RS49542B - Postupak dobijanja obogaćenih enantiomera N- derivata laktama - Google Patents

Postupak dobijanja obogaćenih enantiomera N- derivata laktama

Info

Publication number
RS49542B
RS49542B YUP-693/99A YU69399A RS49542B RS 49542 B RS49542 B RS 49542B YU 69399 A YU69399 A YU 69399A RS 49542 B RS49542 B RS 49542B
Authority
RS
Serbia
Prior art keywords
derivatised
lactams
enantiomerically enriched
preparing enantiomerically
azabicyclo
Prior art date
Application number
YUP-693/99A
Other languages
English (en)
Inventor
Michael John DAWSON
Mahmound MAHMOUDIAN
Christopher John Wallis
Original Assignee
Glaxo Group Limited,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Limited, filed Critical Glaxo Group Limited,
Publication of YU69399A publication Critical patent/YU69399A/sh
Publication of RS49542B publication Critical patent/RS49542B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Postupak dobijanja u osnovi čitog enantiomera N-zaštićenog (1R, 4S)-2-azabiciklo[2.2.1]hept-5-en-3-ona, formule (IV) U kojoj je P aktivirajuća i zaštitna grupa, naznačen time, što se racemska smeša N-zaštićenog (+)-2- azabiciklo[2.2.1]hept-5-en-3-ona (V) U kojoj je P aktivirajuća i zaštitna grupa, tretira sa enzimom acilaze, pa se neizreagovali enantiomer formule (IV) izoluje iz reakcione smeše konvencionalnim postupcima. Prijava sadrži još 13 zavisnih patentnih zahteva.
YUP-693/99A 1997-08-22 1998-08-20 Postupak dobijanja obogaćenih enantiomera N- derivata laktama RS49542B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9717928.7A GB9717928D0 (en) 1997-08-22 1997-08-22 Process for the enatioselective hydrolysis of n-derivatised lactams

Publications (2)

Publication Number Publication Date
YU69399A YU69399A (sh) 2002-06-19
RS49542B true RS49542B (sr) 2007-02-05

Family

ID=10817952

Family Applications (1)

Application Number Title Priority Date Filing Date
YUP-693/99A RS49542B (sr) 1997-08-22 1998-08-20 Postupak dobijanja obogaćenih enantiomera N- derivata laktama

Country Status (35)

Country Link
US (1) US6340587B1 (sr)
EP (1) EP1003903B1 (sr)
JP (1) JP3565868B2 (sr)
KR (1) KR100479894B1 (sr)
CN (1) CN1133749C (sr)
AP (1) AP1104A (sr)
AR (1) AR016395A1 (sr)
AT (1) ATE233323T1 (sr)
AU (1) AU738897B2 (sr)
BR (1) BR9810472B1 (sr)
CA (1) CA2295017A1 (sr)
CZ (1) CZ294302B6 (sr)
DE (1) DE69811677T2 (sr)
DK (1) DK1003903T3 (sr)
EA (1) EA001964B1 (sr)
EE (1) EE03934B1 (sr)
ES (1) ES2193568T3 (sr)
GB (1) GB9717928D0 (sr)
HK (1) HK1025796A1 (sr)
HR (1) HRP990408B1 (sr)
HU (1) HU222657B1 (sr)
ID (1) ID25830A (sr)
IL (1) IL133541A (sr)
IN (1) IN183908B (sr)
IS (1) IS2201B (sr)
NO (1) NO320081B1 (sr)
NZ (1) NZ501880A (sr)
PL (1) PL191108B1 (sr)
PT (1) PT1003903E (sr)
RS (1) RS49542B (sr)
SI (1) SI1003903T1 (sr)
SK (1) SK282782B6 (sr)
TR (1) TR199903210T2 (sr)
TW (1) TW589301B (sr)
WO (1) WO1999010519A1 (sr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1095160T3 (da) * 1998-07-09 2004-05-17 Lonza Ag Fremgangsmåde til fremstilling af (1R,4S)-2-azabicyclo[2.2.1]hept-5-en-3-on-derivater
DE19962543A1 (de) 1999-12-23 2001-07-05 Degussa Chromatographische Enantiomerentrennung von bicyclischen Lactamen
US6780635B2 (en) * 2001-12-27 2004-08-24 Council Of Scientific And Industrial Research Process for the preparation of optically active azabicyclo heptanone derivatives
EP1348765B1 (en) * 2002-03-28 2006-05-24 Council of Scientific and Industrial Research Process for the preparation of optically active azabicyclo heptanone derivatives
HU227663B1 (en) * 2007-07-09 2011-10-28 Univ Szegedi Resolution process
ES2969969T3 (es) 2010-01-27 2024-05-23 Viiv Healthcare Co Combinaciones de dolutegravir y lamivudina para el tratamiento de la infección por VIH
CN103695495B (zh) * 2014-01-14 2014-08-27 营口三征新科技化工有限公司 一种制备(1R,4s)-(-)-2-氮杂双环[2,2,1]庚-5-烯-3-酮的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0424064T3 (da) * 1989-10-16 1995-06-26 Chiroscience Ltd Chirale azabicycloheptanoner og fremgangsmåde til fremstilling deraf
GB9108384D0 (en) 1991-04-19 1991-06-05 Enzymatix Ltd Bicycloheptanes
SK285228B6 (sk) * 1997-05-13 2006-09-07 Lonza Ag Spôsob výroby racemického alebo opticky aktívnehoderivátu 4-(hydroxymetyl)-2-cyklopenténu a racemicky N-butyryl-1-amino-4- (hydroxymetyl)-2-cyklopentén

Also Published As

Publication number Publication date
ID25830A (id) 2000-11-09
EE03934B1 (et) 2002-12-16
BR9810472A (pt) 2000-09-19
JP3565868B2 (ja) 2004-09-15
GB9717928D0 (en) 1997-10-29
IS5297A (is) 1999-12-14
PL191108B1 (pl) 2006-03-31
TR199903210T2 (xx) 2000-07-21
HUP0002661A2 (hu) 2000-12-28
WO1999010519A1 (en) 1999-03-04
ATE233323T1 (de) 2003-03-15
TW589301B (en) 2004-06-01
HRP990408A2 (en) 2000-04-30
SI1003903T1 (en) 2003-08-31
KR100479894B1 (ko) 2005-03-30
DE69811677T2 (de) 2003-10-16
KR20010014078A (ko) 2001-02-26
AU9738698A (en) 1999-03-16
NO996368D0 (no) 1999-12-21
NO320081B1 (no) 2005-10-17
SK282782B6 (sk) 2002-12-03
DK1003903T3 (da) 2003-06-10
AP9901721A0 (en) 1999-12-31
CA2295017A1 (en) 1999-03-04
NO996368L (no) 2000-02-21
YU69399A (sh) 2002-06-19
HU222657B1 (hu) 2003-09-29
AU738897B2 (en) 2001-09-27
IS2201B (is) 2007-02-15
HUP0002661A3 (en) 2001-12-28
BR9810472B1 (pt) 2011-01-11
CN1133749C (zh) 2004-01-07
HRP990408B1 (en) 2006-05-31
DE69811677D1 (de) 2003-04-03
AP1104A (en) 2002-09-04
CN1261405A (zh) 2000-07-26
EP1003903A1 (en) 2000-05-31
HK1025796A1 (en) 2000-11-24
JP2001504354A (ja) 2001-04-03
US6340587B1 (en) 2002-01-22
PT1003903E (pt) 2003-06-30
IN183908B (sr) 2000-05-13
CZ471699A3 (cs) 2000-06-14
IL133541A0 (en) 2001-04-30
EP1003903B1 (en) 2003-02-26
PL337647A1 (en) 2000-08-28
SK184499A3 (en) 2000-09-12
AR016395A1 (es) 2001-07-04
NZ501880A (en) 2001-08-31
ES2193568T3 (es) 2003-11-01
EA199901059A1 (ru) 2000-08-28
EA001964B1 (ru) 2001-10-22
CZ294302B6 (cs) 2004-11-10
EE200000075A (et) 2000-10-16
IL133541A (en) 2003-10-31

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