RU2008139599A - Гетеробициклические производные пиразола и способы их применения - Google Patents
Гетеробициклические производные пиразола и способы их применения Download PDFInfo
- Publication number
- RU2008139599A RU2008139599A RU2008139599/04A RU2008139599A RU2008139599A RU 2008139599 A RU2008139599 A RU 2008139599A RU 2008139599/04 A RU2008139599/04 A RU 2008139599/04A RU 2008139599 A RU2008139599 A RU 2008139599A RU 2008139599 A RU2008139599 A RU 2008139599A
- Authority
- RU
- Russia
- Prior art keywords
- alkyl
- heteroaryl
- aryl
- heterocyclyl
- alkynyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 5
- -1 Heterobicyclic pyrazole derivatives Chemical class 0.000 title claims 4
- 150000001875 compounds Chemical class 0.000 claims abstract 70
- 125000000217 alkyl group Chemical group 0.000 claims abstract 69
- 125000001072 heteroaryl group Chemical group 0.000 claims abstract 66
- 125000003118 aryl group Chemical group 0.000 claims abstract 62
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract 58
- 229910052731 fluorine Inorganic materials 0.000 claims abstract 35
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims abstract 34
- 229910052801 chlorine Inorganic materials 0.000 claims abstract 34
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 claims abstract 33
- 229910052794 bromium Inorganic materials 0.000 claims abstract 33
- 125000004452 carbocyclyl group Chemical group 0.000 claims abstract 31
- 229910052740 iodine Inorganic materials 0.000 claims abstract 31
- 125000000304 alkynyl group Chemical group 0.000 claims abstract 18
- 125000003342 alkenyl group Chemical group 0.000 claims abstract 17
- 229910052760 oxygen Inorganic materials 0.000 claims abstract 8
- 229910052717 sulfur Inorganic materials 0.000 claims abstract 8
- 150000003839 salts Chemical class 0.000 claims abstract 2
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 claims 119
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 36
- 229910005965 SO 2 Inorganic materials 0.000 claims 26
- 229910052739 hydrogen Inorganic materials 0.000 claims 23
- 125000000753 cycloalkyl group Chemical group 0.000 claims 21
- 229910052799 carbon Inorganic materials 0.000 claims 18
- 125000004429 atom Chemical group 0.000 claims 16
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 15
- 125000005842 heteroatom Chemical group 0.000 claims 10
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 9
- 229920006395 saturated elastomer Polymers 0.000 claims 9
- 201000010099 disease Diseases 0.000 claims 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- 229910052736 halogen Inorganic materials 0.000 claims 7
- 125000005843 halogen group Chemical group 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 229910052757 nitrogen Inorganic materials 0.000 claims 5
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 4
- 125000002837 carbocyclic group Chemical group 0.000 claims 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 3
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 3
- 125000002950 monocyclic group Chemical group 0.000 claims 3
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims 2
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 2
- 206010061598 Immunodeficiency Diseases 0.000 claims 2
- 208000029462 Immunodeficiency disease Diseases 0.000 claims 2
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 108091000080 Phosphotransferase Proteins 0.000 claims 2
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 2
- 230000007813 immunodeficiency Effects 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 208000019423 liver disease Diseases 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 102000020233 phosphotransferase Human genes 0.000 claims 2
- GBXQPDCOMJJCMJ-UHFFFAOYSA-M trimethyl-[6-(trimethylazaniumyl)hexyl]azanium;bromide Chemical compound [Br-].C[N+](C)(C)CCCCCC[N+](C)(C)C GBXQPDCOMJJCMJ-UHFFFAOYSA-M 0.000 claims 2
- 125000002733 (C1-C6) fluoroalkyl group Chemical group 0.000 claims 1
- 125000006569 (C5-C6) heterocyclic group Chemical group 0.000 claims 1
- 125000006163 5-membered heteroaryl group Chemical group 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000020084 Bone disease Diseases 0.000 claims 1
- 201000003883 Cystic fibrosis Diseases 0.000 claims 1
- 206010019842 Hepatomegaly Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 208000012902 Nervous system disease Diseases 0.000 claims 1
- 208000025966 Neurological disease Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 230000006044 T cell activation Effects 0.000 claims 1
- 108090000190 Thrombin Proteins 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 230000001028 anti-proliverative effect Effects 0.000 claims 1
- 239000003443 antiviral agent Substances 0.000 claims 1
- 125000002619 bicyclic group Chemical group 0.000 claims 1
- 230000030833 cell death Effects 0.000 claims 1
- 208000015114 central nervous system disease Diseases 0.000 claims 1
- 230000001066 destructive effect Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 208000014951 hematologic disease Diseases 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 230000003463 hyperproliferative effect Effects 0.000 claims 1
- 239000002955 immunomodulating agent Substances 0.000 claims 1
- 230000002584 immunomodulator Effects 0.000 claims 1
- 229940121354 immunomodulator Drugs 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 125000002757 morpholinyl group Chemical group 0.000 claims 1
- 239000003076 neurotropic agent Substances 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 230000001575 pathological effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000004193 piperazinyl group Chemical group 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 102000027426 receptor tyrosine kinases Human genes 0.000 claims 1
- 108091008598 receptor tyrosine kinases Proteins 0.000 claims 1
- 208000037803 restenosis Diseases 0.000 claims 1
- 125000006413 ring segment Chemical group 0.000 claims 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 229960004072 thrombin Drugs 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
- 125000006736 (C6-C20) aryl group Chemical group 0.000 abstract 4
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 3
- 101001043818 Mus musculus Interleukin-31 receptor subunit alpha Proteins 0.000 abstract 1
- 0 C*#CC*1CCC(*)CC1 Chemical compound C*#CC*1CCC(*)CC1 0.000 description 9
- WSUXHRRGCRRLND-UHFFFAOYSA-N CC(C)CCN1CCC(CO)CC1 Chemical compound CC(C)CCN1CCC(CO)CC1 WSUXHRRGCRRLND-UHFFFAOYSA-N 0.000 description 1
- ODIQTOYGORNLPE-UHFFFAOYSA-N CC(C)N1CCN(C)CC1 Chemical compound CC(C)N1CCN(C)CC1 ODIQTOYGORNLPE-UHFFFAOYSA-N 0.000 description 1
- YHVDTQFJIHVZKY-UHFFFAOYSA-N CC(C)NC(C(CCCCN1c(cc2)ccc2F)C1=O)=O Chemical compound CC(C)NC(C(CCCCN1c(cc2)ccc2F)C1=O)=O YHVDTQFJIHVZKY-UHFFFAOYSA-N 0.000 description 1
- LHZHJGMJVWBLMQ-UHFFFAOYSA-N CC(C)NC(c1c[s]c(Nc2ccccc2)n1)=O Chemical compound CC(C)NC(c1c[s]c(Nc2ccccc2)n1)=O LHZHJGMJVWBLMQ-UHFFFAOYSA-N 0.000 description 1
- IWDHXAHTVHIUCA-UHFFFAOYSA-N CCCN(Cc1ccccc1)C(C)=O Chemical compound CCCN(Cc1ccccc1)C(C)=O IWDHXAHTVHIUCA-UHFFFAOYSA-N 0.000 description 1
- ZJJYCXCPUAOXFI-UHFFFAOYSA-N CCCNC(c1ccc[s]1)=O Chemical compound CCCNC(c1ccc[s]1)=O ZJJYCXCPUAOXFI-UHFFFAOYSA-N 0.000 description 1
- ZTUVJYKSRZAMLR-UHFFFAOYSA-N CNC1CCN(CCF)CC1 Chemical compound CNC1CCN(CCF)CC1 ZTUVJYKSRZAMLR-UHFFFAOYSA-N 0.000 description 1
- LGROTADAJQJKBN-UHFFFAOYSA-N O=C(C1(CC1)c1nc(cccc2)c2[o]1)NI Chemical compound O=C(C1(CC1)c1nc(cccc2)c2[o]1)NI LGROTADAJQJKBN-UHFFFAOYSA-N 0.000 description 1
- XGYKCUPKJIDCLW-UHFFFAOYSA-N O=C(Cc1ccccc1)C1(CC1)C(NI)=O Chemical compound O=C(Cc1ccccc1)C1(CC1)C(NI)=O XGYKCUPKJIDCLW-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A61P31/12—Antivirals
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- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Virology (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Transplantation (AREA)
- Obesity (AREA)
- Gastroenterology & Hepatology (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77980506P | 2006-03-07 | 2006-03-07 | |
| US60/779,805 | 2006-03-07 | ||
| US87483206P | 2006-12-14 | 2006-12-14 | |
| US60/874,832 | 2006-12-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2008139599A true RU2008139599A (ru) | 2010-04-20 |
Family
ID=38475465
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2008139599/04A RU2008139599A (ru) | 2006-03-07 | 2007-03-06 | Гетеробициклические производные пиразола и способы их применения |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US7723330B2 (enExample) |
| EP (1) | EP2001880A2 (enExample) |
| JP (1) | JP2009529047A (enExample) |
| KR (1) | KR20080110783A (enExample) |
| AR (1) | AR059887A1 (enExample) |
| AU (1) | AU2007224020A1 (enExample) |
| BR (1) | BRPI0708615A2 (enExample) |
| CA (1) | CA2645137A1 (enExample) |
| CL (1) | CL2007000601A1 (enExample) |
| CO (1) | CO6140061A2 (enExample) |
| CR (1) | CR10338A (enExample) |
| EC (1) | ECSP088791A (enExample) |
| IL (1) | IL193587A0 (enExample) |
| MA (1) | MA31339B1 (enExample) |
| MX (1) | MX2008011220A (enExample) |
| NO (1) | NO20084183L (enExample) |
| RU (1) | RU2008139599A (enExample) |
| TW (1) | TW200800996A (enExample) |
| WO (1) | WO2007103308A2 (enExample) |
| ZA (1) | ZA200807632B (enExample) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2501800C2 (ru) * | 2012-02-07 | 2013-12-20 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Пермский государственный национальный исследовательский университет" | 2-(6-АРИЛ-4-АРОИЛ-3-МЕТИЛ-1-ФЕНИЛ-1Н-ПИРАЗОЛО[3,4-b]ПИРИДИН-5-ИЛ)-2-ОКСО-N-АРИЛАЦЕТАМИДЫ И СПОСОБ ИХ ПОЛУЧЕНИЯ |
| RU2723990C2 (ru) * | 2014-11-16 | 2020-06-18 | Эррэй Биофарма, Инк. | Кристаллическая форма (s)-n-(5-((r)-2-(2,5-дифторфенил)-пирролидин-1-ил)-пиразоло[1,5-a]пиримидин-3-ил)-3-гидроксипирролидин-1-карбоксамида гидросульфата |
| RU2745953C2 (ru) * | 2016-05-18 | 2021-04-05 | Локсо Онколоджи, Инк. | Способ получения (s)-n-(5-((r)-2-(2,5-дифторфенил)пирролидин-1-ил)-пиразоло[1,5-a]пиримидин-3-ил)-3-гидроксипирролидин-1-карбоксамида и его солей |
| RU2723990C9 (ru) * | 2014-11-16 | 2023-01-10 | Эррэй Биофарма, Инк. | Кристаллическая форма (s)-n-(5-((r)-2-(2,5-дифторфенил)-пирролидин-1-ил)-пиразоло[1,5-a]пиримидин-3-ил)-3-гидроксипирролидин-1-карбоксамида гидросульфата |
Families Citing this family (110)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4323957B2 (ja) * | 2002-01-22 | 2009-09-02 | バイオマテラ インコーポレイテッド | 生物分解性ポリマーの乾燥方法 |
| WO2006068760A2 (en) | 2004-11-19 | 2006-06-29 | The Regents Of The University Of California | Anti-inflammatory pyrazolopyrimidines |
| JP2009529047A (ja) * | 2006-03-07 | 2009-08-13 | アレイ バイオファーマ、インコーポレイテッド | ヘテロ二環系ピラゾール化合物およびその使用 |
| WO2008127226A2 (en) | 2006-04-04 | 2008-10-23 | The Regents Of The University Of California | P13 kinase antagonists |
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2007
- 2007-03-06 JP JP2008558335A patent/JP2009529047A/ja active Pending
- 2007-03-06 RU RU2008139599/04A patent/RU2008139599A/ru not_active Application Discontinuation
- 2007-03-06 KR KR1020087024415A patent/KR20080110783A/ko not_active Withdrawn
- 2007-03-06 BR BRPI0708615-6A patent/BRPI0708615A2/pt not_active Application Discontinuation
- 2007-03-06 AU AU2007224020A patent/AU2007224020A1/en not_active Abandoned
- 2007-03-06 EP EP07752297A patent/EP2001880A2/en not_active Withdrawn
- 2007-03-06 CA CA002645137A patent/CA2645137A1/en not_active Abandoned
- 2007-03-06 US US11/714,342 patent/US7723330B2/en not_active Expired - Fee Related
- 2007-03-06 WO PCT/US2007/005583 patent/WO2007103308A2/en not_active Ceased
- 2007-03-06 MX MX2008011220A patent/MX2008011220A/es not_active Application Discontinuation
- 2007-03-07 AR ARP070100948A patent/AR059887A1/es unknown
- 2007-03-07 TW TW096107890A patent/TW200800996A/zh unknown
- 2007-03-07 CL CL2007000601A patent/CL2007000601A1/es unknown
-
2008
- 2008-08-21 IL IL193587A patent/IL193587A0/en unknown
- 2008-09-04 ZA ZA2008/07632A patent/ZA200807632B/en unknown
- 2008-09-19 MA MA31254A patent/MA31339B1/fr unknown
- 2008-09-30 CO CO08104090A patent/CO6140061A2/es unknown
- 2008-10-02 CR CR10338A patent/CR10338A/es unknown
- 2008-10-06 NO NO20084183A patent/NO20084183L/no not_active Application Discontinuation
- 2008-10-06 EC EC2008008791A patent/ECSP088791A/es unknown
-
2010
- 2010-01-26 US US12/693,975 patent/US20100256356A1/en not_active Abandoned
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2501800C2 (ru) * | 2012-02-07 | 2013-12-20 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Пермский государственный национальный исследовательский университет" | 2-(6-АРИЛ-4-АРОИЛ-3-МЕТИЛ-1-ФЕНИЛ-1Н-ПИРАЗОЛО[3,4-b]ПИРИДИН-5-ИЛ)-2-ОКСО-N-АРИЛАЦЕТАМИДЫ И СПОСОБ ИХ ПОЛУЧЕНИЯ |
| RU2723990C2 (ru) * | 2014-11-16 | 2020-06-18 | Эррэй Биофарма, Инк. | Кристаллическая форма (s)-n-(5-((r)-2-(2,5-дифторфенил)-пирролидин-1-ил)-пиразоло[1,5-a]пиримидин-3-ил)-3-гидроксипирролидин-1-карбоксамида гидросульфата |
| RU2723990C9 (ru) * | 2014-11-16 | 2023-01-10 | Эррэй Биофарма, Инк. | Кристаллическая форма (s)-n-(5-((r)-2-(2,5-дифторфенил)-пирролидин-1-ил)-пиразоло[1,5-a]пиримидин-3-ил)-3-гидроксипирролидин-1-карбоксамида гидросульфата |
| RU2745953C2 (ru) * | 2016-05-18 | 2021-04-05 | Локсо Онколоджи, Инк. | Способ получения (s)-n-(5-((r)-2-(2,5-дифторфенил)пирролидин-1-ил)-пиразоло[1,5-a]пиримидин-3-ил)-3-гидроксипирролидин-1-карбоксамида и его солей |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2009529047A (ja) | 2009-08-13 |
| CL2007000601A1 (es) | 2008-01-25 |
| ECSP088791A (es) | 2008-11-27 |
| US20100256356A1 (en) | 2010-10-07 |
| CO6140061A2 (es) | 2010-03-19 |
| TW200800996A (en) | 2008-01-01 |
| WO2007103308A2 (en) | 2007-09-13 |
| IL193587A0 (en) | 2009-08-03 |
| WO2007103308A3 (en) | 2008-02-07 |
| AR059887A1 (es) | 2008-05-07 |
| EP2001880A2 (en) | 2008-12-17 |
| MX2008011220A (es) | 2008-09-11 |
| CR10338A (es) | 2008-10-31 |
| ZA200807632B (en) | 2011-04-28 |
| MA31339B1 (fr) | 2010-05-03 |
| NO20084183L (no) | 2008-11-24 |
| US20070238726A1 (en) | 2007-10-11 |
| AU2007224020A1 (en) | 2007-09-13 |
| BRPI0708615A2 (pt) | 2011-06-07 |
| KR20080110783A (ko) | 2008-12-19 |
| US7723330B2 (en) | 2010-05-25 |
| CA2645137A1 (en) | 2007-09-13 |
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