CA2723563C - Method of forming non-immunogenic hydrophobic protein nanoparticles, and uses therefor - Google Patents

Method of forming non-immunogenic hydrophobic protein nanoparticles, and uses therefor Download PDF

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Publication number
CA2723563C
CA2723563C CA2723563A CA2723563A CA2723563C CA 2723563 C CA2723563 C CA 2723563C CA 2723563 A CA2723563 A CA 2723563A CA 2723563 A CA2723563 A CA 2723563A CA 2723563 C CA2723563 C CA 2723563C
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Prior art keywords
nanoparticles
zein
nanoparticle
prolamine
phospholipid
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CA2723563A
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English (en)
French (fr)
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CA2723563A1 (en
Inventor
Omathanu P. Perumal
Satheesh K. Podaralla
Radhey S. Kaushik
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South Dakota State University
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South Dakota State University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/721—Dextrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
    • A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
    • A61K47/6931—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nanotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Medical Informatics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2723563A 2008-05-09 2009-05-11 Method of forming non-immunogenic hydrophobic protein nanoparticles, and uses therefor Active CA2723563C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12713408P 2008-05-09 2008-05-09
US61/127,134 2008-05-09
PCT/US2009/002935 WO2009137112A1 (en) 2008-05-09 2009-05-11 Method of forming non-immunogenic hydrophobic protein nanoparticles and uses therefor

Publications (2)

Publication Number Publication Date
CA2723563A1 CA2723563A1 (en) 2009-11-12
CA2723563C true CA2723563C (en) 2017-12-12

Family

ID=41264904

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2723563A Active CA2723563C (en) 2008-05-09 2009-05-11 Method of forming non-immunogenic hydrophobic protein nanoparticles, and uses therefor

Country Status (11)

Country Link
US (2) US8669225B2 (enExample)
EP (1) EP2285825B1 (enExample)
JP (2) JP5546532B2 (enExample)
KR (1) KR101616771B1 (enExample)
CN (1) CN102066399B (enExample)
AU (1) AU2009244742B2 (enExample)
BR (1) BRPI0908686B8 (enExample)
CA (1) CA2723563C (enExample)
IL (1) IL209155A (enExample)
RU (1) RU2010146684A (enExample)
WO (1) WO2009137112A1 (enExample)

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* Cited by examiner, † Cited by third party
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DK2170283T3 (en) 2007-06-22 2019-04-15 Univ Texas CREATION OF STABLE SUBMICRON Peptide OR PROTEIN PARTICLES BY THIN FILM FREEZING
US20140234420A1 (en) * 2008-05-09 2014-08-21 Omathanu P. Perumal Method of Treating Skin Disorders using Nanoscale Delivery Devices and Transdermal Enhancing Compositions
AU2009244742B2 (en) * 2008-05-09 2014-11-06 South Dakota State University Method of forming non-immunogenic hydrophobic protein nanoparticles and uses therefor
US8697098B2 (en) 2011-02-25 2014-04-15 South Dakota State University Polymer conjugated protein micelles
JP5711138B2 (ja) 2008-11-16 2015-04-30 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム 高濃度の低粘度懸濁液
CN102958384B (zh) 2010-06-30 2016-02-24 荷兰联合利华有限公司 包含疏水聚合物和疏水酚类化合物的颗粒
AU2011278186B2 (en) 2010-07-16 2015-02-05 Centro Nacional De Tecnologia Y Seguridad Alimentaria, Laboratorio Del Ebro Nanoparticles for the encapsulation of compounds, the obtaining and uses thereof
CN102120823B (zh) * 2011-01-06 2016-08-03 鲁传华 水溶性玉米朊的合成及在药物制剂中的运用
KR101952599B1 (ko) 2011-02-25 2019-05-22 사우스다코타주립대학 고분자 컨쥬게이트화된 단백질 마이셀
EP2678007A4 (en) * 2011-02-25 2015-08-12 Univ South Dakota PROTEIN NANOTRIER FOR TOPICAL ADMINISTRATION
AU2012225277A1 (en) * 2011-03-10 2013-09-26 Board Of Regents, The University Of Texas System Protein nanoparticle dispersions
CA2883080A1 (en) * 2011-08-26 2013-03-07 Vecoy Nanomedicines Ltd. Pathogen and substance traps
EP2625966A1 (en) 2012-02-13 2013-08-14 Bionanoplus, S.L. Nanoparticles comprising a vegetable hydrophobic protein and a water miscible non-volatile organic solvent and uses thereof
WO2014005299A1 (en) * 2012-07-04 2014-01-09 Empire Technology Development Llc Quantum dot-protein complexes, films, and methods of use
KR102045732B1 (ko) * 2012-12-28 2019-11-18 엘지디스플레이 주식회사 온도감응형 계면활성제를 이용한 수용성 나노입자의 제조방법
CN105682646A (zh) * 2013-06-04 2016-06-15 南达科他州立大学 用于口服药物递送的新型核-壳纳米颗粒
IL228528A (en) 2013-09-17 2015-01-29 Technion Res & Dev Foundation Potato-based nanoparticles
WO2016057799A1 (en) * 2014-10-09 2016-04-14 Therakine Use of meso-and nanoporous material for surfactant trapping in nanoparticle suspensions
WO2018071864A1 (en) 2016-10-13 2018-04-19 Thomas Jefferson University Delivery compositions, and methods of making and using same
CN110730656B (zh) * 2017-06-02 2022-09-16 特一华制药株式会社 水难溶性成分增溶胶束及含有该胶束的液体制剂
TWI642685B (zh) * 2017-07-26 2018-12-01 中原大學 新穎胜肽及其應用
CN109432433A (zh) * 2018-10-30 2019-03-08 中国药科大学 一种纳米载体的制备方法和用途
CN109730976B (zh) * 2018-12-24 2020-06-09 华中科技大学 一种基于自由基氧化制备白蛋白纳米粒的方法
CN110251487B (zh) * 2019-08-01 2021-11-02 郑州大学 一种提高多西他赛载药量和口服生物利用度的醇溶蛋白纳米粒的制备方法及其应用
CN112121019B (zh) * 2020-09-23 2022-05-31 合肥工业大学 抗氧化型淀粉基糊精复合纳米颗粒及其制备方法与应用
CN115025054B (zh) * 2022-06-09 2023-12-22 四川普锐特药业有限公司 一种以乳铁蛋白为载体的纳米组合物的制备方法
CN116998582A (zh) * 2023-08-08 2023-11-07 扬州大学 一种高溶解度油料植物蛋白的制备方法

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AU2009244742B2 (en) * 2008-05-09 2014-11-06 South Dakota State University Method of forming non-immunogenic hydrophobic protein nanoparticles and uses therefor
EP2678007A4 (en) * 2011-02-25 2015-08-12 Univ South Dakota PROTEIN NANOTRIER FOR TOPICAL ADMINISTRATION

Also Published As

Publication number Publication date
US9616021B2 (en) 2017-04-11
HK1158221A1 (en) 2012-07-13
EP2285825A4 (en) 2012-11-28
KR101616771B1 (ko) 2016-04-29
US8669225B2 (en) 2014-03-11
BRPI0908686B8 (pt) 2021-05-25
US20140308351A1 (en) 2014-10-16
AU2009244742B2 (en) 2014-11-06
AU2009244742A1 (en) 2009-11-12
IL209155A (en) 2016-07-31
CN102066399B (zh) 2014-11-26
WO2009137112A1 (en) 2009-11-12
KR20110036704A (ko) 2011-04-08
EP2285825A1 (en) 2011-02-23
IL209155A0 (en) 2011-01-31
JP5546532B2 (ja) 2014-07-09
RU2010146684A (ru) 2012-06-20
EP2285825B1 (en) 2020-07-15
CA2723563A1 (en) 2009-11-12
BRPI0908686B1 (pt) 2020-09-29
CN102066399A (zh) 2011-05-18
JP5851550B2 (ja) 2016-02-03
US20110091565A1 (en) 2011-04-21
JP2011519932A (ja) 2011-07-14
JP2014177474A (ja) 2014-09-25

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