RU2013148907A - Способ - Google Patents
Способ Download PDFInfo
- Publication number
- RU2013148907A RU2013148907A RU2013148907/04A RU2013148907A RU2013148907A RU 2013148907 A RU2013148907 A RU 2013148907A RU 2013148907/04 A RU2013148907/04 A RU 2013148907/04A RU 2013148907 A RU2013148907 A RU 2013148907A RU 2013148907 A RU2013148907 A RU 2013148907A
- Authority
- RU
- Russia
- Prior art keywords
- formula
- compound
- pharmaceutically acceptable
- diazaspiro
- oxa
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract 11
- 150000001875 compounds Chemical class 0.000 claims abstract 38
- 150000003839 salts Chemical class 0.000 claims abstract 22
- 239000002904 solvent Substances 0.000 claims abstract 13
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims abstract 13
- 239000003054 catalyst Substances 0.000 claims abstract 6
- 238000006243 chemical reaction Methods 0.000 claims abstract 6
- 229910052751 metal Inorganic materials 0.000 claims abstract 6
- 239000002184 metal Substances 0.000 claims abstract 6
- 150000001412 amines Chemical class 0.000 claims abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 4
- 239000001257 hydrogen Substances 0.000 claims abstract 4
- 230000007935 neutral effect Effects 0.000 claims abstract 4
- 239000003446 ligand Substances 0.000 claims abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims abstract 2
- 150000002431 hydrogen Chemical class 0.000 claims abstract 2
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims abstract 2
- 238000009901 transfer hydrogenation reaction Methods 0.000 claims abstract 2
- 229910052723 transition metal Inorganic materials 0.000 claims abstract 2
- 150000003624 transition metals Chemical class 0.000 claims abstract 2
- 238000010511 deprotection reaction Methods 0.000 claims 3
- -1 oxalate [3 - [[4-fluoro-3- [2-methoxyvinyl] phenyl] methyl] -7-oxa-3,10-diazaspiro [5.5] undecan-10-yl] - (2-isopropylthiazol-4-yl) methanone Chemical compound 0.000 claims 2
- SVIYVIDKRYPMPJ-NSHDSACASA-N (1r)-1-[4-[(2-methylpropan-2-yl)oxy]-2-propan-2-yloxy-1,3-benzothiazol-7-yl]ethane-1,2-diol Chemical compound C1=CC([C@@H](O)CO)=C2SC(OC(C)C)=NC2=C1OC(C)(C)C SVIYVIDKRYPMPJ-NSHDSACASA-N 0.000 claims 1
- IOTXTTWWWBWZJV-UHFFFAOYSA-N 1-oxa-4,9-diazaspiro[5.5]undecane-4-carbaldehyde Chemical compound C1N(C=O)CCOC11CCNCC1 IOTXTTWWWBWZJV-UHFFFAOYSA-N 0.000 claims 1
- RQNZCXFXLKRQJC-UHFFFAOYSA-N 2-[2-fluoro-5-[[4-(2-propan-2-yl-1,3-thiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl]methyl]phenyl]acetaldehyde Chemical compound S1C(C(C)C)=NC(C(=O)N2CC3(CCN(CC=4C=C(CC=O)C(F)=CC=4)CC3)OCC2)=C1 RQNZCXFXLKRQJC-UHFFFAOYSA-N 0.000 claims 1
- WNHSMDNEBCTQAM-UHFFFAOYSA-N 2-[benzyl-[2-[2-fluoro-5-[[4-(2-propan-2-yl-1,3-thiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl]methyl]phenyl]ethyl]amino]-1-[4-[(2-methylpropan-2-yl)oxy]-2-propan-2-yloxy-1,3-benzothiazol-7-yl]ethanone Chemical compound C=12SC(OC(C)C)=NC2=C(OC(C)(C)C)C=CC=1C(=O)CN(CC=1C=CC=CC=1)CCC(C(=CC=1)F)=CC=1CN(CC1)CCC1(OCC1)CN1C(=O)C1=CSC(C(C)C)=N1 WNHSMDNEBCTQAM-UHFFFAOYSA-N 0.000 claims 1
- PGYJSURPYAAOMM-UHFFFAOYSA-N 2-ethenoxy-2-methylpropane Chemical compound CC(C)(C)OC=C PGYJSURPYAAOMM-UHFFFAOYSA-N 0.000 claims 1
- QWGABUOCULMMCS-UHFFFAOYSA-N 3-[2-fluoro-5-[[4-(2-propan-2-yl-1,3-thiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl]methyl]phenyl]propanamide Chemical compound S1C(C(C)C)=NC(C(=O)N2CC3(CCN(CC=4C=C(CCC(N)=O)C(F)=CC=4)CC3)OCC2)=C1 QWGABUOCULMMCS-UHFFFAOYSA-N 0.000 claims 1
- LSGOCJDSLYFJFH-UHFFFAOYSA-N 7-bromo-4-[(2-methylpropan-2-yl)oxy]-2-propan-2-yloxy-1,3-benzothiazole Chemical compound C1=CC(Br)=C2SC(OC(C)C)=NC2=C1OC(C)(C)C LSGOCJDSLYFJFH-UHFFFAOYSA-N 0.000 claims 1
- QMOHGKGFMBSMLE-UHFFFAOYSA-N 7-ethenyl-4-[(2-methylpropan-2-yl)oxy]-2-propan-2-yloxy-1,3-benzothiazole Chemical compound C1=CC(C=C)=C2SC(OC(C)C)=NC2=C1OC(C)(C)C QMOHGKGFMBSMLE-UHFFFAOYSA-N 0.000 claims 1
- PTTGUNRGTKILJR-SFHVURJKSA-N [(2r)-2-hydroxy-2-[4-[(2-methylpropan-2-yl)oxy]-2-propan-2-yloxy-1,3-benzothiazol-7-yl]ethyl] 4-methylbenzenesulfonate Chemical compound C([C@H](O)C=1C=CC(OC(C)(C)C)=C2N=C(SC2=1)OC(C)C)OS(=O)(=O)C1=CC=C(C)C=C1 PTTGUNRGTKILJR-SFHVURJKSA-N 0.000 claims 1
- OCJABRHAKPPGQQ-UHFFFAOYSA-N [9-[(3-bromo-4-fluorophenyl)methyl]-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl]-(2-propan-2-yl-1,3-thiazol-4-yl)methanone Chemical compound S1C(C(C)C)=NC(C(=O)N2CC3(CCN(CC=4C=C(Br)C(F)=CC=4)CC3)OCC2)=C1 OCJABRHAKPPGQQ-UHFFFAOYSA-N 0.000 claims 1
- HHMKBOIYZRFHOO-UHFFFAOYSA-N [9-[[3-(2-aminoethyl)-4-fluorophenyl]methyl]-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl]-(2-propan-2-yl-1,3-thiazol-4-yl)methanone;dihydrochloride Chemical compound Cl.Cl.S1C(C(C)C)=NC(C(=O)N2CC3(CCN(CC=4C=C(CCN)C(F)=CC=4)CC3)OCC2)=C1 HHMKBOIYZRFHOO-UHFFFAOYSA-N 0.000 claims 1
- IGUYIOJQNFOKFB-UHFFFAOYSA-N [9-[[3-[2-(benzylamino)ethyl]-4-fluorophenyl]methyl]-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl]-(2-propan-2-yl-1,3-thiazol-4-yl)methanone Chemical compound S1C(C(C)C)=NC(C(=O)N2CC3(CCN(CC=4C=C(CCNCC=5C=CC=CC=5)C(F)=CC=4)CC3)OCC2)=C1 IGUYIOJQNFOKFB-UHFFFAOYSA-N 0.000 claims 1
- NDNMCXSFTZTDQL-KDXMTYKHSA-N [9-[[3-[2-[benzyl-[(2r)-2-hydroxy-2-[4-[(2-methylpropan-2-yl)oxy]-2-propan-2-yloxy-1,3-benzothiazol-7-yl]ethyl]amino]ethyl]-4-fluorophenyl]methyl]-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl]-(2-propan-2-yl-1,3-thiazol-4-yl)methanone Chemical compound C([C@H](O)C=1C=CC(OC(C)(C)C)=C2N=C(SC2=1)OC(C)C)N(CC=1C=CC=CC=1)CCC(C(=CC=1)F)=CC=1CN(CC1)CCC1(OCC1)CN1C(=O)C1=CSC(C(C)C)=N1 NDNMCXSFTZTDQL-KDXMTYKHSA-N 0.000 claims 1
- NABWWFVUVRZTNN-RIYZIHGNSA-N [9-[[4-fluoro-3-[(e)-2-[(2-methylpropan-2-yl)oxy]ethenyl]phenyl]methyl]-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl]-(2-propan-2-yl-1,3-thiazol-4-yl)methanone Chemical compound S1C(C(C)C)=NC(C(=O)N2CC3(CCN(CC=4C=C(\C=C\OC(C)(C)C)C(F)=CC=4)CC3)OCC2)=C1 NABWWFVUVRZTNN-RIYZIHGNSA-N 0.000 claims 1
- PQVRHBAJSUDXHJ-YTTGMZPUSA-N [9-[[4-fluoro-3-[2-[[(2r)-2-hydroxy-2-[4-[(2-methylpropan-2-yl)oxy]-2-propan-2-yloxy-1,3-benzothiazol-7-yl]ethyl]amino]ethyl]phenyl]methyl]-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl]-(2-propan-2-yl-1,3-thiazol-4-yl)methanone Chemical compound C([C@H](O)C=1C=CC(OC(C)(C)C)=C2N=C(SC2=1)OC(C)C)NCCC(C(=CC=1)F)=CC=1CN(CC1)CCC1(OCC1)CN1C(=O)C1=CSC(C(C)C)=N1 PQVRHBAJSUDXHJ-YTTGMZPUSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 230000001476 alcoholic effect Effects 0.000 claims 1
- 239000003638 chemical reducing agent Substances 0.000 claims 1
- 238000005984 hydrogenation reaction Methods 0.000 claims 1
- 239000003444 phase transfer catalyst Substances 0.000 claims 1
- SNOYOWIQXKTMGE-FXRZFVDSSA-M sodium;[4-fluoro-3-[(e)-2-methoxyethenyl]phenyl]-hydroxymethanesulfonate Chemical compound [Na+].CO\C=C\C1=CC(C(O)S([O-])(=O)=O)=CC=C1F SNOYOWIQXKTMGE-FXRZFVDSSA-M 0.000 claims 1
- KTDWWWMPBHBLQZ-UHFFFAOYSA-N tert-butyl 4-(2-propan-2-yl-1,3-thiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate Chemical compound S1C(C(C)C)=NC(C(=O)N2CC3(CCN(CC3)C(=O)OC(C)(C)C)OCC2)=C1 KTDWWWMPBHBLQZ-UHFFFAOYSA-N 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- FMSQFTVHZUVJBE-LBPRGKRZSA-N CC(C)Oc1nc(c(OC(C)(C)C)ccc2[C@H]3OC3)c2[s]1 Chemical compound CC(C)Oc1nc(c(OC(C)(C)C)ccc2[C@H]3OC3)c2[s]1 FMSQFTVHZUVJBE-LBPRGKRZSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C309/07—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton
- C07C309/08—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton containing hydroxy groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/24—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of a carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
- C07C55/02—Dicarboxylic acids
- C07C55/06—Oxalic acid
- C07C55/07—Salts thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1107985.2 | 2011-05-13 | ||
| GBGB1107985.2A GB201107985D0 (en) | 2011-05-13 | 2011-05-13 | Process |
| PCT/GB2012/051037 WO2012156693A1 (en) | 2011-05-13 | 2012-05-11 | Process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2013148907A true RU2013148907A (ru) | 2015-06-20 |
Family
ID=44260448
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2013148907/04A RU2013148907A (ru) | 2011-05-13 | 2012-05-11 | Способ |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20140364601A1 (enExample) |
| EP (1) | EP2707362A1 (enExample) |
| JP (1) | JP2014520075A (enExample) |
| KR (1) | KR20140045380A (enExample) |
| CN (1) | CN103649060A (enExample) |
| AU (1) | AU2012257630A1 (enExample) |
| BR (1) | BR112013028789A2 (enExample) |
| CA (1) | CA2835237A1 (enExample) |
| GB (1) | GB201107985D0 (enExample) |
| IL (1) | IL229126A0 (enExample) |
| MX (1) | MX2013012484A (enExample) |
| RU (1) | RU2013148907A (enExample) |
| SG (1) | SG194631A1 (enExample) |
| WO (1) | WO2012156693A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3192B1 (ar) | 2011-09-06 | 2018-03-08 | Novartis Ag | مركب بنزوثيازولون |
| CN103193658A (zh) * | 2013-04-18 | 2013-07-10 | 苏州永健生物医药有限公司 | 一种（r）-2-对硝基苯乙胺基-1-苯乙醇及其盐的合成方法 |
| TW201615642A (zh) | 2014-06-02 | 2016-05-01 | 伊史帝夫博士實驗室股份有限公司 | 具有多重模式抗疼痛活性的１－氧雜－４，９－二氮雜螺十一烷化合物之醯胺衍生物 |
| TWI685497B (zh) | 2014-06-02 | 2020-02-21 | 西班牙商伊史帝夫製藥公司 | 具有多重模式抗疼痛活性的１-氧雜-４,９-二氮雜螺十一烷化合物之烷基衍生物 |
| UA123775C2 (uk) | 2015-11-16 | 2021-06-02 | Естев Фармас'Ютікалз, С.А. | Оксадіазаспіросполуки для лікування зловживання наркотичними засобами та залежності від них |
| BR112020007359A2 (pt) | 2017-10-17 | 2020-09-29 | Esteve Pharmaceuticals, S.A. | sais de (r)-9-(2,5-difluorofenetil)-4-etil-2-metil-1-oxa-4,9-diazaespiro[5.5]undecan-3-ona |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1058683E (pt) | 1998-02-02 | 2003-04-30 | Lg Chemical Ltd | Inibidores da farnesil-transferase com uma estrutura de piperidina e seu processo de preparacao |
| AR040962A1 (es) | 2002-08-09 | 2005-04-27 | Novartis Ag | Compuestos derivados de tiazol 1,3-2-ona, composicion farmaceutica y proceso de preparacion del compuesto |
| GB0218629D0 (en) * | 2002-08-09 | 2002-09-18 | Novartis Ag | Organic compounds |
| CN101300239A (zh) * | 2005-08-29 | 2008-11-05 | 阿斯利康(瑞典)有限公司 | 作为β2肾上腺素受体激动剂的7-（2-氨基-1-羟基-乙基）-4-羟基苯并噻唑-2(3H)-酮衍生物 |
| TW200738659A (en) | 2005-08-29 | 2007-10-16 | Astrazeneca Ab | Novel compounds |
| NZ586872A (en) | 2008-02-06 | 2012-03-30 | Astrazeneca Ab | Spirocyclic amide compounds |
-
2011
- 2011-05-13 GB GBGB1107985.2A patent/GB201107985D0/en not_active Ceased
-
2012
- 2012-05-11 RU RU2013148907/04A patent/RU2013148907A/ru not_active Application Discontinuation
- 2012-05-11 MX MX2013012484A patent/MX2013012484A/es not_active Application Discontinuation
- 2012-05-11 BR BR112013028789A patent/BR112013028789A2/pt not_active IP Right Cessation
- 2012-05-11 AU AU2012257630A patent/AU2012257630A1/en not_active Abandoned
- 2012-05-11 CN CN201280034581.XA patent/CN103649060A/zh active Pending
- 2012-05-11 SG SG2013079363A patent/SG194631A1/en unknown
- 2012-05-11 WO PCT/GB2012/051037 patent/WO2012156693A1/en not_active Ceased
- 2012-05-11 EP EP12722808.8A patent/EP2707362A1/en not_active Withdrawn
- 2012-05-11 US US14/117,259 patent/US20140364601A1/en not_active Abandoned
- 2012-05-11 JP JP2014509829A patent/JP2014520075A/ja not_active Withdrawn
- 2012-05-11 KR KR1020137032749A patent/KR20140045380A/ko not_active Withdrawn
- 2012-05-11 CA CA2835237A patent/CA2835237A1/en not_active Abandoned
-
2013
- 2013-10-28 IL IL229126A patent/IL229126A0/en unknown
-
2015
- 2015-09-17 US US14/857,254 patent/US20160002261A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20140364601A1 (en) | 2014-12-11 |
| CN103649060A (zh) | 2014-03-19 |
| GB201107985D0 (en) | 2011-06-29 |
| EP2707362A1 (en) | 2014-03-19 |
| SG194631A1 (en) | 2013-12-30 |
| BR112013028789A2 (pt) | 2016-08-09 |
| CA2835237A1 (en) | 2012-11-22 |
| IL229126A0 (en) | 2013-12-31 |
| JP2014520075A (ja) | 2014-08-21 |
| KR20140045380A (ko) | 2014-04-16 |
| AU2012257630A1 (en) | 2013-11-28 |
| WO2012156693A1 (en) | 2012-11-22 |
| MX2013012484A (es) | 2014-01-24 |
| US20160002261A1 (en) | 2016-01-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2013148907A (ru) | Способ | |
| AR083213A1 (es) | Proceso de preparacion de derivados pirimidinicos, compuestos intermediarios y proceso para prepararlos | |
| RU2013107023A (ru) | Способ получения производных аминобензоилбензофурана | |
| JP2013525265A5 (enExample) | ||
| RU2510397C2 (ru) | Алкилциклогексиловые эфиры дигидротетраазабензоазуленов | |
| US9409926B2 (en) | Chiral 4-boronophenylalanine (BPA) derivative and method for producing same, and method for producing 18F-labeled BPA using said derivative | |
| RU2016133187A (ru) | Способ получения n-[(3-аминооксетан-3-ил)метил]-2-(1,1-диоксо-3,5-дигидро-1,4-бензотиазепин-4ил)-6-метил-хиназолин-4-амина | |
| RU2012141889A (ru) | Производные кетобензофурана, способ их синтеза и промежуточные соединения | |
| CO6310992A2 (es) | Metodo para preparar chalconas de 3-trifluorometilo | |
| ES2614876T3 (es) | Método para preparar compuesto intermedio del rivaroxabán | |
| RU2015103694A (ru) | Способы синтеза спиро-оксиндольных соединений | |
| RU2012116208A (ru) | Способ получения n-ацилбифенилаланина | |
| RU2015134407A (ru) | Способ получения вортиоксетина | |
| RU2013137753A (ru) | Твердые формы ингибитора гиразы (r)-1-этил-3-[5-[2-(1-гидрокси-1-метилэтил)пиримидин-5-ил]-7-(тетрагидрофуран-2-ил)-1н-бензимидазол-2-ил]мочевины | |
| JP2014520075A5 (enExample) | ||
| EA201490998A1 (ru) | Способ получения сложных эфиров (5-фтор-2-метил-3-хинолин-2-илметил-индол-1-ил)-уксусной кислоты | |
| Bortolini et al. | Thiazolium-catalyzed intermolecular Stetter reaction of linear and cyclic alkyl α-diketones | |
| RU2010129556A (ru) | Замещенные 2-метилтиоэтилом гетероциклы в качестве добавок к кормам | |
| RU2018113741A (ru) | Способ получения флутеметамола | |
| AU2016275210A1 (en) | Novel heterocyclic compound, method for preparing the same, and pharmaceutical composition comprising the same | |
| PE20090824A1 (es) | Proceso para la preparacion de trifluoralquil-fenil sulfonamidas y de sulfonamidas heterociclicas | |
| MA35906B1 (fr) | Procédé de préparation d'un composé par le biais d'une nouvelle réaction d'addition de michael en utilisant de l'eau ou divers acides comme additifs | |
| RU2007141199A (ru) | Способ получения производного тиазола | |
| JP6047830B2 (ja) | ホモピペラジン誘導体を含む漂白剤組成物 | |
| RU2007105231A (ru) | Способ синтеза с-2, с-3-замещенных n-алкилированных индолов, используемых в качестве ингибиторов cpla2 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20160816 |