RU2008116314A - Соединения карбоксамина и их применение для лечения hdac-зависимых заболеваний - Google Patents

Соединения карбоксамина и их применение для лечения hdac-зависимых заболеваний Download PDF

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RU2008116314A
RU2008116314A RU2008116314/04A RU2008116314A RU2008116314A RU 2008116314 A RU2008116314 A RU 2008116314A RU 2008116314/04 A RU2008116314/04 A RU 2008116314/04A RU 2008116314 A RU2008116314 A RU 2008116314A RU 2008116314 A RU2008116314 A RU 2008116314A
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Russia
Prior art keywords
amino
propan
dihydroisoindol
dichlorophenyl
piperazin
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RU2008116314/04A
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English (en)
Russian (ru)
Inventor
Маркус Рольф ДОБЛЕР (US)
Маркус Рольф Доблер
Джонатан Э. ГРОБ (US)
Джонатан Э. ГРОБ
Ануп ПАТНАИК (US)
Ануп ПАТНАИК
Бранко РАДЕТИЧ (US)
Бранко Радетич
Майкл ШУЛЬТЦ (US)
Майкл Шультц
Яни ЧЖУ (US)
Яни Чжу
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Новартис АГ (CH)
Новартис Аг
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Publication of RU2008116314A publication Critical patent/RU2008116314A/ru

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
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    • C—CHEMISTRY; METALLURGY
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    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

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RU2008116314/04A 2005-09-27 2006-09-25 Соединения карбоксамина и их применение для лечения hdac-зависимых заболеваний RU2008116314A (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US72090005P 2005-09-27 2005-09-27
US60/720,900 2005-09-27
US75496005P 2005-12-28 2005-12-28
US60/754,960 2005-12-28

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RU2008116314A true RU2008116314A (ru) 2009-11-10

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RU2008116314/04A RU2008116314A (ru) 2005-09-27 2006-09-25 Соединения карбоксамина и их применение для лечения hdac-зависимых заболеваний

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US (1) US20080255149A1 (es)
EP (1) EP1996550A2 (es)
JP (1) JP2009510073A (es)
KR (1) KR20080054417A (es)
AR (1) AR058065A1 (es)
AU (1) AU2006294850A1 (es)
BR (1) BRPI0616755A2 (es)
CA (1) CA2623034A1 (es)
GT (1) GT200600430A (es)
PE (1) PE20070602A1 (es)
RU (1) RU2008116314A (es)
TW (1) TW200800894A (es)
WO (1) WO2007038459A2 (es)

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