CN103649060A - 方法 - Google Patents
方法 Download PDFInfo
- Publication number
- CN103649060A CN103649060A CN201280034581.XA CN201280034581A CN103649060A CN 103649060 A CN103649060 A CN 103649060A CN 201280034581 A CN201280034581 A CN 201280034581A CN 103649060 A CN103649060 A CN 103649060A
- Authority
- CN
- China
- Prior art keywords
- formula
- compound
- compounds
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CC(C)C1=CC*C(C(N2C[C@]3(C*N(Cc(cc4)cc(CCNC[C@](*)c(c(*5)c6N=C5OC(C)C)ccc6OC(C)(C)C)c4F)CC3)*CC2)=O)=CS1 Chemical compound CC(C)C1=CC*C(C(N2C[C@]3(C*N(Cc(cc4)cc(CCNC[C@](*)c(c(*5)c6N=C5OC(C)C)ccc6OC(C)(C)C)c4F)CC3)*CC2)=O)=CS1 0.000 description 7
- IZAOEYVMRKDSCD-UHFFFAOYSA-N CC(C)(C)Oc1ccc(C(CCl)=O)c2c1nc(O)[s]2 Chemical compound CC(C)(C)Oc1ccc(C(CCl)=O)c2c1nc(O)[s]2 IZAOEYVMRKDSCD-UHFFFAOYSA-N 0.000 description 1
- OFTHTUAWLJSDKP-JWZVQWJHSA-N CC(C)C1NC(C(C[C@@H]2CCOCCN(Cc(cc3)cc(CCNCC(C(C=CC(C4(C)N5)O)=C4SC5=O)O)c3F)CCCC2)=O)=CC1 Chemical compound CC(C)C1NC(C(C[C@@H]2CCOCCN(Cc(cc3)cc(CCNCC(C(C=CC(C4(C)N5)O)=C4SC5=O)O)c3F)CCCC2)=O)=CC1 OFTHTUAWLJSDKP-JWZVQWJHSA-N 0.000 description 1
- CEADAORREOCYEF-UHFFFAOYSA-N CC(C)OC(Nc1cc(F)ccc1OC(C)(C)C)=S Chemical compound CC(C)OC(Nc1cc(F)ccc1OC(C)(C)C)=S CEADAORREOCYEF-UHFFFAOYSA-N 0.000 description 1
- UNCUXIFMURRJRJ-UHFFFAOYSA-N CC(C)Oc1nc(c(OC(C)(C)C)ccc2C(CI)=O)c2[s]1 Chemical compound CC(C)Oc1nc(c(OC(C)(C)C)ccc2C(CI)=O)c2[s]1 UNCUXIFMURRJRJ-UHFFFAOYSA-N 0.000 description 1
- QMOHGKGFMBSMLE-UHFFFAOYSA-N CC(C)Oc1nc(c(OC(C)(C)C)ccc2C=C)c2[s]1 Chemical compound CC(C)Oc1nc(c(OC(C)(C)C)ccc2C=C)c2[s]1 QMOHGKGFMBSMLE-UHFFFAOYSA-N 0.000 description 1
- FMSQFTVHZUVJBE-LBPRGKRZSA-N CC(C)Oc1nc(c(OC(C)(C)C)ccc2[C@H]3OC3)c2[s]1 Chemical compound CC(C)Oc1nc(c(OC(C)(C)C)ccc2[C@H]3OC3)c2[s]1 FMSQFTVHZUVJBE-LBPRGKRZSA-N 0.000 description 1
- NUEZKCPTDMEROB-UHFFFAOYSA-N CC(C)c1nc(C=O)c[s]1 Chemical compound CC(C)c1nc(C=O)c[s]1 NUEZKCPTDMEROB-UHFFFAOYSA-N 0.000 description 1
- UFBHQACBYVXASE-UHFFFAOYSA-N Cc(cc(cc1)N=O)c1N Chemical compound Cc(cc(cc1)N=O)c1N UFBHQACBYVXASE-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C309/07—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton
- C07C309/08—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton containing hydroxy groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/24—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of a carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
- C07C55/02—Dicarboxylic acids
- C07C55/06—Oxalic acid
- C07C55/07—Salts thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1107985.2 | 2011-05-13 | ||
| GBGB1107985.2A GB201107985D0 (en) | 2011-05-13 | 2011-05-13 | Process |
| PCT/GB2012/051037 WO2012156693A1 (en) | 2011-05-13 | 2012-05-11 | Process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103649060A true CN103649060A (zh) | 2014-03-19 |
Family
ID=44260448
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280034581.XA Pending CN103649060A (zh) | 2011-05-13 | 2012-05-11 | 方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20140364601A1 (enExample) |
| EP (1) | EP2707362A1 (enExample) |
| JP (1) | JP2014520075A (enExample) |
| KR (1) | KR20140045380A (enExample) |
| CN (1) | CN103649060A (enExample) |
| AU (1) | AU2012257630A1 (enExample) |
| BR (1) | BR112013028789A2 (enExample) |
| CA (1) | CA2835237A1 (enExample) |
| GB (1) | GB201107985D0 (enExample) |
| IL (1) | IL229126A0 (enExample) |
| MX (1) | MX2013012484A (enExample) |
| RU (1) | RU2013148907A (enExample) |
| SG (1) | SG194631A1 (enExample) |
| WO (1) | WO2012156693A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3192B1 (ar) | 2011-09-06 | 2018-03-08 | Novartis Ag | مركب بنزوثيازولون |
| CN103193658A (zh) * | 2013-04-18 | 2013-07-10 | 苏州永健生物医药有限公司 | 一种（r）-2-对硝基苯乙胺基-1-苯乙醇及其盐的合成方法 |
| TW201615642A (zh) * | 2014-06-02 | 2016-05-01 | 伊史帝夫博士實驗室股份有限公司 | 具有多重模式抗疼痛活性的１－氧雜－４，９－二氮雜螺十一烷化合物之醯胺衍生物 |
| TWI685497B (zh) | 2014-06-02 | 2020-02-21 | 西班牙商伊史帝夫製藥公司 | 具有多重模式抗疼痛活性的１-氧雜-４,９-二氮雜螺十一烷化合物之烷基衍生物 |
| HRP20221343T1 (hr) | 2015-11-16 | 2022-12-23 | Esteve Pharmaceuticals, S.A. | Oksadiazaspiro spojevi za liječenje zlouporabe droga i ovisnosti |
| US11236110B2 (en) | 2017-10-17 | 2022-02-01 | Esteve Pharmaceuticals, S.A. | Salts of (R)-9-(2,5-difluorophenethyl)-4-ethyl-2-methyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1701064A (zh) * | 2002-08-09 | 2005-11-23 | 诺瓦提斯公司 | 具有β2－肾上腺素受体激动剂活性的苯并噻唑衍生物 |
| WO2007027134A1 (en) * | 2005-08-29 | 2007-03-08 | Astrazeneca Ab | 7-(2-AMINO-1-HYDROXY-ETHYL)-4-HYDROXYBENZOTHIAZOL-2(3H)-ONE-DERIVATIVES AS β2 ADRENOCEPTOR AGONISTS |
| CN101300239A (zh) * | 2005-08-29 | 2008-11-05 | 阿斯利康(瑞典)有限公司 | 作为β2肾上腺素受体激动剂的7-（2-氨基-1-羟基-乙基）-4-羟基苯并噻唑-2(3H)-酮衍生物 |
| WO2009098448A1 (en) * | 2008-02-06 | 2009-08-13 | Astrazeneca Ab | Compounds |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2185307T3 (es) | 1998-02-02 | 2003-04-16 | Lg Chemical Ltd | Inhibidores de la farnesil transferasa que tienen una estructura piperidinica y procedimiento para su preparacion. |
| PE20050130A1 (es) | 2002-08-09 | 2005-03-29 | Novartis Ag | Compuestos organicos |
-
2011
- 2011-05-13 GB GBGB1107985.2A patent/GB201107985D0/en not_active Ceased
-
2012
- 2012-05-11 MX MX2013012484A patent/MX2013012484A/es not_active Application Discontinuation
- 2012-05-11 SG SG2013079363A patent/SG194631A1/en unknown
- 2012-05-11 EP EP12722808.8A patent/EP2707362A1/en not_active Withdrawn
- 2012-05-11 US US14/117,259 patent/US20140364601A1/en not_active Abandoned
- 2012-05-11 WO PCT/GB2012/051037 patent/WO2012156693A1/en not_active Ceased
- 2012-05-11 CN CN201280034581.XA patent/CN103649060A/zh active Pending
- 2012-05-11 CA CA2835237A patent/CA2835237A1/en not_active Abandoned
- 2012-05-11 KR KR1020137032749A patent/KR20140045380A/ko not_active Withdrawn
- 2012-05-11 JP JP2014509829A patent/JP2014520075A/ja not_active Withdrawn
- 2012-05-11 AU AU2012257630A patent/AU2012257630A1/en not_active Abandoned
- 2012-05-11 BR BR112013028789A patent/BR112013028789A2/pt not_active IP Right Cessation
- 2012-05-11 RU RU2013148907/04A patent/RU2013148907A/ru not_active Application Discontinuation
-
2013
- 2013-10-28 IL IL229126A patent/IL229126A0/en unknown
-
2015
- 2015-09-17 US US14/857,254 patent/US20160002261A1/en not_active Abandoned
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1701064A (zh) * | 2002-08-09 | 2005-11-23 | 诺瓦提斯公司 | 具有β2－肾上腺素受体激动剂活性的苯并噻唑衍生物 |
| WO2007027134A1 (en) * | 2005-08-29 | 2007-03-08 | Astrazeneca Ab | 7-(2-AMINO-1-HYDROXY-ETHYL)-4-HYDROXYBENZOTHIAZOL-2(3H)-ONE-DERIVATIVES AS β2 ADRENOCEPTOR AGONISTS |
| CN101300239A (zh) * | 2005-08-29 | 2008-11-05 | 阿斯利康(瑞典)有限公司 | 作为β2肾上腺素受体激动剂的7-（2-氨基-1-羟基-乙基）-4-羟基苯并噻唑-2(3H)-酮衍生物 |
| WO2009098448A1 (en) * | 2008-02-06 | 2009-08-13 | Astrazeneca Ab | Compounds |
Also Published As
| Publication number | Publication date |
|---|---|
| SG194631A1 (en) | 2013-12-30 |
| MX2013012484A (es) | 2014-01-24 |
| WO2012156693A1 (en) | 2012-11-22 |
| US20140364601A1 (en) | 2014-12-11 |
| AU2012257630A1 (en) | 2013-11-28 |
| IL229126A0 (en) | 2013-12-31 |
| RU2013148907A (ru) | 2015-06-20 |
| US20160002261A1 (en) | 2016-01-07 |
| CA2835237A1 (en) | 2012-11-22 |
| BR112013028789A2 (pt) | 2016-08-09 |
| GB201107985D0 (en) | 2011-06-29 |
| JP2014520075A (ja) | 2014-08-21 |
| KR20140045380A (ko) | 2014-04-16 |
| EP2707362A1 (en) | 2014-03-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20140319 |