) 2004-02-27 2011-03-08 Koninklijke Philips Electronics N.V. Wearable wireless device for monitoring, analyzing and communicating physiological status
CN1284505C (zh) 2004-02-28 2006-11-15 重庆金山科技（集团）有限公司 医用无线电胶囊式内窥系统
US7406105B2 (en) 2004-03-03 2008-07-29 Alfred E. Mann Foundation For Scientific Research System and method for sharing a common communication channel between multiple systems of implantable medical devices
JP4488315B2 (ja) 2004-03-04 2010-06-23 オリンパス株式会社 カプセル型医療システム
GB0405798D0 (en) 2004-03-15 2004-04-21 E San Ltd Medical data display
WO2005092177A1 (en) 2004-03-22 2005-10-06 Bodymedia, Inc. Non-invasive temperature monitoring device
JP4520198B2 (ja) 2004-04-07 2010-08-04 オリンパス株式会社 被検体内位置表示システム
US20050234307A1 (en) 2004-04-15 2005-10-20 Nokia Corporation Physiological event handling system and method
US9011329B2 (en) 2004-04-19 2015-04-21 Searete Llc Lumenally-active device
US9801527B2 (en) 2004-04-19 2017-10-31 Gearbox, Llc Lumen-traveling biological interface device
JP2005304880A (ja) 2004-04-23 2005-11-04 Hitachi Ltd 非接触ｉｃタグを利用した体内物体管理システム
AU2004319427B2 (en) 2004-04-24 2011-04-21 Inrange Systems, Inc. Integrated, non-sequential, remote medication management and compliance system
US20050245794A1 (en) 2004-04-29 2005-11-03 Medtronic, Inc. Communication with implantable monitoring probe
GB0410248D0 (en) 2004-05-07 2004-06-09 Isis Innovation Signal analysis method
WO2005110238A1 (en) 2004-05-16 2005-11-24 Medic4All A.G Method and device for measuring physiological parameters at the hand
US7575005B2 (en) 2004-05-18 2009-08-18 Excel-Tech Ltd. Mask assembly with integrated sensors
US20050261559A1 (en) 2004-05-18 2005-11-24 Mumford John R Wireless physiological monitoring system
US7241266B2 (en) 2004-05-20 2007-07-10 Digital Angel Corporation Transducer for embedded bio-sensor using body energy as a power source
KR100592934B1 (ko) 2004-05-21 2006-06-23 한국전자통신연구원 착용형 생체신호 검출모듈 및 이를 포함한 측정장치
US20050259768A1 (en) 2004-05-21 2005-11-24 Oki Techno Centre (Singapore) Pte Ltd Digital receiver and method for processing received signals
US7653542B2 (en) 2004-05-26 2010-01-26 Verizon Business Global Llc Method and system for providing synthesized speech
US20050267556A1 (en) 2004-05-28 2005-12-01 Allan Shuros Drug eluting implants to prevent cardiac apoptosis
EP1766591B1 (en) 2004-05-28 2008-01-16 Jan De Geest Communication unit for a person's skin
JP4666951B2 (ja) 2004-06-03 2011-04-06 シーケーディ株式会社 ブリスタ包装機及び医薬品固形製剤
US7289855B2 (en) 2004-06-09 2007-10-30 Medtronic, Inc. Implantable medical device package antenna
US7283867B2 (en) 2004-06-10 2007-10-16 Ndi Medical, Llc Implantable system and methods for acquisition and processing of electrical signals from muscles and/or nerves and/or central nervous system tissue
US7697994B2 (en) 2004-06-18 2010-04-13 Medtronic, Inc. Remote scheduling for management of an implantable medical device
US7498940B2 (en) 2004-06-22 2009-03-03 Vubiq, Inc. RFID system utilizing parametric reradiated technology
KR100615431B1 (ko) 2004-06-22 2006-08-25 한국전자통신연구원 생체신호 검출모듈, 다채널 커넥터 모듈 및 이를 포함한생체신호 검출장치
JP2006006377A (ja) 2004-06-22 2006-01-12 Elquest Corp 薬剤包装用の薬包紙
US20050285746A1 (en) 2004-06-25 2005-12-29 Sengupta Uttam K Radio frequency identification based system to track consumption of medication
US7206630B1 (en) 2004-06-29 2007-04-17 Cleveland Medical Devices, Inc Electrode patch and wireless physiological measurement system and method
US20070027383A1 (en) 2004-07-01 2007-02-01 Peyser Thomas A Patches, systems, and methods for non-invasive glucose measurement
US20060001496A1 (en) 2004-07-02 2006-01-05 Abrosimov Igor A Array oscillator and polyphase clock generator
JP4462614B2 (ja) 2004-07-05 2010-05-12 ソニー・エリクソン・モバイルコミュニケーションズ株式会社 近距離無線通信システム、携帯端末装置および無線通信装置
US7505795B1 (en) 2004-07-07 2009-03-17 Advanced Micro Devices, Inc. Power save management with customized range for user configuration and tuning value based upon recent usage
US7343186B2 (en) 2004-07-07 2008-03-11 Masimo Laboratories, Inc. Multi-wavelength physiological monitor
EP1781162A1 (en) 2004-07-09 2007-05-09 Tadiran Spectralink Ltd. Wearable device, system and method for measuring vital parameters
CN1314134C (zh) 2004-07-15 2007-05-02 上海交通大学 硅薄膜异质结太阳电池的制备方法
WO2006008740A1 (en) 2004-07-21 2006-01-26 Aerotel Medical Systems (1998) Ltd. Wearable device, system and method for measuring physiological and/or environmental parameters
CN100459614C (zh) 2004-07-22 2009-02-04 华为技术有限公司 一种手机外设装置与方法
US7537590B2 (en) 2004-07-30 2009-05-26 Microchips, Inc. Multi-reservoir device for transdermal drug delivery and sensing
US20060058602A1 (en) 2004-08-17 2006-03-16 Kwiatkowski Krzysztof C Interstitial fluid analyzer
US7317378B2 (en) 2004-08-17 2008-01-08 Tagent Corporation Product identification tag device and reader
US7253716B2 (en) 2004-08-17 2007-08-07 Tagent Corporation Trackable pills with electronic ID tags
WO2006021932A1 (en) 2004-08-27 2006-03-02 Koninklijke Philips Electronics, N.V. Electronically and remotely controlled pill and system for delivering at least one medicament
EP1794585A1 (en) 2004-08-31 2007-06-13 Lifescan Scotland Ltd Method of manufacturing an auto-calibrating sensor
KR100727817B1 (ko) 2004-09-07 2007-06-13 한국전자통신연구원 인체를 매질로 이용한 통신장치 및 그 방법
JP2008512162A (ja) 2004-09-08 2008-04-24 アラーティス メディカル エイエス センサ
KR20060023228A (ko) 2004-09-09 2006-03-14 이기방 다공질물질을 가지는 배터리와 배터리제조방법
GB2418144A (en) 2004-09-17 2006-03-22 Psimedica Ltd Medical device for delivery of beneficial substance
US20060065713A1 (en) 2004-09-24 2006-03-30 John Russell Kingery System and method for monitored administration of medical products to patients
US7618374B2 (en) 2004-09-27 2009-11-17 Siemens Medical Solutions Usa, Inc. Image plane sensing methods and systems for intra-patient probes
US7341560B2 (en) 2004-10-05 2008-03-11 Rader, Fishman & Grauer Pllc Apparatuses and methods for non-invasively monitoring blood parameters
US20060078765A1 (en) 2004-10-12 2006-04-13 Laixia Yang Nano-structured ion-conducting inorganic membranes for fuel cell applications
JP2008011865A (ja) 2004-10-27 2008-01-24 Sharp Corp 健康管理装置及びこれを機能させるためのプログラム
US10201305B2 (en) 2004-11-02 2019-02-12 Medtronic, Inc. Apparatus for data retention in an implantable medical device
US7917199B2 (en) 2004-11-02 2011-03-29 Medtronic, Inc. Patient event marking in combination with physiological signals
US20060095093A1 (en) 2004-11-04 2006-05-04 Ido Bettesh Apparatus and method for receiving device selection and combining
KR20060040500A (ko) 2004-11-06 2006-05-10 삼성전자주식회사 생체신호 측정 장치 및 방법
US7414534B1 (en) 2004-11-09 2008-08-19 Pacesetter, Inc. Method and apparatus for monitoring ingestion of medications using an implantable medical device
US7930064B2 (en) 2004-11-19 2011-04-19 Parata Systems, Llc Automated drug discrimination during dispensing
US7214107B2 (en) 2004-11-22 2007-05-08 Cardiodynamics International Corporation Electrical connector apparatus and methods
US8374693B2 (en) 2004-12-03 2013-02-12 Cardiac Pacemakers, Inc. Systems and methods for timing-based communication between implantable medical devices
US7154071B2 (en) 2004-12-07 2006-12-26 Dräger Safety AG & Co. KGaA Device for transmitting an electric signal detected by contact with the skin surface
EP1821432B1 (en) 2004-12-08 2011-07-06 Seiko Instruments Inc. Information transmission through-human-body system and transmitter/receiver
WO2006064397A2 (en) 2004-12-13 2006-06-22 Koninklijke Philips Electronics N.V. Mobile monitoring
JP2008522778A (ja) 2004-12-14 2008-07-03 イー−ピル ファーマ リミティド 電気透過性増加を用いた薬物又は物質の局所輸送
US20060136266A1 (en) 2004-12-20 2006-06-22 E-San Limited Medicinal product order processing system
US7146449B2 (en) 2004-12-22 2006-12-05 International Business Machines Corporation Bluetooth association with simple power connection
US7249212B2 (en) 2004-12-22 2007-07-24 International Business Machines Corporation Bluetooth association based on docking connection
DE602005007847D1 (de) 2004-12-30 2008-08-14 Given Imaging Ltd System zur Lokalisation einer in-Vivo Signalquelle
US20060148254A1 (en) 2005-01-05 2006-07-06 Mclean George Y Activated iridium oxide electrodes and methods for their fabrication
WO2006075016A1 (en) 2005-01-17 2006-07-20 Novo Nordisk A/S Fluide delivery device with integrated monitoring of physiological characteristics
EP1861007A2 (en) 2005-01-18 2007-12-05 Koninklijke Philips Electronics N.V. Electronically controlled ingestible capsule for sampling fluids in alimentary tract
US20090306633A1 (en) 2005-01-18 2009-12-10 Koninklijke Philips Electronics, N.V. Electronically controlled capsule
EP1841502A2 (en) 2005-01-18 2007-10-10 Koninklijke Philips Electronics N.V. Electronically controlled capsule for releasing radiation
WO2006077529A2 (en) 2005-01-18 2006-07-27 Koninklijke Philips Electronics, N.V. System for controlling traversal of an ingested capsule
US7686839B2 (en) 2005-01-26 2010-03-30 Lumitex, Inc. Phototherapy treatment devices for applying area lighting to a wound
US8226610B2 (en) 2005-02-01 2012-07-24 Intelliject, Inc. Medical injector with compliance tracking and monitoring
JP4731936B2 (ja) 2005-02-09 2011-07-27 本田技研工業株式会社 回転式可変抵抗器
JP4099484B2 (ja) 2005-02-09 2008-06-11 株式会社カイザーテクノロジー 通信システム。
US7850645B2 (en) 2005-02-11 2010-12-14 Boston Scientific Scimed, Inc. Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power
JP2008529631A (ja) 2005-02-11 2008-08-07 ザ ユニバーシティー コート オブ ザ ユニバーシティー オブ グラスゴー 検査デバイス、検査装置及び検査システム、並びにそれらの駆動方法
US20080009680A1 (en) * 2005-06-24 2008-01-10 Hassler William L Jr Remote monitoring and adjustment of a food intake restriction device
US7504954B2 (en) 2005-03-17 2009-03-17 Spaeder Jeffrey A Radio frequency identification pharmaceutical tracking system and method
US20060224141A1 (en) 2005-03-21 2006-10-05 Abbott Diabetes Care, Inc. Method and system for providing integrated medication infusion and analyte monitoring system
US7859401B2 (en) 2005-03-22 2010-12-28 Koninklijke Philips Electronics N.V. Addressing scheme for smart wireless medical sensor networks
US20060216603A1 (en) 2005-03-26 2006-09-28 Enable Ipc Lithium-ion rechargeable battery based on nanostructures
US20060224326A1 (en) 2005-03-31 2006-10-05 St Ores John W Integrated data collection and analysis for clinical study
US7848820B2 (en) 2005-04-07 2010-12-07 St. Jude Medical Ab System and method for radio communication between an implantable medical device and an external base unit
US7270633B1 (en) 2005-04-22 2007-09-18 Cardiac Pacemakers, Inc. Ambulatory repeater for use in automated patient care and method thereof
US9198608B2 (en) 2005-04-28 2015-12-01 Proteus Digital Health, Inc. Communication system incorporated in a container
US8912908B2 (en) 2005-04-28 2014-12-16 Proteus Digital Health, Inc. Communication system with remote activation
EP2392258B1 (en) * 2005-04-28 2014-10-08 Proteus Digital Health, Inc. Pharma-informatics system
US8836513B2 (en) 2006-04-28 2014-09-16 Proteus Digital Health, Inc. Communication system incorporated in an ingestible product
US20060247505A1 (en) 2005-04-28 2006-11-02 Siddiqui Waqaas A Wireless sensor system
US8802183B2 (en) 2005-04-28 2014-08-12 Proteus Digital Health, Inc. Communication system with enhanced partial power source and method of manufacturing same
EP1879649B1 (en) 2005-04-28 2013-05-15 Second Sight Medical Products, Inc. Package for an implantable neural stimulation device
US7414543B2 (en) 2005-04-28 2008-08-19 Honeywell International Inc. Multiple miniature avionic displays
US8730031B2 (en) 2005-04-28 2014-05-20 Proteus Digital Health, Inc. Communication system using an implantable device
US7359674B2 (en) 2005-05-10 2008-04-15 Nokia Corporation Content distribution & communication system for enhancing service distribution in short range radio environment
US20060262180A1 (en) 2005-05-17 2006-11-23 Robbins Gene A Object processing assembly operable to form dynamically variable images in objects in single shot events
WO2006127355A2 (en) 2005-05-20 2006-11-30 Dow Global Technologies Inc. Oral drug compliance monitoring using radio frequency identification tags
WO2006126965A1 (en) 2005-05-24 2006-11-30 Shl Medical Ab Dose counter device for inhaler
US8285205B2 (en) 2005-05-26 2012-10-09 Broadcom Corporation Method and system for a single chip integrated Bluetooth and FM transceiver and baseband processor
US20060273882A1 (en) 2005-06-01 2006-12-07 Intel Corporation RFID tag with separate transmit and receive clocks and related method
US20060276702A1 (en) 2005-06-03 2006-12-07 Mcginnis William Neurophysiological wireless bio-sensor
US7387607B2 (en) 2005-06-06 2008-06-17 Intel Corporation Wireless medical sensor system
KR100695152B1 (ko) 2005-06-07 2007-03-14 삼성전자주식회사 심전도 측정용 전극 및 그를 포함하는 심전도 측정 장치
WO2006133444A2 (en) 2005-06-09 2006-12-14 Medtronic, Inc. Implantable medical device with electrodes on multiple housing surfaces
US20060282001A1 (en) 2005-06-09 2006-12-14 Michel Noel Physiologic sensor apparatus
WO2006130988A1 (en) 2005-06-10 2006-12-14 Telecommunications Research Laboratories Wireless communication system
ITTO20050407A1 (it) 2005-06-13 2006-12-14 Ist Superiore Mario Boella Sistema di monitoraggio remoto di parametri fisiologici di un individuo, procedimento e prodotto informatico
US7616111B2 (en) 2005-06-20 2009-11-10 Carestream Health, Inc. System to monitor the ingestion of medicines
US7782189B2 (en) 2005-06-20 2010-08-24 Carestream Health, Inc. System to monitor the ingestion of medicines
US7299034B2 (en) 2005-06-21 2007-11-20 Lawrence Kates System and method for wearable electronics
WO2007002697A2 (en) 2005-06-28 2007-01-04 Mayo Foundation For Medical Education And Research System for monitoring a physical parameter of a subject
FI20055366A0 (fi) 2005-06-30 2005-06-30 Gen Electric Elektrodi biopotentiaalisignaalin saamiseksi
WO2007008494A2 (en) 2005-07-06 2007-01-18 Liebert Corporation Maximized battery run-time in a parallel ups system
US20070016089A1 (en) 2005-07-15 2007-01-18 Fischell David R Implantable device for vital signs monitoring
EP1903936B1 (en) 2005-07-20 2018-08-29 Neil R. Euliano Electronic pill for monitoring medication compliance
WO2007014084A1 (en) 2005-07-22 2007-02-01 Dow Global Technologies Inc. Oral drug compliance monitoring using sound detection
CN100471445C (zh) 2005-08-01 2009-03-25 周常安 贴片式生理监测装置
US20090142853A1 (en) 2005-08-11 2009-06-04 Eksigent Technologies, Llc Microfluidic system and methods
WO2007021496A2 (en) 2005-08-18 2007-02-22 Walker Digital, Llc Systems and methods for improved health care compliance
WO2007023477A2 (en) 2005-08-22 2007-03-01 University Of Limerick A tracking system
US8116809B2 (en) 2005-08-29 2012-02-14 Intel Corporation Method and apparatus of multiple entity wireless communication adapter
US8827904B2 (en) 2005-08-31 2014-09-09 Medtronic, Inc. Automatic parameter status on an implantable medical device system
US8547248B2 (en) 2005-09-01 2013-10-01 Proteus Digital Health, Inc. Implantable zero-wire communications system
JP2007068622A (ja) 2005-09-05 2007-03-22 Olympus Corp 被検体内情報取得システム
JP2009507617A (ja) 2005-09-14 2009-02-26 ネオガイド システムズ， インコーポレイテッド 経腔的及び他の操作を行うための方法及び装置
US20070196456A1 (en) 2005-09-15 2007-08-23 Visible Assets, Inc. Smart patch
US7673679B2 (en) 2005-09-19 2010-03-09 Schlumberger Technology Corporation Protective barriers for small devices
US20080058614A1 (en) 2005-09-20 2008-03-06 Triage Wireless, Inc. Wireless, internet-based system for measuring vital signs from a plurality of patients in a hospital or medical clinic
GB0519836D0 (en) 2005-09-29 2005-11-09 Smartlife Technology Ltd Contact sensors
GB0519837D0 (en) 2005-09-29 2005-11-09 Smartlife Technology Ltd Knitting techniques
US20070078324A1 (en) 2005-09-30 2007-04-05 Textronics, Inc. Physiological Monitoring Wearable Having Three Electrodes
GB0519945D0 (en) 2005-09-30 2005-11-09 Cambridge Silicon Radio Ltd Communication in dual protocol environments
CN100466966C (zh) 2005-10-08 2009-03-11 周常安 呼吸气流生理信号提取和监测装置及系统
US7733224B2 (en) 2006-06-30 2010-06-08 Bao Tran Mesh network personal emergency response appliance
US9154616B2 (en) 2005-10-18 2015-10-06 Oia Intellectuals, Inc. Wearable capture and communication
US7720036B2 (en) 2005-10-26 2010-05-18 Intel Corporation Communication within a wireless network using multiple frequency bands
US7499739B2 (en) 2005-10-27 2009-03-03 Smiths Medical Pm, Inc. Single use pulse oximeter
US8515348B2 (en) 2005-10-28 2013-08-20 Electro Industries/Gauge Tech Bluetooth-enable intelligent electronic device
US9067047B2 (en) 2005-11-09 2015-06-30 The Invention Science Fund I, Llc Injectable controlled release fluid delivery system
GB0523447D0 (en) 2005-11-17 2005-12-28 E San Ltd System and method for communicating environmentally-based medical support advice
US8016776B2 (en) 2005-12-02 2011-09-13 Medtronic, Inc. Wearable ambulatory data recorder
US8295932B2 (en) 2005-12-05 2012-10-23 Metacure Limited Ingestible capsule for appetite regulation
NL1030608C2 (nl) 2005-12-06 2007-06-07 Patrick Antonius Hendri Meeren Blisterverpakking, samenstel van een blisterverpakking en een houder, alsmede werkwijze voor het verpakken van objecten.
CN1985752A (zh) 2005-12-19 2007-06-27 周常安 分布式生理信号监测设备
US7678043B2 (en) 2005-12-29 2010-03-16 Given Imaging, Ltd. Device, system and method for in-vivo sensing of a body lumen
WO2007073702A2 (es) 2005-12-29 2007-07-05 Osmotica Corp. Comprimido multicapa con combinación de triple liberación
US20070156016A1 (en) 2005-12-29 2007-07-05 Ido Betesh Method and system for communication with an ingestible imaging device
US8301254B2 (en) 2006-01-09 2012-10-30 Greatbatch Ltd. Cross-band communications in an implantable device
US20070162089A1 (en) 2006-01-09 2007-07-12 Transoma Medical, Inc. Cross-band communications in an implantable device
US8078278B2 (en) 2006-01-10 2011-12-13 Remon Medical Technologies Ltd. Body attachable unit in wireless communication with implantable devices
RU2008134459A (ru) 2006-01-23 2010-02-27 Конинклейке Филипс Электроникс Н.В. (Nl) Усовершенствованный биомедицинский электрод для улучшенного ношения пациентом в виде язычка или кнопки, который(ая) изолирован(а) от удерживающей прокладки
US20070185393A1 (en) 2006-02-03 2007-08-09 Triage Wireless, Inc. System for measuring vital signs using an optical module featuring a green light source
US7809399B2 (en) 2006-02-10 2010-10-05 Syntek International Holding Ltd. Method and device for providing multiple communication protocols with a single transceiver
WO2007096810A1 (en) 2006-02-24 2007-08-30 Koninklijke Philips Electronics N.V. Wireless body sensor network
EP1993437A4 (en) 2006-02-24 2014-05-14 Hmicro Inc MEDICAL SYSTEM WITH DISTRIBUTED WIRELESS SENSORS FOR SIGNAL PROCESSING
US8200320B2 (en) 2006-03-03 2012-06-12 PhysioWave, Inc. Integrated physiologic monitoring systems and methods
US8457798B2 (en) 2006-03-14 2013-06-04 Jamie Hackett Long-range radio frequency receiver-controller module and wireless control system comprising same
US8131376B1 (en) 2007-09-11 2012-03-06 Second Sight Medical Products, Inc. Method of inspection of materials for defects
US8920343B2 (en) 2006-03-23 2014-12-30 Michael Edward Sabatino Apparatus for acquiring and processing of physiological auditory signals
CA2647487C (en) 2006-03-29 2014-10-21 Electronic Dietary Foods Inc. Ingestible implement for weight control
CN102323984A (zh) 2006-03-30 2012-01-18 陶氏环球技术有限责任公司 用于监控并分析体内用药方案的依从的方法与系统
TW200738212A (en) 2006-04-12 2007-10-16 Guo Terry Bo Jau Miniature wireless apparatus for collecting physiological signals of animals
CA2649447A1 (en) 2006-04-25 2007-11-08 Dow Global Technologies Inc. Oral drug compliance monitoring using magnetic-field sensors
US7912537B2 (en) 2006-04-27 2011-03-22 Medtronic, Inc. Telemetry-synchronized physiological monitoring and therapy delivery systems
US20070255125A1 (en) 2006-04-28 2007-11-01 Moberg Sheldon B Monitor devices for networked fluid infusion systems
KR101568660B1 (ko) 2006-05-02 2015-11-12 프로테우스 디지털 헬스, 인코포레이티드 환자 주문형 치료법
GB0608829D0 (en) 2006-05-04 2006-06-14 Husheer Shamus L G In-situ measurement of physical parameters
WO2007128165A1 (fr) 2006-05-09 2007-11-15 Fangen Xiong Systèmes de réseaux sans fil courte portée et procédé de montage consistant à attribuer des créneaux temporels avec un émetteur-récepteur rf multivoie
US20080051647A1 (en) 2006-05-11 2008-02-28 Changwang Wu Non-invasive acquisition of large nerve action potentials (NAPs) with closely spaced surface electrodes and reduced stimulus artifacts
US7558622B2 (en) 2006-05-24 2009-07-07 Bao Tran Mesh network stroke monitoring appliance
WO2007132282A1 (en) 2006-05-15 2007-11-22 Nokia Corporation Contactless programming and testing of memory elements
US7539533B2 (en) 2006-05-16 2009-05-26 Bao Tran Mesh network monitoring appliance
US20080074307A1 (en) 2006-05-17 2008-03-27 Olga Boric-Lubecke Determining presence and/or physiological motion of one or more subjects within a doppler radar system
CN101073494B (zh) 2006-05-18 2010-09-08 周常安 非侵入式生命迹象监测设备、系统及方法
US20070279217A1 (en) 2006-06-01 2007-12-06 H-Micro, Inc. Integrated mobile healthcare system for cardiac care
US8562526B2 (en) 2006-06-01 2013-10-22 Resmed Sensor Technologies Limited Apparatus, system, and method for monitoring physiological signs
US7346380B2 (en) 2006-06-16 2008-03-18 Axelgaard Manufacturing Co., Ltd. Medical electrode
JP2009540932A (ja) 2006-06-21 2009-11-26 プロテウス バイオメディカル インコーポレイテッド 陰極アーク製作構造物を備えるインプラント型医療デバイス
WO2008076464A2 (en) 2006-06-21 2008-06-26 Surgisense Corporation Wireless medical telemetry system and methods using radio-frequency energized biosensors
US8597278B2 (en) 2006-06-23 2013-12-03 MEDIMETRICS Personalized Drug Delivery B.V. Medicament delivery system and process
US7949404B2 (en) 2006-06-26 2011-05-24 Medtronic, Inc. Communications network for distributed sensing and therapy in biomedical applications
US20080046038A1 (en) 2006-06-26 2008-02-21 Hill Gerard J Local communications network for distributed sensing and therapy in biomedical applications
WO2008008281A2 (en) 2006-07-07 2008-01-17 Proteus Biomedical, Inc. Smart parenteral administration system
US20080020037A1 (en) 2006-07-11 2008-01-24 Robertson Timothy L Acoustic Pharma-Informatics System
US7962174B2 (en) 2006-07-12 2011-06-14 Andrew Llc Transceiver architecture and method for wireless base-stations
US20080021521A1 (en) 2006-07-18 2008-01-24 Cardiac Pacemakers, Inc. Implantable Medical Device Communication System
DE102007020583B4 (de) 2006-07-19 2012-10-11 Erbe Elektromedizin Gmbh Elektrodeneinrichtung mit einerImnpedanz-Messeinrichtung und Verfahren zum Herstellen einer derartigen Elektrodeneinrichtung
US20090318761A1 (en) 2006-08-10 2009-12-24 Elisha Rabinovitz System and method for in vivo imaging
EP2061549B1 (en) 2006-08-18 2014-04-09 Second Sight Medical Products, Inc. Package for an implantable neural stimulation device
US20080097549A1 (en) 2006-09-01 2008-04-24 Colbaugh Michael E Electrode Assembly and Method of Using Same
US7756573B2 (en) 2006-09-05 2010-07-13 Cardiac Pacemakers, Inc. Implantable medical device diagnostic data acquisition and storage
WO2008030480A2 (en) 2006-09-06 2008-03-13 Innurvation, Inc. Ingestible low power sensor device and system for communicating with same
US20080112885A1 (en) 2006-09-06 2008-05-15 Innurvation, Inc. System and Method for Acoustic Data Transmission
CN101516256A (zh) 2006-09-18 2009-08-26 皇家飞利浦电子股份有限公司 基于ip的监测和报警
US20080077184A1 (en) 2006-09-27 2008-03-27 Stephen Denker Intravascular Stimulation System With Wireless Power Supply
US20080077028A1 (en) 2006-09-27 2008-03-27 Biotronic Crm Patent Personal health monitoring and care system
US9227011B2 (en) 2006-09-29 2016-01-05 MEDIMETRICS Personalized Drug Delivery B.V. Miniaturized threshold sensor
US20080091114A1 (en) 2006-10-11 2008-04-17 Pacesetter, Inc. Techniques for Correlating Thoracic Impedance with Physiological Status
US20080091089A1 (en) 2006-10-12 2008-04-17 Kenneth Shane Guillory Single use, self-contained surface physiological monitor
US8054140B2 (en) 2006-10-17 2011-11-08 Proteus Biomedical, Inc. Low voltage oscillator for medical devices
US20080097917A1 (en) 2006-10-24 2008-04-24 Kent Dicks Systems and methods for wireless processing and medical device monitoring via remote command execution
EP2083680B1 (en) 2006-10-25 2016-08-10 Proteus Digital Health, Inc. Controlled activation ingestible identifier
US20080119705A1 (en) 2006-11-17 2008-05-22 Medtronic Minimed, Inc. Systems and Methods for Diabetes Management Using Consumer Electronic Devices
EP2069004A4 (en) 2006-11-20 2014-07-09 Proteus Digital Health Inc PERSONAL HEALTH SIGNAL RECEIVERS WITH ACTIVE SIGNAL PROCESSING
US8852172B2 (en) 2006-11-21 2014-10-07 Medimetrics Personalized Drug Delivery Ingestible electronic capsule and in vivo drug delivery or diagnostic system
GB0624081D0 (en) 2006-12-01 2007-01-10 Oxford Biosignals Ltd Biomedical signal analysis method
GB0624085D0 (en) 2006-12-01 2007-01-10 Oxford Biosignals Ltd Biomedical signal analysis method
US20080137566A1 (en) 2006-12-06 2008-06-12 Bojko Marholev Method and System for Shared High-Power Transmit Path for a Multi-Protocol Transceiver
US20080146889A1 (en) 2006-12-13 2008-06-19 National Yang-Ming University Method of monitoring human physiological parameters and safty conditions universally
US8157730B2 (en) 2006-12-19 2012-04-17 Valencell, Inc. Physiological and environmental monitoring systems and methods
TWI334747B (en) 2006-12-22 2010-12-11 Unimicron Technology Corp Circuit board structure having embedded electronic components
AU2007342218A1 (en) 2007-01-10 2008-07-17 Camillo Ricordi Mobile emergency alert system
EP2104482A1 (en) 2007-01-16 2009-09-30 Dow Global Technologies Inc. Oral drug capsule component incorporating a communication device
US20080294020A1 (en) 2007-01-25 2008-11-27 Demetrios Sapounas System and method for physlological data readings, transmission and presentation
US20080183245A1 (en) 2007-01-31 2008-07-31 Van Oort Geeske Telemetry of external physiological sensor data and implantable medical device data to a central processing system
US8858432B2 (en) 2007-02-01 2014-10-14 Proteus Digital Health, Inc. Ingestible event marker systems
US20080214985A1 (en) 2007-02-02 2008-09-04 Activatek, Inc. Active transdermal medicament patch
WO2008097652A2 (en) 2007-02-08 2008-08-14 Senior Vitals, Inc. Body patch for none-invasive physiological data readings
EP2111661B1 (en) 2007-02-14 2017-04-12 Proteus Digital Health, Inc. In-body power source having high surface area electrode
WO2008112578A1 (en) 2007-03-09 2008-09-18 Proteus Biomedical, Inc. In-body device having a deployable antenna
US8932221B2 (en) 2007-03-09 2015-01-13 Proteus Digital Health, Inc. In-body device having a multi-directional transmitter
US20080303638A1 (en) 2007-03-24 2008-12-11 Hap Nguyen Portable patient devices, systems, and methods for providing patient aid and preventing medical errors, for monitoring patient use of ingestible medications, and for preventing distribution of counterfeit drugs
WO2008120128A2 (en) 2007-03-30 2008-10-09 Koninklijke Philips Electronics N.V. System and method for pill communication and control
US7998110B2 (en) 2007-04-25 2011-08-16 Hong Kong Polytechnic University Medical device for delivering drug and/or performing physical therapy
KR100895297B1 (ko) 2007-04-30 2009-05-07 한국전자통신연구원 다양한 생체 신호의 동시 측정을 위한 다채널 전극센서장치
US20100256461A1 (en) 2007-05-01 2010-10-07 Urodynamix Technologies Ltd. Apparatus and methods for evaluating physiological conditions of tissue
GB0709248D0 (en) 2007-05-14 2007-06-20 T & Medical Ltd System for monitoring chemotherapy associated adverse drug reactions
US8412293B2 (en) 2007-07-16 2013-04-02 Optiscan Biomedical Corporation Systems and methods for determining physiological parameters using measured analyte values
US8540632B2 (en) 2007-05-24 2013-09-24 Proteus Digital Health, Inc. Low profile antenna for in body device
US20080300572A1 (en) 2007-06-01 2008-12-04 Medtronic Minimed, Inc. Wireless monitor for a personal medical device system
US20080311852A1 (en) 2007-06-15 2008-12-18 Broadcom Corporation Multiple communication link coordination for shared data transmissions
US8060175B2 (en) 2007-06-15 2011-11-15 General Electric Company System and apparatus for collecting physiological signals from a plurality of electrodes
EP2008584A1 (en) 2007-06-26 2008-12-31 Julius-Maximilians-Universität Würzburg In vivo device, system and usage thereof
GB2450517A (en) 2007-06-27 2008-12-31 Smartlife Technology Ltd Electrical resistance of yarn or fabric changes with temperature
US8404275B2 (en) * 2007-07-01 2013-03-26 Vitalis Llc Combination tablet with chewable outer layer
US20090009332A1 (en) 2007-07-03 2009-01-08 Endotronix, Inc. System and method for monitoring ingested medication via rf wireless telemetry
JP5065780B2 (ja) 2007-07-03 2012-11-07 株式会社日立製作所 Ｒｆｉｄタグ実装基板
JP4520491B2 (ja) 2007-07-09 2010-08-04 オリンパス株式会社 カプセル型医療システム
US8340750B2 (en) 2007-07-19 2012-12-25 Medtronic, Inc. Mechanical function marker channel for cardiac monitoring and therapy control
EP2185236B1 (en) 2007-07-27 2015-10-07 Second Sight Medical Products Implantable device for the brain
GB0714807D0 (en) 2007-07-30 2007-09-12 Oxford Biosignals Ltd Method and apparatus for measuring breathing rate
KR100863064B1 (ko) 2007-08-03 2008-10-13 한국전자통신연구원 생체 신호 측정용 의복 및 그 제조 방법
KR101080423B1 (ko) 2007-08-03 2011-11-04 삼성전자주식회사 멀티모듈결합형 휴대전자장치
US9295412B2 (en) 2007-08-15 2016-03-29 Integrity Tracking, Llc Wearable health monitoring device and methods for step detection
US20090048498A1 (en) 2007-08-17 2009-02-19 Frank Riskey System and method of monitoring an animal
US8926509B2 (en) 2007-08-24 2015-01-06 Hmicro, Inc. Wireless physiological sensor patches and systems
US20090062670A1 (en) 2007-08-30 2009-03-05 Gary James Sterling Heart monitoring body patch and system
CN101827555B (zh) 2007-09-07 2012-11-21 英戈·弗洛尔 诊断用传感器单元
US20090069642A1 (en) 2007-09-11 2009-03-12 Aid Networks, Llc Wearable Wireless Electronic Patient Data Communications and Physiological Monitoring Device
US20090076343A1 (en) 2007-09-14 2009-03-19 Corventis, Inc. Energy Management for Adherent Patient Monitor
WO2009036334A1 (en) 2007-09-14 2009-03-19 Corventis, Inc. Adherent multi-sensor device with empathic monitoring
ES2928197T3 (es) 2007-09-25 2022-11-16 Otsuka Pharma Co Ltd Dispositivo intracorpóreo con amplificación de señal de dipolo virtual
US20090087483A1 (en) 2007-09-27 2009-04-02 Sison Raymundo A Oral dosage combination pharmaceutical packaging
US20090088618A1 (en) 2007-10-01 2009-04-02 Arneson Michael R System and Method for Manufacturing a Swallowable Sensor Device
PE20090965A1 (es) 2007-10-12 2009-07-13 Bigtec Private Ltd Micro chip
US20090105561A1 (en) 2007-10-17 2009-04-23 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Medical or veterinary digestive tract utilization systems and methods
US20090105567A1 (en) 2007-10-19 2009-04-23 Smiths Medical Pm, Inc. Wireless telecommunications network adaptable for patient monitoring
US8134459B2 (en) 2007-10-19 2012-03-13 Smiths Medical Asd, Inc. Wireless telecommunications system adaptable for patient monitoring
US8139225B2 (en) 2007-10-24 2012-03-20 Siemens Medical Solutions Usa, Inc. System for processing patient monitoring power and data signals
GB0721117D0 (en) 2007-10-26 2007-12-05 T & Medical Ltd system for assisting in drug dose optimisaion
US20090112626A1 (en) 2007-10-30 2009-04-30 Cary Talbot Remote wireless monitoring, processing, and communication of patient data
WO2009063377A1 (en) 2007-11-13 2009-05-22 Koninklijke Philips Electronics N.V. Ingestible electronic capsule
DK2215726T3 (en) 2007-11-27 2018-04-09 Proteus Digital Health Inc Transbody communication modules with communication channels
US20090149839A1 (en) 2007-12-11 2009-06-11 Hyde Roderick A Treatment techniques using ingestible device
US20090157113A1 (en) 2007-12-18 2009-06-18 Ethicon Endo-Surgery, Inc. Wearable elements for implantable restriction systems
EP2241032B1 (en) 2007-12-20 2018-02-28 Koninklijke Philips N.V. Capacitive sensing and communicating
JP5091657B2 (ja) 2007-12-21 2012-12-05 株式会社東芝 無線通信装置及び無線通信方法
US9259591B2 (en) 2007-12-28 2016-02-16 Cyberonics, Inc. Housing for an implantable medical device
US20090171180A1 (en) 2007-12-28 2009-07-02 Trevor Pering Method and apparatus for configuring wearable sensors
US7844341B2 (en) 2008-01-15 2010-11-30 Cardiac Pacemakers, Inc. Implantable medical device with antenna
WO2009091910A1 (en) 2008-01-15 2009-07-23 Cardiac Pacemakers, Inc. Implantable medical device with wireless communications
US20090182207A1 (en) 2008-01-16 2009-07-16 Tenxsys Inc. Ingestible animal health sensor
GB2456567B (en) 2008-01-18 2010-05-05 Oxford Biosignals Ltd Novelty detection
JP5132335B2 (ja) 2008-01-29 2013-01-30 富士フイルム株式会社 カプセル内視鏡及びカプセル内視鏡システム
JP5156427B2 (ja) 2008-02-13 2013-03-06 富士フイルム株式会社 カプセル内視鏡システム
JP2011513865A (ja) 2008-03-05 2011-04-28 プロテウス バイオメディカル インコーポレイテッド マルチモード通信の摂取可能なイベントマーカーおよびシステム、ならびにそれを使用する方法
JP5324604B2 (ja) 2008-03-06 2013-10-23 ストライカー・コーポレイション 折り畳むことができる移植可能な電極アレイアセンブリおよび該アセンブリを移植するためのツール
US20090243833A1 (en) 2008-03-31 2009-10-01 Ching Ching Huang Monitoring system and method for patient care
JP2009240474A (ja) * 2008-03-31 2009-10-22 Hiroshima Univ 経口摂取用バイオセンサーおよびバイオセンサーシステム
US20110163871A1 (en) 2008-04-01 2011-07-07 Shmuel Einav Rfid monitoring of drug regimen compliance
ATE542468T1 (de) 2008-04-03 2012-02-15 Olympus Medical Systems Corp Antenneneinheit und empfangsvorrichtung für medizinische kapselvorrichtung
EP2110232B1 (de) 2008-04-18 2016-09-14 Korsch AG Vorrichtung zum Einlegen von Einlegern in Matrizen einer Rundläufer-Tablettenpresse
US8690769B2 (en) 2008-04-21 2014-04-08 Philometron, Inc. Metabolic energy monitoring system
WO2009154707A2 (en) 2008-06-18 2009-12-23 The Smartpill Corporation System and method of evaluating a subject with an ingestible capsule
US20090318303A1 (en) 2008-06-20 2009-12-24 International Business Machines Corporation Microfluidic selection of library elements
US9014778B2 (en) 2008-06-24 2015-04-21 Biosense Webster, Inc. Disposable patch and reusable sensor assembly for use in medical device localization and mapping systems
CH699071A2 (fr) 2008-07-02 2010-01-15 Flakes S A Dispositif de freinage et/ou de blocage mécanique.
WO2010005953A2 (en) 2008-07-07 2010-01-14 Cardullo Mario W Dynamically distributable nano rfid device and related method
ES2696984T3 (es) 2008-07-08 2019-01-21 Proteus Digital Health Inc Infraestructura de datos de marcadores de eventos de ingestión
EP2320875B1 (en) 2008-07-23 2019-07-03 I-Property Holding Corp. Secure tracking of tablets
AU2009281876B2 (en) 2008-08-13 2014-05-22 Proteus Digital Health, Inc. Ingestible circuitry
US20100056878A1 (en) 2008-08-28 2010-03-04 Partin Dale L Indirectly coupled personal monitor for obtaining at least one physiological parameter of a subject
US9943644B2 (en) 2008-08-31 2018-04-17 Abbott Diabetes Care Inc. Closed loop control with reference measurement and methods thereof
US20100063841A1 (en) 2008-09-05 2010-03-11 Vital Data Technology, Llc System and method of notifying designated entities of access to personal medical records
US8224596B2 (en) 2008-09-09 2012-07-17 International Business Machines Corporation Portable device battery optimization routing system
US20100069002A1 (en) 2008-09-16 2010-03-18 Vcan Sports, Inc. Method and apparatus for a wireless communication device utilizing bluetooth technology
US8036748B2 (en) * 2008-11-13 2011-10-11 Proteus Biomedical, Inc. Ingestible therapy activator system and method
JP2012511961A (ja) * 2008-12-11 2012-05-31 プロテウス バイオメディカル インコーポレイテッド 携帯用内臓電気記録システムを用いた消化管機能の判断およびそれを用いた方法
TWI503101B (zh) 2008-12-15 2015-10-11 Proteus Digital Health Inc 與身體有關的接收器及其方法
RU82321U1 (ru) * 2008-12-29 2009-04-20 Виктор Васильевич Дьяченко Устройство для контроля расхода жидкости и газов в трубопроводе
TWI602561B (zh) 2009-01-06 2017-10-21 波提亞斯數位康健公司 醫藥劑量傳送系統
SG196787A1 (en) 2009-01-06 2014-02-13 Proteus Digital Health Inc Ingestion-related biofeedback and personalized medical therapy method and system
WO2010080765A2 (en) 2009-01-06 2010-07-15 Proteus Biomedical, Inc. High-throughput production of ingestible event markers
US8395521B2 (en) 2009-02-06 2013-03-12 University Of Dayton Smart aerospace structures
US8073400B2 (en) 2009-02-17 2011-12-06 Rfaxis, Inc. Multi mode radio frequency transceiver front end circuit
CA2789521A1 (en) 2009-02-25 2010-09-02 Xanthia Global Limited Wireless physiology monitor
US8452366B2 (en) 2009-03-16 2013-05-28 Covidien Lp Medical monitoring device with flexible circuitry
US8805528B2 (en) 2009-03-31 2014-08-12 Medtronic, Inc. Channel assessment and selection for wireless communication between medical devices
SG10201810784SA (en) 2009-04-28 2018-12-28 Proteus Digital Health Inc Highly Reliable Ingestible Event Markers And Methods For Using The Same
EP2432458A4 (en) 2009-05-12 2014-02-12 Proteus Digital Health Inc ACCEPTABLE EVENT MARKER WITH SUGAR COMPONENT
US11589754B2 (en) 2009-05-20 2023-02-28 Sotera Wireless, Inc. Blood pressure-monitoring system with alarm/alert system that accounts for patient motion
WO2010141100A1 (en) 2009-06-04 2010-12-09 Morgan Advanced Ceramics, Inc. Co-fired metal and ceramic composite feedthrough assemblies for use at least in implantable medical devices and methods for making the same
US8758237B2 (en) 2009-08-21 2014-06-24 3M Innovative Properties Company Methods and products for illuminating tissue
US20110230732A1 (en) 2009-09-14 2011-09-22 Philometron, Inc. System utilizing physiological monitoring and electronic media for health improvement
UA109424C2 (uk) 2009-12-02 2015-08-25 Фармацевтичний продукт, фармацевтична таблетка з електронним маркером і спосіб виготовлення фармацевтичної таблетки
WO2011112972A2 (en) 2010-03-11 2011-09-15 Philometron, Inc. Physiological monitor system for determining medication delivery and outcome
BR112012025650A2 (pt) 2010-04-07 2020-08-18 Proteus Digital Health, Inc. dispositivo ingerível miniatura
US9872637B2 (en) 2010-04-21 2018-01-23 The Rehabilitation Institute Of Chicago Medical evaluation system and method using sensors in mobile devices
CN106408309A (zh) 2010-06-14 2017-02-15 特鲁塔格科技公司 用于使用数据库验证包装中的物品的系统
JP5855646B2 (ja) 2010-06-14 2016-02-09 トルタグ・テクノロジーズ・インコーポレーテッドＴｒｕｔａｇ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｉｎｃｏｒｐｏｒａｔｅｄ 識別子を伴うパッケージング商品を作成するためのシステム、商品のパッケージ、及び商品
KR101760663B1 (ko) 2010-06-14 2017-08-04 트루테그 테크놀로지스, 인코포레이티드 패키지에서 아이템을 검증하기 위한 시스템
US20110304131A1 (en) 2010-06-14 2011-12-15 Trutag Technologies, Inc. Labeling and verifying an item with an identifier
US20120016231A1 (en) 2010-07-18 2012-01-19 Medical Scan Technologies, Inc. System and method for three dimensional cosmetology imaging with structured light
EP2616905A4 (en) 2010-09-13 2017-11-29 Nokia Technologies Oy Haptic communication
US20130129869A1 (en) 2011-11-23 2013-05-23 Hooman Hafezi Compositions comprising a shelf-life stability component
KR20150038038A (ko) 2012-07-23 2015-04-08 프로테우스 디지털 헬스, 인코포레이티드 섭취 가능한 부품을 포함하는 섭취 가능한 이벤트 마커를 제조하기 위한 기술
US9796576B2 (en) 2013-08-30 2017-10-24 Proteus Digital Health, Inc. Container with electronically controlled interlock
JP6248326B2 (ja) * 2013-10-18 2017-12-20 国立大学法人東北大学 食事型センサ、及びセンシング方法
US10084880B2 (en) 2013-11-04 2018-09-25 Proteus Digital Health, Inc. Social media networking based on physiologic information
US20150127738A1 (en) 2013-11-05 2015-05-07 Proteus Digital Health, Inc. Bio-language based communication system

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JP5805315B2 (ja) 2015-11-04
WO2013009788A3 (en) 2013-03-14
AU2012282690A1 (en) 2014-01-30
HK1196240A1 (zh) 2014-12-12
JP2014525780A (ja) 2014-10-02
US8836513B2 (en) 2014-09-16
KR20140051299A (ko) 2014-04-30
EP2731496A4 (en) 2014-12-17

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