RU2009133784A - АНТИ-Robo4-АНТИТЕЛА И ИХ ПРИМЕНЕНИЯ - Google Patents
АНТИ-Robo4-АНТИТЕЛА И ИХ ПРИМЕНЕНИЯ Download PDFInfo
- Publication number
- RU2009133784A RU2009133784A RU2009133784/10A RU2009133784A RU2009133784A RU 2009133784 A RU2009133784 A RU 2009133784A RU 2009133784/10 A RU2009133784/10 A RU 2009133784/10A RU 2009133784 A RU2009133784 A RU 2009133784A RU 2009133784 A RU2009133784 A RU 2009133784A
- Authority
- RU
- Russia
- Prior art keywords
- hvr
- cancer
- seq
- antibody
- sequence
- Prior art date
Links
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims abstract 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims abstract 4
- 125000000539 amino acid group Chemical group 0.000 claims abstract 2
- 238000012217 deletion Methods 0.000 claims abstract 2
- 230000037430 deletion Effects 0.000 claims abstract 2
- 238000003780 insertion Methods 0.000 claims abstract 2
- 230000037431 insertion Effects 0.000 claims abstract 2
- 238000000034 method Methods 0.000 claims 13
- 241000124008 Mammalia Species 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 5
- 229940127089 cytotoxic agent Drugs 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 210000001519 tissue Anatomy 0.000 claims 5
- 230000033115 angiogenesis Effects 0.000 claims 4
- 239000002254 cytotoxic agent Substances 0.000 claims 4
- 231100000599 cytotoxic agent Toxicity 0.000 claims 4
- 206010009944 Colon cancer Diseases 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 2
- -1 3-mercapto-1-oxopropyl Chemical group 0.000 claims 2
- 201000001320 Atherosclerosis Diseases 0.000 claims 2
- 201000009030 Carcinoma Diseases 0.000 claims 2
- 206010012689 Diabetic retinopathy Diseases 0.000 claims 2
- 206010017993 Gastrointestinal neoplasms Diseases 0.000 claims 2
- 208000010412 Glaucoma Diseases 0.000 claims 2
- 201000004681 Psoriasis Diseases 0.000 claims 2
- 206010038933 Retinopathy of prematurity Diseases 0.000 claims 2
- 206010038934 Retinopathy proliferative Diseases 0.000 claims 2
- 230000032683 aging Effects 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 208000037976 chronic inflammation Diseases 0.000 claims 2
- 230000006020 chronic inflammation Effects 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 201000011066 hemangioma Diseases 0.000 claims 2
- 201000007270 liver cancer Diseases 0.000 claims 2
- 208000014018 liver neoplasm Diseases 0.000 claims 2
- 201000003142 neovascular glaucoma Diseases 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- NKIJBSVPDYIEAT-UHFFFAOYSA-N 1,4,7,10-tetrazacyclododec-10-ene Chemical compound C1CNCCN=CCNCCN1 NKIJBSVPDYIEAT-UHFFFAOYSA-N 0.000 claims 1
- 206010061424 Anal cancer Diseases 0.000 claims 1
- 201000003076 Angiosarcoma Diseases 0.000 claims 1
- 208000007860 Anus Neoplasms Diseases 0.000 claims 1
- 208000003950 B-cell lymphoma Diseases 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 206010014733 Endometrial cancer Diseases 0.000 claims 1
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 1
- 208000001258 Hemangiosarcoma Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 208000032271 Malignant tumor of penis Diseases 0.000 claims 1
- 229930126263 Maytansine Natural products 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 208000002471 Penile Neoplasms Diseases 0.000 claims 1
- 206010034299 Penile cancer Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- WDLRUFUQRNWCPK-UHFFFAOYSA-N Tetraxetan Chemical compound OC(=O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1 WDLRUFUQRNWCPK-UHFFFAOYSA-N 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006593 Urologic Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 206010047741 Vulval cancer Diseases 0.000 claims 1
- 208000004354 Vulvar Neoplasms Diseases 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- 201000011165 anus cancer Diseases 0.000 claims 1
- 239000011616 biotin Substances 0.000 claims 1
- 229960002685 biotin Drugs 0.000 claims 1
- 235000020958 biotin Nutrition 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 239000002738 chelating agent Substances 0.000 claims 1
- 210000001072 colon Anatomy 0.000 claims 1
- 230000007850 degeneration Effects 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 239000007850 fluorescent dye Substances 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 210000004907 gland Anatomy 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 1
- 210000003494 hepatocyte Anatomy 0.000 claims 1
- 238000011503 in vivo imaging Methods 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000002780 macular degeneration Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- WKPWGQKGSOKKOO-RSFHAFMBSA-N maytansine Chemical compound CO[C@@H]([C@@]1(O)C[C@](OC(=O)N1)([C@H]([C@@H]1O[C@@]1(C)[C@@H](OC(=O)[C@H](C)N(C)C(C)=O)CC(=O)N1C)C)[H])\C=C\C=C(C)\CC2=CC(OC)=C(Cl)C1=C2 WKPWGQKGSOKKOO-RSFHAFMBSA-N 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 239000002923 metal particle Substances 0.000 claims 1
- 239000002105 nanoparticle Substances 0.000 claims 1
- 201000008968 osteosarcoma Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 201000002628 peritoneum cancer Diseases 0.000 claims 1
- 206010038038 rectal cancer Diseases 0.000 claims 1
- 201000001275 rectum cancer Diseases 0.000 claims 1
- 206010041823 squamous cell carcinoma Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- TXEYQDLBPFQVAA-UHFFFAOYSA-N tetrafluoromethane Chemical compound FC(F)(F)F TXEYQDLBPFQVAA-UHFFFAOYSA-N 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 206010046766 uterine cancer Diseases 0.000 claims 1
- 208000012991 uterine carcinoma Diseases 0.000 claims 1
- 201000005102 vulva cancer Diseases 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
- Transplantation (AREA)
- Cardiology (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88921407P | 2007-02-09 | 2007-02-09 | |
| US60/889,214 | 2007-02-09 | ||
| US89147507P | 2007-02-23 | 2007-02-23 | |
| US60/891,475 | 2007-02-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2009133784A true RU2009133784A (ru) | 2011-03-20 |
Family
ID=39591442
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2009133784/10A RU2009133784A (ru) | 2007-02-09 | 2008-02-08 | АНТИ-Robo4-АНТИТЕЛА И ИХ ПРИМЕНЕНИЯ |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US7834154B2 (enExample) |
| EP (2) | EP2125896A2 (enExample) |
| JP (1) | JP2010518115A (enExample) |
| KR (1) | KR20090114443A (enExample) |
| CN (1) | CN101652389A (enExample) |
| AR (1) | AR065271A1 (enExample) |
| AU (1) | AU2008216495A1 (enExample) |
| BR (1) | BRPI0806403A2 (enExample) |
| CA (1) | CA2676766A1 (enExample) |
| CL (1) | CL2008000420A1 (enExample) |
| CO (1) | CO6220835A2 (enExample) |
| CR (1) | CR11017A (enExample) |
| EC (1) | ECSP099619A (enExample) |
| IL (1) | IL200012A0 (enExample) |
| MA (1) | MA31231B1 (enExample) |
| MX (1) | MX2009008430A (enExample) |
| NZ (1) | NZ578701A (enExample) |
| PE (1) | PE20081760A1 (enExample) |
| RU (1) | RU2009133784A (enExample) |
| TW (1) | TW200840822A (enExample) |
| WO (1) | WO2008100805A2 (enExample) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002361610B2 (en) | 2001-11-07 | 2007-01-11 | Agensys, Inc. | Nucleic acid and corresponding protein entitled 161P2F10B useful in treatment and detection of cancer |
| US20100111856A1 (en) | 2004-09-23 | 2010-05-06 | Herman Gill | Zirconium-radiolabeled, cysteine engineered antibody conjugates |
| JP2010518115A (ja) * | 2007-02-09 | 2010-05-27 | ジェネンテック， インコーポレイテッド | 抗Ｒｏｂｏ４抗体およびそれらのための使用 |
| AU2008312457B2 (en) * | 2007-10-19 | 2014-04-17 | Genentech, Inc. | Cysteine engineered anti-TENB2 antibodies and antibody drug conjugates |
| ES2547552T3 (es) * | 2008-02-01 | 2015-10-07 | Genentech, Inc. | Metabolito de nemorrubicina y reactivos análogos, conjugados anticuerpo-fármaco y métodos |
| US8790642B2 (en) * | 2008-08-29 | 2014-07-29 | Genentech, Inc. | Cross-reactive and bispecific anti-IL-17A/F antibodies |
| AR074369A1 (es) * | 2008-11-20 | 2011-01-12 | Genentech Inc | Anticuerpos anti-unc 5b (receptor de netrina) y metodos de uso |
| KR20250091300A (ko) | 2008-12-09 | 2025-06-20 | 제넨테크, 인크. | 항-ｐｄ-ｌ１ 항체 및 ｔ 세포 기능을 향상시키기 위한 그의 용도 |
| JP5818688B2 (ja) * | 2009-01-08 | 2015-11-18 | バイオ−ラッド ラボラトリーズ インコーポレーティッド | 核酸増幅反応の効率を改善するための方法および組成物 |
| SG175716A1 (en) * | 2009-05-07 | 2011-12-29 | Novozymes Biopharma Dk As | Method of controlling o-linked glycosylation of antibodies |
| US9403898B2 (en) | 2009-05-07 | 2016-08-02 | Novozymes Biopharma Dk A/S | Method for purifying albumin |
| KR20120025601A (ko) * | 2009-06-11 | 2012-03-15 | 미네르바 바이오테크놀로지 코포레이션 | 줄기 세포 및 전구 세포를 배양하는 방법 |
| US8609092B2 (en) | 2010-02-08 | 2013-12-17 | Agensys, Inc. | Antibody drug conjugates (ADC) that bind to 161P2F10B proteins |
| AU2011237679B2 (en) * | 2010-04-07 | 2014-11-06 | Abbvie Inc. | TNF-alpha binding proteins |
| AU2011265054B2 (en) | 2010-06-08 | 2016-09-15 | Genentech, Inc. | Cysteine engineered antibodies and conjugates |
| BR112012031727B1 (pt) * | 2010-06-15 | 2022-03-29 | Genmab A/S | Conjugado de droga-anticorpo, composição farmacêutica, e, uso do conjugado de droga- anticorpo |
| TW201300417A (zh) | 2010-11-10 | 2013-01-01 | Genentech Inc | 用於神經疾病免疫療法之方法及組合物 |
| US8911729B2 (en) | 2011-01-10 | 2014-12-16 | The Regents Of The University Of Michigan | Stem cell factor inhibitor |
| DK2663579T3 (en) | 2011-01-14 | 2017-07-31 | Univ California | THERAPEUTIC ANTIBODIES AGAINST ROR-1 PROTEIN AND PROCEDURES FOR USE THEREOF |
| BR112013020369B1 (pt) | 2011-02-10 | 2021-11-03 | Deutsches Krebsforschungszentrum Stiftung Desöffentlichen Rechts | Peptídeos modificados hidrofóbicos para diagnóstico específico do fígado |
| MX356749B (es) * | 2012-04-27 | 2018-06-12 | Daiichi Sankyo Co Ltd | Anticuerpo anti-homologo 4 de roundabout (robo4). |
| RU2666990C2 (ru) | 2012-08-13 | 2018-09-13 | Дженентек, Инк. | Антитела к jagged и способы их применения |
| JP6445446B2 (ja) * | 2012-11-08 | 2018-12-26 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 骨転移の治療のための方法及び医薬組成物 |
| WO2014089177A2 (en) | 2012-12-04 | 2014-06-12 | Massachusetts Institute Of Technology | Compounds, conjugates and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines |
| AU2014284809B2 (en) | 2013-07-03 | 2016-12-15 | Seoul National University R&Db Foundation | Chicken antibody transformed into cysteine and site-specific conjugation using same |
| WO2015006554A1 (en) * | 2013-07-10 | 2015-01-15 | The Regents Of The University Of Michigan | Therapeutic antibodies and uses thereof |
| CN103389376B (zh) * | 2013-08-21 | 2015-08-19 | 中南大学湘雅医院 | 评估肝细胞癌临床分期和预后的试剂盒及ecscr的应用 |
| CA2926262C (en) | 2013-10-14 | 2025-06-17 | Janssen Biotech Inc | CYSTEINE MODIFIED TYPE III FIBRONECTIN DOMAIN BINDING MOLECULES (FN3) |
| EP3107569A4 (en) | 2014-02-20 | 2018-02-21 | Alder Biopharmaceuticals, Inc. | Anti-acth antibodies and use thereof |
| JP2017531620A (ja) | 2014-09-12 | 2017-10-26 | ジェネンテック， インコーポレイテッド | システイン操作抗体及びコンジュゲート |
| EP3221364B1 (en) | 2014-11-19 | 2020-12-16 | Genentech, Inc. | Antibodies against bace1 and use thereof for neural disease immunotherapy |
| EP3221361B1 (en) | 2014-11-19 | 2021-04-21 | Genentech, Inc. | Anti-transferrin receptor / anti-bace1 multispecific antibodies and methods of use |
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-
2008
- 2008-02-08 JP JP2009549247A patent/JP2010518115A/ja active Pending
- 2008-02-08 AU AU2008216495A patent/AU2008216495A1/en not_active Abandoned
- 2008-02-08 CN CN200880011514A patent/CN101652389A/zh active Pending
- 2008-02-08 WO PCT/US2008/053376 patent/WO2008100805A2/en not_active Ceased
- 2008-02-08 CL CL200800420A patent/CL2008000420A1/es unknown
- 2008-02-08 EP EP08729348A patent/EP2125896A2/en not_active Withdrawn
- 2008-02-08 KR KR1020097018734A patent/KR20090114443A/ko not_active Withdrawn
- 2008-02-08 PE PE2008000289A patent/PE20081760A1/es not_active Application Discontinuation
- 2008-02-08 BR BRPI0806403-2A patent/BRPI0806403A2/pt not_active IP Right Cessation
- 2008-02-08 EP EP11195237A patent/EP2468776A3/en not_active Withdrawn
- 2008-02-08 CA CA002676766A patent/CA2676766A1/en not_active Abandoned
- 2008-02-08 AR ARP080100554A patent/AR065271A1/es not_active Application Discontinuation
- 2008-02-08 US US12/028,124 patent/US7834154B2/en not_active Expired - Fee Related
- 2008-02-08 RU RU2009133784/10A patent/RU2009133784A/ru not_active Application Discontinuation
- 2008-02-08 MX MX2009008430A patent/MX2009008430A/es active IP Right Grant
- 2008-02-08 NZ NZ578701A patent/NZ578701A/en not_active IP Right Cessation
- 2008-02-12 TW TW097104860A patent/TW200840822A/zh unknown
-
2009
- 2009-07-22 IL IL200012A patent/IL200012A0/en unknown
- 2009-08-06 CO CO09082361A patent/CO6220835A2/es not_active Application Discontinuation
- 2009-09-01 MA MA32194A patent/MA31231B1/fr unknown
- 2009-09-08 CR CR11017A patent/CR11017A/es unknown
- 2009-09-09 EC EC2009009619A patent/ECSP099619A/es unknown
-
2010
- 2010-09-22 US US12/888,316 patent/US20110059013A1/en not_active Abandoned
- 2010-09-22 US US12/888,312 patent/US20110059112A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| PE20081760A1 (es) | 2009-01-01 |
| ECSP099619A (es) | 2009-10-30 |
| BRPI0806403A2 (pt) | 2011-09-06 |
| EP2125896A2 (en) | 2009-12-02 |
| US20080247951A1 (en) | 2008-10-09 |
| MA31231B1 (fr) | 2010-03-01 |
| IL200012A0 (en) | 2010-04-15 |
| US20110059112A1 (en) | 2011-03-10 |
| AU2008216495A1 (en) | 2008-08-21 |
| KR20090114443A (ko) | 2009-11-03 |
| CA2676766A1 (en) | 2008-08-21 |
| MX2009008430A (es) | 2009-10-28 |
| TW200840822A (en) | 2008-10-16 |
| AR065271A1 (es) | 2009-05-27 |
| US7834154B2 (en) | 2010-11-16 |
| CN101652389A (zh) | 2010-02-17 |
| CR11017A (es) | 2009-10-09 |
| WO2008100805A2 (en) | 2008-08-21 |
| EP2468776A2 (en) | 2012-06-27 |
| EP2468776A3 (en) | 2012-11-14 |
| NZ578701A (en) | 2012-02-24 |
| WO2008100805A3 (en) | 2008-10-09 |
| JP2010518115A (ja) | 2010-05-27 |
| CL2008000420A1 (es) | 2008-06-27 |
| CO6220835A2 (es) | 2010-11-19 |
| US20110059013A1 (en) | 2011-03-10 |
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| Date | Code | Title | Description |
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| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
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