RU2010146684A - Способ получения неиммуногенных гидрофобных белковых наночастиц и их применения - Google Patents

Способ получения неиммуногенных гидрофобных белковых наночастиц и их применения Download PDF

Info

Publication number
RU2010146684A
RU2010146684A RU2010146684/10A RU2010146684A RU2010146684A RU 2010146684 A RU2010146684 A RU 2010146684A RU 2010146684/10 A RU2010146684/10 A RU 2010146684/10A RU 2010146684 A RU2010146684 A RU 2010146684A RU 2010146684 A RU2010146684 A RU 2010146684A
Authority
RU
Russia
Prior art keywords
specified
nanoparticles
solution
aqueous phase
protein
Prior art date
Application number
RU2010146684/10A
Other languages
English (en)
Russian (ru)
Inventor
Оматану П. ПЕРУМАЛ (US)
Оматану П. ПЕРУМАЛ
Сатиш К. ПОДАРАЛЛА (US)
Сатиш К. ПОДАРАЛЛА
Рэдхей С. КАУШИК (US)
Рэдхей С. КАУШИК
Original Assignee
Саут Дакота Стейт Юниверсити (US)
Саут Дакота Стейт Юниверсити
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Саут Дакота Стейт Юниверсити (US), Саут Дакота Стейт Юниверсити filed Critical Саут Дакота Стейт Юниверсити (US)
Publication of RU2010146684A publication Critical patent/RU2010146684A/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/721—Dextrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
    • A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
    • A61K47/6931—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nanotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Medical Informatics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2010146684/10A 2008-05-09 2009-05-11 Способ получения неиммуногенных гидрофобных белковых наночастиц и их применения RU2010146684A (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12713408P 2008-05-09 2008-05-09
US61/127,134 2008-05-09

Publications (1)

Publication Number Publication Date
RU2010146684A true RU2010146684A (ru) 2012-06-20

Family

ID=41264904

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2010146684/10A RU2010146684A (ru) 2008-05-09 2009-05-11 Способ получения неиммуногенных гидрофобных белковых наночастиц и их применения

Country Status (11)

Country Link
US (2) US8669225B2 (enExample)
EP (1) EP2285825B1 (enExample)
JP (2) JP5546532B2 (enExample)
KR (1) KR101616771B1 (enExample)
CN (1) CN102066399B (enExample)
AU (1) AU2009244742B2 (enExample)
BR (1) BRPI0908686B8 (enExample)
CA (1) CA2723563C (enExample)
IL (1) IL209155A (enExample)
RU (1) RU2010146684A (enExample)
WO (1) WO2009137112A1 (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2170283T3 (en) 2007-06-22 2019-04-15 Univ Texas CREATION OF STABLE SUBMICRON Peptide OR PROTEIN PARTICLES BY THIN FILM FREEZING
US20140234420A1 (en) * 2008-05-09 2014-08-21 Omathanu P. Perumal Method of Treating Skin Disorders using Nanoscale Delivery Devices and Transdermal Enhancing Compositions
AU2009244742B2 (en) * 2008-05-09 2014-11-06 South Dakota State University Method of forming non-immunogenic hydrophobic protein nanoparticles and uses therefor
US8697098B2 (en) 2011-02-25 2014-04-15 South Dakota State University Polymer conjugated protein micelles
JP5711138B2 (ja) 2008-11-16 2015-04-30 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム 高濃度の低粘度懸濁液
CN102958384B (zh) 2010-06-30 2016-02-24 荷兰联合利华有限公司 包含疏水聚合物和疏水酚类化合物的颗粒
AU2011278186B2 (en) 2010-07-16 2015-02-05 Centro Nacional De Tecnologia Y Seguridad Alimentaria, Laboratorio Del Ebro Nanoparticles for the encapsulation of compounds, the obtaining and uses thereof
CN102120823B (zh) * 2011-01-06 2016-08-03 鲁传华 水溶性玉米朊的合成及在药物制剂中的运用
KR101952599B1 (ko) 2011-02-25 2019-05-22 사우스다코타주립대학 고분자 컨쥬게이트화된 단백질 마이셀
EP2678007A4 (en) * 2011-02-25 2015-08-12 Univ South Dakota PROTEIN NANOTRIER FOR TOPICAL ADMINISTRATION
AU2012225277A1 (en) * 2011-03-10 2013-09-26 Board Of Regents, The University Of Texas System Protein nanoparticle dispersions
CA2883080A1 (en) * 2011-08-26 2013-03-07 Vecoy Nanomedicines Ltd. Pathogen and substance traps
EP2625966A1 (en) 2012-02-13 2013-08-14 Bionanoplus, S.L. Nanoparticles comprising a vegetable hydrophobic protein and a water miscible non-volatile organic solvent and uses thereof
WO2014005299A1 (en) * 2012-07-04 2014-01-09 Empire Technology Development Llc Quantum dot-protein complexes, films, and methods of use
KR102045732B1 (ko) * 2012-12-28 2019-11-18 엘지디스플레이 주식회사 온도감응형 계면활성제를 이용한 수용성 나노입자의 제조방법
CN105682646A (zh) * 2013-06-04 2016-06-15 南达科他州立大学 用于口服药物递送的新型核-壳纳米颗粒
IL228528A (en) 2013-09-17 2015-01-29 Technion Res & Dev Foundation Potato-based nanoparticles
WO2016057799A1 (en) * 2014-10-09 2016-04-14 Therakine Use of meso-and nanoporous material for surfactant trapping in nanoparticle suspensions
WO2018071864A1 (en) 2016-10-13 2018-04-19 Thomas Jefferson University Delivery compositions, and methods of making and using same
CN110730656B (zh) * 2017-06-02 2022-09-16 特一华制药株式会社 水难溶性成分增溶胶束及含有该胶束的液体制剂
TWI642685B (zh) * 2017-07-26 2018-12-01 中原大學 新穎胜肽及其應用
CN109432433A (zh) * 2018-10-30 2019-03-08 中国药科大学 一种纳米载体的制备方法和用途
CN109730976B (zh) * 2018-12-24 2020-06-09 华中科技大学 一种基于自由基氧化制备白蛋白纳米粒的方法
CN110251487B (zh) * 2019-08-01 2021-11-02 郑州大学 一种提高多西他赛载药量和口服生物利用度的醇溶蛋白纳米粒的制备方法及其应用
CN112121019B (zh) * 2020-09-23 2022-05-31 合肥工业大学 抗氧化型淀粉基糊精复合纳米颗粒及其制备方法与应用
CN115025054B (zh) * 2022-06-09 2023-12-22 四川普锐特药业有限公司 一种以乳铁蛋白为载体的纳米组合物的制备方法
CN116998582A (zh) * 2023-08-08 2023-11-07 扬州大学 一种高溶解度油料植物蛋白的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2236521A (en) 1937-08-12 1941-04-01 Zein Corp Of America Ink
US5330778A (en) 1988-09-19 1994-07-19 Opta Food Ingredients, Inc. Hydrophobic protein microparticles
AU642932B2 (en) * 1989-11-06 1993-11-04 Alkermes Controlled Therapeutics, Inc. Protein microspheres and methods of using them
US5254673A (en) * 1991-12-26 1993-10-19 Opta Food Ingredients, Inc. Purification of zein from corn gluten meal
IE80468B1 (en) * 1995-04-04 1998-07-29 Elan Corp Plc Controlled release biodegradable nanoparticles containing insulin
MY153295A (en) * 2004-09-29 2015-01-29 Nestec Sa Nanoparticulated whey proteins
US20070148251A1 (en) 2005-12-22 2007-06-28 Hossainy Syed F A Nanoparticle releasing medical devices
KR20080111033A (ko) * 2006-03-29 2008-12-22 후지필름 가부시키가이샤 카제인 나노입자
EP2054036B1 (en) * 2006-07-24 2019-12-18 Singh-Broemer and Company, Inc. Solid nanoparticle formulation of water insoluble pharmaceutical substances with reduced ostwald ripening
CN101485629B (zh) * 2008-01-16 2013-01-23 沈阳药科大学 一种给药系统及其制备方法
AU2009244742B2 (en) * 2008-05-09 2014-11-06 South Dakota State University Method of forming non-immunogenic hydrophobic protein nanoparticles and uses therefor
EP2678007A4 (en) * 2011-02-25 2015-08-12 Univ South Dakota PROTEIN NANOTRIER FOR TOPICAL ADMINISTRATION

Also Published As

Publication number Publication date
US9616021B2 (en) 2017-04-11
HK1158221A1 (en) 2012-07-13
EP2285825A4 (en) 2012-11-28
CA2723563C (en) 2017-12-12
KR101616771B1 (ko) 2016-04-29
US8669225B2 (en) 2014-03-11
BRPI0908686B8 (pt) 2021-05-25
US20140308351A1 (en) 2014-10-16
AU2009244742B2 (en) 2014-11-06
AU2009244742A1 (en) 2009-11-12
IL209155A (en) 2016-07-31
CN102066399B (zh) 2014-11-26
WO2009137112A1 (en) 2009-11-12
KR20110036704A (ko) 2011-04-08
EP2285825A1 (en) 2011-02-23
IL209155A0 (en) 2011-01-31
JP5546532B2 (ja) 2014-07-09
EP2285825B1 (en) 2020-07-15
CA2723563A1 (en) 2009-11-12
BRPI0908686B1 (pt) 2020-09-29
CN102066399A (zh) 2011-05-18
JP5851550B2 (ja) 2016-02-03
US20110091565A1 (en) 2011-04-21
JP2011519932A (ja) 2011-07-14
JP2014177474A (ja) 2014-09-25

Similar Documents

Publication Publication Date Title
RU2010146684A (ru) Способ получения неиммуногенных гидрофобных белковых наночастиц и их применения
Kim et al. Ceria‐based therapeutic antioxidants for biomedical applications
JP7290881B2 (ja) ＡｕＣ含有物質の使用
Vigani et al. Recent advances in the development of in situ gelling drug delivery systems for non-parenteral administration routes
JP2011519932A5 (enExample)
Han et al. Macrophage membrane-coated nanocarriers Co-Modified by RVG29 and TPP improve brain neuronal mitochondria-targeting and therapeutic efficacy in Alzheimer's disease mice
US20180369425A1 (en) LINKED AND OTHER pH-TRIGGERED COMPOUNDS
CN111683653A (zh) 用于局部递送的方法和组合物
CN101330912A (zh) 一种多西他赛的药用组合物、制备方法及用途
Xin et al. PLGA nanoparticles introduction into mitoxantrone-loaded ultrasound-responsive liposomes: In vitro and in vivo investigations
US20040180094A1 (en) Activation agents on the surface of encapsulation vesicles
KR20190066040A (ko) Tie2 신호전달을 활성화시키기 위한 화합물 및 방법
WO2010069138A1 (zh) 一种谷维素组合物及其制备方法
Tollemeto et al. Mucoadhesive dendrons conjugated to mesoporous silica nanoparticles as a drug delivery approach for orally administered biopharmaceuticals
AU2016358125A1 (en) Peptides with anti-angiogenic, anti-lymphangiogenic, and anti-edemic properties and nanoparticle formulations
Pradhan et al. Nanomodulators that target Alzheimer’s disease: A review
Zhang et al. Cascade-targeting multifunctional nanochaperone remodels brain microenvironment for synergistic therapy of Alzheimer’s disease
CN113577016A (zh) 一种雷公藤甲素-金纳米颗粒/透明质酸复合水凝胶及其制备与应用
CN113413470A (zh) 肿瘤诊疗剂及其制备方法和应用
TW202140036A (zh) 治療性多烯巨環內酯(polyene macrolide)之醫藥組合物及其使用方法
JP2020517687A (ja) 水難溶性薬物が内封されたタンパク質粒子およびその調製方法
CN119235817B (zh) 含胍基结构的抗炎纳米载药体系及其制备方法和应用
Zhu et al. Intranasal administration of pullulan-based nanoparticles for enhanced delivery of adriamycin into the brain: In vitro and in vivo evaluation
Demina et al. Development strategies and biopharmaceutical aspects of drug delivery systems
TWI616210B (zh) 經修飾微氣泡及其製備方法

Legal Events

Date Code Title Description
FA93 Acknowledgement of application withdrawn (no request for examination)

Effective date: 20120512