RU2013148907A - Способ - Google Patents
Способ Download PDFInfo
- Publication number
- RU2013148907A RU2013148907A RU2013148907/04A RU2013148907A RU2013148907A RU 2013148907 A RU2013148907 A RU 2013148907A RU 2013148907/04 A RU2013148907/04 A RU 2013148907/04A RU 2013148907 A RU2013148907 A RU 2013148907A RU 2013148907 A RU2013148907 A RU 2013148907A
- Authority
- RU
- Russia
- Prior art keywords
- formula
- compound
- pharmaceutically acceptable
- diazaspiro
- oxa
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract 11
- 150000001875 compounds Chemical class 0.000 claims abstract 38
- 150000003839 salts Chemical class 0.000 claims abstract 22
- 239000002904 solvent Substances 0.000 claims abstract 13
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims abstract 13
- 239000003054 catalyst Substances 0.000 claims abstract 6
- 238000006243 chemical reaction Methods 0.000 claims abstract 6
- 229910052751 metal Inorganic materials 0.000 claims abstract 6
- 239000002184 metal Substances 0.000 claims abstract 6
- 150000001412 amines Chemical class 0.000 claims abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 4
- 239000001257 hydrogen Substances 0.000 claims abstract 4
- 230000007935 neutral effect Effects 0.000 claims abstract 4
- 239000003446 ligand Substances 0.000 claims abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims abstract 2
- 150000002431 hydrogen Chemical class 0.000 claims abstract 2
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims abstract 2
- 238000009901 transfer hydrogenation reaction Methods 0.000 claims abstract 2
- 229910052723 transition metal Inorganic materials 0.000 claims abstract 2
- 150000003624 transition metals Chemical class 0.000 claims abstract 2
- 238000010511 deprotection reaction Methods 0.000 claims 3
- -1 oxalate [3 - [[4-fluoro-3- [2-methoxyvinyl] phenyl] methyl] -7-oxa-3,10-diazaspiro [5.5] undecan-10-yl] - (2-isopropylthiazol-4-yl) methanone Chemical compound 0.000 claims 2
- SVIYVIDKRYPMPJ-NSHDSACASA-N (1r)-1-[4-[(2-methylpropan-2-yl)oxy]-2-propan-2-yloxy-1,3-benzothiazol-7-yl]ethane-1,2-diol Chemical compound C1=CC([C@@H](O)CO)=C2SC(OC(C)C)=NC2=C1OC(C)(C)C SVIYVIDKRYPMPJ-NSHDSACASA-N 0.000 claims 1
- IOTXTTWWWBWZJV-UHFFFAOYSA-N 1-oxa-4,9-diazaspiro[5.5]undecane-4-carbaldehyde Chemical compound C1N(C=O)CCOC11CCNCC1 IOTXTTWWWBWZJV-UHFFFAOYSA-N 0.000 claims 1
- RQNZCXFXLKRQJC-UHFFFAOYSA-N 2-[2-fluoro-5-[[4-(2-propan-2-yl-1,3-thiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl]methyl]phenyl]acetaldehyde Chemical compound S1C(C(C)C)=NC(C(=O)N2CC3(CCN(CC=4C=C(CC=O)C(F)=CC=4)CC3)OCC2)=C1 RQNZCXFXLKRQJC-UHFFFAOYSA-N 0.000 claims 1
- WNHSMDNEBCTQAM-UHFFFAOYSA-N 2-[benzyl-[2-[2-fluoro-5-[[4-(2-propan-2-yl-1,3-thiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl]methyl]phenyl]ethyl]amino]-1-[4-[(2-methylpropan-2-yl)oxy]-2-propan-2-yloxy-1,3-benzothiazol-7-yl]ethanone Chemical compound C=12SC(OC(C)C)=NC2=C(OC(C)(C)C)C=CC=1C(=O)CN(CC=1C=CC=CC=1)CCC(C(=CC=1)F)=CC=1CN(CC1)CCC1(OCC1)CN1C(=O)C1=CSC(C(C)C)=N1 WNHSMDNEBCTQAM-UHFFFAOYSA-N 0.000 claims 1
- PGYJSURPYAAOMM-UHFFFAOYSA-N 2-ethenoxy-2-methylpropane Chemical compound CC(C)(C)OC=C PGYJSURPYAAOMM-UHFFFAOYSA-N 0.000 claims 1
- QWGABUOCULMMCS-UHFFFAOYSA-N 3-[2-fluoro-5-[[4-(2-propan-2-yl-1,3-thiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl]methyl]phenyl]propanamide Chemical compound S1C(C(C)C)=NC(C(=O)N2CC3(CCN(CC=4C=C(CCC(N)=O)C(F)=CC=4)CC3)OCC2)=C1 QWGABUOCULMMCS-UHFFFAOYSA-N 0.000 claims 1
- LSGOCJDSLYFJFH-UHFFFAOYSA-N 7-bromo-4-[(2-methylpropan-2-yl)oxy]-2-propan-2-yloxy-1,3-benzothiazole Chemical compound C1=CC(Br)=C2SC(OC(C)C)=NC2=C1OC(C)(C)C LSGOCJDSLYFJFH-UHFFFAOYSA-N 0.000 claims 1
- QMOHGKGFMBSMLE-UHFFFAOYSA-N 7-ethenyl-4-[(2-methylpropan-2-yl)oxy]-2-propan-2-yloxy-1,3-benzothiazole Chemical compound C1=CC(C=C)=C2SC(OC(C)C)=NC2=C1OC(C)(C)C QMOHGKGFMBSMLE-UHFFFAOYSA-N 0.000 claims 1
- PTTGUNRGTKILJR-SFHVURJKSA-N [(2r)-2-hydroxy-2-[4-[(2-methylpropan-2-yl)oxy]-2-propan-2-yloxy-1,3-benzothiazol-7-yl]ethyl] 4-methylbenzenesulfonate Chemical compound C([C@H](O)C=1C=CC(OC(C)(C)C)=C2N=C(SC2=1)OC(C)C)OS(=O)(=O)C1=CC=C(C)C=C1 PTTGUNRGTKILJR-SFHVURJKSA-N 0.000 claims 1
- OCJABRHAKPPGQQ-UHFFFAOYSA-N [9-[(3-bromo-4-fluorophenyl)methyl]-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl]-(2-propan-2-yl-1,3-thiazol-4-yl)methanone Chemical compound S1C(C(C)C)=NC(C(=O)N2CC3(CCN(CC=4C=C(Br)C(F)=CC=4)CC3)OCC2)=C1 OCJABRHAKPPGQQ-UHFFFAOYSA-N 0.000 claims 1
- HHMKBOIYZRFHOO-UHFFFAOYSA-N [9-[[3-(2-aminoethyl)-4-fluorophenyl]methyl]-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl]-(2-propan-2-yl-1,3-thiazol-4-yl)methanone;dihydrochloride Chemical compound Cl.Cl.S1C(C(C)C)=NC(C(=O)N2CC3(CCN(CC=4C=C(CCN)C(F)=CC=4)CC3)OCC2)=C1 HHMKBOIYZRFHOO-UHFFFAOYSA-N 0.000 claims 1
- IGUYIOJQNFOKFB-UHFFFAOYSA-N [9-[[3-[2-(benzylamino)ethyl]-4-fluorophenyl]methyl]-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl]-(2-propan-2-yl-1,3-thiazol-4-yl)methanone Chemical compound S1C(C(C)C)=NC(C(=O)N2CC3(CCN(CC=4C=C(CCNCC=5C=CC=CC=5)C(F)=CC=4)CC3)OCC2)=C1 IGUYIOJQNFOKFB-UHFFFAOYSA-N 0.000 claims 1
- NDNMCXSFTZTDQL-KDXMTYKHSA-N [9-[[3-[2-[benzyl-[(2r)-2-hydroxy-2-[4-[(2-methylpropan-2-yl)oxy]-2-propan-2-yloxy-1,3-benzothiazol-7-yl]ethyl]amino]ethyl]-4-fluorophenyl]methyl]-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl]-(2-propan-2-yl-1,3-thiazol-4-yl)methanone Chemical compound C([C@H](O)C=1C=CC(OC(C)(C)C)=C2N=C(SC2=1)OC(C)C)N(CC=1C=CC=CC=1)CCC(C(=CC=1)F)=CC=1CN(CC1)CCC1(OCC1)CN1C(=O)C1=CSC(C(C)C)=N1 NDNMCXSFTZTDQL-KDXMTYKHSA-N 0.000 claims 1
- NABWWFVUVRZTNN-RIYZIHGNSA-N [9-[[4-fluoro-3-[(e)-2-[(2-methylpropan-2-yl)oxy]ethenyl]phenyl]methyl]-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl]-(2-propan-2-yl-1,3-thiazol-4-yl)methanone Chemical compound S1C(C(C)C)=NC(C(=O)N2CC3(CCN(CC=4C=C(\C=C\OC(C)(C)C)C(F)=CC=4)CC3)OCC2)=C1 NABWWFVUVRZTNN-RIYZIHGNSA-N 0.000 claims 1
- PQVRHBAJSUDXHJ-YTTGMZPUSA-N [9-[[4-fluoro-3-[2-[[(2r)-2-hydroxy-2-[4-[(2-methylpropan-2-yl)oxy]-2-propan-2-yloxy-1,3-benzothiazol-7-yl]ethyl]amino]ethyl]phenyl]methyl]-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl]-(2-propan-2-yl-1,3-thiazol-4-yl)methanone Chemical compound C([C@H](O)C=1C=CC(OC(C)(C)C)=C2N=C(SC2=1)OC(C)C)NCCC(C(=CC=1)F)=CC=1CN(CC1)CCC1(OCC1)CN1C(=O)C1=CSC(C(C)C)=N1 PQVRHBAJSUDXHJ-YTTGMZPUSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 230000001476 alcoholic effect Effects 0.000 claims 1
- 239000003638 chemical reducing agent Substances 0.000 claims 1
- 238000005984 hydrogenation reaction Methods 0.000 claims 1
- 239000003444 phase transfer catalyst Substances 0.000 claims 1
- SNOYOWIQXKTMGE-FXRZFVDSSA-M sodium;[4-fluoro-3-[(e)-2-methoxyethenyl]phenyl]-hydroxymethanesulfonate Chemical compound [Na+].CO\C=C\C1=CC(C(O)S([O-])(=O)=O)=CC=C1F SNOYOWIQXKTMGE-FXRZFVDSSA-M 0.000 claims 1
- KTDWWWMPBHBLQZ-UHFFFAOYSA-N tert-butyl 4-(2-propan-2-yl-1,3-thiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate Chemical compound S1C(C(C)C)=NC(C(=O)N2CC3(CCN(CC3)C(=O)OC(C)(C)C)OCC2)=C1 KTDWWWMPBHBLQZ-UHFFFAOYSA-N 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- FMSQFTVHZUVJBE-LBPRGKRZSA-N CC(C)Oc1nc(c(OC(C)(C)C)ccc2[C@H]3OC3)c2[s]1 Chemical compound CC(C)Oc1nc(c(OC(C)(C)C)ccc2[C@H]3OC3)c2[s]1 FMSQFTVHZUVJBE-LBPRGKRZSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C309/07—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton
- C07C309/08—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton containing hydroxy groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/24—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of a carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
- C07C55/02—Dicarboxylic acids
- C07C55/06—Oxalic acid
- C07C55/07—Salts thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pulmonology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1107985.2A GB201107985D0 (en) | 2011-05-13 | 2011-05-13 | Process |
| GB1107985.2 | 2011-05-13 | ||
| PCT/GB2012/051037 WO2012156693A1 (en) | 2011-05-13 | 2012-05-11 | Process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2013148907A true RU2013148907A (ru) | 2015-06-20 |
Family
ID=44260448
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2013148907/04A RU2013148907A (ru) | 2011-05-13 | 2012-05-11 | Способ |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20140364601A1 (enExample) |
| EP (1) | EP2707362A1 (enExample) |
| JP (1) | JP2014520075A (enExample) |
| KR (1) | KR20140045380A (enExample) |
| CN (1) | CN103649060A (enExample) |
| AU (1) | AU2012257630A1 (enExample) |
| BR (1) | BR112013028789A2 (enExample) |
| CA (1) | CA2835237A1 (enExample) |
| GB (1) | GB201107985D0 (enExample) |
| IL (1) | IL229126A0 (enExample) |
| MX (1) | MX2013012484A (enExample) |
| RU (1) | RU2013148907A (enExample) |
| SG (1) | SG194631A1 (enExample) |
| WO (1) | WO2012156693A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3192B1 (ar) | 2011-09-06 | 2018-03-08 | Novartis Ag | مركب بنزوثيازولون |
| CN103193658A (zh) * | 2013-04-18 | 2013-07-10 | 苏州永健生物医药有限公司 | 一种（r）-2-对硝基苯乙胺基-1-苯乙醇及其盐的合成方法 |
| TWI685497B (zh) | 2014-06-02 | 2020-02-21 | 西班牙商伊史帝夫製藥公司 | 具有多重模式抗疼痛活性的１-氧雜-４,９-二氮雜螺十一烷化合物之烷基衍生物 |
| TW201615642A (zh) * | 2014-06-02 | 2016-05-01 | 伊史帝夫博士實驗室股份有限公司 | 具有多重模式抗疼痛活性的１－氧雜－４，９－二氮雜螺十一烷化合物之醯胺衍生物 |
| TN2018000122A1 (en) | 2015-11-16 | 2019-10-04 | Esteve Labor Dr | Oxadiazaspiro compounds for the treatment of drug abuse and addiction |
| FI3697795T3 (fi) | 2017-10-17 | 2024-02-23 | Acondicionamiento Tarrasense | (R)-9-(2,5-difluorifenetyyli)-4-etyyli-2-metyyli-1-oksa-4,9-diatsaspiro[5.5]undekan-3-onin suoloja |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2185307T3 (es) | 1998-02-02 | 2003-04-16 | Lg Chemical Ltd | Inhibidores de la farnesil transferasa que tienen una estructura piperidinica y procedimiento para su preparacion. |
| AR040962A1 (es) | 2002-08-09 | 2005-04-27 | Novartis Ag | Compuestos derivados de tiazol 1,3-2-ona, composicion farmaceutica y proceso de preparacion del compuesto |
| GB0218629D0 (en) * | 2002-08-09 | 2002-09-18 | Novartis Ag | Organic compounds |
| TW200738659A (en) * | 2005-08-29 | 2007-10-16 | Astrazeneca Ab | Novel compounds |
| CN101300239A (zh) * | 2005-08-29 | 2008-11-05 | 阿斯利康(瑞典)有限公司 | 作为β2肾上腺素受体激动剂的7-（2-氨基-1-羟基-乙基）-4-羟基苯并噻唑-2(3H)-酮衍生物 |
| CN102083839B (zh) * | 2008-02-06 | 2014-03-26 | 阿斯利康(瑞典)有限公司 | 化合物 |
-
2011
- 2011-05-13 GB GBGB1107985.2A patent/GB201107985D0/en not_active Ceased
-
2012
- 2012-05-11 RU RU2013148907/04A patent/RU2013148907A/ru not_active Application Discontinuation
- 2012-05-11 KR KR1020137032749A patent/KR20140045380A/ko not_active Withdrawn
- 2012-05-11 JP JP2014509829A patent/JP2014520075A/ja not_active Withdrawn
- 2012-05-11 AU AU2012257630A patent/AU2012257630A1/en not_active Abandoned
- 2012-05-11 WO PCT/GB2012/051037 patent/WO2012156693A1/en not_active Ceased
- 2012-05-11 BR BR112013028789A patent/BR112013028789A2/pt not_active IP Right Cessation
- 2012-05-11 CA CA2835237A patent/CA2835237A1/en not_active Abandoned
- 2012-05-11 MX MX2013012484A patent/MX2013012484A/es not_active Application Discontinuation
- 2012-05-11 CN CN201280034581.XA patent/CN103649060A/zh active Pending
- 2012-05-11 SG SG2013079363A patent/SG194631A1/en unknown
- 2012-05-11 EP EP12722808.8A patent/EP2707362A1/en not_active Withdrawn
- 2012-05-11 US US14/117,259 patent/US20140364601A1/en not_active Abandoned
-
2013
- 2013-10-28 IL IL229126A patent/IL229126A0/en unknown
-
2015
- 2015-09-17 US US14/857,254 patent/US20160002261A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| BR112013028789A2 (pt) | 2016-08-09 |
| US20140364601A1 (en) | 2014-12-11 |
| MX2013012484A (es) | 2014-01-24 |
| EP2707362A1 (en) | 2014-03-19 |
| GB201107985D0 (en) | 2011-06-29 |
| AU2012257630A1 (en) | 2013-11-28 |
| US20160002261A1 (en) | 2016-01-07 |
| KR20140045380A (ko) | 2014-04-16 |
| WO2012156693A1 (en) | 2012-11-22 |
| SG194631A1 (en) | 2013-12-30 |
| JP2014520075A (ja) | 2014-08-21 |
| IL229126A0 (en) | 2013-12-31 |
| CN103649060A (zh) | 2014-03-19 |
| CA2835237A1 (en) | 2012-11-22 |
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