RU2003122817A - Применение гедерагенин 3-о-a-l-рамнопиранозил (1-2)-[b-d-глюкопиранозил (1-4)-a-l-арабинопиранозида или содержащего его экстракта из pulsatillae radix в качестве терапевтического средства для солидных опухолей - Google Patents
Применение гедерагенин 3-о-a-l-рамнопиранозил (1-2)-[b-d-глюкопиранозил (1-4)-a-l-арабинопиранозида или содержащего его экстракта из pulsatillae radix в качестве терапевтического средства для солидных опухолей Download PDFInfo
- Publication number
- RU2003122817A RU2003122817A RU2003122817/15A RU2003122817A RU2003122817A RU 2003122817 A RU2003122817 A RU 2003122817A RU 2003122817/15 A RU2003122817/15 A RU 2003122817/15A RU 2003122817 A RU2003122817 A RU 2003122817A RU 2003122817 A RU2003122817 A RU 2003122817A
- Authority
- RU
- Russia
- Prior art keywords
- extract
- pulsatillae radix
- arabinopyranoside
- glucopyranosyl
- ramnopyranosyl
- Prior art date
Links
- 239000009806 pulsatillae Substances 0.000 title claims abstract 10
- 239000000284 extract Substances 0.000 title claims abstract 8
- NTWLPZMPTFQYQI-UHFFFAOYSA-N (3alpha)-olean-12-ene-3,23-diol Natural products C1CC(O)C(C)(CO)C2CCC3(C)C4(C)CCC5(C)CCC(C)(C)CC5C4=CCC3C21C NTWLPZMPTFQYQI-UHFFFAOYSA-N 0.000 claims abstract 4
- GCGBHJLBFAPRDB-UHFFFAOYSA-N Hederagenin Natural products CC1(C)CCC2(CCC3(C)C4CCC5C(C)(CO)C(O)CCC5(C)C4CC=C3C2C1)C(=O)O GCGBHJLBFAPRDB-UHFFFAOYSA-N 0.000 claims abstract 4
- GCGBHJLBFAPRDB-KCVAUKQGSA-N Scutellaric acid Natural products CC1(C)CC[C@@]2(CC[C@@]3(C)[C@@H]4CC[C@H]5[C@@](C)(CO)[C@H](O)CC[C@]5(C)[C@H]4CC=C3[C@@H]2C1)C(=O)O GCGBHJLBFAPRDB-KCVAUKQGSA-N 0.000 claims abstract 4
- PGOYMURMZNDHNS-MYPRUECHSA-N hederagenin Chemical compound C1C[C@H](O)[C@@](C)(CO)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CCC(C)(C)C[C@H]5C4=CC[C@@H]3[C@]21C PGOYMURMZNDHNS-MYPRUECHSA-N 0.000 claims abstract 4
- 206010028980 Neoplasm Diseases 0.000 claims abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- 239000000243 solution Substances 0.000 claims 4
- 230000037396 body weight Effects 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 230000001376 precipitating effect Effects 0.000 claims 2
- 239000007864 aqueous solution Substances 0.000 claims 1
- 238000000605 extraction Methods 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- XELZGAJCZANUQH-UHFFFAOYSA-N methyl 1-acetylthieno[3,2-c]pyrazole-5-carboxylate Chemical compound CC(=O)N1N=CC2=C1C=C(C(=O)OC)S2 XELZGAJCZANUQH-UHFFFAOYSA-N 0.000 claims 1
- 235000015097 nutrients Nutrition 0.000 claims 1
- 239000002504 physiological saline solution Substances 0.000 claims 1
- 238000005507 spraying Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/256—Polyterpene radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Mycology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Alternative & Traditional Medicine (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Steroid Compounds (AREA)
- Saccharide Compounds (AREA)
Claims (8)
1. Средство для лечения солидных опухолей, включающее в качестве активного ингредиента экстракт Pulsatillae radix, причем экстракт Pulsatillae radix содержит гедерагенин 3-О-α-L-рамнопиранозил(1→2)-[β-D-глюкопиранозил(1→4)]-α-L-арабинопиранозид.
2. Средство по пункту 1, где экстракт Pulsatillae radix получают путем экстракции Pulsatillae radix водным раствором этанола и образования осадков при добавлении ацетона с получением водорастворимой фракции.
3. Средство по пункту 2, где экстракт Pulsatillae radix вводят в суточной дозе от 200 до 300 мг/кг веса тела.
4. Средство по пункту 1, где экстракт Pulsatillae radix представляет фракцию с Rf в диапазоне от 0,48 до 0,50 и дает красное окрашивание, а затем синее окрашивание после опрыскивания серной кислотой с последующим нагреванием, а указанную фракцию получают путем экстракции Pulsatillae radix водным раствором этанола, образования осадков при добавлении ацетона с получением водорастворимой фракции и пропускания данной фракции через колонку Sephadex LH20.
5. Средство по пункту 4, где экстракт Pulsatillae radix вводят в суточной дозе от 20 до 40 мг/кг веса тела.
6. Средство для лечения солидных опухолей, включающее в качестве активного ингредиента гедерагенин 3-О-α-L-рамнопиранозил(1→2)-[β-D-глюкопиранозил(1→4)]-α-L-арабинопиранозид.
7. Средство по пункту 6, где гедерагенин 3-О-α-L-рамнопиранозил(1→2)-[β-D-глюкопиранозил(1→4)]-α-L-арабинопиранозид вводят в суточной дозе от 3,5 до 8 мг/кг веса тела.
8. Средство по любому из пунктов с 1 по 7, которое для введения растворяют в растворе, выбранном из группы, включающей физиологический раствор, раствор Рингера и питательный раствор.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020020043016A KR100568607B1 (ko) | 2002-07-22 | 2002-07-22 | 헤데라게닌3-Ｏ-α-Ｌ-람노피라노실(1→2)-[β-Ｄ-글루코피라노실(1→4)]-α-Ｌ-아라비노피라노사이드 또는 그를 함유하는백두옹 추출물의 고형암 치료제로서의 용도 |
| KR2002-43016 | 2002-07-22 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2003122817A true RU2003122817A (ru) | 2005-01-27 |
| RU2325178C2 RU2325178C2 (ru) | 2008-05-27 |
Family
ID=30439383
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2003122817/15A RU2325178C2 (ru) | 2002-07-22 | 2003-07-21 | Применение гедерагенин 3-о-альфа-l-рамнопиранозил (1→2)-[бета-d-глюкопиранозил (1→4)]-альфа-l-арабинопиранозида или содержащего его экстракта из pulsatillae radix в качестве терапевтического средства для солидных опухолей |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US20040082528A1 (ru) |
| EP (1) | EP1388542B1 (ru) |
| JP (1) | JP4642330B2 (ru) |
| KR (1) | KR100568607B1 (ru) |
| CN (1) | CN1308000C (ru) |
| AT (1) | ATE373670T1 (ru) |
| AU (1) | AU2003208120B2 (ru) |
| BR (1) | BR0302590A (ru) |
| CA (1) | CA2435524C (ru) |
| DE (1) | DE60316389T2 (ru) |
| DK (1) | DK1388542T3 (ru) |
| ES (1) | ES2292883T3 (ru) |
| MX (1) | MXPA03006473A (ru) |
| RU (1) | RU2325178C2 (ru) |
| TW (1) | TWI280881B (ru) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2803739C1 (ru) * | 2022-12-23 | 2023-09-19 | федеральное государственное автономное образовательное учреждение высшего образования "Казанский (Приволжский) федеральный университет" (ФГАОУ ВО КФУ) | Фосфониевые соли на основе гликозидов бетулиновой кислоты, обладающие противоопухолевой активностью |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPP702498A0 (en) * | 1998-11-09 | 1998-12-03 | Silverbrook Research Pty Ltd | Image creation method and apparatus (ART77) |
| US20050163734A1 (en) * | 2002-09-23 | 2005-07-28 | Kim Jong S. | Cosmetic composition having whitening effect comprising extract of pulsatilla radix as main ingredient |
| KR100667955B1 (ko) * | 2004-05-07 | 2007-01-15 | 주식회사 에스비피 | 백두옹으로부터 분리된 트리터펜 사포닌 및 이를 포함하는항-고형암 조성물 |
| KR100628334B1 (ko) * | 2004-07-30 | 2006-09-27 | 김송배 | 백두옹의 항암효과를 증진시키는 방법 및 이 방법으로제조된 항암 조성물 |
| JP4892833B2 (ja) * | 2004-12-17 | 2012-03-07 | 大正製薬株式会社 | 脂肪吸収抑制剤 |
| AU2005326850B2 (en) * | 2005-02-03 | 2011-09-22 | Sk Chemicals Co., Ltd. | Pulsatilla spp. extracts effective in brain function |
| KR100748248B1 (ko) * | 2006-06-26 | 2007-08-10 | 주식회사 에스비피 | 백두옹으로부터 분리된 트리터펜 사포닌 및 이를 포함하는항-고형암 조성물 |
| CN102199184B (zh) * | 2011-04-07 | 2013-03-06 | 江西本草天工科技有限责任公司 | 一种常春藤皂苷类衍生物、其盐的制备方法及其抗肿瘤的用途 |
| CN102178688B (zh) * | 2011-04-07 | 2012-11-21 | 江西本草天工科技有限责任公司 | 一种常春藤皂苷类成分的制备方法及其抗肿瘤的用途 |
| CN102633857A (zh) * | 2012-04-24 | 2012-08-15 | 吉林大学 | 一种常春藤皂苷元的提取方法 |
| JP2012246311A (ja) * | 2012-09-05 | 2012-12-13 | Sk Chemicals Co Ltd | 脳機能改善効果を有するオキナグサ抽出物 |
| CN104622880B (zh) * | 2015-02-09 | 2017-05-17 | 南京医科大学第一附属医院 | 一种抗肿瘤药物组合物 |
| CN104761610A (zh) * | 2015-02-10 | 2015-07-08 | 江西本草天工科技有限责任公司 | 一类新型的α-常春藤皂苷衍生物及其制备方法和用途 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE670523A (ru) * | 1964-10-09 | |||
| KR940000234B1 (ko) * | 1989-09-04 | 1994-01-12 | 김송배 | 신규 항암작용을 가지는 약학적 제제 및 제조방법 |
| US5098870A (en) * | 1990-07-12 | 1992-03-24 | Lanxide Technology Company, Lp | Process for preparing self-supporting bodies having controlled porosity and graded properties and products produced thereby |
| US5595756A (en) * | 1993-12-22 | 1997-01-21 | Inex Pharmaceuticals Corporation | Liposomal compositions for enhanced retention of bioactive agents |
| KR0128494B1 (ko) * | 1994-07-26 | 1998-04-04 | 최무섭 | 색전이 없는 생약 추출물-함유 줄무늬 치약 조성물 |
| KR100205045B1 (ko) * | 1996-12-05 | 1999-06-15 | 김송배 | 신규한 트리테르펜 글리코사이드 화합물, 그의 제조방법 및 그를 함유하는 항암제 조성물 |
| WO1999001474A1 (en) * | 1997-07-02 | 1999-01-14 | Washington State University Research Foundation | Methods for the isolation of proteinase inhibitor proteins from potato tubers |
| KR19990016761A (ko) * | 1997-08-19 | 1999-03-15 | 김송배 | 신규한 트리테르펜 글리코사이드 화합물, 그의 제조방법 및 그를 함유하는 항암제 조성물 |
| KR100312622B1 (ko) * | 1998-11-03 | 2002-02-28 | 김송배 | 생약을주성분으로한안정화된항암제조성물및그제조방법 |
| KR100315200B1 (ko) | 1998-11-10 | 2002-03-21 | 김송배 | 데옥시포도필로톡신을유효성분으로함유하는고형암치료제조성물 |
| KR100340941B1 (ko) * | 1999-05-14 | 2002-06-20 | 김일웅 | 항 종양 효과가 있는 화합물 및 그것을 함유하는 항종양제 |
| US6686456B2 (en) * | 2001-07-06 | 2004-02-03 | Kemin Foods, L.C. | Method for the elimination of Kunitz and Bowman-Birk trypsin inhibitors and carboxypeptidase inhibitor from potato proteins |
| US7371418B2 (en) * | 2001-07-06 | 2008-05-13 | Sheabar Fayad Z | Method for controlling the yield and purity of proteinase inhibitor II during extraction |
-
2002
- 2002-07-22 KR KR1020020043016A patent/KR100568607B1/ko active IP Right Grant
-
2003
- 2003-07-03 AT AT03015114T patent/ATE373670T1/de active
- 2003-07-03 EP EP03015114A patent/EP1388542B1/en not_active Expired - Lifetime
- 2003-07-03 AU AU2003208120A patent/AU2003208120B2/en not_active Ceased
- 2003-07-03 DK DK03015114T patent/DK1388542T3/da active
- 2003-07-03 ES ES03015114T patent/ES2292883T3/es not_active Expired - Lifetime
- 2003-07-03 DE DE60316389T patent/DE60316389T2/de not_active Expired - Lifetime
- 2003-07-14 TW TW092119105A patent/TWI280881B/zh not_active IP Right Cessation
- 2003-07-15 US US10/620,709 patent/US20040082528A1/en not_active Abandoned
- 2003-07-17 BR BR0302590-0A patent/BR0302590A/pt not_active Application Discontinuation
- 2003-07-18 CA CA002435524A patent/CA2435524C/en not_active Expired - Fee Related
- 2003-07-18 MX MXPA03006473A patent/MXPA03006473A/es active IP Right Grant
- 2003-07-21 RU RU2003122817/15A patent/RU2325178C2/ru not_active IP Right Cessation
- 2003-07-22 JP JP2003277209A patent/JP4642330B2/ja not_active Expired - Fee Related
- 2003-07-22 CN CNB031787975A patent/CN1308000C/zh not_active Expired - Fee Related
-
2005
- 2005-04-15 US US11/107,665 patent/US7682638B2/en not_active Expired - Fee Related
-
2010
- 2010-02-22 US US12/709,907 patent/US8075923B2/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2803739C1 (ru) * | 2022-12-23 | 2023-09-19 | федеральное государственное автономное образовательное учреждение высшего образования "Казанский (Приволжский) федеральный университет" (ФГАОУ ВО КФУ) | Фосфониевые соли на основе гликозидов бетулиновой кислоты, обладающие противоопухолевой активностью |
Also Published As
| Publication number | Publication date |
|---|---|
| US7682638B2 (en) | 2010-03-23 |
| KR100568607B1 (ko) | 2006-04-07 |
| US8075923B2 (en) | 2011-12-13 |
| EP1388542B1 (en) | 2007-09-19 |
| AU2003208120B2 (en) | 2008-09-11 |
| US20050239718A1 (en) | 2005-10-27 |
| CA2435524A1 (en) | 2004-01-22 |
| US20100152124A1 (en) | 2010-06-17 |
| AU2003208120A1 (en) | 2004-02-05 |
| DE60316389D1 (de) | 2007-10-31 |
| ATE373670T1 (de) | 2007-10-15 |
| TWI280881B (en) | 2007-05-11 |
| RU2325178C2 (ru) | 2008-05-27 |
| EP1388542A1 (en) | 2004-02-11 |
| KR20040009172A (ko) | 2004-01-31 |
| CA2435524C (en) | 2009-11-03 |
| MXPA03006473A (es) | 2004-02-04 |
| US20040082528A1 (en) | 2004-04-29 |
| CN1494910A (zh) | 2004-05-12 |
| JP2004051641A (ja) | 2004-02-19 |
| ES2292883T3 (es) | 2008-03-16 |
| CN1308000C (zh) | 2007-04-04 |
| JP4642330B2 (ja) | 2011-03-02 |
| BR0302590A (pt) | 2004-08-24 |
| DE60316389T2 (de) | 2008-06-26 |
| DK1388542T3 (da) | 2008-01-02 |
| TW200410704A (en) | 2004-07-01 |
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